143
Views
3
CrossRef citations to date
0
Altmetric
Research Article

High Frequency of Mutations in the PIK3CA Gene Helical and Kinase Coding Regions in a Group of Iranian Patients with High-Grade Glioblastomas: Five Novel Mutations

, , , , &
Pages 189-194 | Received 29 May 2011, Accepted 09 Sep 2011, Published online: 25 Oct 2011

REFERENCES

  • Broderick D. K., Di C., Parrett T. J., Samuels Y. R., Cummins J. M., & McLendon R. E., Fults (2004). Mutations of PIK3CA in anaplasticoligodendrogliomas, high-grade astrocytomas, and medulloblastomas. Cancer Res, 64, 5048–5050.
  • DeAngelis, L. M. (2001). Brain tumors. N Engl J Med, 344, 114–123.
  • Derakhshandeh-Peykar P., Esmaili M., Ousati-Ashtiani Z., Rahmani M., Babrzadeh F., Farshidi S., Attaran E., Sajedifar M. M., & Farhud D. D. (2007). Molecular analysis of the SMN1 and NAIP genes in iranian patients with spinal muscular atrophy. Ann Acad Med Singapore, 36, 937–941.
  • Dilmaghani Zadeh M., Amini R., Firoozray M., & Derakhshandeh-Peykar P. (2007). Frequent homozygous deletion of p16/CDKN24 gene in malignant gliomas of Iranian patients. Pakistan J Biol Sci, 10, 4246–4250.
  • Fruman, D. A., Meyers, R. E., & Cantley, L. C. (1998). Phosphoinositide kinase. Annu Rev Biochem, 67, 481–507.
  • Gallia G. L., Rand V., Siu I. M. Eberhart C. G., James C. D., Marie S. K., Oba-Shinjo S. M., Carlotti C. G., Caballero O. L., Simpson A. J., Brock M. V., Massion P. P., Carson B. S. Sr, & Riggins G. J. (2006). PIK3CA gene mutations in pediatric and adult glioblastoma multiforme. Mol Cancer Res, 4, 709–714.
  • Habibi Roudknar M., Najmabadi H., Derakhshandeh-Peykar P., & Farhud D. D. (2003). Detection of rare and unknown mutations in β-thalassemia traits in Iran. Iran J Public Health, 32, 11–14.
  • Hartmann C., Bartels G., Gehlhaar C., Holtkamp N., & von Deimling A. (2005). PIK3CA mutations in glioblastoma multiforme. Acta Neuropathol, 109, 639–642.
  • Kamb A., Gruis N. A., Weaver-Feldhaus J., Liu Q., Harshman K., Tavtigian S. V., Stockert E., Day R. S. 3rd, Johnson B. E., & Skolnick M. H. (1994). A cell cycle regulator potentially involved in genesis of many tumor types. Science, 264, 436–440.
  • Kleihues, P., & Cavenee, W. (2000). Pathology and genetics of tumors of the nervous system. Lyon: IARC.
  • Knobbe, C. B., Trampe-Kieslich, A., & Reifenberger, G. (2005). Genetic alteration, and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. Neuropathol Applied Neurobiol, 31, 486–490.
  • Kyritsis, A. P., Bondy, M. L., Rao, J. S., & Sioka, C. (2010). Inherited predisposition to glioma. Neuro Oncol, 12, 104–13.
  • Louis D. N., Ohgaki H., Wiestler O. D., Cavenee W. K., Burger P. C., Jouvet A., Scheithauer B. W., Kleihues P. Comp: Space all ref au initials pls. (2007). WHO classification of tumors of the central nervous system. Lyon: IARC.
  • Mueller W., Mizoguchi M., Silen E. D'Amore K., Nutt C. L., & Louis D. N. (2005). Mutations of the PIK3CA gene are rare in human glioblastoma. Acta Neuropathol, 109, 654–655.
  • Newcomb E. W., Alonso M., Sung T., & Miller D. C. (2000). Incidence of p14ARF gene deletion in high-grade adult and pediatric astrocytomas. Human Pathol, 31, 115–119.
  • Ohgaki H., Dessen P., Jourde B., Horstmann S., Nishikawa T., Di Patre P. L., Burkhard C., Schüler D., Probst-Hensch N. M., Maiorka P. C., Baeza N., Pisani P., Yonekawa Y., Yasargil M. G., Lütolf U. M., & Kleihues P. (2004). Genetic pathways to glioblastoma: A population-based study. Cancer Res, 64, 6892–6899.
  • Ohgaki H., & Kleihues P. (2007). Genetic pathways to primary and secondary Glioblastoma. Am J Pathol, 170, 1445–1453.
  • Pollack I. F., Finkelstein S. D., Burnham J., Holmes E. J., Hamilton R. L., Yates A. J., Finlay J. L., Sposto R.; Children's Cancer Group. (2001). Age and TP53 mutation frequency in childhood malignant gliomas: Results in a multi-institutional cohort. Cancer Res, 61, 7404–7407.
  • Samuels Y., Wang Z., Bardelli, Silliman N., Ptak J., Szabo S., Yan H., Gazdar A., Powell S. M., Riggins G. J., Willson J. K., Markowitz S., Kinzler K. W., Vogelstein B., & Velculescu V. E. (2004). High frequency of mutations of the PIK3CA gene in human cancers. Science, 304, 554.
  • Shi S. R., Cote R. J., Wu L., Liu C., Datar R., Shi Y., Liu D., Lim H., & Taylor C. R. (2002). DNA extraction from archival formalin-fixed, paraffin-embedded tissue sections based on the antigen retrieval principle: Heating under the influence of pH. J Histochem Cytochem, 50, 1005–1011.
  • Zhao J. J., Cheng H., Jia S., Wang L., Gjoerup O. V., Mikami A., & Roberts T. M. (2006). The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc Natl Acad Sci U S A, 103, 16296–300.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.