8
Views
35
CrossRef citations to date
0
Altmetric
Original Article

Cyclophosphamide-Induced Depression of the Antioxidant Defense Mechanisms of the Lung

&
Pages 153-165 | Received 02 Jun 1984, Published online: 02 Jul 2009

References

  • Clark J M, Lambertson C J. Pulmonary oxygen toxicity: A review. Pharmacol Rev 1971; 23: 37–133
  • Fridovich I. The biology of oxygen radicals. Science 1978; 201: 875–880
  • Boyd M R. Biochemical mechanisms in chemical induced lung injury: Roles of metabolic activation. CRC Crit Rev Toxicol 1980; 4: 103–176
  • Batist G, Andrews J L, Jr. Pulmonary toxicity of antineoplastic drugs. JAMA 1981; 246: 1449–1453
  • Trush M A, Mimnaugh E G, Ginsburg E, Gram T E. Studies on the in vitro interaction of mitomycin C, nitrofurantoin and paraquat with pulmonary microsomes. Biochem Pharmacol 1982; 31: 805–814
  • Fisher H K, Clements J A, Wright R R. Enhancement of oxygen toxicity by the herbicide paraquat. Am Rev Respir Dis 1973; 107: 246–252
  • Deneke S M, Fanburg B L. Oxygen toxicity of the lung: An update. Br J Anaesthesia 1982; 54: 737–749
  • Goodman J, Hochstein P. Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin. Biochem Biophys Res Commun 1977; 77: 797–803
  • Burger R M, Peisach J, Horwitz S B. Activated bleomycin: A transient complex of drug, iron, and oxygen that degrades DNA. J Biol Chem 1981; 256: 11636–11644
  • Yam J, Roberts R J. Pharmacologic alterations of oxygen-induced lung toxicity. Toxicol Appl Pharmacol 1979; 47: 367–375
  • Deneke S M, Gershoff S N, Fanburg B L. Potentiation of oxygen toxicity in rats by dietary protein or amino acid deficiency. J Appl Physiol: Respirat Environ Exercise Physiol 1983; 54: 147–151
  • Gurtoo H L, Hipkens J H, Sharma S D. Role of glutathione in the metabolism-dependent toxicity and chemotherapy of cyclophosphamide. Cancer Res 1981; 41: 3584–3591
  • Hakkinen P J, Whitele J W, Witschi H P. Hyperoxida, but not thoracic x-irradiation, potentiates bleomycin- and cyclophosphamide-induced lung damage in mice. Am Rev Respir Dis 1982; 126: 281–285
  • Hakkinen P J, Morse C C, Martin F M, Dalbey W E, Haschek W M, Witschi H R. Potentiating effects of oxygen in lungs damaged by methylcyclopentadienyl manganese tricarbonyl, cadmium chloride, oleic acid and antitumor drugs. Toxicol Appl Pharmacol 1983; 67: 55–69
  • Alarcon R A. Studies on the in vitro formation of acrolein: 3-Hydroxypropylmer-capturic acid as an index of cyclophosphamide (NSC-26271) activation. Cancer Treat Rep 1976; 60: 327–335
  • Hook G ER, Bend J R, Hoel D, Fouts J R, Gram T E. Preparation of lung microsomes and a comparison of the distribution of enzymes between subcellular fractions of rabbit lung and liver. J Pharmacol Exp Ther 1972; 182: 474–490
  • Ellman G L. Tissue sulfhydryl groups. Arch Biochem Biophys 1959; 82: 70–79
  • Little C, Olinescu R, Rein K G, O'Brien P J. Properties and regulation of glutathione peroxidase. J Biol Chem 1970; 245: 3632–3636
  • Bergmeyer H U. Methods of Enzymatic Analysis. Academic, New York 1974
  • McCord J M, Fridovich I. Superoxide dismutase: An enzymic function for eryth-rocuprein (hemocuprein). J Biol Chem 1969; 274: 6049–6055
  • Lowry O H, Rosebrough N J, Farr A L, Randall R J. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265–275
  • Winer B J. Statistical Principles In Experimental Designs, 2nd Ed. McGraw-Hill, New York 1971
  • Armitage P. Statistical Methods in Medical Research. Wiley, New York 1977
  • Calabresi P, Parks R E, Jr. Antiproliferative agents and drugs used for immunosuppression. The Pharmacologic Basis of Therapeutics, A G Gilman, L S Goodman, A Gilman. Macmillan, New York 1980; 1256–1313
  • Topilow A A, Rotherberg S P, Cottress J S. Interstitial pneumonia after prolonged treatment with cyclophosphamide. Am Rev Respir Dis 1973; 108: 114–117
  • Meschan I, De Armas C R, Scharyi M. Adult bronchopulmonary dysplasia: The similarity in roentgen and histologic appearance between some cases of oxygen toxicity, radiation pneumonitis, and postcytotoxic nonspecific bronchopneumonia. Radiology 1969; 92: 612–615
  • Rodin A E, Haggard M E, Travis L B. Lung changes and chemotherapeutic agents in childhood. Am J Dis Child 1970; 120: 337–340
  • Patel J M, Block E R, Hood C I. Biochemical indices of cyclophosphamide-induced lung toxicity. Toxicol Appl Pharmacol 1984; 76: 128–138
  • Crapo J D, Tierney D F. Superoxide dismutase and pulmonary O2 toxicity. Am J Physiol 1974; 226: 1401–1407
  • Frank L, Yam J, Roberts R J. The role of endotoxin in protection of adult rats from oxygen-induced lung toxicity. J Clin Invest 1978; 61: 269–275

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.