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Research Article

Mutagenicity and preclinical safety assessment of the aqueous extract of Clinacanthus nutans leaves

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Pages 461-473 | Received 13 Jun 2015, Accepted 21 Feb 2016, Published online: 01 Apr 2016

References

  • Abdullah WZ, Moufak SK, Yusof Z, et al. (2010). Shortened activated partial thromboplastin time, a hemostatic marker for hypercoagulable state during acute coronary event. Transl Res 155:315–319
  • Ames BN, Mccann J, Yamasaki E. (1975). Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test. Mutat Res 31:347–363
  • Baker HJ, Lindsey JR, Wesibroth SH. (2013). The laboratory rat: biology and diseases. Pennsylvania: Elsevier Science
  • Chin JH, Akyirem A, Chacko MIbrahim S. (2014). Sub-acute (28 days) toxicity study of methanol leaves extract of Clinacanthus nutans in rats. Int J Pharm 4:61–69
  • Cho YE, Lomeda RR, Ryu SH, et al. (2007). Zinc deficiency negatively affects alkaline phosphatase and the concentration of Ca, Mg and P in rats. Nutr Res Pract 1:113–119
  • European Medicines Agency. (2007). Guideline on the limits of genotoxic impurities [Online]. Available from: http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/general/general_content_000397.jsp&mid=WC0b01ac058002956f
  • Evans GO. (2008). Animal hematotoxicology: a practical guide for toxicologists and biomedical researchers. Abingdon: CRC Press
  • Evans GO. (2009). Animal clinical chemistry: a practical handbook for toxicologists and biomedical researchers. 2nd ed. Abingdon: CRC Press
  • Farsi E, Shafaei A, Hor SY, et al. (2013). Genotoxicity and acute and subchronic toxicity studies of a standardized methanolic extract of Ficus deltoidea leaves. Clinics (Sao Paulo) 68:865–875
  • Feng LJ, Yu CH, Ying KJ, et al. (2011). Hypolipidemic and antioxidant effects of total flavonoids of Perilla Frutescens leaves in hyperlipidemia rats induced by high-fat diet. Food Res Int 44:404–409
  • Gad SC. (2008). Preclinical development handbook: toxicology. New York City: John Wiley & Sons
  • Gad SC. (2009). Drug safety evaluation. New York City: John Wiley & Sons
  • Gan G, Leong Y, Bee P, Chin ETeh A. (2015). Complementary and alternative medicine use in patients with hematological cancers in Malaysia. Support Care Cancer 23:1–8
  • Guajardo JR, Plotnick LM, Fende JM, et al. (2002). Eosinophil-associated gastrointestinal disorders: a world-wide-web based registry. J Pediatrics 141:576–581
  • Hamdy RC, Lewiecki EM. (2013). Osteoporosis. Northamptonshire: OUP
  • Hanson RW, Owen OE. (2013). Gluconeogenesis. In: Lane WJLD, ed. Encyclopedia of biological chemistry. Waltham (MA): Academic Press, 381–386
  • Hayes AW. (2007). Principles and methods of toxicology. 5th ed. Boca Raton: Taylor & Francis
  • Hor SY, Farsi E, Yam MF, et al. (2011). Lipid-lowering effects of Coriolus versicolor extract in poloxamer 407-induced hypercholesterolaemic rats and high cholesterol-fed rats. J Med Plant Res 5:2261–2266
  • Inoue Y, Matsuwaki Y, Shin S-H, et al. (2005). Nonpathogenic, environmental fungi induce activation and degranulation of human eosinophils. J Immunol 175:5439–5447
  • Janwitayanuchit W, Suwanborirux K, Patarapanich C, et al. (2003). Synthesis and anti-herpes simplex viral activity of monoglycosyl diglycerides. Phytochemistry 64:1253–1264
  • Naber TH, Baadenhuysen H, Jansen JB, et al. (1996). Serum alkaline phosphatase activity during zinc deficiency and long-term inflammatory stress. Clin Chim Acta 249:109–127
  • NPCB. (2015). Product registration [Online]. Malaysia National Pharmaceutical Control Bureau. Available from: http://portal.bpfk.gov.my/index.php/product-registration
  • OECD. (1998). Test No. 408: repeated dose 90-day oral toxicity study in rodents: OECD Guidelines for the Testing of Chemicals. Paris: OECD Publishing
  • OECD. (2008a). Test No. 407: repeated dose 28-day oral toxicity study in rodents: OECD Guidelines for the Testing of Chemicals. Paris: OECD Publishing
  • OECD. (2008b). Test No. 425: acute oral toxicity: up-and-down procedure: OECD Guidelines for the Testing of Chemicals. Paris: OECD Publishing
  • Patchareewan P, Pisamai L, Veerapol K, et al. (2007). Antioxidant activity and protective effect against oxidative hemolysis of Clinacanthus nutans (Burm. f) Lindau. J Sci Technol 29:1–9
  • P’ng XW, Akowuah GA, Chin JH. (2012). Acute oral toxicity study of Clinacanthus nutans in mice. Int J Pharm Sci Res 3:4202–4205
  • P’ng XW, Akowuah GA, Chin JH. (2013). Evaluation of the sub-acute oral toxic effect of methanol extract of Clinacanthus nutans leaves in rats. J Acute Dis 2:29–32
  • P’ng TW, Wen PX, Han CJ, Akowuah GA. (2014). Effect of methanol extract of clinacanthus nutans on serum biochemical parameters in rat. J Appl Pharm Sci 6:77–86
  • Rathnasamy S, Mohamed KB, Sulaiman SF, Akinboro A. (2013). Evaluation of cytotoxic, mutagenic and antimutagenic potential of leaf extracts of three medicinal plants using Allium cepa chromosome assay. Int Curr Pharm J 2:131–140
  • Sakdarat S, Shuyprom A, Pientong C, et al. (2009). Bioactive constituents from the leaves of Clinacanthus nutans Lindau. Bioorg Med Chem 17:1857–1860
  • Sangkitporn S, Chaiwat S, Balachandra K, et al. (1995). Treatment of herpes zoster with Clinacanthus nutans (bi phaya yaw) extract. J Med Assoc Thai 78:624–627
  • Tunnicliffe JM, Shearer J. (2008). Coffee, glucose homeostasis, and insulin resistance: physiological mechanisms and mediators. Appl Physiol Nutr Metab 33:1290–1300
  • Wang X, Zhao X, Gu L, et al. (2014). Simultaneous determination of five free and total flavonoids in rat plasma by ultra HPLC-MS/MS and its application to a comparative pharmacokinetic study in normal and hyperlipidemic rats. J Chromatogr B 953–954:1–10
  • Wanikiat P, Panthong A, Sujayanon P, et al. (2008). The anti-inflammatory effects and the inhibition of neutrophil responsiveness by Barleria lupulina and Clinacanthus nutans extracts. J Ethnopharmacol 116:234–244
  • Wechsler JB, Bryce PJ. (2014). Allergic mechanisms in eosinophilic esophagitis. Gastroenterol Clin North Am 43:281–296
  • Woodman D. (1988). Assessment of hepatic function and damage in animal species. A review of the current approach of the academic, governmental and industrial institutions represented by the Animal Clinical Chemistry Association. J Appl Toxicol 8:249–254

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