In vitro genoprotective and genotoxic effect of nicotine on human leukocytes evaluated by the comet assay

References

• Abreu-Villaca Y, Seidler FJ, Qiao D, et al. (2005). Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells. Brain Res Dev Brain Res 154:239–246
   PubMedGoogle Scholar
• Arabi M. (2004). Nicotinic infertility: assessing DNA and plasma membrane integrity of human spermatozoa. Andrologia 36:305–310
   PubMed Web of Science ®Google Scholar
• Argentin G, Cicchetti R. (2004). Genotoxic and antiapoptotic effect of nicotine on human gingival fibroblasts. Toxicol Sci 79:75–81
   PubMed Web of Science ®Google Scholar
• Arias HR, Richards VE, Ng D, et al. (2009). Role of non-neuronal nicotinic acetylcholine receptors in angiogenesis. Int J Biochem Cell Biol 41:1441–1451
   PubMed Web of Science ®Google Scholar
• Attia SM. (2007a). Chromosomal composition of micronuclei in mouse bone marrow treated with rifampicin and nicotine, analyzed by multicolor fluorescence in situ hybridization with pancentromeric DNA probe. Toxicology 235:112–118
   PubMed Web of Science ®Google Scholar
• Attia SM. (2007b). The genotoxic and cytotoxic effects of nicotine in the mouse bone marrow. Mutat Res 632:29–36
   PubMed Web of Science ®Google Scholar
• Baron JA. (1996). Beneficial effects of nicotine and cigarette smoking: the real, the possible and the spurious. Br Med Bull 52:58–73
   PubMed Web of Science ®Google Scholar
• Benowitz NL, Hukkanen J, Jacob P 3rd. (2009). Nicotine chemistry, metabolism, kinetics and biomarkers. Handb Exp Pharmacol 192:29–60
   PubMedGoogle Scholar
• Collins AR. (2004). The comet assay for DNA damage and repair: principles, applications, and limitations. Mol Biotechnol 26:249–261
   PubMed Web of Science ®Google Scholar
• Collins AR, Oscoz AA, Brunborg G, et al. (2008). The comet assay: topical issues. Mutagenesis 23:143–151
   PubMed Web of Science ®Google Scholar
• DeMarini DM, Gudi R, Szkudlinska A, et al. (2008). Genotoxicity of 10 cigarette smoke condensates in four test systems: comparisons between assays and condensates. Mutat Res 650:15–29
   PubMed Web of Science ®Google Scholar
• Doolittle DJ, Winegar R, Lee CK, et al. (1995). The genotoxic potential of nicotine and its major metabolites. Mutat Res 344:95–102
   PubMed Web of Science ®Google Scholar
• Faust F, Kassie F, Knasmüller S, et al. (2004). The use of the alkaline comet assay with lymphocytes in human biomonitoring studies. Mutat Res 566:209–229
   PubMed Web of Science ®Google Scholar
• Ferger B, Spratt C, Earl CD, et al. (1998). Effects of nicotine on hydroxyl free radical formation in vitro and on MPTP-induced neurotoxicity in vivo. Naunyn Schmiedebergs Arch Pharmacol 358:351–359
   PubMed Web of Science ®Google Scholar
• Ginzkey C, Kampfinger K, Friehs G, et al. (2009). Nicotine induces DNA damage in human salivary glands. Toxicol Lett 184:1–4
   PubMed Web of Science ®Google Scholar
• Ginzkey C, Stueber T, Friehs G, et al. (2012). Analysis of nicotine-induced DNA damage in cells of the human respiratory tract. Toxicol Lett 208:23–29
   PubMed Web of Science ®Google Scholar
• Gosselin RE, Smith RP, Hodge HC. (1988). Clinical toxicology of commercial products, 6th ed. Baltimore, MD: Williams & Wilkins
   Google Scholar
• Guan ZZ, Yu WF, Nordberg A. (2003). Dual effects of nicotine on oxidative stress and neuroprotection in PC12 cells. Neurochem Int 43:243–249
   PubMed Web of Science ®Google Scholar
• Gvozdjakova A, Kucharska J, Gvozdják J. (1992). Effect of smoking on the oxidative processes of cardiomyocytes. Cardiology 81:81–84
   PubMed Web of Science ®Google Scholar
• Hall J, Brésil H, Donato F, et al. (1993). Alkylation and oxidative-DNA damage repair activity in blood leukocytes of smokers and non-smokers. Int J Cancer 54:728–733
   PubMed Web of Science ®Google Scholar
• Harris G, Holmes A, Sabovljev SA, et al. (1986). Sensitivity to X-irradiation of peripheral blood lymphocytes from ageing donors. Int J Radiat Biol Relat Stud Phys Chem Med 50:685–694
   PubMed Web of Science ®Google Scholar
• Hartmann A, Elhajouji A, Kiskinis E, et al. (2001). Use of the alkaline comet assay for industrial genotoxicity screening: comparative investigation with the micronucleus test. Food Chem Toxicol 39:843–858
   PubMed Web of Science ®Google Scholar
• Hartmann A, Schumacher M, Plappert-Helbig U, et al. (2004). Use of the alkaline in vivo comet assay for mechanistic genotoxicity investigations. Mutagenesis 19:51–59
   PubMed Web of Science ®Google Scholar
• Herman AI, Sofuoglu M. (2010). Comparison of available treatments for tobacco addiction. Curr Psychiatry Rep 12:433–440
   PubMed Web of Science ®Google Scholar
• Hoffmann H, Speit G. (2005). Assessment of DNA damage in peripheral blood of heavy smokers with the comet assay and the micronucleus test. Mutat Res 581:105–114
   PubMed Web of Science ®Google Scholar
• Hukkanen J, Jacob P 3rd, Benowitz NL. (2005). Metabolism and disposition kinetics of nicotine. Pharmacol Rev 57:79–115
   PubMed Web of Science ®Google Scholar
• IARC (International Agency for Research on Cancer). (2004). IARC monographs on the evaluation of carcinogenic risks to humans: tobacco smoke and involuntary smoking, vol. 83. Lyon, France: IARC Scientific Publications
   Google Scholar
• IARC (International Agency for Research on Cancer). (2007). IARC monographs on the evaluation of carcinogenic risks to humans: smokeless tobacco and some tobacco-specific N-nitrosamines, vol. 89. Lyon, France: IARC Scientific Publications
   Google Scholar
• Idris AM, Ibrahim SO, Vasstrand EN, et al. (1998). The Swedish snus and the Sudanese toombak: are they different? Oral Oncol 34:558–566
   PubMed Web of Science ®Google Scholar
• Jarvik ME. (1991). Beneficial effects of nicotine. Br J Addict 86:571–575
   PubMedGoogle Scholar
• Kleinsasser NH, Sassen AW, Semmler MP, et al. (2005). The tobacco alkaloid nicotine demonstrates genotoxicity in human tonsillar tissue and lymphocytes. Toxicol Sci 86:309–317
   PubMed Web of Science ®Google Scholar
• Kohn KW, Bohr VA. (2002). Genomic instability and DNA repair. In: Alison M, ed. The cancer handbook. London: Nature Publishing Group, 87–106
   Google Scholar
• Koleva II, van Beek TA, Soffers AE, et al. (2012). Alkaloids in the human food chain – natural occurrence and possible adverse effects. Mol Nutr Food Res 56:30–52
   PubMed Web of Science ®Google Scholar
• Konca K, Lankoff A, Banasik A, et al. (2003). A cross-platform public domain PC image-analysis program for the comet assay. Mutat Res 534:15–20
   PubMed Web of Science ®Google Scholar
• Lee E, Oh E, Lee J, et al. (2004). Use of the tail moment of the lymphocytes to evaluate DNA damage in human biomonitoring studies. Toxicol Sci 81:121–132
   PubMed Web of Science ®Google Scholar
• Leroy T, Van Hummelen P, Anard D, et al. (1996). Evaluation of three methods for the detection of DNA single-strand breaks in human lymphocytes: alkaline elution, nick translation, and single-cell gel electrophoresis. J Toxicol Environ Health 47:409–422
   PubMed Web of Science ®Google Scholar
• Lovell DP, Omori T. (2008). Statistical issues in the use of the comet assay. Mutagenesis 23:171–182
   PubMed Web of Science ®Google Scholar
• Matta SG, Balfour DJ, Benowitz NL, et al. (2007). Guidelines on nicotine dose selection for in vivo research. Psychopharmacology (Berl) 190:269–319
   PubMed Web of Science ®Google Scholar
• Mizusaki S, Okamoto H, Akiyama A, Fukuhara Y. (1977). Relation between chemical constituents of tobacco and mutagenic activity of cigarette smoke condensate. Mutat Res 48:319–325
   PubMed Web of Science ®Google Scholar
• Møller P. (2006). The alkaline comet assay: towards validation in biomonitoring of DNA damaging exposures. Basic Clin Pharmacol Toxicol 98:336–345
   PubMed Web of Science ®Google Scholar
• Møller P, Knudsen LE, Loft S, Wallin H. (2000). The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors. Cancer Epidemiol Biomarkers Prev 9:1005–1015
   PubMed Web of Science ®Google Scholar
• Muthukumaran S, Sudheer AR, Nalini N, Menon VP. (2008). Effect of quercetin on nicotine-induced biochemical changes and DNA damage in rat peripheral blood lymphocytes. Redox Rep 13:217–224
   PubMed Web of Science ®Google Scholar
• Olive PL, Banath JP. (2006). The comet assay: a method to measure DNA damage in individual cells. Nat Protoc 1:23–29
   PubMed Web of Science ®Google Scholar
• Olive PL, Durand RE, Le Riche J, et al. (1993). Gel electrophoresis of individual cells to quantify hypoxic fraction in human breast cancers. Cancer Res 53:733–736
   PubMed Web of Science ®Google Scholar
• Pogocki D, Ruman T, Danilczuk M, et al. (2007). Application of nicotine enantiomers, derivatives and analogues in therapy of neurodegenerative disorders. Eur J Pharmacol 563:18–39
   PubMed Web of Science ®Google Scholar
• Sassen AW, Richter E, Semmler MP, et al. (2005). Genotoxicity of nicotine in mini-organ cultures of human upper aerodigestive tract epithelia. Toxicol Sci 88:134–141
   PubMed Web of Science ®Google Scholar
• Singh NP. (2000). Microgels for estimation of DNA strand breaks, DNA protein crosslinks and apoptosis. Mutat Res 455:111–127
   PubMed Web of Science ®Google Scholar
• Singh NP, McCoy MT, Tice RR, Schneider EL. (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184–191
   PubMed Web of Science ®Google Scholar
• Sobkowiak R, Lesicki A. (2009). Genotoxicity of nicotine in cell culture of Caenorhabditis elegans evaluated by the comet assay. Drug Chem Toxicol 32:252–257
   PubMed Web of Science ®Google Scholar
• Sobkowiak R, Lesicki A. (2011). Cell signaling pathways activated by nicotine. Adv Cell Biol 38:581–596
   Google Scholar
• Soto-Otero R, Méndez-Alvarez E, Hermida-Ameijeiras A, et al. (2002). Effects of (−)-nicotine and (−)-cotinine on 6-hydroxydopamine-induced oxidative stress and neurotoxicity: relevance for Parkinson’s disease. Biochem Pharmacol 64:125–135
   PubMed Web of Science ®Google Scholar
• Speit G, Witton-Davies T, Heepchantree W, et al. (2003). Investigations on the effect of cigarette smoking in the comet assay. Mutat Res 542:33–42
   PubMed Web of Science ®Google Scholar
• Sudheer AR, Muthukumaran S, Devipriya N, Menon VP. (2007a). Ellagic acid, a natural polyphenol protects rat peripheral blood lymphocytes against nicotine-induced cellular and DNA damage in vitro: with the comparison of N-acetylcysteine. Toxicology 230:11–21
   PubMed Web of Science ®Google Scholar
• Sudheer AR, Muthukumaran S, Kalpana C, et al. (2007b). Protective effect of ferulic acid on nicotine-induced DNA damage and cellular changes in cultured rat peripheral blood lymphocytes: a comparison with N-acetylcysteine. Toxicol In Vitro 21:576–585
   PubMed Web of Science ®Google Scholar
• Swan GE, Lessov-Schlaggar CN. (2009). Tobacco addiction and pharmacogenetics of nicotine metabolism. J Neurogenet 23:262–271
   PubMed Web of Science ®Google Scholar
• Turner DR, Griffith VC, Morley AA. (1982). Ageing in vivo does not alter the kinetics of DNA strand break repair. Mech Ageing Dev 19:325–331
   PubMed Web of Science ®Google Scholar
• Villablanca AC. (1998). Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro. J Appl Physiol 84:2089–2098
   PubMed Web of Science ®Google Scholar
• Wu HJ, Chi CW, Liu TY. (2005). Effects of pH on nicotine-induced DNA damage and oxidative stress. J Toxicol Environ Health A 68:1511–1523
   PubMed Web of Science ®Google Scholar
• Yildiz D, Ercal N, Armstrong DW. (1998). Nicotine enantiomers and oxidative stress. Toxicology 130:155–165
   PubMed Web of Science ®Google Scholar