Inhibition by Oral N-Acetylcysteine of Cigarette Smoke-Induced “Bronchitis” in the Rat

References

• U.S. Department of Health Education & Welfare. The Health Consequences of Smoking: A report of the surgeon general. U.S. Govt. Printing Office, Washington 1972
   Google Scholar
• Goldstein R A. Lung disease: Review of past initiatives. Arch Environ Hlth 1984; 39: 183–186
   PubMed Web of Science ®Google Scholar
• Royal College of Physicians. Smoking or Health: The Third Report. Pitman Medical Publishing Co., London 1977
   Google Scholar
• Marini J J. Chronic airflow obstruction: Pathophysiology and management. Compr Ther 1980; 6: 65–74
   PubMedGoogle Scholar
• Goldstein R A, Craighead J G. Summary of the work group on lung disease. Arch Environ Hlth 1984; 39: 249–252
   Web of Science ®Google Scholar
• Huhti E. Chronic bronchitis in non-smokers—does it exist. Eur J Resp Dis 1982; 63(suppl.no. 118)35–41
   PubMedGoogle Scholar
• Doll R, Hill A B. Mortality in relation to smoking: Ten year's observations of British doctors. Brit Med J 1964; 1: 1399–1410
   PubMed Web of Science ®Google Scholar
• Thurlbeck W M. Aspects of chronic airflow obstruction. Chest 1977; 72: 341–349
   PubMed Web of Science ®Google Scholar
• Fletcher C M, Pride N B. Definitions of emphysema, chronic bronchitis, asthma and airflow obstruction: 25 years on from the Ciba symposium. Thorax 1984; 39: 81–85
   PubMed Web of Science ®Google Scholar
• Reid L. Pathology of chronic bronchitis. Lancet 1954; 1: 275–279
   Web of Science ®Google Scholar
• Niewoehner D E, Kleinerman J, Rice D B. Pathologic changes in the peripheral airways of young cigarette smokers. New Eng J Med 1974; 291: 755–758
   PubMed Web of Science ®Google Scholar
• Karpick R J, Pratt P C, Asmundsson T, Kilburn K H. Pathological Findings in Respiratory Failure. Goblet cell metaplasia, alveolar damage and myocardial infarction. Ann Int Med 1970; 72: 189–197
   PubMedGoogle Scholar
• Thurlbeck W M, Malaka D, Murphy K. Goblet cells in the peripheral airways in chronic bronchitis. Am Rev Respir Dis 1975; 112: 65–69
   PubMed Web of Science ®Google Scholar
• de Haller R, Reid L. Adult chronic bronchitis, morphology, histochemistry and vascularisation of the bronchial mucous glands. Medicina thoracalis 1965; 22: 549–567
   PubMedGoogle Scholar
• Cutz E, Levison H, Cooper D M. Ultrastructure of airways in children with asthma. Histopathology 1978; 2: 407–421
   PubMed Web of Science ®Google Scholar
• Lopez-Vidriero M T, Reid L. Pathological changes in asthma. Asthma, T. J.H. Clark, S. Godfrey. Chapman and Hall, London 1983; 79–98, 2nd edition
   Google Scholar
• Esterly J R, Oppenheimer E H. Cystic fibrosis of the pancreas: Structural changes in peripheral airways. Thorax 1968; 23: 670–675
   PubMed Web of Science ®Google Scholar
• Lamb D, Reid L. Goblet cell increase in rat bronchial epithelium after exposure to cigarette and cigar tobacco smoke. Brit Med J 1969; 1: 33–35
   PubMed Web of Science ®Google Scholar
• Jones R, Bolduc P, Reid L. Protection of rat bronchial epithelium against tobacco smoke. Brit Med J 1972; 2: 142–144
   PubMed Web of Science ®Google Scholar
• Jeffery P K, Reid L M. The effect of tobacco smoke, with or without phenyl-methyloxadiazole (PMO), on rat bronchial epithelium—a light and electron microscopic study. J Pathol 1981; 133: 341–359
   PubMed Web of Science ®Google Scholar
• Huber G L, Davies P, Zqilling G R, Pochay V E, Hinds W C, Nicholas H A, Mahajan V K, Hayashi M, First M W. A morphologic and physiologic bioassay for quantifying alterations in the lung following experimental chronic inhalation of tobacco smoke. Bull Europ Physio-path Resp 1981; 17: 269–327
   PubMedGoogle Scholar
• Jones R, Reid L. Secretory cell hyperplasia and modification of intracellular glycoprotein in rat airways induced by short periods of exposure to tobacco smoke, and the effect of the anti-inflammatory agent phenylmethyloxadiazole. Lab Invest 1978; 39: 41–49
   PubMed Web of Science ®Google Scholar
• Greig N, Ayers M, Jeffery P K. The effect of indomethacin on the response of bronchial epithelium to tobacco smoke. J Pathol 1980; 132: 1–9
   PubMed Web of Science ®Google Scholar
• Jeffery P K, Ayers M, Rogers D F. The mechanisms and control of bronchial mucous cell hyperplasia. 2nd Symposium on Mucus in Health and Disease, E. Chant-Ler. Plenum Press. 1982, Advance in Experimental Medicine and Biology 144:399–410
   Google Scholar
• Jeffery P K, Ayers M, Rogers D F. The mechanisms and control of bronchial mucous cell hyperplasia. Chest 1982; 81(suppl)27S–29S
   PubMedGoogle Scholar
• Rogers D F, Jeffery P K. Inhibition of cigarette smoke-induced airway secretory cell hyperplasiabyindomethacin, dexamethasone, prednisolone or hydrocortisone in the rat. Exp Lung Res 1986; 10: 285–298
   PubMed Web of Science ®Google Scholar
• Boman G, Backer U, Larsson S, Melander B, Wahlander L. Oral acetylcysteine reduces exacerbation rate in chronic bronchitis: Report of a trial organized by the Swedish Society for Pulmonary Diseases. Eur J Respir Dis 1983; 64: 405–415
   PubMedGoogle Scholar
• Richardson P S, Phipps R J. The anatomy, physiology, pharmacology and pathology of tracheo-bronchial mucus secretion and the use of expectorant drugs in human disease. J Pharmacol Exp Ther (B) 1978; 3: 441–479
   Web of Science ®Google Scholar
• Multicenter Study Group. Long-term oral acetylcysteine in chronic bronchitis. A double-blind controlled study. Eur J Respir Dis 1980; 61(suppl 111)93–108
   Google Scholar
• Reid L. Evaluation of model systems for study of airway epithelium, cilia and mucus. Arch Intern Med 1970; 126: 428–434
   PubMed Web of Science ®Google Scholar
• Bolduc P, Reid L. Mitotic index of the bronchial and alveolar lining of the normal rat lung. Am Rev Respir Dis 1976; 144: 1121–1128
   Google Scholar
• Wright M. A cigarette smoking machine for animal experiments. Lab Pract 1972; 21: 881–884
   PubMedGoogle Scholar
• Laboratory of the Government Chemist. Report fo the government chemist. HMSO, London 1973–1983
   Google Scholar
• Rogers D F. The effect of tobacco smoke and nicotine on rat airway epithelium and the response of tobacco smoke-induced secretory cell hyperplasia to anti-inflammatory drugs. 1984, PhD thesis, University of London
   Google Scholar
• Russell M AH, Wilson C, Cole P V, Idle M, Feyerabend C. Comparison of increases in carboxyhaemoglobin after smoking ‘extra mild’ and ‘non-mild’ cigarettes. Lancet 1973; 2: 687–690
   PubMed Web of Science ®Google Scholar
• Wald N, Idle M, Smith P G, Bailey A. Carboxyhaemoglobin levels in smokers of filter and plain cigarettes. Lancet 1977; 1: 110–112
   PubMed Web of Science ®Google Scholar
• Dennis R C, Valeri C R. Measuring percent oxygen saturation of hemoglobin, percent carboxyhemoglobin and methemoglobin and concentrations of total hemoglobin and oxygen in blood of man, dogs and baboon. Clin Chem 1980; 26: 1304–1308
   PubMed Web of Science ®Google Scholar
• Mowry R W, Winkler C H. The colouration of acid carbohydrates of bacteria and fungi in tissue sections with special reference to capsule of Crytococcus neo-formons, Pneumococcus and Staphylococcus. Am J Path 1956; 32: 628
   Web of Science ®Google Scholar
• Jones R, Reid L. Secretory cell hyperplasia and modification of intracellular glycoprotein in rat airways induced by short periods of exposure to tobacco smoke, and the effect of the anti-inflammatory agent phenylmethyloxadiazole. Lab Invest 1978; 39: 41–49
   PubMed Web of Science ®Google Scholar
• Reid L, Jones R. Experimental chronic bronchitis. International Review of Experimental Pathology. Academic Press, Inc., London 1983; 24: 335–382
   Google Scholar
• Jones R, Bolduc P, Reid L. Goblet cell glycoprotein and tracheal gland hypertrophy in rat airways: The effect of tobacco smoke with or without the anti-inflammatory agent phenylmethyloxadiazole. Br J Exp Path 1973; 54: 229
   PubMed Web of Science ®Google Scholar
• Quevauviller A, Huyen N V, Garcet S. Methodes d'etude experimentale des modifi-cateurs des secretions bronchiques. Poumon Coeur 1970; 26: 71–80
   PubMedGoogle Scholar
• Huyen V N. Etude histochemique chez l'animal de l'activite de la S-carboxy-methyl-cysteine. Bull Physio-pathol Resp 1973; 9: 463–464
   Google Scholar
• Jeffery P K, Rogers D F, Ayers M M. Effect of oral acetylcysteine on tobacco smoke-induced secretory cell hyperplasia. Eur J Res Dis 1985; 66(Suppl 139)117–122
   Google Scholar
• Camner P, Mossberg B, Philipson K. Tracheobronchial clearance and chronic ob-structuve lung disease. Scand J Respir Dis 1973; 54: 272–281
   PubMedGoogle Scholar
• Hogg J C, Macklem P T, Thurlbeck W M. Site and nature of airway obstruction in chronic obstructive lung disease. New Eng J Med 1968; 278: 1355–1360
   PubMed Web of Science ®Google Scholar
• Camner P. Studies on the removal of inhaled particles from the lungs by voluntary coughing. Chest 1981; 80(suppl)824–287
   PubMedGoogle Scholar
• Jeffery P K, Marriott C, Rogers D F, Turner N C. Tobacco smoke-induced tracheal hypersecretion in the rat. J Physiol 1984; 351: 53P
   Web of Science ®Google Scholar
• Ebert R V, Hanks P B. Mucus secretion by the epithelium of the bronchioles of cigarette smokers. Br J Dis Chest 1981; 75: 277–282
   PubMedGoogle Scholar
• Peto R, Speizer F E, Cochrane A L, Moore F, Fletcher C M, Tinker C M, Higgins I TT, Gray R G, Richards S M, Grilliland J, Norman-Smith B. The relevance in adults of air-flow obstruction, but not of mucus hypersecretion, to mortality from chronic lung disease. Am Rev Respir Dis 1983; 128: 491–500
   PubMed Web of Science ®Google Scholar
• Wright J L, Lawson L M, Pare P D, Kennedy S, Wiggs B, Hogg J C. The detection of small airways disease. Amer Rev Respir Dis 1984; 129: 989–994
   PubMed Web of Science ®Google Scholar
• Macklem P T, Proctor D F, Hogg J C. The stability of peripheral airways. Resp Physiol 1970; 8: 191–203
   PubMedGoogle Scholar
• Gepts L. Oral acetylcysteine treatment in exacerbation of chronic bronchitis in 49 patients (Summary). Eur J Respir Dis 1980; 61(suppl. 111)109
   Google Scholar
• Gotz M, Kraemer R, Kerrebijn K F, Popow P. Oral acetylcysteine in cystic fibrosis. A co-operative study. Eur J Respir Dis 1980; 61(suppl. 111)122–126
   Google Scholar
• Ravez P, Delwarte J, Libert P, Richez M, Halloy J L, Robience Y L. Short treatment of respiratory disorders with an oral mucolytic agent. Double-blind study with acetylcysteine vs. placebo (Summary). Eur J Respir Dis 1980; 61(suppl. 111)76
   Google Scholar
• Aylward M, Maddock J, Dewland P. Clinical evaluation of acetylcysteine in the treatment of patients with chronic obstructive bronchitis—A balanced double-blind trial with placebo control. Eur J Respir Dis 1980; 61(Suppl. 111)81–89
   Google Scholar
• Codosh S. Acetylcysteine in chronic bronchitis. Eur J Respir Dis 1980; 61(Suppl. 111)90–92
   Google Scholar
• Verstraeten J M. Mucolytic treatment in chronic airways obstruction. Double-blind clinical trial with acetylcysteine, bromhexine and placebo (Summary). Eur J Respir Dis 1980; 61(Suppl. 111)77
   PubMedGoogle Scholar
• Mitchell J R, Jollow P J, Potter W Z, Gillette J R, Brodie B B. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther 1973; 187: 211–217
   PubMed Web of Science ®Google Scholar
• Olson R D, MacDonald J S, van Boxtel C J, Boerth R C, Harbison R D, Slonim A E, Freeman R W, Oates J A. Regulatory role of glutathione and soluble sulfhydryl groups in the toxicity of adriamycin. J Pharmacol Exp Ther 1980; 215: 450–454
   PubMed Web of Science ®Google Scholar
• Olson R D, Boerth R C, Gerber J G, Nies A S. Mechanism of adriamycin cardio-toxicity: Evidence for oxidative stress. Life Sci 1981; 21: 1393–1401
   Google Scholar
• Flohe L, Gunzler W. Glutathione-dependent enzymatic oxidoreduction reactions. Glutathione: Metabolism and function, I. M. Arias, W. B. Jakoby. Raven Press, New York 1976; 6: 17–34
   Google Scholar
• Sprince H, Parker C M, Smith G G. Comparison of protection by L-ascorbic acid, L-cysteine, and adrenergic-blocking agents against acetaldehyde, acrolein, and formaldehyde toxicity: Implications in smoking. Agents and Actions 1979; 9: 407–414
   PubMedGoogle Scholar