8
Views
5
CrossRef citations to date
0
Altmetric
Original Article

Sequential Pathological Changes Induced in Rats with the Anti-Cancer Drug I, 3-Bis (2-Chloroethyl)-I-Nitrosourea (BCNU)

, , &
Pages 327-339 | Received 10 Dec 1984, Published online: 02 Jul 2009

References

  • DeVita V T, Carbone P, Owens A, Gold L M, Krant M J, Edmonson J. Clinical trials with 3-bis(2-chloroethyl)-1-nitrosourea, NSC-409962. Cancer Res 1965; 25: 1876–1881
  • Carter S K, Schabel F A, Broder L E, Johnston T P. 1,2,-Bis(2-chloroethyl)-1-nitro-sourea (BCNU) and other nitrosoureas in cancer treatment: A review. Adv Cancer Res 1976; 16: 273–332
  • Levin V A, Wilson C B. Nitrosourea chemotherapy for primary malignant gliomas. Cancer Treat Rep 1976; 60: 179–724
  • Bailey C C, Marsden H B, Jones P HM. Fatal pulmonary fibrosis following 1,3-bis(2-Chloroethyl)-1-nitrosourea (BCNU) therapy. Cancer 1978; 42: 74–76
  • Crittenden D, Tranum B L, Haut A. Pulmonary fibrosis after prolonged therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea. Chest 1977; 72: 372–373
  • Durand J R, Norgard M J, Murad T M, Bartolucci A A, Langford K H. Pulmonary toxicity associated with bischloroethylnitrosourea (BCNU). Ann Intern Med 1979; 90: 191–194
  • Holoye P Y, Jenkins D E, Greenberg S D. Pulmonary toxicity in long-term administration of BCNU. Cancer Treat Rep 1976; 60: 1691–1694
  • Richter J E, Hastedt R, Dalton J F, Marshall D, Raymond L W. Pulmonary toxicity with bischloroethylnitrosourea: Report of case with transient response to cortico-steroid therapy. Cancer 1979; 43: 1607–1612
  • Selker R G, Jakobs S A, Moore P B, Wald M, Fisher E R, Cohen M, Bellot P. 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced pulmonary fibrosis. Neuro-surgery 1980; 7: 560–565
  • Weiss R B, Muggia F M. Pulmonary effects of carmustine (bischloroethyl-nitrosourea, BCNU). Ann Intern Med 1979; 91: 131–132
  • Weiss R B, Muggia F M. Cytotoxic drug-induced pulmonary disease: Update 1980. Am J Med 1980; 68: 259–266
  • Barker M, Deen D F, Baker D G. BCNU and X-ray therapy of intracerebral 9L rat tumors. Int J Radiat Oncol Biol Phys 1979; 5: 1581–1583
  • Smith A, Boyd M R. Effects of bischloroethylnitrosourea (BCNU) on pulmonary and serum angiotensi converting enzyme activity in rats. Biochem Pharmacol 1984; 32: 3719–3722
  • Smith A C, Boyd M R. Preferential effects of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on pulmonary glutathione reductase and glutathione disulfide ratios: Possible implications for lung toxicity. J Pharmacol Exp Therap 1984; 229: 16–20
  • Reznik-Schuller H M, Smith A C, Thenot J P, Boyd M R. Pulmonary toxicity of the anticancer drug his-chloroethylnitrosourea (BCNU) in rats. Toxicologist 1984; 4: 29
  • Reznik-Schuller H M, Gregg M. Ultrastructure of nitrosoheptamethylene-imine-induced lung tumors in Fischer rats. Anticancer Res 1982; 2: 381–384
  • Bedrossian C WM, Luna M A, Mackay B, Lichtiger B. Ultrastructure of pulmonary bleomycin toxicity. Cancer 1973; 32: 33–41
  • Adamson Y R, Bowden D H. The pathogenesis of bleomycin induced pulmonary fibrosis in mice. Am J Pathol 1974; 77: 185–198
  • Fasske E, Morgenroth K. Experimental bleomycin lung in mice. A contribution to the pathogenesis of pulmonary fibrosis. Lung 1983; 161: 133–146
  • Snider G L, Celli B R, Goldstein R H, Hages J A. Endotracheal bleomycin in hamsters: A model of interstitial pulmonary fibrosis. Am Rev Resp Dis (Suppl) 1977; 115: 245–251
  • Tryka A F, Godleski J J, Skornik W A, Brain J D. Progressive pulmonary fibrosis in hamsters. Exp Lung Res 1983; 5: 155–171
  • Adamson Y R, Bowdwn D H, Cote M G, Witschi H. Lung injury induced by butylated hydroxytoluene. Lab Invest 1977; 36: 26–43
  • Etherton J E, Gresham G A. Early bronchiolar damage following paraquat poisoning in mice. J Pathol 1978; 128: 21–27
  • Vijeeyaratnam G S, Corrin B. Experimental paraquat poisoning: A histological and electron-optical study of the changes in the lung. J Pathol 1970; 103: 123–129
  • Smith P, Heath D, Kay J M. The pathogenesis and structure of paraquat induced pulmonary fibrosis in rats. J Pathol 1973; 114: 57–74
  • Sykes B I, Purchase F H, Smith L L. Pulmonary ultrastructure after oral and intravenous dosages of paraquat to rats. J Pathol 1976; 121: 233–246
  • Witschi H, Kacew S, Hirai J C. In vivo oxidation of reduced nicotinamide-adenine dinucleotide phosphate of paraquat and diquat in rat lung. Chem Biol Interact 1977; 19: 143–160

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.