Advanced search
Publication Cover
Experimental Lung Research Volume 17, 1991 - Issue 4
Submit an article Journal homepage
3
Views
6
CrossRef citations to date
0
Altmetric
Original Article

Biochemical and Pharmacological Characterization of ICI 186,756: A Novel, Potent, and Selective Inhibitor of Human Neutrophil Elastase

J. C. Williams Pulmonary Section, Department of Pharmacology, ICI Pharmaceuticals Group, ICI Americas, Inc., Wilmington, Delaware; Merck, Sharp & Dohme Research Laboratories, Rahway, New Jersey; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut
,
R. L. Stein Pulmonary Section, Department of Pharmacology, ICI Pharmaceuticals Group, ICI Americas, Inc., Wilmington, Delaware; Merck, Sharp & Dohme Research Laboratories, Rahway, New Jersey; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut
,
A. M. Strimpler Pulmonary Section, Department of Pharmacology, ICI Pharmaceuticals Group, ICI Americas, Inc., Wilmington, Delaware; Merck, Sharp & Dohme Research Laboratories, Rahway, New Jersey; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut
,
B. Reaves Pulmonary Section, Department of Pharmacology, ICI Pharmaceuticals Group, ICI Americas, Inc., Wilmington, Delaware; Merck, Sharp & Dohme Research Laboratories, Rahway, New Jersey; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut
&
R. D. Krell Pulmonary Section, Department of Pharmacology, ICI Pharmaceuticals Group, ICI Americas, Inc., Wilmington, Delaware; Merck, Sharp & Dohme Research Laboratories, Rahway, New Jersey; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut
Pages 725-741 | Received 12 Feb 1990, Accepted 28 Aug 1990, Published online: 02 Jul 2009

References

  • Hunninghake G W, Crystal R G. Cigarette smoking and lung destruction: Accumulation of neutrophils in the lung of cigarette smokers. Am Rev Respir Dis 1983; 128: 833–838
  • Ludwig P W, Schwartz B A, Hoidal J R, Niewoehner D E. Cigarette smoking causes accumulation of polymorphonuclear leukocytes in alveolar septum. Am Rev Respir Dis 1985; 131: 828–830
  • Damiano V V, Tsang A, Kuchich V, Weinbaum G. Immunolocalization of elastase in human emphysematous lungs. J Clin Invest 1986; 78: 482–493
  • Fox B, Bull T B, Guz A, Harris E, Tetley T D. Is neutrophil elastase associated with elastic tissue in emphysema?. J Clin Pathol 1988; 41: 435–440
  • Groutus W C. Inhibitors of leukocyte elastase and leukocyte cathepsin G: Agents for the treatment of emphysema and related ailments. Res Rev 1987; 7(2)227–241
  • Powers J C, Gupton B F, Harley A D, Nighino N, Whitley R J. Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G: Inhibition with peptide chloromethyl ketones. Biochem Biophys Acta 1977; 484: 156–166
  • Kettner C, Shenvi A, Watanabe S, Soskel N. A peptide boronic acid inhibitor of elastase. Pulmonary Emphysema and Proteolysis: 1986, J C Taylor, C Mittman. Academic Press, New York 1987; 65–72
  • Kennedy A J, Cline A, Ney U M, Johnson W H, Roberts N A. The effect of a peptide aldehyde reversible inhibitor of elastase on a human leukocyte elastase induced model of emphysema in the hamster. Eur J Respir Dis 1987; 71: 472–478
  • Casezon T, De Wilde M, Merion P, Loriau R, Bollen A. Expression of human α-antitrypsin cDNA in the yeast Saccharomyces cervisiae. Proc Natl Acad Sci USA 1984; 81: 6594
  • Baici A, Seemüller U. Kinetics of the inhibition of human leukocyte elastase by eglin from the leech Hirudo medicinalis. Biochem J 1984; 218: 829–833
  • Boudier C, Bieth J G. Mucus proteinase inhibitor: A fast-acting inhibitor of leukocyte elastase. Biochem Biophys Acta 1989; 995: 36–41
  • Segel I H. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady State Systems. John Wiley & Sons, New York 1985; 109–111
  • Viscarello B R, Stein R L, Kusner E J, Holsclaw D, Krell R D. Purification of human leukocyte elastase and cathepsin G by chromatography on immobilized elastin. Prep Biochem 1983; 13: 57–67
  • Bonney R J, Ashe B, Maycock A, Dellea P, Hand K, Oginga D, Fletcher D, Mumford K, Davies Frankenfield P. D., Nolan T, Schaeffer L, Hagmann W, Finke P, Shah S, Dorn C, Doherty J. Pharmacological profile of the substituted Beta-Lactam L-659,286: A member of a new class of human PMN elastase inhibitors. J Cell Biochem 1989; 39: 47–53
  • Hassal C H, Johnson W H, Kennedy A J, Roberts N A. A new class of inhibitors of human leukocyte elastase. FEBS Lett 1985; 183(2)201–205
  • Janoff A, Sloan B, Weinbaum G, Damiano V, Sandhaus R A, Elias J, Kimbel P. Experimental emphysema induced with human neutrophil elastase: Tissue localization of the instilled protease. Am Rev Respir Dis 1977; 115: 461
  • Senior R M, Tegner H, Kuhn C, Ohlsson K, Starcher B C, Pierce J A. The induction of pulmonary emphysema with human leukocyte elastase. Am Rev Respir Dis 1977; 116: 469–475
  • Snider G L, Sherter G B. A one-year study of the evolution of elastase-induced emphysema in hamsters. J Appl Physiol 1977; 43: 721–729
  • Kuhn C, Slodkowska J, Smith T, Starcher B. The tissue response to exogenous elastase. Bull Eur Physiopathol Respir 1980; 16: 127–137
  • Stone P J, Pereira W, Biles D, Snider G L, Kagan H M, Franzblau C. Studies on the fate of pancreatic elastase in the hamster lung: 14C-guanidated elastase. Am Rev Respir Dis 1977; 116: 49–56
  • Giles R E, Finkel M P, Williams J C. The therapeutic effect of progesterone in papain-induced emphysema. Proc Soc Exp Biol Med 1974; 147: 489–493
  • Lucey E C, Stone P J, Christensen T G, Breuer R, Snider G L. An 18-month study of the effects on hamster lungs of intratracheally administered human neutrophil elastase. Exp Lung Res 1988; 14: 671–686
  • Maratorana P A, van Evan P, Schaper J. The effect of lung growth on the evolution of elastase-induced emphysema in the hamster. Lung 1982; 160: 19–27

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.