181
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Alveolar macrophages reduce airway hyperresponsiveness and modulate cytokine levels

, , &
Pages 255-261 | Received 25 Jun 2009, Accepted 13 Oct 2009, Published online: 24 May 2010

REFERENCES

  • Wardlaw AJ, Brightling CE, Green R, Woltmann G, Bradding P, Pavord ID: New insights into the relationship between airway inflammation and asthma. Clin Sci (Lond). 2002;103:201–211.
  • Townley RG, Horiba M: Airway hyperresponsiveness: a story of mice and men and cytokines. Clin Rev Allergy Immunol. 2003;24:85–110.
  • Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM: Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med. 2000;161:1720–1745.
  • Le Gros G, Erb K, Harris N, Holloway J, McCoy K, Ronchese F: Immunoregulatory networks in asthma. Clin Exp Allergy. 1998;28(Suppl 5):92–96; discussion 117–118.
  • Bissonnette EY: Alveolar macrophages in asthma pathogenesis. Recent Res Devel Allergy Clin Immunol. 2000;1:129–141.
  • Haslett C: Granulocyte apoptosis and its role in the resolution and control of lung inflammation. Am J Respir Crit Care Med. 1999;160:S5–S11.
  • Thepen T, McMenamin C, Oliver J, Kraal G, Holt PG: Regulation of immune response to inhaled antigen by alveolar macrophages: differential effects of in vivo alveolar macrophage elimination on the induction of tolerance vs. immunity. Eur J Immunol. 1991;21:2845–2850.
  • Thepen T, McMenamin C, Girn B, Kraal G, Holt PG: Regulation of IgE production in pre-sensitized animals: in vivo elimination of alveolar macrophages preferentially increases IgE responses to inhaled allergen. Clin Exp Allergy. 1992;22:1107–1114.
  • Careau E, Bissonnette EY: Adoptive transfer of alveolar macrophages abrogates bronchial hyperresponsiveness. Am J Respir Cell Mol Biol 2004;31:22–27.
  • Waserman S, Olivenstein R, Renzi P, Xu LJ, Martin JG: The relationship between late asthmatic responses and antigen-specific immunoglobulin. J Allergy Clin Immunol. 1992;90:661–669.
  • Renzi PM, Olivenstein R, Martin JG: Inflammatory cell populations in the airways and parenchyma after antigen challenge in the rat. Am Rev Respir Dis. 1993;147:967–974.
  • Bellofiore S, Martin JG: Antigen challenge of sensitized rats increases airway responsiveness to methacholine. J Appl Physiol. 1988;65:1642–1646.
  • Pouliot P, Spahr A, Careau E, Turmel V, Bissonnette EY: Alveolar macrophages from allergic lungs are not committed to a pro-allergic response and can reduce airway hyperresponsiveness following ex vivo culture. Clin Exp Allergy. 2008;38:529–538.
  • Careau E, Sirois J, Bissonnette EY: Characterization of lung hyperresponsiveness, inflammation, and alveolar macrophage mediator production in allergy resistant and susceptible rats. Am J Respir Cell Mol Biol. 2002;26:579–586.
  • Hamid Q, Tulic M: Immunobiology of asthma. Annu Rev Physiol. 2009;71:489–507.
  • Eum SY, Maghni K, Tolloczko B, Eidelman DH, Martin JG: IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2005;288:L576–L584.
  • Kips JC, Tavernier J, Pauwels RA: Tumor necrosis factor causes bronchial hyperresponsiveness in rats. Am Rev Respir Dis. 1992;145:332–336.
  • Wardlaw AJ, Dunnette S, Gleich GJ, Collins JV, Kay AB: Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am Rev Respir Dis. 1988;137:62–69.
  • Bradley BL, Azzawi M, Jacobson M, Assoufi B, Collins JV, Irani AM, : Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J Allergy Clin Immunol. 1991;88:661–674.
  • Crimi E, Spanevello A, Neri M, Ind PW, Rossi GA, Brusasco V: Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma. Am J Respir Crit Care Med. 1998;157:4–9.
  • Alvarez MJ, Olaguibel JM, Garcia BE, Rodriquez A, Tabar AI, Urbiola E: Airway inflammation in asthma and perennial allergic rhinitis. Relationship with nonspecific bronchial responsiveness and maximal airway narrowing. Allergy. 2000;55:355–362.
  • Brusasco V, Pellegrino R: Complexity of factors modulating airway narrowing in vivo: relevance to assessment of airway hyperresponsiveness. J Appl Physiol. 2003;95:1305–1313.
  • Hancock A, Armstrong L, Gama R, Millar A: Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung. Am J Respir Cell Mol Biol. 1998;18:60–65.
  • Minty A, Chalon P, Derocq JM, Dumont X, Guillemot JC, Kaghad M, : Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature. 1993;362:248–250.
  • Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, : Interleukin-13: central mediator of allergic asthma. Science. 1998;282:2258–2261.
  • Kellner J, Gamarra F, Welsch U, Jorres RA, Huber RM, Bergner A: IL-13Ralpha2 reverses the effects of IL-13 and IL-4 on bronchial reactivity and acetylcholine-induced Ca2+ signaling. Int Arch Allergy Immunol. 2007;142:199–210.
  • Leigh R, Ellis R, Wattie J, Donaldson DD, Inman MD: Is interleukin-13 critical in maintaining airway hyperresponsiveness in allergen-challenged mice? Am J Respir Crit Care Med. 2004;170:851–856.
  • Cosentino G, Soprana E, Thienes CP, Siccardi AG, Viale G, Vercelli D: IL-13 down-regulates CD14 expression and TNF-alpha secretion in normal human monocytes. J Immunol. 1995;155:3145–3151.
  • Yanagawa H, Sone S, Haku T, Mizuno K, Yano S, Ohmoto Y, : Contrasting effect of interleukin-13 on interleukin-1 receptor antagonist and proinflammatory cytokine production by human alveolar macrophages. Am J Respir Cell Mol Biol. 1995;12:71–76.
  • Thomas PS, Yates DH, Barnes PJ: Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects. Am J Respir Crit Care Med. 1995;152:76–80.
  • Howarth PH, Babu KS, Arshad HS, Lau L, Buckley M, McConnell W, : Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax. 2005;60:1012–1018.
  • Berry MA, Hargadon B, Shelley M, Parker D, Shaw DE, Green RH, : Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med. 2006;354:697–708.
  • Kim J, McKinley L, Natarajan S, Bolgos GL, Siddiqui J, Copeland S, : Anti-tumor necrosis factor-alpha antibody treatment reduces pulmonary inflammation and methacholine hyper-responsiveness in a murine asthma model induced by house dust. Clin Exp Allergy. 2006;36:122–132.
  • Haddad EB, Rousell J, Lindsay MA, Barnes PJ: Synergy between tumor necrosis factor alpha and interleukin 1beta in inducing transcriptional down-regulation of muscarinic M2 receptor gene expression. Involvement of protein kinase A and ceramide pathways. J Biol Chem. 1996;271:32586–32592.
  • Fryer AD, Maclagan J: Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig. Br J Pharmacol. 1984;83:973–978.
  • Lee AM, Fryer AD, van Rooijen N, Jacoby DB: Role of macrophages in virus-induced airway hyperresponsiveness and neuronal M2 muscarinic receptor dysfunction. Am J Physiol Lung Cell Mol Physiol. 2004;286:L1255–L1259.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.