9
Views
9
CrossRef citations to date
0
Altmetric
Original Article

Injury to the Isolated, Perfused Lung by Exposure in vitro to Monocrotaline Pyrrole

&
Pages 201-212 | Received 30 Dec 1983, Published online: 02 Jul 2009

References

  • Chesney C F, Allen J R. Cardiopulmonary disease. Am J Pathol 1973; 70: 489–492
  • Chesney C F, Allen J R. Endocardial fibrosis associated with monocrotaline-induced pulmonary hypertension in nonhuman primates (Macaca aretoides). Am J Vet Res 1973; 34: 1577–1581
  • Turner J H, Lalich J J. Experimental cor pulmonale in the rat. Arch Pathol 1965; 79: 409–418
  • Roth R A, Dotzlaf L A, Baranyi B, Kuo C H, Hook J B. Effect of monocrotaline ingestion on liver, kidney, and lung of rats. Toxicol Appl Pharmacol 1981; 60: 193–203
  • Hilliker K S, Bell T G, Roth R A. Pneumotoxicity and thrombocytopenia after a single injection of monocrotaline. Am J Physiol 1982; 242: H573–H579
  • Bruner L H, Hilliker K S, Roth R A. Pulmonary hypertension and EKG changes from monocrotaline pyrrole in the rat. Am J Physiol 1983; 245: H300–H306
  • Valdivia E, Lalich J J, Hayashi Y, Sonnad J. Alterations in pulmonary alveoli after a single injection of monocrotaline. Arch Pathol 1967; 84: 64–76
  • Merkow L, Kleinerman J. An electron microscopic study of pulmonary vasculitis induced by monocrotaline. Lab Invest 1966; 15: 547–564
  • Meyrick B, Gamble W, Reid L. Development of Crotalaria pulmonary hypertension: Hemodynamic and structural study. Am J Physiol 1980; 239: H692–H702
  • Meyrick B O, Reid L M. Crotalaria-induced pulmonary hypertension: Uptake of 3H-thymidine by the cells of the pulmonary circulation and alveolar walls. Am J Pathol 1982; 106: 84–94
  • Ghodsi F, Will J A. Changes in pulmonary structure and function induced by monocrotaline intoxication. Am J Physiol 1981; 240: H149–H155
  • Lalich J J, Ehrhart L A. Monocrotaline induced pulmonary arteritis in rats. J Atheroscler Res 1962; 2: 482–492
  • Roth R A. Effect of pneumotoxicants on lactate dehydrogenase activity in airways of rats. Toxicol Appl Pharmacol 1981; 57: 69–78
  • Chesney C F, Hsu I C, Allen J R. Modifications of the in vitro metabolism of the hepatotoxic pyrrolizidine alkaloid, monocrotaline. Res Commun Chem Pathol Pharmacol 1974; 8: 567–570
  • Mattocks A R. Dihydropyrrolizidine derivatives from unsaturated pyrrolizidine alkaloids. J Chem Soc 1969; C: 1155–1162
  • White I NH, Mattocks A R. Reaction of dihydropyrrolizidines with deoxyribonucleic acids in vitro. Biochem J 1972; 128: 291–297
  • Butler W H. An ultrastructural study of the pulmonary lesion induced by pyrrole derivatives of the pyrrolizidine alkaloids. J Pathol 1970; 102: 15–19
  • Chesney C F, Allen J R, Hsu I C. Right ventricular hypertrophy in monocrotaline pyrrole treated rats. Exp Mol Pathol 1974; 20: 257–268
  • Plestina R, Stoner H B. Pulmonary oedema in rats given monocrotaline pyrrole. J Pathol 1972; 106: 235–249
  • Hurley J V, Jago M V. Pulmonary oedema in rats given dehydromonocrotaline: A topographic and electron-microscope study. J Pathol 1975; 117: 23–32
  • Henderson R F, Damon E G, Henderson T R. Early damage indicators in the lung. I. Lactate dehydrogenase activity in the airways. Toxicol Appl Pharmacol 1978; 44: 291–297
  • Henderson R F, Rebar A H, Pickrell J A, Newton G J. Early damage indicators in the lung. III. Biochemical and cytological response to inhaled metal salts. Toxicol Appl Pharmacol 1979; 50: 123–136
  • Henderson R F, Rebar A H, Denicola D B. Early damage indicators in the lungs. IV. Biochemical and cytologic response of the lung to lavage with metal salts. Toxicol Appl Pharmacol 1979; 51: 129–135
  • Sugita T, Hyers T M, Dauber I M, Wagner W W, McMurtry I F, Reeves J T. Lung vessel leak precedes right ventricular hypertrophy in monocrotaline-treated rats. J Appl Physiol 1983; 54: 371–374
  • Bruner L H, Bell T G, Bull R W, Roth R A. Is the immune system involved in the pneumotoxicity of monocrotaline pyrrole in the rat?. Fed Proc 1983; 42: 799
  • Hilliker K S, Garcia C M, Roth R A. Effects of monocrotaline and monocrotaline pyrrole on 5-hydroxytryptamine and paraquat uptake by lung slices. Res Commun Chem Pathol Pharmacol 1983; 40: 179–197
  • Bergmeyer H V, Bernt E. Lactate dehydrogenase UV assay with pyruvate and NADH. Methods of Enzymatic Analysis, H V Bergmeyer. Academic Press, New York 1974; 2: 524–579
  • Lowry O H, Rosebrough N J, Farr A L, Randall R J. Protein measurements with the Folin phenol reagent. J Biol Chem 1951; 193: 265–275
  • Mattocks A R, White I NH. Estimation of metabolites of pyrrolizidine alkaloids in animal tissues. Anal Biochem 1970; 38: 5529–53
  • Steel R GD, Torrie J H. Principles and Procedures of Statistics. McGraw-Hill, New York 1960; 73–76
  • Hollander M, Wolfe D A. Nonparametric Statistical Methods. Wiley, New York 1973; 68–75

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.