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Original Article

Tritiated Thymidine-Labeled Bronchioloalveolar Cells and Radiation Dose Following Inhalation of Plutonium in Rats

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Pages 755-769 | Received 21 Dec 1988, Accepted 19 Apr 1989, Published online: 02 Jul 2009

References

  • Sanders C L, Dagle G E, Cannon W C, Craig D K, Powers G, Meier D M. Inhalation carcinogenesis of high-fired 239PuO2 in rats. Radiat Res 1976; 68: 349–360
  • Sanders C L, Mahaffey J A. Carcinogenicity of inhaled air-oxidized 239PuO2 in rats. Radiat Biol 1979; 35: 95–98
  • Sanders C L, Mahaffey J A. Inhalation carcinogenesis of repeated exposures to high-fired 239PuO2. Health Phys 1981; 41: 629–644
  • Sanders C L, Mc Donald K E, Mahaffey J A. Lung tumor response to inhaled Pu and its implications for radiation protection. Health Phys 1988; 55: 455–462
  • Sanders C L, Mc Donald K E, Lauhala K E. Promotion of pulmonary carcinogenesis by plutonium particle aggregation following inhalation of 239PuO2. Radiat Res 1988; 116: 393–405
  • Sanders C L, Adee R R, Jackson T A. Fine structure of alveolar areas in the lung following inhalation of 239PuO2 particles. Arch Environ Health 1971; 22: 525–533
  • Rhoads K, Mahaffey J A, Sanders C L. Dosimetry and response in rat pulmonary epithelium following inhalation of 239PuO2. Current Concepts in Lung Dosimetry. NTIS, Springfield, VA 1983; 18–28, CONF-820492, Pt. 1
  • Sanders C L, Mc Donald K E, Lauhala K E. SEM autoradiography: Aggregation of inhaled 239PuO2. J Radiat Biol 1988; 54: 115–121
  • Lauhala K E, Sanders C L, Mc Donald K E. Scanning electron microscopic autoradiography of lung. Scanning Micro 1988; 2: 1631–1634
  • Sanders C L, Lauhala K E, Mc Donald K E. Quantitative scanning electron microscopic autoradiography of inhaled 239PuO2. Health Phys 1988; 56: 321–325
  • Sanders C L, Mc Donald K E, Killand B W, Mahaffey J A, Cannon W C. Low-level lifespan studies with inhaled 239PuO2 in rats. Life-Span Radiation Effects Studies in Animals: What Can They Tell Us?. NTIS, Springfield, VA 1986; 429–449, CONF-830951
  • Matulionis D H. Lung Deformation and macrophage displacement in smoke-exposed and normal mice (Mus musculus) following different fixation procedures. Virchows Arch A (Pathol Anat) 1986; 410: 49–56
  • Tyler W S, Dungworth D L, Plopper C G, Hyde D M, Tyler N K. Structural evaluation of the respiratory system. Fundam Appl Toxicol 1985; 5: 405–422
  • Brain J D, Peter G, Kavet R I. Airway macrophages—The importance of the fixation method. Am Rev Respir Dis 1984; 129: 823–826
  • Filipy R E. Cigarette smoke and plutonium. 1983; 71–73, In: PNL-4600, PT. 1, Pacific Northwest Laboratory Annual Report for 1982
  • Henshaw D L, Fews A P, Webster D J. A technique for high-sensitivity alpha autoradiography of bronchial epithelium tissue. Phys Med Biol 1979; 24: 1227–1242
  • Travis E L. Relative radiosensitivity of the human lung. Adv Radia Bio 1987; 12: 205–238
  • Jeffery P K, Reid L. New observation of rat airway epithelium: A quantitative and electron microscope study. J Anat 1975; 120: 295–320
  • Reid L, Jones R. Experimental chronic bronchitis. Int Rev Exp Pathol 1983; 24: 335–382
  • Shami S G, Silbaugh S AF, Hahn F F, Griffith W C, Hobbs C H. Cytokinetic and morphological changes in the lungs and lung-associated lymph nodes of rats after inhalation of fly ash. Environ Res 1985; 35: 373–393
  • Evans M J, Cabral L J, Stephen R J, Freeman G. Cell division of alveolar macrophages in the rat lung following exposure to NO2. Am J Pathol 1973; 70: 199–205
  • Evans M J, Bils R F. Identification of tritiated thymidine labeled cells in the pulmonary alveolar walls of the mouse. Am Rev Respir Dis 1969; 100: 372
  • Evans M J, Johnson L V, Stephens R J, Freeman G. Renewal of the terminal bronchiolar epithelium in the rat following exposure to NO2 or O3. Lab Invest 1976; 35: 246–257
  • Kaufman S L. Alterations in cell proliferation in mouse lung following urethane exposure. III. Effects of chronic exposure on type 2 alveolar epithelial cells. Am J Pathol 1972; 68: 317–323
  • Adamson I YR, Bowden D H. Pulmonary injury and repair: Organ culture studies on murine lung after oxygen. Arch Pathol Lab Med 1976; 100: 640–643
  • Adamson I YR, Bowden D H. Bleomycin-induced injury and metaplasia of alveolar type 2 cells. J Pathol 1979; 96: 531–544
  • Dyson P, Heppleston A G. Cell kinetics of urethane-induced murine pulmonary adenomata. I. The growth rate. B J Cancer 1975; 31: 405–416
  • Kaufman S L. Autoradiographic study of type 2 cell hyperplasia in lungs of mice chronically exposed to urethane. Cell Tissue Kinet 1976; 9: 489–497
  • Brody A R, Overby L H. Tritiated thymidine incorporation by epithelial and interstitial cells in bronchiolar-alveolar regions of asbestos-exposed rates. Am J Pathol 1989; 134: 133–140
  • Coultas P G, Ahier R G, Field S B. Effects of neutron and X irradiation on cell proliferation in mouse lung. Radiat Res 1981; 85: 516–528
  • Adamson I YR, Bowden D H. Endothelial injury and repair in radiation-induced pulmonary fibrosis. Am J Pathol 1983; 112: 224–230
  • Adamson I YR, Bowden D H, Wyatt J P. A pathway to pulmonary fibrosis: An ultrastructural study of mouse and rat following radiation to the whole body and hemithorax. Am J Pathol 1970; 58: 481–498
  • Anderson M W. Issues in biochemical application to risk assessment: How do we evaluate individual components of multistage models?. Environ Health Perspect 1987; 76: 175–179
  • Travis E L, Harley R A, Fenn J O, Klobukowski C J, Hargrove H B. Pathologic changes in the lung following single and multifraction irradiation. Int J Radiat Oncol Biol Phys 1977; 2: 475–490
  • Faulkner C S, Connolly K S. The ultrastructure of 60-Co radiation pneumonitis in rats. Lab Invest 1973; 28: 545–553
  • Stearner S P, Devine R, Christian E JB. Late changes in the irradiated microvascu-lature: An electron microscope study of the effects of fission neutrons. Radiat Res 1976; 65: 351–370
  • ICRP. Biological effects of inhaled radionuclides. International Commission on Radiological Protection, Pergamon Press, Oxford 1980; Vol. 31
  • Tryka A F, Witschi H, Lindenschmidt R C. Progressive pulmonary fibrosis in rats: A biochemical, cell kinetic, and morphologic analysis. Exp Mol Pathol 1985; 43: 348–358

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