474
Views
27
CrossRef citations to date
0
Altmetric
Research Article

Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice

, , , , , , , & show all
Pages 135-146 | Received 25 Aug 2011, Accepted 14 Jan 2012, Published online: 06 Mar 2012

REFERENCES

  • Levine SJ: Bronchial epithelial cell-cytokine interactions in airway inflammation. J Investig Med. 1995;43:241–249.
  • Nelson S, Mason CM: The inflammatory response in chronic bronchitis. Semin Respir Crit Care Med. 2000;21:79–86.
  • Knight D: Epithelium-fibroblast interactions in response to airway inflammation. Immunol Cell Biol. 2001;79:160–164.
  • Knight DA, Holgate ST: The airway epithelium: structural and functional properties in health and disease. Respirology. 2003;8:432–446.
  • Sacco O, Silvestri M, Sabatini F, Sale R, Defilippi AC, Rossi GA: Epithelial cells and fibroblasts: structural repair and remodelling in the airways. Paediatr Respir Rev. 2004;5(Suppl A):S35–S40.
  • Busse W, Elias J, Sheppard D, Banks-Schlegel S: Airway remodeling and repair. Am J Respir Crit Care Med. 1999;160:1035–1042.
  • Jeffery PK: Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2004;1:176–183.
  • Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, Pare PD: The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med. 2004;350:2645–2653.
  • Wilcox AG: Small airway involvement in interstitial lung disease: radiologic evidence. Curr Opin Pulm Med. 2000;6:399–403.
  • Pappas K: Bronchiolitis and bronchial disorders in interstitial lung disease. Curr Opin Pulm Med. 2011;17:316–324.
  • Holgate ST, Davies DE, Lackie PM, Wilson SJ, Puddicombe SM, Lordan JL: Epithelial-mesenchymal interactions in the pathogenesis of asthma. J Allergy Clin Immunol. 2000;105:193–204.
  • Holgate ST: Epithelial damage and response. Clin Exp Allergy. 2000;30(Suppl 1):37–41.
  • Crystal RG, Randell SH, Engelhardt JF, Voynow J, Sunday ME: Airway epithelial cells: current concepts and challenges. Proc Am Thorac Soc. 2008;5:772–777.
  • Davies DE: The role of the epithelium in airway remodeling in asthma. Proc Am Thorac Soc. 2009;6:678–682.
  • Polosukhin VV, Cates JM, Lawson WE, Zaynagetdinov R, Milstone AP, Massion PP, Ocak S, Ware LB, Lee JW, Bowler RP, Kononov AV, Randell SH, Blackwell TS: Bronchial secretory immunoglobulin A deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011;184:317–327.
  • Kumar RK: Experimental models in pulmonary pathology. Pathology. 1995;27:130–132.
  • Nikula KJ, Green FH: Animal models of chronic bronchitis and their relevance to studies of particle-induced disease. Inhal Toxicol. 2000;12(Suppl 4):123–153.
  • Fehrenbach H: Animal models of chronic obstructive pulmonary disease: some critical remarks. Pathobiology. 2002;70:277–283
  • Kenyon NJ, Ward RW, Last JA: Airway fibrosis in a mouse model of airway inflammation. Toxicol Appl Pharmacol. 2003;186:90–100.
  • Shinagawa K, Kojima M: Mouse model of airway remodeling: strain differences. Am J Respir Crit Care Med. 2003;168:959–967.
  • Tsuchiya T, Nishimura Y, Nishiuma T, Kotani Y, Funada Y, Yoshimura S, Yokoyama M: Airway remodeling of murine chronic antigen exposure model. J Asthma. 2003;40:935–944.
  • Groneberg DA, Chung KF: Models of chronic obstructive pulmonary disease. Respir Res. 2004;5:18.
  • Stevenson CS, Belvisi MG: Preclinical animal models of asthma and chronic obstructive pulmonary disease. Expert Rev Respir Med. 2008;2:631–643.
  • Stevenson CS, Birrell MA: Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance. Pharmacol Ther. 2011;130:93–105.
  • Lawson WE, Polosukhin VV, Zoia O, Stathopoulos GT, Han W, Plieth D, Loyd JE, Neilson EG, Blackwell TS: Characterization of fibroblast-specific protein 1 in pulmonary fibrosis. Am J Respir Crit Care Med. 2005;171:899–907.
  • Polosukhin VV, Stathopoulos GT, Lawson WE, Blackwell TS: Variability of interalveolar septal remodeling after bleomycin treatment in mice. Ultrastruct Pathol. 2005;29:53–64.
  • American Thoracic Society: Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS). Am J Respir Crit Care Med. 2000;161:646–664.
  • American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med. 2002;165:277–304.
  • Lawson WE, Polosukhin VV, Stathopoulos GT, Zoia O, Han W, Lane KB, Li B, Donnelly EF, Holburn GE, Lewis KG, Collins RD, Hull WM, Glasser SW, Whitsett JA, Blackwell TS: Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin. Am J Pathol. 2005;167:1267–1277.
  • Tanjore H, Xu XC, Polosukhin VV, Degryse AL, Li B, Han W, Sherrill TP, Plieth D, Neilson EG, Blackwell TS, Lawson WE: Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis. Am J Respir Crit Care Med. 2009;180:657–665.
  • Degryse AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE: Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2010;299:L442–L452.
  • Degryse AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, Boomershine CS, Ortiz C, Sherrill TP, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE: TGFbeta signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment. Am J Physiol Lung Cell Mol Physiol. 2011;300:L887–L897.
  • Lawson WE, Cheng DS, Degryse AL, Tanjore H, Polosukhin VV, Xu XC, Newcomb DC, Jones BR, Roldan J, Lane KB, Morrisey EE, Beers MF, Yull FE, Blackwell TS: Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proc Natl Acad Sci U S A. 2011;108:10562–10567.
  • Mangili F, Cigala C, Santambrogio G: Staining apoptosis in paraffin sections. Advantages and limits. Anal Quant Cytol Histol. 1999;21:273–276.
  • Stadelmann C, Lassmann H: Detection of apoptosis in tissue sections. Cell Tissue Res. 2000;301:19–31.
  • Strutz F, Okada H, Lo CW, Danoff T, Carone RL, Tomaszewski JE, Neilson EG: Identification and characterization of a fibroblast marker: FSP1. J Cell Biol. 1995;130:393–405.
  • Warburton D, Schwarz M, Tefft D, Flores-Delgado G, Anderson KD, Cardoso WV: The molecular basis of lung morphogenesis. Mech Dev. 2000;92:55–81.
  • Vignola AM, Mirabella F, Costanzo G, Di GR, Gjomarkaj M, Bellia V, Bonsignore G: Airway remodeling in asthma. Chest. 2003;123:417S–422S.
  • Jeffery PK: Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med. 2001;164:S28–S38.
  • Postma DS, Timens W: Remodeling in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006;3:434–439.
  • Hogg JC, Timens W: The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol. 2009;4:435–459.
  • Burgel PR: The role of small airways in obstructive airway diseases. Eur Respir Rev. 2011;20:23–33.
  • Burgel PR, Bourdin A, Chanez P, Chabot F, Chaouat A, Chinet T, de BJ, Devillier P, Deschildre A, Didier A, Garcia G, Jebrak G, Laurent F, Morel H, Perez T, Pilette C, Roche N, Tillie-Leblond I, Verbanck S, Dusser D: Update on the roles of distal airways in COPD. Eur Respir Rev. 2011;20:7–22.
  • Salazar LM, Herrera AM: Fibrotic response of tissue remodeling in COPD. Lung. 2011;189:101–109.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.