Ultrastructural Diagnosis of Amelanotic Malignant Melanoma: Aberrant Melanosomes, Myelin Figures or Lysosomes?

References

• Weston J A. The migration an differentiation of neural crest cells. Adv Morphogen 1970; 8: 41–115
   PubMedGoogle Scholar
• Quevedo W C, Jr, Fleischmann R D. Developmental biology of mammalian melanocytes. J Invest Dermatol 1980; 75: 116–120
   PubMed Web of Science ®Google Scholar
• Jimbow K, Oikawa O, Sugiyama S, Takeuchi T. Comparison of eumelanogenesis and pheomelanogenesis in retinal and follicular melanocytes; role of vesiculoglobular bodies in melanosome differentiation. J Invest Dermatol 1979; 73: 278–284
   PubMedGoogle Scholar
• Jimbow K, Quevedo W C, Jr, Fitzpatrick T B, Szabo G. Some aspects of melanin biology: 1950–1975. J Invest Dermatol 1976; 67: 72–89
   PubMed Web of Science ®Google Scholar
• Jimbow K, et al. Characterization of melanogenesis and morphogenesis of melanosomes by physio-chemical properties of melanin and melanosomes in malignant melanoma. Cancer Res 1984; 44: 1128–1134
   PubMed Web of Science ®Google Scholar
• Prota G. Recent advances in the chemistry of melanogenesis in mammals. J Invest Dermatol 1980; 75: 122–127
   PubMed Web of Science ®Google Scholar
• Fitzpatrick T B, Szabo G, Selji M, Quevedo W C. Biology of the melanin pigmentary system. Dermatology in General Medicine 2nd ed, T B Fitzpatrick, et al. McGraw-Hill, New York 1979; 131–163
   Google Scholar
• Seiji M, Fitzpatrick T B, Birbeck M SC. The melanosome: A distinctive subcellular particle of mammalian melanocytes and the site of melanogenesis. J Invest Dermatol 1961; 36: 243–252
   PubMedGoogle Scholar
• Ghadially F N. Diagnostic Electron Microscopy of Tumours, 2nd ed. Butterworths, London 1985; 106–122
   Google Scholar
• Birbeck M SC. Electron microscopy of melanocytes: The fine structure of hair bulb melanosomes. Ann NY Acad Sci 1963; 100: 540–547
   PubMed Web of Science ®Google Scholar
• Fitzpatrick T B, Quevedo W C, Jr, Szabo G, Seiji M. Biology of the melanin pigmentary system. Dermatology in General Medicine, T B Fitzpatrick, et al. McGraw-Hill, New York 1971; 117–146
   Google Scholar
• Wellings S R, Siegel B V. Role of the Golgi apparatus in the formation of melanin granules in human malignant melanoma. J Ultrastruct Res 1959; 3: 147–154
   PubMedGoogle Scholar
• Allegra S R. Golgi apparatus and melanogenesis. Ultrastructural study of a human cellular blue nevus (melanocytoma). Lab Invest 1974; 34: 258–267
   Google Scholar
• Jimbow K, Szabo G, Fitzpatrick T B. Ultrastructure of giant pigment granules (macromelanosomes) in the cutaneous pigmented macules of neurofibromatosis. J Invest Dermatol 1973; 61: 300–309
   PubMed Web of Science ®Google Scholar
• Konrad K, Wolff K, Hönigsmann H. The giant melanosomes: A model of deranged melanosome-morphogenesis. J Ultrastruct Res 1974; 48: 102–123
   PubMedGoogle Scholar
• Horikoshi T, Jimbow K, Sugiyama S. Comparison of macromelanosomes and autophagic giant melanosome complexes in nevocellular nevi, lentigo simplex and malignant melanoma. J Cutan Pathol 1982; 9: 329–339
   PubMedGoogle Scholar
• Bhawan J. Melanocytic nevi. A review. J Cutan Pathol 1979; 6: 153–169
   PubMedGoogle Scholar
• Hernandez F J. Malignant blue nevus. A light and electron microscopic study. Arch Dermatol 1973; 107: 741–744
   PubMedGoogle Scholar
• Human Malignant Melanoma. Clinical Oncology Monographs, W H Clark, Jr, L I Goldman, M J Mastrgelo. Grune & Stratton, New York 1979
   Google Scholar
• Clark W H, et al. A study of tumor progression: The precursor lesions of superficial spreading and nodular melanoma. Hum Pathol 1984; 15: 1147–1165
   PubMed Web of Science ®Google Scholar
• Hasumik, et al. Primary malignant melanoma of the vagina. Study of four autopsy cases with ultrastructural findings. Cancer 1978; 42: 2675–2686
   PubMedGoogle Scholar
• Regezi J A, Hayward J R, Pickens T N. Superficial melanomas of oral mucous membranes. Oral Pathol 1978; 45: 730–740
   Google Scholar
• Merkow L P, et al. A cellular and malignant blue nevus: A light and electron microscopic study. Cancer 1969; 24: 888–896
   PubMedGoogle Scholar
• Roth A M. Malignant change in melanocytomas of the uveal tract. Survey Opthalmol 1978; 22: 404–412
   PubMed Web of Science ®Google Scholar
• Chang P, Knapper W H. Metastatic melanoma of the unknown primary. Cancer 1982; 49: 1106–1111
   PubMedGoogle Scholar
• Bhawan J. Amelanotic melanoma or poorly differentiated melanoma?. J Cut Pathol 1980; 7: 55–56
   PubMedGoogle Scholar
• Erlandson R A. Diagnostic Transmission Electron Microscopy of Human Tumors. Masson, New York 1981; 71–77
   Google Scholar
• Erlandson R A. Diagnostic electron microscopy with the Zeiss EM 109 (amelanotic malignant melanoma). Zeiss Info, MEM 1982; 1: 8–13
   Google Scholar
• Costa J, Rosai J, Philpott G W. Pigmentation of “amelanotic” melanoma in culture. A finding of diagnostic relevance. Arch Pathol 1973; 95: 371–373
   PubMedGoogle Scholar
• Klug H, Günther W. Ultrastructural differences in human malignant melanomata. An electron microscopical study. Br J Dermatol 1972; 86: 395–407
   PubMed Web of Science ®Google Scholar
• Hunter J AA, et al. Cellular fine structure in the invasive nodules of different histogenetic types of malignant melanoma. Br J Dermatol 1978; 98: 255–272
   PubMed Web of Science ®Google Scholar
• Mazur M T, Katzenstein A-L A. Metastatic melanoma: The spectrum of ultrastructural morphology. Ultrastruct Pathol 1980; 1: 337–356
   PubMed Web of Science ®Google Scholar
• Persky B, Meyskens F L, Jr, Hendrix M JC. Diagnostic electron microscopy for amelanotic melanoma: Correlation of patient biopsy, soft agar assay, and xenograft. J Pathol 1983; 141: 17–27
   PubMedGoogle Scholar
• Curran R C, McCann B G. The ultrastructure of benign pigmented naevi and melanocarcinomas in man. J Pathol 1976; 119: 135–146
   PubMedGoogle Scholar
• Silbert S W, Smith K R, Jr, Horenstein S. Primary leptomeningeal melanoma. An ultrastructural study. Cancer 1978; 41: 519–527
   PubMedGoogle Scholar
• Toshima S, Moore G E, Sandberg A A. Ultrastructure of human melanoma in cell culture. Electron microscopic studies. Cancer 1968; 21: 202–216
   PubMedGoogle Scholar
• Clark W H, Bretton R. A comparative fine structural study of melanogenesis in normal human epidermal melanocytes and in certain human malignant melanoma cells. The Skin, International Academy of Pathology. Williams & Wilkins, Baltimore 1971; 192–214, Monograph 10
   Google Scholar
• Foa C, Aubert C. Ultrastructural comparison between cultured and tumor cells of human malignant melanomas. Cancer Res 1977; 37: 3957–3963
   PubMedGoogle Scholar
• Takahashi H, Horikoshi T, Jimbow K. Fine structural characterization of melanosomes in dysplastic nevi. Cancer 1985; 56: 111–123
   PubMed Web of Science ®Google Scholar
• Dingemans K P, Mooi W J, van den Bergh Weerman M A. Angulate lysosomes. Ultrastruct Pathol 1983; 5: 113–122
   PubMed Web of Science ®Google Scholar
• Mullins J D. A pigmented differentiating neuroblastoma. A light and ultrastructural study. Cancer 1980; 46: 522–528
   PubMed Web of Science ®Google Scholar
• Graham D G. On the origin and significance of neuromelanin. Arch Pathol Lab Med 1979; 103: 359–362
   PubMed Web of Science ®Google Scholar
• Mackay B, Ayala A G. Intracisternal tubules in human melanoma cells. Ultrastruct Pathol 1980; 1: 1–6
   PubMed Web of Science ®Google Scholar
• Bhuta S, Mirra J M, Cochran A J. Myxoid malignant melanoma. A previously undescribed histologic pattern noted in metastatic lesions and a report of four cases. Am J Surg Pathol 1986; 10: 203–211
   PubMedGoogle Scholar
• Wetzel W J, Reuhl K R. Microtubular aggregates in the rough endoplasmic reticulum of a myxold chondrosarcoma. Ultrastruct Pathol 1980; 1: 519–525
   PubMed Web of Science ®Google Scholar
• DeBlois G, Wang S, Kay S. Microtubular aggregates within rough endoplasmic reticulum. An unusual ultrastructural feature of extraskeletal myxoid chondrosarcoma. Hum Pathol 1986; 17: 469–475
   PubMed Web of Science ®Google Scholar
• Thorstenson S. Case for the panel. Amelanotic malignant melanoma. Ultrastruct Pathol 1984; 6: 351–357
   PubMedGoogle Scholar
• Erlandson R A. Axillary sweat gland carcinoma versus amelanotic malignant melanoma. Ultrastruct Pathol 1985; 9: 51–57
   PubMed Web of Science ®Google Scholar
• Rodriguez H A, McGavran M H. A modified dopa reaction for the diagnosis and investigation of pigment cells. Am J Clin Pathol 1969; 52: 219–227
   PubMed Web of Science ®Google Scholar
• Nakajima T, et al. Immunohistochemical demonstration of S-100 protein in malignant melanoma and pigmented nevus, and its diagnostic application. Cancer 1982; 50: 912–918
   PubMed Web of Science ®Google Scholar
• Stefansson K, Wollmann R, Jerkovic M. S-100 protein in soft tissue tumors derived from Schwann cells and melanocytes. Am J Pathol 1982; 106: 261–268
   PubMed Web of Science ®Google Scholar
• Erlandson R A. Diagnostic immunohistochemistry of human tumors. An interim evaluation. Am J Surg Pathol 1984; 8: 615–624, (Editorial)
   PubMed Web of Science ®Google Scholar
• Kahn H J, Marks A, Thom H, Baumal R. Role of antibody to S-100 protein in diagnostic pathology. Am J Clin Pathol 1983; 79: 341–347
   PubMed Web of Science ®Google Scholar
• Weiss S W, Langloss J M, Enzinger F M. Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant Schwann cell tumors. Lab Invest 1983; 49: 299–308
   PubMed Web of Science ®Google Scholar
• Vanstapel M-J, et al. New sites of human S-100 immunoreactivity detected with monoclonal antibodies. Am J Clin Pathol 1986; 85: 160–168
   PubMed Web of Science ®Google Scholar
• Miettinen M, Lehto V-P, Virtanen I. Presence of fibroblast-type intermediate filaments (vimentin) and absence of neurofilaments in pigmented nevi and malignant melanomas. J Cutan Pathol 1983; 10: 188–192
   PubMedGoogle Scholar
• Natali P G, et al. The impact of monoclonal antibodies on the study of human malignant melanoma. J Cutan Pathol 1983; 10: 514–528
   PubMedGoogle Scholar
• Gatter K C, et al. An immunocytochemical study of malignant melanoma and its differential diagnosis from other malignant tumours. J Clin Pathol 1985; 38: 1353–1357
   PubMed Web of Science ®Google Scholar
• Boesel C P, Suhan J P, Sayers M P. Melanotic medulloblastoma. Report of a case with ultrastructural findings. J Neuropathol Exp Neurol 1978; 37: 531–543
   PubMed Web of Science ®Google Scholar
• Dehner L P, et al. Malignant melanotic neuroectodermal tumor of infancy. A clinical, pathological, ultrastructural and tissue culture study. Cancer 1979; 43: 1389–1410
   PubMed Web of Science ®Google Scholar
• Cutler L S, Chaudrhy A P, Topazian R. Melanotic neuroectodermal tumor of infancy: An ultrastructural study, literature review, and reevaluation. Cancer 1981; 48: 257–270
   PubMed Web of Science ®Google Scholar
• Cebelin M S. Melanocytic bronchial carcinoid tumor. Cancer 1980; 46: 1843–1848
   PubMed Web of Science ®Google Scholar
• Marcus J N, Dise C A, Livolsi V A. Melanin production in a medullary thyroid carcinoma. Cancer 1982; 49: 2518–2526
   PubMed Web of Science ®Google Scholar
• Chumas J C, Lorelle C A. Melanotic adenocarcinoma of the anorectum. Am J Surg Pathol 1981; 5: 711–717
   PubMed Web of Science ®Google Scholar
• Burns D K, Silva F G, Forde K A, Mount P M, Clark H B. Primary melanocytic schwannoma of the stomach. Evidence of dual melanocytic and schwannian differentiation in an extra-axial site in a patient without neurofibromatosis. Cancer 1983; 52: 1432–1441
   PubMed Web of Science ®Google Scholar
• Mennemeyer R P, et al. Melanotic schwannoma. Clinical and ultrastructural studies of three cases with evidence of intracellular melanin synthesis. Am J Surg Pathol 1979; 3: 3–10
   PubMed Web of Science ®Google Scholar
• Janzer R C, Makek M. Intraoral malignant melanotic schwannoma. Ultrastructural evidence for melanogenesis by Schwann's cells. Arch Pathol Lab Med 1983; 107: 298–301
   PubMedGoogle Scholar
• Erlandson R A. Melanotic schwannoma of spinal nerve origin. Ultrastruct Pathol 1985; 9: 123–129
   PubMed Web of Science ®Google Scholar
• Ranchod M. Metastatic melanoma with balloon cell changes. Cancer 1972; 30: 1006–1013
   PubMedGoogle Scholar
• Søndergaard K, Henschel A, Hou-Jensen K. Metastatic melanoma with balloon cell changes: An electron microscopic study. Ultrastruct Pathol 1980; 1: 357–360
   PubMed Web of Science ®Google Scholar
• Enzinger F M. Clear cell sarcoma of tendons and aponeuroses: An analysis of 21 cases. Cancer 1965; 18: 1163–1174
   PubMed Web of Science ®Google Scholar
• Kindblom L-G, Lodding P, Angervall L. Clear-cell sarcoma of tendons and aponeuroses. An immunohistochemical and electron microscopic analysis indicating neural crest origin. Virchows Arch (Pathol Anat) 1983; 401: 109–128
   Google Scholar
• Chung E B, Enzinger F M. Malignant melanoma of soft parts. A reassessment of clear cell sarcoma. Am J Surg Pathol 1983; 7: 406–413
   Google Scholar
• Mukai M, et al. Histogenesis of clear cell sarcoma of tendons and aponeuroses. An electron-microscopic, biochemical, enzyme histochemical, and immunohistochemical study. Am J Pathol 1984; 114: 264–272
   PubMed Web of Science ®Google Scholar
• Parker J B, Marcus P B, Martin J H. Spinal melanotic clear-cell sarcoma. A light and electron microscopic study. Cancer 1980; 46: 718–724
   PubMed Web of Science ®Google Scholar
• Azumi N, Turner R R. Clear cell sarcoma of tendons and aponeuroses: Electron microscopic findings suggesting Schwann cell differentiation. Human Pathol 1983; 14: 1084–1089
   PubMedGoogle Scholar
• Font R L, Truong L D. Melanotic schwannoma of soft tissues. Electron-microscopic observations and review of literature. Am J Surg Pathol 1984; 8: 129–138
   PubMedGoogle Scholar
• Ohno T, et al. Ultrastructural study of a clear cell sarcoma suggesting schwannian differentiation. Ultrastruct Pathol 1986; 10: 39–48
   PubMed Web of Science ®Google Scholar
• Kubo T. Clear-cell sarcoma of patellar tendon studied by electron microscopy. Cancer 1969; 24: 948–953
   PubMed Web of Science ®Google Scholar
• Hajdu S I, Shiu M H, Fortner J G. Tendosynovial sarcoma. A clinicopathologic study of 136 cases. Cancer 1977; 39: 1201–1217
   PubMed Web of Science ®Google Scholar
• Tsuneyoshi M, Enjoji M, Kubo T. Clear cell sarcoma of tendons and aponeuroses. A comparative study of 13 cases with a provisional subgrouping into melanotic and synovial types. Cancer 1978; 42: 243–252
   PubMed Web of Science ®Google Scholar
• Conley J, Lattes R, Orr W. Desmoplastic malignant melanoma (a rare variant of spindle cell melanoma). Cancer 1971; 28: 914–936
   PubMed Web of Science ®Google Scholar
• Labrecque P G, Hu C-H, Winkelmann R K. On the nature of desmoplastic melanoma. Cancer 1976; 38: 1205–1213
   PubMed Web of Science ®Google Scholar
• Valensi Q J. Desmoplastic malignant melanoma. A light and electron microscopic study of two cases. Cancer 1979; 43: 1148–1155
   PubMed Web of Science ®Google Scholar
• From L, et al. Origin of the desmoplasia in desmoplastic malignant melanoma. Human Pathol 1983; 14: 1072–1080
   PubMed Web of Science ®Google Scholar
• Di Maio S M, Mackay B, Leslie Smith J, Jr, Dickersin G R. Neurosarcomatous transformation in malignant melanoma. An ultrastructural study. Cancer 1982; 50: 2345–2354
   PubMedGoogle Scholar
• Reed R J, Leonard D D. Neurotropic melanoma. A variant of desmoplastic melanoma. Am J Surg Pathol 1979; 3: 301–311
   PubMed Web of Science ®Google Scholar
• Ackerman B A, Godomski J. Neurotropic malignant melanoma and other neurotropic neoplasms in the skin. Am J Dermatopathol 1984; 6(Suppl 1)63–80
   PubMedGoogle Scholar