249
Views
18
CrossRef citations to date
0
Altmetric
Research Article

Thearubigins protect against acetaminophen-induced hepatic and renal injury in mice: biochemical, histopathological, immunohistochemical, and flow cytometry study

, , , , &
Pages 190-198 | Received 01 Feb 2015, Accepted 03 Jul 2015, Published online: 03 Aug 2015

References

  • Aqil F, Ahmad I, Mehmood Z. (2006). Antioxidant and free radical scavenging properties of twelve traditionally used Iranian medicinal plants. Turk J Bio 30:177–183
  • Bessems JG, Vermeulen NP. (2001). Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues, and protective approaches. Rev Toxicol 31:55–138
  • Cekmen M, Ilbey YO, Ozbek E, et al. (2009). Curcumin prevents oxidative renal damage induced by acetaminophen in rats. Food Chem Toxicol 47:1480–1484
  • Chaudhuri L, Basu S, Seth P, et al. (2000). Prokinetic effect of black tea on gastrointestinal motility. Life Sci 66:847–854
  • Chen X, Sun CK, Han GZ, et al. (2009). Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significantly correlated with cytochrome P450 suppression. World J Gastroenterol 15:1829–1835
  • Cover C, Mansouri A, Knight TR, et al. (2005). Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exper Therap 315:879–887
  • Das J, Ghosh J, Manna P, Sil PC. (2010). Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation. Toxicology 269:24–34
  • Gopi KS, Reddy AG, Jyothi K, Kumar BA. (2010). Acetaminophen-induced hepato- and nephrotoxicity and amelioration by silymarin and terminalia chebula in rats. Toxicol Int 17:64–66
  • Gu J, Cui H, Behr M, et al. (2005). In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa. Mol Pharmacol 67:623–630
  • Gupta S, Chaudhuri T, Ganguly DK, Giri AK. (2001). Anticlastogenic effect of black tea (world blend) and its two active polyphenols theaflavins in vitro in Swiss albino mice. Life Sci 69:2735–2744
  • Higdon JV, Frei B. (2003). Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit Rev Food Sci Nutr 43:89–143
  • Hinson JA, Roberts DW, James LP. (2010). Mechanisms of acetaminophen-induced liver necrosis. Handb Exp Pharmacol 196:369–405
  • Imaeda AB, Watanabe A, Sohail MA, et al. (2009). Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest 119:305–314
  • Jaeschke H, Bajt ML. (2006). Intracellular signaling mechanisms of acetaminophen-induced liver cell death. Toxicol Sci 89:31–41
  • James LP, McCullough SS, Lamps LW, Hinson JA. (2003). Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation. Toxicol Sci 75:458–467
  • Karori SM, Wachira FN, Wanyoko JK, Ngure RM. (2007). Antioxidant capacity of different types of tea products. Af J Biotech 6:2287–2296
  • Kuhnert N. (2010). Unraveling the structure of the black tea thearubigins. Arch Biochem Biophys 501:37–51
  • Larson AM, Polson J, Fontana RJ, et al. (2005). Acute Liver Failure Study Group. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 42:1364–1372
  • Lawson JA, Farhood A, Hopper RD, et al. (2000). The hepatic inflammatory response after acetaminophen overdose: role of neutrophils. Toxicol Sci 54:509–516
  • Leung LK, Su Y, Chen R, et al. (2001). Theaflavins in black tea and catechins in green tea are equally effective antioxidants. J Nutrition 131:2248–2251
  • Li D, Wang N, Wan X. (2005). Thearubigins: the complicated polyphenols in black tea. 2005 International Symposium on Innovation in Tea Science and Sustainable Development in Tea Industry. 2005 Nov 11–15; Hangzhou, China, pp. 647–658
  • Lim AY, Segarra I, Chakravarthi S, et al. (2010). Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice. BMC Pharmacol 15:10–14
  • Lorz C, Justo P, Sanz A, et al. (2004). Paracetamol-induced renal tubular injury: a role for ER stress. J Am Soc Nephrol 15:380–389
  • Lorz C, Justo P, Sans AB, et al. (2005). Role of Bcl-xL in paracetamol-induced tubular epithelial cell death. Kidney Int 67:592–601
  • Manov I, Hirsh M, Iancu TC. (2002). Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells. Exp Toxicol Pathol 53:489–500
  • Mazer M, Perrone J. (2008). Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management. J Med Toxicol 4:2–6
  • McGill MR, Williams CD, Xie Y, et al. (2012). Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. Toxicol Appl Pharmacol 264:387–394
  • Mehri D, Monsef-Esfahani HR, Gharibzadeh S, et al. (2008). Effects of black tea extract and its thearubigins on whole gut transit time in mice: involvement of 5-HT3 receptors. Jundishapur J Nat Pharm Prod 3:39–44
  • Mour G, Feinfeld DA, Caraccio T, McGuigan M. (2005). Acute renal dysfunction in acetaminophen poisoning. Ren Fail 27:381–383
  • Murad HA, Abdallah HM. (2014). Black tea extract and its thearubigins relieve the sildenafil-induced delayed gut motility in mice: a possible role of nitric oxide. Phytother Res 28:1687–1691
  • Oz HS, McClain CJ, Nagasawa HT, et al. (2004). Diverse antioxidants protect against acetaminophen hepatotoxicity. J Biochem Mol Toxicol 18:361–368
  • Pozarowski P, Darzynkiewicz Z. (2004). Analysis of cell cycle by flow cytometry methods. Methods Mol Biol 281:301–311
  • Saito C, Zwingmann C, Jaeschke H. (2010). Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine. Hepatology 51:246–254
  • Stern ST, Bruno MK, Hennig GE, et al. (2005). Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity in CD-1 mice: I. Enhancement of acetaminophen nephrotoxicity by acetaminophen-cysteine. Toxicol Appl Pharmacol 202:151–159
  • Sun S, Pan S, Ling C, et al. (2012). Free radical scavenging abilities in vitro and antioxidant activities in vivo of black tea and its main polyphenols. J Medic Plant Res 6:114–121
  • Von Mach MA, Hermanns-Clausen M, Koch I, et al. (2005). Experiences of a poison center network with renal insufficiency in acetaminophen overdose: an analysis of 17 cases. Clin Toxicol 43:31–37
  • Wancket LM, Meng X, Rogers LK, Liu Y. (2012). Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury. Toxicol Pathol 40:1095–1105
  • Yoshino K, Hara Y, Sano M, Tomita I. (1994). Antioxidative effects of black tea theaflavins and thearubigin on lipid peroxidation of rat liver homogenates induced by tert-butyl hydroperoxide. Biol Pharm Bull 17:146–149

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.