References
- Lehnert B E, Morrow P E. Association of 59iron oxide with alveolar macrophages during alveolar clearance. Exp Lung Res 1985; 9: 1–16
- Sorokin S P, Brain J D. Pathways of clearance in mouse lungs exposed to iron oxide aerosols. Anat Rec 1975; 181: 581–626
- Gibb F R, Morrow P E. Alveolar clearance in dogs following inhalation of an iron-59 oxide aerosol. J Appl Physiol 1962; 17: 429–432
- Macklin C C. Pulmonary sumps, dust accumulations, alveolar fluid, and lymph vessels. Acta Anat 1955; 23: 1–33
- Gross P. The mechanism of dust clearance from the lung. A theory. Am J Clin Pathol 1953; 23: 116–120
- Kilburn K. Functional morphology of the distal lung. Int Rev Cytol 1974; 37: 153–270
- Morrow P E. Possible mechanisms to explain overloading of the lungs. Fund Appl Toxicol 1988; 10: 369–384
- Warheit D B, Overby L H, George G, Brody A R. Pulmonary macrophages are attracted to inhaled particles through complement activation. Exp Lung Res 1988; 14: 51–66
- Yu C P, Chen Y K, Morrow P E. An analysis of alveolar macrophage mobility at dust overloading of the lungs. J Aerosol Med 1988; 1: 213
- Ferin J, Feldstein M L. Pulmonary clearance and hilar lymph node content in rats after particle exposure. Environ Res 1978; 16: 342–352
- Lee K P, Trochimowicz H J, Reinhardt C F. Transmigration of titanium dioxide (TiO2) particles in rats after inhalation exposure. Exp Mol Pathol 1987; 42: 331–343
- Lee K P, Henry N W, III, Trochimowicz H J, Reinhardt C F. Pulmonary response to impaired lung clearance in rats following excessive TiO2 dust deposition. Environ Res 1986; 41: 144–167
- Lehnert B E, Valdez Y E, Bomalaski S H. Lung and pleural “free-cell responses” to the intrapulmonary deposition of particles in the rat. J Toxicol Environ Health 1985; 16: 823–839
- Lehnert B E, Valdez Y E, Tietjen G L. Alveolar macrophage-particle relationships during lung clearance. J Respir Cell Mol Biol 1989; 1: 145–154
- Lehnert B E, Toevs K E, Valdez Y E, Sebring R J. Particle-macrophage relationships during the clearance of particles from the alveolar macrophage compartment. National Technical Information Services, US Dept. of Commerce, Washington, DC 1988, Los Alamos Technical Report No. LA-11428
- Draper N R, Smith H. Applied Regression Analysis. Wiley, New York 1966; 263–304
- Fiserova-Bergerova V. Introduction to mathematical modeling. Modeling of Inhalation Exposure to Vapors: Uptake, Distribution, and Elimination, V Fiserova-Bergerova. CRC Press, Inc., Boca Raton, FL 1983; vol 1: 51–70
- Lehnert B E, Cline A, London J E. Kinetics of appearance of polymorphonuclear leukocytes and their particle burdens during the alveolar clearance of a high lung burden of particles. Toxicologist 1989; 9: 307A
- Snyderman R, Pike M C. Interaction of complex polysaccharides with the complement system: effect of calcium depletion on terminal component consumption. Infect Immunol 1975; 11: 273–277
- Shaw J O, Henson P M, Henson J, Webster R O. Lung inflammation induced by complement-derived chemotactic fragments in the alveolus. Lab Invest 1980; 42: 547–558
- Warheit D B, George G, Hill L H, Snyderman R, Brody A R. Inhaled asbestos activates a complement-dependent chemoattractant for macrophages. Lab Invest 1985; 52: 505–514
- Falk W, Goodwin R H, Leonard E J. A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration. J Immunol Methods 1980; 33: 239–247
- Harvath L, Falk W, Leonard E J. Rapid quantification of neutrophil chemotaxis: use of a polyvinylpyrrolidone-free polycarbonate membrane in a multiwell assembly. J Immunol Methods 1980; 37: 39–45
- Kagan E, Oghiso Y, Hartmann D-P. Enhanced release of a chemoattractant for the alveolar macrophages following asbestos inhalation. Am Rev Respir Dis 1983; 128: 680–687
- Minkin C, Bannon D J, Jr, Pokress S, Melnick M. Multiwell chamber chemotaxis assays: improved experimental design and data analysis. J Immunol Methods 1985; 78: 307–321
- Scheffe H. The Analysis of Variance. Wiley, New York 1959; 55–89
- Dethloff L A, Lehnert B E. Compartmental origin of pulmonary macrophages harvested from mechanically disrupted lung tissue. Exp Lung Res 1987; 13: 361–383
- Lehnert B E, Valdez Y E, Holland L M. Pulmonary macrophages: alveolar and interstitial populations. Exp Lung Res 1985; 9: 177–190
- Dethloff L A, Lehnert B E. Pulmonary interstitial macrophages: isolation and flow cytometric comparisons with alveolar macrophages and blood monocytes. J Leukocyte Biol 1988; 43: 80–90
- Snipes M B, Olson T R, Yeh H C. Deposition and retention patterns for 3-, 9-, and 15-μm latex microspheres inhaled by rats and guinea pigs. Exp Lung Res 1988; 14: 37–50
- Graybill F A. An Introduction to Linear Statistical Models. McGraw-Hill, New York 1961; vol 1: 135
- Ferin J. Pulmonary alveolar pores and alveolar macrophage-mediated particle clearance. Anat Rec 1982; 203: 265–272
- Hill J O, Rothenberg S J, Kanapilly G M, Hanson R L, Scott B R. Activation of immune complement by fly ash particles from coal combustion. Environ Res 1982; 28: 113–122
- Warheit D B, Hill L H, George G, Brody A R. Time course of chemotactic factor generation and the corresponding macrophage response to asbestos inhalation. Am Rev Respir Dis 1986; 134: 128–133
- Saint-Remy J MR, Cole P. Interactions of chrysotile asbestos fibres with the complement system. Immunology 1980; 41: 431–437
- Wilson M R, Gaumer H R, Salvaggio J E. Activation of the alternative complement pathway and generation of chemotactic factors by asbestos. J Allergy Clin Immunol 1977; 60: 218–222
- Robertson J, Caldwell J R, Castle J R, Waldman R H. Evidence for the presence of components of the alternative (properdin) pathway of complement activation in respiratory secretions. J Immunol 1976; 117: 900–903
- Kolb W P, Kolb L M, Wetsel R A, Rogers W R, Shaw J O. Quantitation and stability of the fifth component of complement (C5) in bronchoalveolar lavage fluids obtained from non-human primates. Am Rev Respir Dis 1981; 123: 226–231
- Kazmieroski J A, Gallin J I, Reynolds H Y. Mechanisms for the inflammatory response in primate lungs: demonstration and partial characterization of an alveolar macrophage chemotactic factor with preferential activity for polymorphonuclear leukocytes. J Clin Invest 1977; 59: 273–281
- Dauber J H, Daniele R P. Secretion of chemotaxins by guinea pig lung macrophages. I. The spectrum of inflammatory cell responses. Exp Lung Res 1980; 1: 23–32