Increased poly(ADP-ribose) polymerase (PARP)-1 expression and activity are associated with inflammation but not goblet cell metaplasia in murine models of allergen-induced airway inflammation

REFERENCES

• Busse W, Elias J, Sheppard D, Banks-Schlegel S: Airway remodeling and repair. Am J Respir Crit Care Med. 1999;160:1035–1042.
   PubMed Web of Science ®Google Scholar
• Fahy JV, Corry DB, Boushey HA: Airway inflammation and remodeling in asthma. Curr Opin Pulm Med. 2000;6:15–20.
   PubMedGoogle Scholar
• Rogers DF: Airway goblet cell hyperplasia in asthma: hypersecretory and anti-inflammatory? Clin Exp Allergy. 2002;32:1124–1127.
   PubMed Web of Science ®Google Scholar
• Blyth DI: The homeostatic role of bronchoconstriction. Respiration. 2001;68:217–223.
   PubMed Web of Science ®Google Scholar
• Gavett SH, Chen X, Finkelman FD, Wills-Karp M: Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am J Respir Cell Mol Biol. 1994;10:587–593.
   PubMed Web of Science ®Google Scholar
• Blyth DI, Pedrick MS, Savage TJ, Hessel EM, Fattah D: Lung inflammation and epithelial changes in a murine model of atopic asthma. Am J Respir Cell Mol Biol. 1996;14:425–438.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Lamm WJE, Albert RK, Chi EY, Henderson WR, Lewis DB: Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response. Am J Respir Crit Care Med. 1997;155:661–669.
   PubMed Web of Science ®Google Scholar
• Wills-Karp M: Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol. 1999;17: 255–281.
   PubMed Web of Science ®Google Scholar
• Morcillo EJ, Estrela J, Cortijo J: Oxidative stress and pulmonary inflammation: pharmacological intervention with antioxidants. Pharmacol Res. 1999;40:393–404.
   PubMed Web of Science ®Google Scholar
• Dworski R, Murray JJ, Roberts LJ, Oates JA, Morrow JD, Fisher L, : Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress. Am J Respir Crit Care Med. 1999;160:1947–1951.
   PubMed Web of Science ®Google Scholar
• MacNee W: Oxidative stress and lung inflammation in airways disease. Eur J Pharmacol. 2001;429:195–207.
   PubMed Web of Science ®Google Scholar
• Dizdaroglu M: Oxidative damage to DNA in mammalian chromatin [review]. Mutat Res. 1992;275:331–342.
   PubMed Web of Science ®Google Scholar
• Breen AP, Murphy JA: Reactions of oxyl radicals with DNA. Free Radic Biol Med. 1995;18:1033–1077.
   PubMed Web of Science ®Google Scholar
• Barker GF, Manzo ND, Cotich KL, Shone RK, Waxman AB: DNA damage induced by hyperoxia: quantitation and correlation with lung injury. Am J Respir Cell Mol Biol. 2006;35(3):277–288.
   PubMed Web of Science ®Google Scholar
• Berger NA: Poly(ADP-ribose) in the cellular response to DNA damage [review]. Radiat Res. 1985;101:4–15.
   PubMed Web of Science ®Google Scholar
• Althaus FR, Richter C: ADP-ribosylation of proteins. Enzymology and biological significance. Mol Biol Biochem Biophys. 1987;37:1–237.
   PubMedGoogle Scholar
• Burkle A: Poly(ADP-ribose). The most elaborate metabolite of NAD+ [review]. FEBS J. 2005;272:4576–4589.
   PubMed Web of Science ®Google Scholar
• Soriano FG, Pacher P, Mabley J, Liaudet L, Szabo C: Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase. Circ Res. 2001;89:684–691.
   PubMed Web of Science ®Google Scholar
• Koksel O, Yildirim C, Cinel L, Tamer L, Ozdulger A, Basturk M, : Inhibition of poly(ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia-reperfusion in rats. Pharmacol Res. 2005;51:453–462.
   PubMed Web of Science ®Google Scholar
• Liaudet L, Pacher P, Mabley JG, Virag L, Soriano FG, Hasko G, : Activation of poly(ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation. Am J Respir Crit Care Med. 2002;165: 372–377.
   PubMed Web of Science ®Google Scholar
• Pagano A, Metrailler-Ruchonnet I, Aurrand-Lions M, Lucattelli M, Donati Y, Argiroffo CB: Poly(ADP-ribose) polymerase-1 (PARP-1) controls lung cell proliferation and repair after hyperoxia-induced lung damage. Am J Physiol Lung Cell Mol Physiol. 2007;293:L619–L629.
   PubMed Web of Science ®Google Scholar
• Oliver FJ, Menissier-de Murcia J, Nacci C, Decker P, Andriantsitohaina R, Muller S, : Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J. 1999;18:4446–4454.
   PubMed Web of Science ®Google Scholar
• Zingarelli B, Szabo C, Salzman AL: Blockade of poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis. Gastroenterology. 1999;116:335–345.
   PubMed Web of Science ®Google Scholar
• Burkart V, Wang ZQ, Radons J, Heller B, Herceg Z, Stingl L, : Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin. Nat Med. 1999;5:314– 319.
   PubMed Web of Science ®Google Scholar
• Dantzer F, Nasheuer HP, Vonesch JL, De Murcia G, Menissier-de Murcia J: Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication. Nucleic Acids Res. 1998;26:1891–1898.
   PubMed Web of Science ®Google Scholar
• Simbulan-Rosenthal CM, Rosenthal DS, Boulares AH, Hickey RJ, Malkas LH, Coll JM, : Regulation of the expression or recruitment of components of the DNA synthesome by poly(ADP-ribose) polymerase. Biochemistry. 1998;37:9363–9370.
   PubMed Web of Science ®Google Scholar
• Bhatia M, Kirkland JB, Meckling-Gill KA: Overexpression of poly(ADP-ribose) polymerase promotes cell cycle arrest and inhibits neutrophilic differentiation of NB4 acute promyelocytic leukemia cells. Cell Growth Differ. 1996;7:91–100.
   PubMedGoogle Scholar
• McNerney R, Tavasolli M, Shall S, Brazinski A, Johnstone A: Changes in mRNA levels of poly(ADP-ribose) polymerase during activation of human lymphocytes. Biochim Biophys Acta. 1989;1009:185–187.
   PubMed Web of Science ®Google Scholar
• Butler AJ, Ordahl CP: Poly(ADP-ribose) polymerase binds with transcription enhancer factor 1 to MCAT1 elements to regulate muscle-specific transcription. Mol Cell Biol. 1999;19:296–306.
   PubMed Web of Science ®Google Scholar
• Cherney BW, Midura RJ, Caplan AI: Poly(ADP-ribose) synthetase and chick limb mesenchymal cell differentiation. Dev Biol. 1985;112:115–125.
   PubMed Web of Science ®Google Scholar
• Smulson ME, Kang VH, Ntambi JM, Rosenthal DS, Ding R, Simbulan CM: Requirement for the expression of poly(ADP-ribose) polymerase during the early stages of differentiation of 3T3-L1 preadipocytes, as studied by antisense RNA induction. J Biol Chem. 1995;270:119–127.
   PubMed Web of Science ®Google Scholar
• Ha HC, Snyder SH: Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc Natl Acad Sci U S A. 1999;96:13978–13982.
   PubMed Web of Science ®Google Scholar
• de Murcia JM, Niedergang C, Trucco C, Ricoul M, Dutrillaux B, Mark M, : Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci U S A. 1997;94:7303–7307.
   PubMed Web of Science ®Google Scholar
• Ertsey R, Chapin CJ, Kitterman JA, Scavo LM: Ontogeny of poly(ADP-ribose) polymerase-1 in lung and developmental implications. Am J Respir Cell Mol Biol. 2004;30:853– 861.
   PubMed Web of Science ®Google Scholar
• Wang ZQ, Stingl L, Morrison C, Jantsch M, Los M, Schulze-Osthoff K, : PARP is important for genomic stability but dispensable in apoptosis. Genes Dev. 1997;11:2347–2358.
   PubMed Web of Science ®Google Scholar
• Szabo C: Role of poly(ADP-ribose)synthetase in inflammation. Eur J Pharmacol. 1998;350:1–19.
   PubMed Web of Science ®Google Scholar
• Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, : Interleukin-13: central mediator of allergic asthma. Science. 1998;282:2258–2261.
   PubMed Web of Science ®Google Scholar
• Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, : Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 1998;282:2261–2263.
   PubMed Web of Science ®Google Scholar
• Whittaker L, Niu N, Temann A, Stoddard A, Flavell R, Ray A, : IL-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and IL-9. Am J Respir Cell Mol Biol. 2002;27:593–602.
   PubMed Web of Science ®Google Scholar
• Wills-Karp M, Chiaramonte M: Interleukin-13 in asthma. Curr Opin Pulm Med. 2003;9:21–27.
   PubMed Web of Science ®Google Scholar
• Alimam MZ, Piazza FM, Selby D, Letwin N, Huang L, Rose MC: Muc5ac mRNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am J Respir Cell Mol Biol. 2000;22:253–260.
   PubMed Web of Science ®Google Scholar
• Shahzeidi S, Aujla P, Nickola T, Chen Y, Alimam MZ, Rose MC: Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma. Exp Lung Res. 2003;29:549–565.
   PubMed Web of Science ®Google Scholar
• Boulares AH, Zoltoski AJ, Sherif ZA, Jolly P, Massaro D, Smulson ME: Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma. Am J Respir Cell Mol Biol. 2003;28:322–329.
   PubMed Web of Science ®Google Scholar
• Virag L, Bai P, Bak I, Pacher P, Mabley JG, Liaudet L, : Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma. Med Sci Monit. 2004;10:BR77–BR83.
   PubMed Web of Science ®Google Scholar
• Szabo C, Lim LH, Cuzzocrea S, Getting SJ, Zingarelli B, Flower RJ, : Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects. J Exp Med. 1997;186:1041–1049.
   PubMed Web of Science ®Google Scholar
• Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, : Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalitites, and eotaxin production. J Clin Invest. 1999;103:779–788.
   PubMed Web of Science ®Google Scholar
• Oumouna M, Datta R, Oumouna-Benachour K, Suzuki Y, Hans C, Matthews K, : Poly(ADP-ribose) polymerase-1 inhibition prevents eosinophil recruitment by modulating Th2 cytokines in a murine model of allergic airway inflammation: a potential specific effect on IL-5 [erratum appears in J Immunol. 2007;179:5604]. J Immunol. 2006;177:6489–6496.
   PubMed Web of Science ®Google Scholar
• Schreiber V, Dantzer F, Ame JC, De Murcia G: Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol. 2006;7:517–528.
   PubMed Web of Science ®Google Scholar