126
Views
2
CrossRef citations to date
0
Altmetric
Clinical Research

Formation of intracellular lumina in human prostate carcinoma (DU145) cells, maturation into signet cells, and the cribriform morphology of tumors

, BSc, MSc, EdM, DSc, , BSc, , BSc & , MSc, PhD
Pages 189-199 | Received 11 Jan 2016, Accepted 15 Feb 2016, Published online: 04 Apr 2016

References

  • Ghadially FN. Diagnostic Electron Microscopy, 2nd edn. London: Butterworths, Churchill Livingstone, 1985; 361–8.
  • Ghadially FN. Ultrastructural Pathology of the Cell and Matrix, vol. 2. Boston: Butterworth-Heinemann, 1997; 1072–83.
  • Erlandsen RA. Intracytoplasmic lumens. In: Diagnostic Transmission Electron Microscopy of Tumors. New York: Raven Press, 1994; 205–07.
  • Gilloteaux J, Jamison JM, Venugopal M, et al. Scanning electron microscopy and transmission electron microscopy aspects of synergistic antitumor activity of vitamin C-vitamin K3 combinations against human prostatic carcinoma cells. Scan Microsc Intl 1995;9:159–73.
  • Jamison JM, Gilloteaux J, Venugopal M, Koch JA, Sowick C, Shah R, Summers JL. Flow cytometric and ultrastructural aspects of the synergistic antitumor activity of vitamin C-vitamin K3 combinations against human prostatic carcinoma cells. Tissue Cell 1996;28:687–701.
  • Gilloteaux J, Jamison JM, Neal DR, Summers JL. Synergistic antitumor cytotoxic actions of ascorbate and menadione on human prostate (DU145) cancer cells in vitro: Nucleus and other injuries preceding cell death by autoschizis. Ultrastruct Pathol 2014;8(1): 116–40.
  • Taper HS, Jamison JM, Gilloteaux J, Gwin CA, Gordon T, Summers JL. In vivo reactivation of DNases in implanted human prostate tumors after administration of a vitamin C: K3. J Histochem Cytochem 2001;49:109–19.
  • Gilloteaux J. Jamison JM, Neal DR, Summers JL. Xenotransplanted human prostate carcinoma (DU145) cells develop into carcinomas and cribriform carcinomas: Ultrastructural aspects. Ultrastruct Pathol 2012;36:294–311.
  • Stone KR, Mickey DD, Wunderli H, et al. Isolation of a human prostate carcinoma cell line (DU 145). Int J Cancer 1978;21:274–81.
  • Venugopal M, Jamison JM, Gilloteaux J, et al. Synergistic antitumor activity of vitamins C and K3 on human urologic tumor cell lines. Life Sci1996;59:1389–400.
  • Venugopal M, Jamison JM, Gilloteaux J, et al. Synergistic antitumor activity of vitamins C and K3 against human prostate carcinoma cell lines. Cell Biol Int 1996;20:787–97.
  • Gilloteaux J, Eze N, Jamison JM, et al. A rare, human prostate oncocyte cell originates from the prostatic carcinoma (DU145) cell line. Ultrastruct Pathol 2013;37:440–8.
  • Gilloteaux J, Jamison JM, Arnold D, et al. Human prostate DU145 carcinoma cells implanted in nude mice remove the peritoneal mesothelium to invade and grow as carcinomas. Anat Rec A Disc Mol Cell Evol Biol 2013;296:40–55.
  • Gilloteaux J, Jamison JM, Summers Ll. Pro-oxidant treatment of human prostate carcinoma (DU145) cells induces autoschizis cell death: autophagosomes build up out of injured endomembranes and mitochondria. Ultrastruct Pathol 2014;38(5): 315–28.
  • Higgins LH, Withers HG, Garbens A, et al. Hypoxia and the metabolic phenotype of prostate cancer cells. Biochim Biophys Acta 2009;1787:1433–43
  • Féron O. Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells. Radiother Oncol 2009;92:329–33.
  • Porporato PE, Dhup S, Dadhich RK, et al. Anticancer targets in the glycolytic metabolism of tumors: A comprehensive review. Front Pharmacol 2011;2: (Article 49); 1–18.
  • Dhup S, Dadhich RK, Porporato PE, et al. Multiple biological activities of lactic acid in cancer: Influences of tumor growth, angiogenesis and metastasis. Curr Pharmacol Design 2012;18:1319–30.
  • Mickey DD, Stone KR, Wunderli H, et al. Heterotransplantation of a human prostatic adenocarcinoma cell line in nude mice. Cancer Res 1977;37:4049–58.
  • Wells CM, Whale AD, Parsons M, et al. PAK4: A pluripotent kinase that regulates prostate cancer cell adhesion. J Cell Sci 2010;123:1663–73.
  • Chunthapong J, Seftor EA, Khalkhali-Ellis Z, et al. Dual roles of E-cadherin in prostate cancer invasion. J Cell Biochem 2004;91:649–61.
  • De Marzo AM, Knudsen B, Chan-Tack K, et al. E-cadherin expression as a marker of tumor aggressiveness in routinely processed radical prostatectomy specimens. Urology 1999;53:707–13.
  • Shimoyama Y, Hiroshashi S, Hirano S, et al. Cadherin cell adhesion molecules in human epithelial tissues and carcinomas. Cancer Res 1989;49:2128–33.
  • Otto T, Rembrink K, Goepel M, et al. E-cadherin: A marker for differentiation and invasiveness in prostatic carcinoma. Urol Res 1993;21:359–62.
  • Umbas R, Isaaacs WB, Bringuier PP, et. Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res 1994;54:3929–33.
  • Cheng L, Nagabhushan M, Pretlow TP, et al. Expression of E-cadherin in primary and metastatic prostate cancer. Am J Pathol 1996;148:1375–80.
  • Paul R, Ewing CM, Jarrard DF, et al. The cadherin cell–cell adhesion pathway in prostate cancer progression. Br J Urol 1997;1:37–43.
  • Rubin MA, Mucci NR, Figurski J, et al. E-cadherin expression in prostate cancer: A broad survey using high-density tissue microarray technology. Hum Pathol 2001;32:690–7.
  • Kuefer R, Hofer MD, Zorn CS, et al. Assessment of a fragment of E-cadherin as a serum biomarker with predictive value for prostate cancer. Brit J Cancer 2005;92:2018–23.
  • Morton RA, Ewing CM, Nagafuchi A, et al. Reduction of E-cadherin levels and deletion of the alpha catenin gene in human prostate cancer cells. Cancer Res 1993;53:3585–90.
  • Rios-Doria J, Day KC, Kuefer R, et al. The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells. J Biol Chem 2003;278:1372–79.
  • Katayama M, Hirai S, Kamihagi K, et al. Soluble E-cadherin fragments increased in circulation of cancer patients. Br J Cancer 1994;69:580–5.
  • De Wever O, Derycke L, Hendrix A, et al. Soluble cadherins as cancer biomarkers. Clin Exp Metastasis 2007;24:685–97.
  • Morita N, Uemura H, Tsumatani K, et al. E-cadherin and alpha-, beta- and gamma-catenin expression in prostate cancers: Correlation with tumour invasion. Br J Cancer 1999;79:1879–83.
  • Hirano S, Kimoto N, Shimoyama Y, et al. Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization. Cell 1992;70(2): 293–301.
  • Aaltomaa S, Kärjä V, Lipponen P, et al. Reduced alpha- and beta-catenin expression predicts shortened survival in local prostate cancer. Anticancer Res 2005;25:4707–12.
  • Umbas R, Isaacs WB, Bringuier PP, et al. Relation between aberrant alpha-catenin expression and loss of E-cadherin function in prostate cancer. Int J Cancer 1997;74(4): 374–7.
  • Gravdal K, Halvorsen OJ, Haukaas SA, et al. A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer. Clin Cancer Res 2007;13:7003–11.
  • Jennbacken K, Tesan T, Wang W, et al. N-cadherin increases after androgen deprivation and is associated with metastasis in prostate cancer. Endocrin Relat Cancer 2010;17:469–79.
  • Kümper S, Ridley AJ. P120ctn and P-cadherin but not E-cadherin regulate cell motility and invasion of DU145 prostate cancer cells. PLos One 2010;5: e11801.
  • Nalai AK, Estes N, Patel J, et al. N-cadherin mediates angiogenesis by regulating monocyte chemoattractant protein-1 expression via PI3K/Akt signalling in prostate cancer cells. Exp Cell Res 2011;317:2511–21.
  • Tran NL, Nagle RB, Cress AE, et al. N-cadherin expression in human prostate carcinoma cell lines: an epithelial-mesenchymal transformation mediating adhesion with stromal cells. Am J Pathol 1999;155:787–98.
  • Huber MA, Kraut N, Beug H. Molecularrequirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 2005;17:548–58.
  • De Wever O, Pauwels P, De Craene B, et al. Molecular and pathological signatures of epithelial–mesenchymal transitions at the cancer invasion front. Histochem Cell Biol 2008;130:481–94.
  • Park ER, Pullikuth AK, Bailey EM, et al. Differential requirement for MEK Partner 1 in DU145 prostate cancer cell migration. Cell Commun Signal 2009;7:26–34.
  • Turner T, Chen P, Goodly LJ, et al. EGF receptor signalling enhances in vivo invasiveness of DU-145 human prostate carcinoma cells. Clin Exp Metastasis 1996;14:409–18.
  • Chatterjee S, Park ES, Soloff MS. Proliferation of DU145 prostate cancer cells is inhibited by suppressing insulin-like growth factor binding protein-2. Int J Urol 2004;11:876–84.
  • Mamoune A, Kassis J, Kharait S, et al. DU145 human prostate carcinoma invasiveness is modulated by urokinase receptor (uPAR) downstream of epidermal growth factor receptor (EGFR) signaling. Exp Cell Res 2004;299:91–100.
  • Wu W, Walker AM. Human chorionic gonadotrophin beta (HCGbeta) down-regulates E-cadherin and promotes human prostate carcinoma cell migration and invasion. Cancer 2006;106:68–78.
  • Camparo P, Vieillefond A. Molecular aspects of prostate cancer: recent data from the literature. Bull Cancer 2007;94(7Suppl): F77. [Article in French].
  • Wang Y, Yue D, Li K, et al. The role of TRPC6 in HGF- induced cell proliferation of human prostate cancer DU145 and PC3 cells. Asian J Androl 2010;12:841–52.
  • Schulz WA, Ingenwerth M, Djuidje CE, et al. Changes in cortical cytoskeletal and extracellular matrix gene expression in prostate cancer are related to oncogenic ERG deregulation. BMC Cancer 2010;10:505–14.
  • Sobrinho-Simões M, Johannessen JV, Gould VE. The diagnostic significance of intracytoplasmic lumina in metastatic neoplasms. Ultrastruct Pathol 1981;2:327–35.
  • Remy L, Marvaldi J, Rua S, et al. The role of intracellular lumina in the repolarization process of a colonic adenocarcinoma cell line. Virchows Arch B Cell Pathol Incl Mol Pathol 1984;46:297–305.
  • Remy L, Marvaldi J. Origin of intracellular lumina in HT 29 colonic adenocarcinoma cell line. An ultrastructural study. Virchows Arch B Cell Pathol Incl Mol Pathol 1985;48:145–153.
  • Remy L. The intracellular lumen: origin, role and implications of a cytoplasmic neostructure. Biol Cell 1986;56:97–105.
  • Remy L, Gorvel JP, Jacquier MF, et al. Confocal microscopy as a tool to reveal the tridimensional organization of intracellular lumens and intercellular cysts in a human colon adenocarcinoma cell line. Biol Cell 1990;69:129–38.
  • Djakiew D, Pflug B, Delsite R, et al. Density dependent polarized secretion of a prostatic epithelial cell line. Prostate 1992;20(1): 15–27.
  • Alroy J, Pauli BU, Hayden JE, et al. Intracytoplasmic lumina in bladder carcinomas. Hum Pathol 1979;10:549–55.
  • Li XM, Wang H, Zhu LL, et al. Genes regulating epithelial polarity are critical suppressors of esophageal oncogenesis. J Cancer 2015;6(8): 694–700.
  • Lehmann M, Rigot-Remy L, Marvaldi J. Origin of intracellular lumina in HT 29 colonic adenocarcinoma cell line. An ultrastructural study. Virchows Arch B Cell Pathol Incl Mol Pathol 1985;48(2): 145–53.
  • Bae SI, Kang GH, Kim YI, et al. Development of intracytoplasmic lumens in a colon cancer cell line cultured on a non-adhesive surface. Cancer Biochem Biophys 1999; 17 (1–2): 35–47.
  • Xu X, Eyden B, Hou W, et al. Gastrointestinal stroma tumor with structures resembling intracytoplasmic lumina. Ultrastruct Pathol 2010;34:301–6.
  • Lennigton WJ, Jensen RA, Dalton LW et al. Ductal carcinoma in situ of the breast. Heterogeneity of individual lesions. Cancer 1994;73:118–124.
  • Battifora H. Intracytoplasmic lumina in breast carcinoma: A helpful histopathologic feature. Arch Pathol 1975;99:614–7.
  • Tsuchiya S. Intracytopalsmic lumina of human breast cancer-a microscopic study and practical application in cytological diagnosis. Acta Pathol Jpn 1981;31:45–54.
  • Ferguson DJ, Anderson TJ, Wells CA, et al. An ultrastructural study of mucoid carcinoma of the breast: Variability of cytoplasmic features. Histopathology 1986;10:1219–30.
  • Nesland JM, Holm R, Lunde S, et al. Diagnostic problems in breast pathology: The benefit of ultrastructural and immunocytochemical analysis. Ultrastruct Pathol 1987; 11: 293–311.
  • Hagiwara H, Ohwada N, Fujimoto T. Intracytoplasmic lumina in human oviduct epithelium. Ultrastruct Pathol 1997;21:163–72.
  • Nejjari M, Berthet V, Rigot V, et al. Inhibition of proprotein convertases enhances cell migration and metastases development of human colon carcinoma cells in a rat model. Am J Pathol 2004;164(6): 1925–33.
  • Le Bivic A, Arsanto JP. Differential expression of alkaline phosphatase and ATPase activities in human colon carcinoma cell line HT-29.18 during differentiation. Biol Cell 1987; 60(1): 41–7.
  • Dermer GB, Sherwin RP. Autoradiographic localization of glycoprotein in human breast cancer cells maintained in organ culture after incubation with [3H]fucose or [3H] glucosamine. Cancer Res 1975;35:63–7.
  • Wahnschaffe U, Emura M, Mohr U. Development of intracytoplasmic lumina in diethylnitrosamine-induced tracheal papillomas of Syrian golden hamster. Virchows Arch B 1997;54:59–66.
  • Bosland MC, Prinsen MK, Dirksen TMJ, et al. Characterization of adenocarcinomas of the dorsolateral prostate induced in Wistar rats by N-methyl-N-nitrourea, 7,12-dimethylbenz(a)anthracene, and 3-2’-dimethyl-4-aminobisphenyl, following sequential treatment with cytoperone acetate and testosterone propionate. Cancer Res1990;50:700–9.
  • Gilloteaux J, Naud J. The zinc iodide-osmium tetroxide staining-fixative of Maillet. Nature of the precipitate studied by x-ray microanalysis and detection of Ca2+-affinity subcellular sites in a tonic smooth muscle. Histochemistry 1979;63(2): 227–43.
  • Leong FJ, Leong AS, Swift J. Signet-ring carcinoma of the prostate. Pathol Res Pract 1996;192:1232–8.
  • Ro JY, el-Naggar A, Ayala AG, et al. Signet-ring-cell carcinoma of the prostate: Electron-microscopic and immunohistochemical studies of eight cases. Am J Surg Pathol 1988;12:453–60.
  • Hejka AG, England DM. Signet ring cell carcinoma of prostate. Immunohistochemical and ultrastructural study of a case. Urology 1989;34:155–8.
  • Alline KM, Cohen MB. Signet-ring cell carcinoma of the prostate. Arch Pathol Lab Med 1992;116:99–102.
  • Kuroda N, Yamsaki I, Nakayama H, et al. Prostatic signet ring cell carcinoma: Case report and literature review. Pathol Int 1999;49:457–61.
  • Jiang Z, Zhang H, Chen J, et al. Pathologic diagnosis and histogenesis of primary signet ring cell carcinoma of the prostate. Zhonghua Bingh Li Xue Za Zhi 2002;31:514–7.
  • Epstein JI. Precursor lesions to prostatic adenocarcinoma. Virchows Arch 2009;454:1–16.
  • Dema A, Borda A, Lazar E, et al. Prostate lesions with cribriform/pseudocribriform pattern. Rom J Morph Embryol 2010;51:413–25.
  • Iczkowski KA, Torkko KC, Kotnis GR, et al. Digital quantification of five high-grade prostate cancer patterns, including the cribriform pattern, and their association with adverse outcome. Am J Clin Pathol 2011;136(1): 98–107.
  • Robinson B, Magi-Galluzzi C, Zhou M. Intraductal carcinoma of the prostate. Arch Pathol Lab Med 2012;136(4): 418–25.
  • Shah RB, Zhou M. Atypical cribriform lesions of the prostate: Clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate. Adv Anat Pathol 2012;19(4): 270–8.
  • Gilloteaux J, Jamison JM, Neal DR, et al. Cell damage and death by autoschizis in human bladder (RT4) carcinoma cells resulting from treatment by ascorbate and menadione. Ultrastruct Pathol 2010;34:140–60.
  • McGuire K, Jamison JM, Neal D, et al. Elucidating the pathway of Apatone ® induced DNase II reactivation during autoschizic cell death. Microsc Microanal 2009;15(suppl 2): 888–9.
  • Jamison JM, Gilloteaux J, Taper HS, et al. The in vitro and in vivo antitumor activity of vitamin C: K3 combinations against prostate cancer. In: Lucas JL, ed. Trends in Prostate Cancer Research. Hauppauge, New York: Nova Science Publishers, 2005, 423–71.
  • Ahn SK, Kim K, Choi IJ, et al. Adenoid cystic carcinoma of the prostate gland. Yonsei Med J 1991;32:74–8.
  • Helpap B, Köllermann J. Atypical acinar proliferations of the prostate. Pathol Res Pract 1999;195:795–9.
  • Epstein JI, Egevad L, Amin MB, et al.; and the Grading Committee. The 2014 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma: Definition of grading patterns and proposal for a new grading system. Am J Surg Pathol 2015;40:244–252.
  • Siadat F, Sykes J, Zlotta AR, et al. Not all Gleason pattern 4 prostate cancers are created equal: A study of latent prostatic carcinomas in a cystoprostatectomy and autopsy series. Prostate 2015;75(12):1277–84.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.