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Original Article

Ultrastructure and Electron Inununocytochemistry of Insulin-producing B-Cell Tumors from Transgenic Mice: Comparison with Counterpart Human Tumors

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Pages 547-559 | Published online: 10 Jul 2009

References

  • Wilder RM, Allen FN, Power MH, Robertson HE. Carcinoma of the islets of the pancreas-hyperinsulinism and hypoglycemia. JAMA 1927; 89: 348
  • Heitz PU, Kloppel G. Pancreatic endocrine tumors. Evolution and Tumour Pathology of the Neuroendocrine System, S. Falkmer, R. Hakanson, F. Sundler. Fernstrom Foundation, Amsterdam 1984; 481
  • Howard JM, Moss NH, Rhoads JE. Hyperinsu-linism and islet cell tumors of the pancreas with 398 recorded tumors. Surg Gynecol Ob-stet 1950; 90: 417
  • Stefanini P., Carboni M., Patrassi N., Basoli A. Beta-islet cell tumors of the pancreas: Results of a study on 1067 cases. Surgery 1974; 75: 597
  • Lundstam S., Lundholm K., Schersten T. A ten-year material of insulinoma Diagnosis and surgical treatment. Scand J Gastroenterol 1979; 14: 653
  • Larsson L-l, Larsson L-l, Hakanson R., Re-Hfeld JF, Standi! F., Hoist J J, Angerwall L., Sun-Dler F. Mixed endocrine pancreatic tumors producing several peptide hormones. Am J Pathol 1975; 79: 271
  • Polak JM, Bloom SR, Adrian TE, Bryant MG, Heitz PH, Pearse AGE. Pancreatic polypeptide in insulinomas, gastrinomas, vipomas and glu-cagonomas. Lancet 1976; i: 328
  • Arnold R., Creutzfeldt C., Creutzfeldt W. Multiple hormone production of endocrine tumours of the gastrointestinal tract. Endocrinology, VHT James. Excerpta Medica Amsterdam, Oxford 1977; Vol. 2: 448
  • Heitz PU, Kasper M., Polak JM, Kloppel G. Pancreatic endocrine tumors: Immunocytochemi-cal analysis of 1 25 tumors. Hum Pathol 1982; 13: 263
  • Yamakuchi K., Abe K. Macromolecular forms of VIP in VIP-secreting tumours. The Vasoactive Intestinal Peptide, SI Said. Raven Press, New York 1982; 469
  • Alumets J., Sundler F., Falkmer S., Ljungberg O., Hakanson R., Martensson H., Nobin A., Larsson A. Neurohormonal peptides in endocrine tumors of the pancreas, stomach, and upper small intestine. An immunohistochemical study of 27 cases. Ultrastruct Pathol 1983; 5: 55
  • Suzuki H., Matsuyama M. Ultrastructure of functioning beta cell tumors of the pancreatic islets. Cancer 1971; 28: 1302
  • Bordi C., Bussolati G., Ballerio G. Endocrine tumour of the pancreas composed of argyrophil and B-cells. Cancer 1975; 35: 436
  • Berger M., Bordi C., Cuppers H-J, Berchtold P., Gries A., Minterfering H., Sailer R., Zimmerman H., Orci L. Functional and morphologic characterization of human insulinomas. Diabetes 1983; 32: 921
  • Bordi C., Bussolati G. Immunofluorescence, histochemical and ultrastructural studies for the detection of multiple endocrine polypeptide tumours of the pancreas. Virchows Arch (Cell Path) 1974; 17: 13
  • Orci L., Halban P., Amherdt M., Ravazzola M., Vassalli D., Perrelet A. Noncoverted, amino acid analog-modified proinsulin stays in a Golgi-derived clathrin-coated membrane comparted. J Cell Biol 1984; 99: 2187
  • Orci L., Ravazzola M., Amherdt M., Madsen O., Vassalli J-D, Perrelet A. Direct identification of the prohormone conversion site in insulin-secreting cells. Cell 1985; 42: 671
  • Creutzfeldt W., Arnold R., Creutzfeldt C., Deuticke U., Frerichs H., Track NS. Biochemical and morphological investigations of 30 human insulinomas. Diabetologia 1973; 9: 217
  • Capella C., Solci E., Frigeno B., Buffa R., Usellini L., Fontana P. The endocrine cells of the pancreas and related tumours. Virch Arch (A) 1977; 373: 327
  • Akagi T., Fujii Y. Histology, ultrastructure, and tissue culture of human insulinomas. Cancer 1981; 47: 417
  • Gordon JW, Scango GA, Plotkin DJ, Barbosa JA, Ruddle FH. Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci USA 1980; 77: 7380
  • Palmiter RD, Brinster RL. Germ line transformation of mice. Annu Rev Genet 1986; 20: 465
  • Stewart TA, Pattengale PK, Leder P. Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV-/myc fusion genes. Cell 1984; 38: 627
  • Brinster RL, Chen HY, Messing A., Van Dyke T., Lecine AJ, Palmiter RD. Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell 1984; 37: 367
  • Messing A., Chen HY, Palmiter RD, Brinster RL. Peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas in transgenic mice. Nature 1985; 316: 461
  • Hanahan D. Heritable formation of pancreatic /S-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 31 1985; 5: 115
  • Hanahan D. Oncogenesis in transgenic mice. Oncogenes and Growth Control, P. Kahn, T. Graft. Springer-Verlag, Berlin, Heidelberg 1986; 349
  • Madsen OD, Cohen RM, Fitch FW, Rubenstein AH, Steiner DF. The production and characterization of monoclonal antibodies specific for human proinsulin using a sensitive microdot assay procedure. Endocrinology 1983; 113: 2135
  • De Mey J., Moeremans M., Geuens G., Nuydens R., De Brabander M. High resolution light and electron microscopic localization of tubuli with the IGS (immunogold staining) method. Cell Biol Int Rep 1981; 5: 889
  • Varndell IM, Polak JM. Electron microscopical immunocytochemistry. Immunocyto-chemistry. Modern methods and applications, 2nd ed., JM Polak, S. Van Noor-Den. John Wright and Sons, Bristol 1986; 146
  • Bendayan M., Zollinger M. Ultrastructural localization of antigenic sites on osmium-fixed tissue applying the protein A-gold technique. J Histochem Cytochem 1983; 31: 101
  • Tapia FJ, Varndell IM, Probert L., De Mey J., Polak JM. Double immunogold staining method for the simultaneous ultrastructural localization of regulatory peptides. J Histochem Cytochem 1983; 31: 977
  • Lacy PE. Electron microscopy of the beta cell of the pancreas. Am J Med 1961; 31: 851
  • Lacy PE. Electron microscopy of the islets of Langerhans. Diabetes 1962; 11: 509
  • Deconinck JF, Potvliege PR, Gepts W. The ultrastructure of the human pancreatic islets I The islets of adults. Diabetologia 1971; 7: 266
  • Fujita H. Pancreatic islets. An Atlas of Electron Micrographs. Functional Morphology of Endocrine Glands, K. Kurasumi, H. Fujita. George Thieme, Stuttgart 1975; 262
  • Bendayan M. Parallel processing and secretion of insulin and C-peptide by the pancreatic B-cell as revealed by the quantitative high resolution of protein A-gold immunocytochemical approach. J Histochem Cytochem 1986; 34: 125
  • Orci L. Macro- and micro-domains in the endocrine pancreas. Diabetes 1982; 31: 538
  • Orci L. Patterns of cellular and subcellular organization in the endocrine pancreas. J Endocrinol 1984; 102: 3
  • Orci L., Halban P., Amherdt M., Ravazzola M., Vassalli J-D, Perrelet A. A clathrin-coated, Golgi-related compartment of the insulin secreting cell accumulates proinsulin in the presence of monensin. Cell 1984; 39: 39
  • Orci L. The insulin factory: A tour of the plant surroundings and a visit to the assembly line. Diabetologia 1985; 28: 528
  • Bordi C., Tardini A. Electron microscopy of islet cell tumors. Progress in Surgical Pathology, CE Fenoglio, D. Wolff. Masson Publishing USA, Inc., New York 1980; Vol. 1: 135
  • Yamashita Y., Okuzono Y., Yokata T., Takahashi M., Ishihara T., Uchino F., Kamei T., Adachi H., Iwata T., Matsumoto N., Hirai S., Hatoo K., Kaku K., Kaneko T. Morphologic study of three cases of insulinoma. Cancer 1985; 55: 841
  • Heitz PU, Polak JM, Bloom SR, Pearse AGE. Identification of D1-cell as a source of human pancreatic polypeptide (HPP). Gut 1976; 17: 755
  • Larsson L-I, Sundler F., Hakanson R. Pancreatic polypeptide -A postulated new hormone: Identification of its cellular storage site by light and electron microscopic immunocyto-chemistry. Diabetologia 1976; 12: 211
  • Baetens D., De Mey J., Gepts W. Immunohisto-chemical and ultrastructural identification of the pancreatic polypeptide-producing cell (PP-cell) in the human pancreas. Cell Tissue Res 1977; 185: 239
  • Roth J., Ravazzola M., Bendayan M., Orci L. Application of the protein A-gold technique for electron microscopy demonstration of polypeptide hormone. Endocrinology 1981; 108: 247
  • Creutzfeldt W. Endocrine tumours of the pancreas. The Diabetic Pancreas, BW Volk, KF Wellmann. Balliere Tindall, London 1977; Vol. 22: 551
  • Ravazzola M., Orci L. Glucagon and glicentin immunoreactivity are topologically segregated in the alpha-granule of the human pancreatic A cell. Nature 1980; 284: 66
  • Varndell IM, Bishop AE, Sikri KL, Uttenthal LO, Bloom SR, Polak JM. Localization of glucagon like peptide (GLP) immunoreactants in human gut and pancreas using light and electron microscopic immunocytochemistry. J Histochem Cytochem 1985; 33: 1080
  • Dudek RW, Boyne AF, Charles TM. Novel secretory granule morphology in physically fixed pancreatic islets. J Histochem Cytochem 1984; 32: 929
  • Dudek RW, Boyne AF. An excursion through the ultrastuctural world of quick-frozen pancreatic islets. Am J Anat 1986; 175: 217
  • Dudek RW, Varndell IM, Polak JM. Combined quick-freeze and freeze-drying techniques for improved electron immunocytochemistry. Immunolabelling for Electron Microscopy, JM Polak, IM Varndell. Elsevier, Amsterdam, New York, Oxford 1984; 235
  • Liu T-H, Tseng H-C., Zhu Y., Zhangs-X Chen J, Cui Q-L. Insulinoma An immunocytochemical and morphological analysis of 95 cases. Cancer 1985; 56: 1420
  • Kobayashi S., Fujita T., Ho S. Secretory granules in the insulinoma cell: An interpretation of their fine structural changes. Proinsulin, Insulin, C-peptide, S. Baba. International Congress Series 468, Excerpta Medica, Amsterdam/Oxford 1979; 394

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