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Research Article

Bronchoconstrictor effect of the tachykinin NK3-receptor agonists [MePhe7]-neurokinin B and senktide in the isolated guinea pig lung

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Pages 509-521 | Received 09 Feb 2010, Accepted 15 Mar 2010, Published online: 13 Oct 2010

REFERENCES

  • Nilsson G, Dahlberg K, Brodin E, Sundler F, Strandberg K: Distribution and constrictor effect of substance P in guinea pig tracheobronchial tissue. In: von Euler US, Pernow B, ed. Substance P. New York: Raven Press; 1977:57–61.
  • Balluck P, McDonald DM: Proinflammatory peptides in sensory nerves of the airways. In: Said SS, ed. Proinflammatory and Anti-inflammatory Peptides. New York: Marcel Decker; 1998:112;45–87.
  • Barnes PJ, Baraniuk JN, Belvisi MG: Neuropeptides in the respiratory tract: part II. Am Rev Respir Dis. 1991;144: 1187–1198.
  • Corboz MR, Rivelli MA, Ramos SI, Rizzo CA, Hey JA: Tachykinin NK1 receptor-mediated vasorelaxation in human pulmonary arteries. Eur J Pharmacol. 1998;350:R1–R3.
  • Barnes PJ, Baraniuk JN, Belvisi MG: Neuropeptides in the respiratory tract. Am Rev Respir Dis. 1991;144:1391–1399.
  • Solway J, Leff AR: Sensory neuropeptides and airway function. J Appl Physiol. 1991;71:2077–2087.
  • Phillips JE, Hey JA, Corboz MR: Tachykinin NK3 and NK1 receptor activation elicicts secretion from porcine airway submucosal glands. Br J Pharmacol. 2003;138:254–260.
  • Nenan S, Germaine N, Lagente V, Emonds-Alt X, Advenier C, Boichot E: Inhibition of inflammatory cell recruitment by the tachykinin NK3-receptor antagonist, SR 142801, in a murine model of asthma. Eur J Pharmacol. 2001;421:201–205.
  • Piedimonte G, Hoffman JIE, Husseini WK, Snider RM, Desai MC, Nadel JA: NK1 receptors mediate neurogenic inflammatory increase in blood flow in rat airways. J Appl Physiol. 1993;74:2462–2468.
  • Ellis JL, Undem BJ, Kays JS, Ghanekar SV, Barthlow HG, Buckner CK: Pharmacological examination of receptors mediating contractile responses to tachykinins in airways isolated from human, guinea pig and hamster. J Pharmacol Exp Ther. 1993;267:95–101.
  • Cook JA, Brunner SL, Tanaka DT: Neurokinin receptors mediating substance P-induced contraction in adult rabbit airways. Am J Physiol. 1990;258:L99–L106.
  • Maggi CA, Eglezos A, Quatara L, Patachini R, Giachetti ?. Heterogenity of NK2 tachykinin receptors in hamster and rabbit smooth muscles. Regul Pept. 1992;37:85–93.
  • Canning BJ: Neurokinin3 receptor regulation of the airways. Vascul Pharmacol. 2006;45:227–234.
  • Mukaiyama O, Morimoto K, Nosaka E, Takahashi S, Yamashita M: Involvement of enhanced neurokinin NK3 receptor expression in the severe asthma guinea pig model. Eur J Pharmacol. 2004;498:287–294.
  • Daoui S, Cui YY, Lagente V, Emonds-Alt X, Advenier C: A tachykinin NK3 receptor antagonist, SR 142801 (osanetant), prevents substance P-induced bronchial hyperreactivity in guinea-pigs. Pulm Pharmacol Ther. 1997;10:261–270.
  • Daoui S, Cognon C, Naline E, Emonds-Alt X: Involvement of tachykinin NK3 receptor in citric-acid-induced cough and bronchial responses in guinea-pigs. Am J Respir Crit Care Med. 1998;158:42–48.
  • Daoui S, Naline E, Lagente V, Emonds-Alt X, Advenier C: Neurokinin B- and specific tachykinin NK3 receptor agonists-induced airway hyperresponsiveness in the guinea-pig. Br J Pharmacol. 2000;130:49–56.
  • Hua XY, Theodorsson-Norheim E, Brodin E, Lundberg JM, Hokfelt T: Multiple tachykinins (neurokinin A, neurokinin K and substance P) in capsaicin-sensitive sensory neurons in the guinea-pig. Regul Pept. 1985;13:1–19.
  • Lundberg JM, Hokfelt T, Martling CR, Saria A, Cuello C: Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man. Cell Tissue Res. 1984;235:251–261.
  • Kummer W, Fischer A, Kurkowski R, Heym C: The sensory and sympathetic innervation of guinea-pig lung and trachea as studied by retrograde neuronal tracing and double labeling immunohistochemistry. Neuroscience. 1992;49:715–737.
  • Uchida Y, Nomura A, Ohtsuka M, Hasegawa S, Goto K, Kimura S, Sugita Y, Uchiyama Y: Neurokinin A as a potent bronchoconstrictor. Am Rev Respir Dis. 1987;136:718– 721.
  • Ireland SJ, Bailey F, Hagan RM, Jordan CC, Stephens-Smith ML: Receptors mediating tachykinin-induced contractile responses in guinea-pig trachea. Br J Pharmacol. 1991;103:1463–1469.
  • Maggi CA, Patachini R, Rovero P, Santicioli P: Tachykinin receptors and noncholinergic bronchoconstriction in the guinea-pig isolated bronchi. Am Rev Respir Dis. 1991;144:363–367.
  • Yuan L, Burcher E, Nail BS: Use of selective agonists and antagonists to characterize tachykinin receptors mediating airway responsiveness in anaesthetized guinea-pigs. Pulm Pharmacol. 1994;7:169–178.
  • Advenier C, Naline E, Drapeau G, Regoli D: Relative potencies of neurokinins in guinea pig trachea and human bronchus. Eur J Pharmacol. 1987;139:133–137.
  • Naline E, Devillier P, Drapeau G, Toty L, Bakdach H, Regoli D, Advenier C: Characterization of neurokinin effects and receptor selectivity in human isolated bronchi. Am Rev Respir Dis. 1989;140:679–686.
  • Pinto FM, Saulnier J-P, Faisy C, Naline E, Molimard M, Prieto L, Martin JD, Emonds-Alt X, Advenier C, Candenas ML: SR 142801, a tachykinin NK3 receptor antagonist, prevents β2-adrenoceptor agonist-induced hyperresponsiveness to neurokinin A in guinea-pig isolated trachea. Life Sciences. 2002;72:307–320.
  • Pinto FM, Almeida TA, Hernandez M, Devillier P, Advenier C, Candenas ML: mRNA expression of tachykinins and tachykinin receptors in different human tissues. Eur J Pharmacol. 2004;494:233–239.
  • Killingsworth CR, Shore SA: Tachykinin receptors mediating contraction of guinea pig lung strips. Regul Pept. 1995;57:149–161.
  • Van Schoor J, Joos G, Chasson B, Brouard R, Pauwels R: The effect of the NK2 receptor antagonist SR 48968 (saredutant) on neurokinin A-induced bronchoconstriction in asthmatics. Eur Respir J. 1998;12:17–23.
  • Joos G, Schelfhout VJ, Van de Velde V, Pauwels R: The effect of the tachykinin NK2 receptor antagonist MEN 11420 (nepadutant) on neurokinin A-induced bronchoconstriction in patients with asthma. Am J Respir Crit Care Med. 2001;163:A628.
  • Joos GF, Vincken W, Louis R, Schelfhout VJ, Wang JH, Shaw MJ, Cioppa GD, Pauwels RA: Dual tachykinin NK1/NK2 antagonist DNK333 inhibits neurokinin A-induced broncho- constriction in asthma patients. Eur Respir J. 2004;23:76–81.
  • Lundberg JM, Saria A. Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants. Nature. 1983;302:251–253.
  • Schelfhout V, Louis R, Lenz W, Heyrman R, Pauwels R, Joos G: The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma. Pulm Pharmacol Ther. 2006;19:413–418.
  • Cheng Y-C, Prusoff WH: Relation between the inhibition constant Ki and the concentration of inhibitor which causes fifty per cent inhibition (IC50) of an enzymatic reaction. Biochem Pharmacol. 1973;22:3099–3108.
  • Corboz MR, Rivelli MA, Egan RW, Tulshian D, Matasi J, Fawzi AB, Benbow L, Smith-Torhan A, Zhang H, Hey JA: Nociceptin inhibits capsaicin-induced bronchoconstriction in isolated guinea pig lung. Eur J Pharmacol. 2000;402:171–179.
  • Corboz MR, Fernandez X, Rizzo CA, Tozzi S, Monahan ME, Hey JA: Increased blocking activity of combined tachykinin NK1- and NK2-receptor antagonists on tachykinergic bronchomotor responses in the guinea-pig. Auton Autac Pharmacol. 2003;23:79–93.
  • Tallarida RJ: Pharmacologic methods for identification of receptors. Life Sci. 1988;43:2169–2176.
  • Anthes JC, Chapman RW, Richard C, Eckel S, Corboz M, Hey JA, Fernandez X, Greenfeder S, McLeod R, Sehring S, Rizzo C, Crawley Y, Shih N-Y, Piwinski J, Reichard G, Ting P, Carruthers N, Cuss FM, Billah M, Kreutner W, Egan RW: SCH 206272: a potent, orally active tachykinin NK1, NK2, and NK3 receptor antagonist. Eur J Pharmacol. 2002;450:191–202.
  • Sarau HM, Feild JA, Ames RS, Foley JJ, Nuthulaganti P, Schmidt DB, Buckley PT, Elshourbagy NA, Brawner ME, Lutmann MA, Giardina GAM, Hay DWP: Molecular and pharmacological characterization of the murine tachykinin NK3 receptor. Eur J Pharmacol. 2001;413:143–150.
  • Sarau HM, Griswold DE, Potts W, Foley JJ, Schmidt DB, Webb EF, Martin LD, Brawner ME, Elshourbagy NA, Medhurst AD, Giardina GAM, Hay DWP: Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. J Pharmacol Exp Ther. 1997;281:1303–1311.
  • Joos GF, Germonpre PR, Pauwels RA: Role of tachykinins in asthma. Allergy. 2000;55:321–337.
  • Shigemoto R, Yokota Y, Tsuchida K, Nakanishi S: Cloning and expression of a rat neuromedin K receptor cDNA. J Biol Chem. 1990;265:623–628.
  • Regoli D, Nantel F: Phharmacology of neurokinin receptors. Biopolymers 1991;31:777–791.
  • Petitet F, Beaujouan J-C, Saffroy M, Torrens Y, Glowinski J: The nonpeptide NK-2 antagonist SR 48968 is also a NK-3 antagonist in the guinea pig but not in the rat. Biochem Biophys Res Commun. 1993;191:180–187.
  • Gerard NP, Bao L, He XP, Gerard C: Molecular aspects of the tachykinin receptors. Regul Pept. 1993;43:21–35.
  • Myers AC, Undem BJ: Electrophysiological effects of tachykinins and capsaicin on guinea-pig bronchial parasympathetic ganglion neurones. J Physiol. 1993;470:665–679.
  • Arenas E, Alberch J, Perez-Navarro E, Solsona C, Marsal J: Neurokin receptors differentially mediate endogenous acetylcholine release evoked by tachykinins in the neostriatum. J Neurol. 1991;11:2332–2338.
  • Maggi CA, Patacchini R, Giachetti A, Meli A: Tachykinin receptors in the circular muscle of the guinea-pig ileum. Br J Pharmacol. 1990;101:996–1000.
  • Schemann M, Kayser H: Effects of tachykinins on myenteric neurons of the guinea pig gastric corpus: involvement of NK-3 receptors. Pfluegers Arch. 1991;419:566–571.
  • Ramirez MJ, Cenarruzabeitia Del Rio J, Lasheras B: Involvement of neurokinins in the non-cholinergic response to activation of 5-HT3 and 5-HT4 receptors in guinea pig ileum. Br J Pharmacol. 1994;111:419–424.
  • Girard V, Feletou M, Advenier C, Canet E: Effects of tachykinins and capsaicin on the mechanical and electrical activity of the guinea pig isolated trachea. Br J Pharmacol. 1997;122: 841–848.
  • Maggi CA, Patachini R, Quartara L, Rovero P, Santicioli P: Tachykinin receptors in the guinea pig isolated bronchi. Eur J Pharmacol. 1991;197:167–174.
  • Daoui S, Cuit Y-Y, Lagente V, Emonds-Alt X, Advenier C: A tachykinin NK3 receptor antagonist, SR 142801 (Osanetant), prevents substance P-induced bronchial hyperreactivity in guinea-pigs. Pulm Pharmacol Ther. 1997;10:261–70.
  • Nishi T, Ishibashi K, Takemoto T, Nakajima K, Fukazawa T, Iio Y, Itoh K, Mukaiyama O, Yamaguchi T: Combined tachykinin receptor antagonist: synthesis and stereochemical structure-activity relationships of novel morpholine analogues. Bioorg Med Chem Lett. 2000;10:1665–1668.
  • Daoui S, Ahnaou A, Naline E, Emonds-Alt X, Lagente V, Advenier C: Tachykinin NK3 receptor agonists induced microvascular leakage hypersensitivity in the guinea-pig airways. Eur J Pharmacol. 2001;433:199–207.
  • Hay DWP, Giardina GAM, Griswold DE, Underwood DC, Kotzer CJ, Bush B, Potts W, Sandhu P, Lundberg D, Foley JJ, Schmidt DB, Martin LD, Kilian D, Legos JJ, Barone FC, Luttmann MA, Grugni M, Raveglia LF, Sarau HM: Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs. J Pharmacol Exp Ther. 2002;300:314–323.
  • Canning BJ, Fischer A, Undem BJ: Pharmacological analysis of the tachykinin receptors that mediate activation of nonadrenergic, noncholinergic relaxant nerves that innervate guinea pig trachealis. J Pharmacol Exp Ther. 1998;284:370–377.
  • Myers A, Undem B, Kummer W: Anatomical and electrophysiological comparison of the sensory innervation of bronchial and tracheal parasympathetic ganglion neurons. J Auton Nerv Syst. 1996;61:162–168.
  • Myers AC, Goldie RG, Hay DWP: A novel role for tachykinin neurokinin-3 receptors in regulation of human bronchial ganglia neurons. Am J Respir Crit Care Med. 2005;171:212–216.

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