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Original Article

Cytoskeletal Proteins including Myofilaments in Human Tumors

Pages 155-186 | Published online: 10 Jul 2009

References

  • Cooke P. A filamentous cytoskeleton in vertebrate smooth muscle fibers. J Cell Biol 1976; 68: 539–556
  • Virtanen I, Miettinen M, Lehto V-P. Cytoske-letal proteins as ti markers for cancer. Cancer Bull 1984; 36: 174–178
  • Weber K, Osborn M. The molecules of the cell matrix. Sci Am 1985; 253: 110–120
  • Schliwa M. The Cytoskeleton. An Introductory Survey. Cell Biology Monographs, Springer-Verlag, New York 1986; vol. 113
  • Fawcett D W. Bloom and Fawcett-A Textbook of Histology, 11th ed. Saunders, Philadelphia 1986; 265–310
  • Makin C A, Bobrow L G, Bodner W F. Monoclonal antibody to cytokeratin for use in routine histopathology. J Clin Pathol 1984; 37: 975–982
  • Leader M, Patel J, Makin C, Henry K. An analysis of the sensitivity and specificity of the cytokeratin marker CAM 5.2 for epithelial tumours. Results of a study of 203 sarcomas, 50 carcinomas and 28 malignant melanomas. Histopathology 1986; 10: 1315–1324
  • Pinkus G S, O'Connor E M, Etheridge C L, Corson J M. Optimal immunoreactivity of keratin proteins in formatin-fixed, paraffin-embedded ti requires preliminary trypsinization. An immunoperoxidase study of various tumors using polyclonal and monoclonal antibodies. J Histochem Cytochem 1985; 33: 465–473
  • Ordóñez N G, Manning J T, Brooks H T. Effect of trypsinization on the immunostaining of formalin-fixed, paraffin-embedded tis. Am J Surg Pathol 1988; 12: 121–129
  • Swanson P E, Hagen K A, Wick M R. Avidin-biotin-peroxidase-antiperoxidase (ABPAP) complex. An immunocytochemical method with enhanced sensitivity. Am J Clin Pathol 1987; 88: 162–176
  • Bonnard C, Papermaster D S, Kraehenbohn J-P. The streptavidin-bridge technique: Applications in light and electron microscopic im-munohistochemistry. Immunolabeling for Electron Microscopy, J M Polak, I M Varndell. Elsevier, Amsterdam 1984; 95–111
  • Milios J, Leong S-Y. Avidin-biotin-peroxidase complex reagents for routine histological application: A comparison of four commercial kits. J Histotechnol 1988; 11: 81–83
  • Dewhurst S, Stevenson M, McComb R D, Volsky D J. Expression of glial fibrillary acidic protein in human glioma cell lines as detected by molecular hybridization. Acta Neuropathol (Berl) 1987; 73: 383–386
  • Bosch F X, Leube R E, Acthstatter T, Moll R, Franke W W. Expression of simple epithelial type cytokeratins in stratified epithelia as detected by immunolocalization and hybridization in situ. J Cell Biol 1988; 106: 1635–1648
  • Erlandson R A. Diagnostic immunohisto-chemistry of human tumors. An interim evaluation. Am J Surg Pathol (editorial) 1984; 8: 615–624
  • Nadji M. Immunoperoxidase techniques. I. Facts or artifacts. Am J Dermatopathol 1986; 8: 32–36
  • Reid W A, Branch T, Thompson W D, Kay J. The effect of diffusion on the immunolocalization of antigen. Histopathology 1987; 11: 1277–1284
  • Gould V E. The coexpression of distinct classes of intermediate filaments in human neoplasms. Arch Pathol Lab Med (editorial) 1985; 109: 984–985
  • van Muijen G NP, Ruiter D J, Warnaar S O. Coexpression of intermediate filament polypeptides in human fetal and adult tis. Lab Invest 1987; 57: 359–369
  • DeLellis R A, Kwan P. Technical considerations in the immunohistochemical demonstration of intermediate filaments. Am J Surg Pathol 1988; 12(Suppl 1)17–23
  • Polak J M, Varndell I M. Immunolabelling for Electron Microscopy. Elsevier, Amsterdam 1984
  • DeLellis R A. Ultrastructural immunocyto-chemistry: An overview of methodology and applications in diagnostic pathology. Tumor Diagnosis by Electron Microscopy, J Russo, S C Sommers. Field and Wood, Philadelphia 1988; vol. 2: 67–97
  • Bendayan M. Protein A-gold electron microscopic immunocytochemistry: Methods, applications, and limitations. JEM Tech 1984; 1: 243–270
  • Silver M M, Hearn S A. Postembedding immu-noelectron microscopy using protein A-gold. Ultrastruct Pathol 1987; 11: 693–703
  • Bendayan M. Introduction of the protein G-gold complex for high resolution immunocytochemistry. JEM Tech 1987; 6: 7–13
  • Bendayan M, Garzon S. Protein G-gold complex: Comparative evaluation with protein A-gold for high resolution immunocytochemistry. J Histochem Cytochem 1988; 36: 597–607
  • Armbruster B L, Carlemalm E, Chiovetti R, Garavito R M, Hobot J A, Kellenberger E, Villiger W. Specimen preparation for electron microscopy using low temperature embedding resins. J Microsc 1982; 126: 77–85
  • Carlemalm E, Garavito R M, Villiger W. Resin development for electron microscopy and an analysis of embedding at low temperature. J Microsc 1982; 126: 123–143
  • Altman L G, Schneider G, Papermaster D S. Rapid embedding of tis in Lowicryl K4M for immunoelectron microscopy. J Histochem Cytochem 1984; 32: 1217–1223
  • Lemanski L F, Paulson D J, Hill C S, Davis L A, Riles L C, Lim S-S. Immunoelectron microscopic localization of α-actinin on Lowicryl-embedded thin-sectioned ti. J Histochem Cytochem 1985; 33: 515–522
  • Warhol M J, Lucocq J M, Carlemalm E, Roth J. Ultrastructural localization of keratin proteins in human skin using low-temperature embedding and the protein A-gold technique. J Invest Dermatol 1985; 84: 69–72
  • Morris R E, Saelinger C B. Combined use of immunoferritin and immunocolloidal gold for the simultaneous demonstration of two antigens by immuno-electron microscopy. Stain Technol 1982; 57: 225–237
  • Bendayan M. Double immunocytochemical labeling applying the protein A-gold technique. J Histochem Cytochem 1982; 30: 81–85
  • Roth J. The preparation of protein A-gold complexes with 3 nm and 15 nm gold particles and their use in labeling multiple antigens on ultra-thin sections. Histochem J 1982; 14: 791–801
  • Holm R, Nesland J M, Attramadal A, Johan-Nessen J V. Double-staining methods at the ultrastructural level applying colloidal gold conjugates. Ultrastruct Pathol 1988; 12: 279–290
  • Varndell I M. Double staining: Questions redoubled?. Ultrastruct Pathol (editorial) 1988; 12: iii–iv
  • Dustin P. Microtubules. Springer-Verlag, New York 1978
  • Wolin S L, Kucherlapati R S. Expression of microtubule networks in normal cells, transformed cells, and their hybrids. J Cell Biol 1979; 82: 76–85
  • Wiche G. High-moleuclar-weight microtubule associated proteins (MAPS): A ubiquitous family of cytoskeletal connecting links. Trends Biol Sci 1985; 2: 67–71
  • Allen R D. The microtubule as an intracellular engine. Sci Am 1987; 256: 42–49
  • Triche T J, Askin F B. Neuroblastoma and the differential diagnosis of small-, round-, blue-cell tumors. Hum Pathol 1983; 14: 569–595
  • Erlandson R A. Electron microscopy of tumors of the central and peripheral nervous system including meninges. Tumor Diagnosis by Electron Microscopy, J Russo, S C Sommers. Field and Wood, Philadelphia 1988; vol. 2: 165–206
  • Artlieb U, Krepler R, Wiche G. Expression of microtubule-associated proteins, Map-1 and Map-2, in human neuroblastomas and differential diagnosis of immature neuroblasts. Lab Invest 1985; 53: 684–691
  • Mackay B, Ayala A G. Intracistemal tubules in human melanoma cells. Ultrastruct Pathol 1980; 1: 1–6
  • Mazur M T, Katzenstein A-L A. Metastatic melanoma: The spectrum of ultrastructural morphology. Ultrastruct Pathol 1980; 1: 337–356
  • Specht C S, Smith T W, DeGirolami U, Price J M. Myxopapillary ependymoma of the filum terminate. A light and electron microscopic study. Cancer 1986; 58: 310–317
  • Wetzel W J, Reuhl K R. Microtubular aggregates in the rough endoplasmic reticulum of a myxoid chondrosarcoma. Ultrastruct Pathol 1980; 1: 519–525
  • DeBlois G, Wang S, Kay S. Microtubular aggregates within rough endoplasmic reticulum. An unusual ultrastructural feature of ex-traskeletal myxoid chondrosarcoma. Hum Pathol 1986; 17: 469–475
  • Lazarides E. Intermediate filaments as mechanical integrators of cellular space. Nature 1980; 283: 249–256
  • Osborn M, Weber K. Tumor diagnosis by intermediate filament typing: A novel tool for surgical pathology. Lab Invest 1983; 48: 372–394
  • Miettinen M, Lehto V-P, Virtanen I. Antibodies to intermediate filament proteins in the diagnosis and classification of human tumors. Ultrastruct Pathol 1984; 7: 83–107
  • Steinert P M, Jones J CR, Goldman R D. Intermediate filaments. J Cell Biol 1984; 99: 22s–27s
  • Wang E, Fischman D, Leim R KH, Sun T-T. Intermediate Filaments. Ann NY Acad Sci 1985; 455: 1–832
  • Weber K, Geisler N. Intermediate filaments: Structural conservation and divergence. Ann NY Acad Sci 1985; 455: 126–143
  • Bolen J W, McNutt M A. Cytoskeletal intermediate filaments: Practical applications of intermediate filament analysis. Ultrastruct Pathol 1987; 11: 175–189
  • Nagel R B. Intermediate filaments: A review of the basic biology. Am J Surg Pathol 1988; 12(Suppl 1)4–16
  • Moll R, Franke W W, Schiller D L, Geiger B, Krepler R. The catalog of human cyto-keratins: Patterns of expression in normal epithelia, tumors and cultured cells. Cell 1982; 31: 11–24
  • Sun T-T, Eichner R, Schermer A, Cooper D, Nelson W G, Weiss R A. Classification, expression, and possible mechanisms of evaluation of mammalian epithelial keratins: A unifying model. The Transformed Phenotype: Cancer Cell, A J Levine, G F van de Wonde, W C Topp, J D Watson. Cold Spring Habor Laboratory, Cold Spring Harbor, New York 1984; vol. 1: 169–176
  • Eichner R, Bonitz P, Sun T-T. Classification of epidermal keratins according to their immu-noreactivity, isoelectric point, and node of expression. J Cell Biol 1984; 98: 1388–1396
  • Heid H W, Moll I, Franke W W. Patterns of expression of trichocytic and epithelial cyto-keratins in mammalian tis. I. Human and bovine hair follicles. Differentiation 1988; 37: 137–157
  • Cooper D, Schermer A, Sun T-T. Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: Strategies, applications, and limitations. Lab Invest 1985; 52: 243–256
  • Holthöfer H, Miettinen A, Lehto V-P, Lehtonen E, Virtanen I. Expression of vimentin and keratin types of intermediate filament proteins in developing and adult human kidneys. Lab Invest 1984; 50: 552–559
  • Gown A M, Vogel A M. Monoclonal antibodies to intermediate filament proteins of human cells: Unique and cross-reacting antibodies. J Cell Biol 1982; 95: 414–424
  • Gown A M, Vogel A M. Monoclonal antibodies to human intermediate filament proteins. II. Distribution of filament proteins in normal human tis. Am J Pathol 1984; 114: 309–321
  • Gown A M, Vogel A M. Monoclonal antibodies to intermediate filaments. III. Analysis of tumors. Am J Clin Pathol 1985; 84: 413–424
  • Debus E, Weber K, Osborn M. Monoclonal cytokeratin antibodies that distinguish simple from statified squamous epithelia: Characterization on human tis. EMBO J 1982; 1: 1641–1647
  • Debus E, Moll R, Franke W W, Weber K, Osborn M. Immunohistochemical distinction of human carcinomas by cytokeratin typing with monoclonal antibodies. Am J Pathol 1984; 114: 121–130
  • Brabon A C, Williams J F, Carditt R D. A monoclonal antibody to a human breast tumor protein released in response to estrogen. Cancer Res 1984; 44: 2404–2710
  • Chan R, Edwards B F, Hu R, Rossitto P V, Min B H, Lund J K, Cardiff R D. Characterization of two monoclonal antibodies in an immunohistochemical study of keratin 8 and 18 expression. Am J Clin Pathol 1988; 89: 472–480
  • Gigi D, Geiger B, Eshhar Z, et al. Detection of a cytokeratin determinant common to diverse epithelial cells by a broadly cross-reacting monoclonal antibody. EMBO J 1982; 1: 1429–1437
  • van Muijen G MP, Ruiter D J, Huiskens-van der May C, Warnaar S O. Monoclonal antibodies with different specificities against cyto-keratins. An immunohistochemical study of normal tis and tumors. Am J Pathol 1984; 114: 9–17
  • Kahn H J, Horner T PS, Yeger H, Bailey O, Baumal R. Distinct keratin patterns demonstrated by immunoperoxidase staining of adenocarcinomas, carcinoids, and mesotheliomas using polyclonal and monoclonal anti-keratin antibodies. Am J Clin Pathol 1986; 86: 566–574
  • Yeger H, Baumal R, Kahn H J, Duewe G, Phillips M J. The use of cytoskeletal characteristics for the diagnosis of colon and breast adenocarcinomas. Am J Clin Pathol 1986; 86: 697–705
  • Spagnolo D V, Michie S A, Crabtree G S, Warnke R A, Rouse R V. Monoclonal anti-keratin (AE1) reactivity in routinely processed ti from 166 human neoplasm. Am J Clin Pathol 1985; 84: 697–704
  • Listrom M B, Dalton L W. Comparison of keratin monoclonal antibodies MAK-6, AE1:AE3, and CAM-5.2. Am. J. Clin. Pathol 1987; 88: 297–301
  • Shah K D, Tabibzadeh S S, Gerber M A. Comparison of cytokeratin expression in primary and metastatic carcinomas. Diagnostic application in surgical pathology. Am J Clin Pathol 1987; 87: 708–715
  • Angus B, Kiberu S, Purvis J, Wilkinson L, Home C HW. Cytokeratins in cervical dysplasia and neoplasia: A comparative study of immunohistochemical staining using monoclonal antibodies NCL-5D3, CAM 5.2, and PKK1. J Pathol 1988; 155: 71–75
  • Battifora H. Clinical applications of the im-munohistochemistry of filamentous proteins. Am J Surg Pathol 1988; 12(Suppl 1)24–42
  • Moll R, Krepler R, Franke W W. Complex cytokeratin polypeptide patterns observed in certain human carcinomas. Differentiation 1983; 23: 256–269
  • Kahn H J, Huang S-N, Hanna W M, Baumal R, Phillips J. Immunohistochemical localization of epidermal and Mallory body cytokeratin in undifferentiated epithelial tumors. Comparison with ultrastructural features. Am J Clin Pathol 1984; 81: 184–191
  • Aebi U, Fowler W E, Rew P, Sun T-T. The fibrillar substructure of keratin filaments unraveled. J Cell Biol 1983; 97: 1131–1143
  • Quinlan R A, Cohlberg J A, Schiller D L, Hatz-Feld M, Franke W W. Heterotypic tetramer (A2D2) complexes of nonepidermal keratins isolated from cytoskeletons of rat hepato-cytes and hepatoma cells. J Mol Biol 1984; 78: 365–388
  • Hatzfeld M, Franke W W. Pair formation and promiscuity of cytokeratins: Formation in vitro of heterotypic complexes and intermediate-sized filaments by homologous and heterologous recombinations of purified polypeptides. J Cell Biol 1985; 101: 1826–1841
  • Franke W W, Schmid E, Grund C, Geiger B. Intermediate filament proteins in nonfilamen-tous structures: Transient disintegration and inclusion of subunit proteins in granular aggregates. Cell 1982; 30: 103–113
  • Denk H, Drepler R, Artlieb U, et al. Proteins of intermediate filaments. An immunohistochemical and biochemical approach to the classification of soft ti tumors. Am J Pathol 1983; 110: 193–208
  • Osborn M, Debus E, Weber K. Monoclonal antibodies specific for vimentin. Eur J Cell Biol 1984; 34: 137–143
  • Azumi N, Battifora H. The distribution of vimentin and keratin in epithelial and non-epithelial neoplasms. A comprehensive immunohistochemical study on formalin- and alcohol-fixed tumors. Am J Clin Pathol 1987; 88: 286–296
  • Leader M, Collins M, Patel J, Henry K. Vimentin: An evaluation of its role as a tumour marker. Histopathology 1987; 11: 63–72
  • Roholl P JM, de Jong A SH, Ramaekers F CS. Application of markers in the diagnosis of soft ti tumours. Histopathology 1985; 9: 1019–1035
  • McNutt M A, Bolen J, Gown A M, Hammar S P, Vogel A M. Coexpression of intermediate filaments in human epithelial neoplasms. Ultrastruct Pathol 1985; 9: 31–43
  • Granger B L, Lazarides E. Desmin and vimen-tin co-exist at the periphery of the myofibril Z disc. Cell 1979; 18: 1053–1063
  • Tokuyasu K T, Dutton A H, Singer S J. Immu-noelectron microscopic studies of desmin (skeletin) localization and intermediate filament organization in chicken skeletal muscle. J Cell Biol 1983; 96: 1727–1735
  • Wang K, Ramirez-Mitchell R. A network of transverse and longitudinal intermediate filaments is associated with sarcomeres of adult vertebrate skeletal muscle. J Cell Biol 1983; 96: 562–570
  • Cooke P. A filamentous cytoskeleton in vertebrate smooth muscle fibers. J Cell Biol 1976; 68: 539–556
  • Altmannsberger M, Osborn M, Treuner J, Holscher A, Weber K, Schauer A. Diagnosis of human childhood rhabdomyosarcomas by antibodies to desmin, the structural protein of muscle specific intermediate filaments. Virchows Arch (Cell Pathol) 1982; 39: 203–215
  • Altmannsberger M, Weber K, Droste R, Osborn M. Desmin is a specific marker for rhabdomyosarcomas of human and rat origin. Am J Pathol 1985; 118: 85–95
  • Miettinen M, Lehto V-P, Badley R A, Virtanen I. Alveolar rhabdomyosarcoma. Demonstration of the muscle type of intermediate filament protein, desmin, as a diagnostic tool. Am J Pathol 1982; 108: 246–251
  • Schmid E, Osborn M, Rungger-Brandle E, Gabbiani G, Weber K, Franke W W. Distribution of vimentin and desmin filaments in smooth muscle ti of mammalian and avian aorta. Exp Cell Res 1982; 137: 329–340
  • Molenaar W M, Oosterhuis J W, Oosterhuis A M, Ramaekers F CS. Mesenchymal and muscle-specific intermediate filaments (vimentin and desmin) in relation to differentiation in childhood rhabdomyosarcoma. Hum pathol 1985; 16: 838–843
  • Eng L F, DeArmond S J. Immunochemistry of the glial fibrillary acid protein. Progress in Neuropathology, H M Zimmerman. Raven Press, New York 1983; 19–39
  • Friede R L, Pollak A. The cytogenetic basis for classifying ependymomas. J Neuropathol Exp Neurol 1978; 37: 103–118
  • Velasco M E, Dahl D, Roessmann U, Gambetti P. Immunohistochemical localization of glial fibrillary acidic protein in human glial neoplasms. Cancer 1980; 45: 484–494
  • Trojanowski J Q, Lee V M-Y, Schlaepfer W W. An immunohistochemical study of human central and peripheral nervous system tumors, using monoclonal antibodies against neurofilaments and glial filaments. Hum Pathol 1984; 15: 248–257
  • Memoli V A, Brown E F, Gould V E. Glial fibrillary acidic protein (GFAP) immunoreactivity in peripheral nerve sheath tumors. Ultrastruct Pathol 1984; 7: 269–275
  • Fields K L, Yen S H. A subset of Schwann cells in peripheral nerves contain a 50-KDa protein antigenically related to astrocyte intermediate filaments. J Neuroimmunol 1985; 8: 311–330
  • Herpers M JHM, Ramaekers F CS, Alde-Weireldt J, Moesker O, Sloof J. Coexpression of glial fibrillary acidic protein- and vimentin-type intermediate filaments in human astrocytomas. Acta Neuropathol (Berl) 1986; 70: 333–339
  • Schiffer D, Giordana M T, Mauro A, Migheli A, Germano I, Giaccone G. Immunohistochemical demonstration of vimentin in human cerebral tumors. Acta Neuropathol (Berl) 1986; 70: 209–219
  • Debus E, Weber K, Osborn M. Monoclonal antibodies specific for glial fibrillary acidic (GFA) protein and for each of the neurofilament triplet polypeptides. Differentiation 1983; 25: 193–203
  • Trojanowski J Q, Lee V M-Y. Anti-neurofilament monoclonal antibodies. Reagents for the evaluation of human neoplasms. Acta Neuropathol (Berl) 1983; 59: 155–158
  • Weber K, Shaw G, Osborn M, Debus E, Geisler N. Neurofilament, a subclass of intermediate filaments: Structure and expression. Cold Springs Harbor Symp Quart Biol 1983; 47: 717–729
  • Wen G Y, Wisniewski H M. Substructure of neurofilaments. Acta Neuropathol (Berl) 1984; 64: 339–343
  • Shaw G, Weber K. The distribution of the neurofilament triplet proteins within individual neurones. Exp Cell Res 1981; 136: 119–125
  • Liem R HK, Yeh S-H, Salomon G D, Shelanski M L. Intermediate filaments in nervous tis. J Cell Biol 1978; 79: 637–645
  • Osborn M, Altmannsberger M, Shaw G, Schauer A, Weber K. Various sympathetic derived human tumors differ in neurofilament expression. Use in diagnosis of neuroblastoma, ganglioneuroblastom and pheochromo-cytoma. Virchows Arch (Cell Pathol) 1982; 40: 141–156
  • Osborn M, Dirk T, Kaser H, Weber K, Altmannsberger M. Immunohistochemical localization of neurofilaments and neuron-specific enolase in 29 cases of neuroblastoma. Am J Pathol 1986; 122: 433–442
  • Axe S, Kuhajda F P. Esthesioneuroblastoma. Intermediate filaments, neuroendocrine and ti specific antigen. Am J Clin Pathol 1987; 88: 139–145
  • Trojanowski J G. Neurofilament proteins and human nervous system tumors. J Histochem Cytochem 1987; 35: 999–1003
  • Mukai M, Torikata C, Iri H, et al. Expression of neurofilament triplet proteins in human neural tumors. An immunohistochemical study of parganglioma, ganglioneuroma, ganglioneuroblastoma, and neuroblastoma. Am J Pathol 1986; 122: 28–35
  • Lehto V-P, Miettinen M, Dahl D, Virtanen I. Bronchial carcinoid cells contain neural-type intermediate filaments. Cancer 1984; 54: 624–628
  • Miettinen M, Lehto V-P, Dahl D, Virtanen I. Varying expression of cytokeratin and neurofilaments in neuroendocrine tumors of human gastrointestinal tract. Lab Invest 1985; 52: 429–436
  • Carlson G J, Ewing S L, Sibley R K. Coexpres-sion of intermediate filaments in giant cell carcinoma of the lung. Lab Invest 1985; 52: 12A
  • van Muijen G NP, Ruiter D J, van Leeuwen C, Prins F A, Rietsema K, Warnaar S O. Cytokeratin and neurofilament in lung carcinomas. Am J Pathol 1984; 116: 363–369
  • Höfler H, Kerl H, Lackinger E, Helleis G, Denk H. The intermediate filament cytoskeleton of cutaneous neuroendocrine carcinoma (Merkel cell tumour). Immunohistochemical and biochemical analyses. Virchows Arch (Pathol Anat) 1985; 406: 339–350
  • Moll R, Franke W W. Cytoskeletal differences between human neuroendocrine tumors: A cytoskeletal protein of molecular weight 46,000 distinguishes cutaneous from pulmonary neuroendocrine neoplasms. Differentiation 1985; 30: 165–175
  • Moll R, Osborn M, Hartschuh W, Moll I, Mahrle G, Weber K. Variability of expression and arrangement of cytokeratin and neurofilaments in cutaneous neuroendocrine carcinomas (Merkel cell tumors): Immunocytochemi-cal and biochemical analysis of twelve cases. Ultrastruct Pathol 1986; 10: 473–495
  • Miettinen M, Clark R, Lehto V-P, Virtanen I, Damjanov I. Intermediate-filament proteins in parathyroid glands and parathyroid adenomas. Arch Pathol Lab Med 1985; 109: 986–989
  • Fawcett D W. On the occurrence of a fibrous lamina on the inner aspect of the nuclear envelope in certain cells of vertebrates. Am J Pathol 1966; 119: 129–145
  • Franke W W, Scheer U, Krohne G, Jarasch E D. The nuclear envelope and the architecture of the cell periphery. J Cell Biol 1981; 91(Suppl)39s–50s
  • Fischer D Z, Chaudbury N, Blobel G. cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins. Proc Natl Acad Sci USA 1986; 83: 6450–6454
  • Franke W W. Nuclear lamins and cytoplasmic intermediate filament proteins: A growing multigene family. Cell 1987; 48: 3–4
  • Huvos A G, Marcove R C, Erlandson R A, Mike V. Chondroblastoma of bone. A clinicopatho-logic and electron microscopic study. Cancer 1972; 29: 760–771
  • Ghadially F N. Diagnostic Electron Microscopy of Tumors, 2nd ed. Butterworths, London 1985; 25–50; 374–378
  • Geisler N, Kaufmann E, Weber K. Protein chemical characterization of three structurally distinct domains along the protofilament unit of desmin 10 nm filaments. Cell 1982; 30: 277–286
  • Parry D AD, Fraser R BD. Intermediate filament structure: I. Analysis of IF protein sequence data. Int J Biol Macromol 1985; 7: 203–213
  • Steinart P M, Steven A C, Roop D R. The molecular biology of intermediate filaments. Cell 1985; 42: 411–419
  • Firtel R A. Multigene families encoding actin and tubulin. Cell 1981; 24: 6–7
  • Bravo R, Fey S J, Larsen P M, Celis J E. Coexistence of three major isoactins in a single sarcoma 180 cell. Cell 1981; 25: 195–202
  • Erlandson R A. Diagnostic Transmission Electron Microscopy of Human Tumors. The Interpretation of Submicroscopic Structures in Human Neoplastic Cells. Masson, New York 1981
  • Mukai K, Schollmeyer J V, Rosai J. Immunohistochemical localization of actin. Applications in surgical pathology. Am J Surg Pathol 1981; 5: 91–97
  • Schürch W, Skalli O, Seemayer T A, Gabbiani G. Intermediate filament proteins and actin isoforms as markers for soft ti tumor differentiation and origin. I. Smooth muscle tumors. Am J Pathol 1987; 128: 91–103
  • Otey C A, Kalnoski M H, Bulinski J C. Immuno-localization of muscle and nonmuscle isoforms of actin in myogenic cells and adult skeletal muscle. Cell Motil Cytoskel 1988; 9: 337–348
  • Tsukada T, Tippens D, Gordon D, Ross R, Gown A M. HHF35, a muscle-actin-specific monoclonal antibody. I. Immunocytochemical and biochemical characterization. Am J Pathol 1984; 126: 51–60
  • Tsukada T, McNutt M A, Ross R, Gown A M. HHF35, a muscle actin-specific monoclonal antibody. II. Reactivity in normal, reactive, and neoplastic human tis. Am J Pathol 1987; 127: 389–402
  • Miettinen M. Antibody specific to muscle actins in the diagnosis and classification of soft ti tumors. Am J Pathol 1988; 130: 205–215
  • Schmidt R A, Cone R, Haas J E, Gown A M. Diagnosis of rhabdomyosarcomas with HHF35, a monoclonal antibody directed against muscle actins. Am J Pathol 1988; 131: 19–28
  • Vasudev K S, Harris M. A sarcoma of myofibroblasts. An ultrastructural study. Arch Pathol Lab Med 1978; 102: 185–188
  • d'Andiran Gabbiani G. A metastasizing sarcoma of the pleura composed of myofibroblasts. Progress in Surgical Pathology, C M Fenoglio, M Wolff. Masson, New York 1980; vol. 2: 31–40
  • Ghadially F N, McNaughton J O, Lalonde J-M A. Myofibroblastoma: A tumour of myofibroblasts. J Submicrosoc Cytol 1983; 15: 1055–1063
  • Mazur M T, Clark H B. Gastric stromal tumors. Reappraisal of histogenesis. Am J Surg Pathol 1983; 7: 507–519
  • Mackay B, Ro J, Floyd C, Orddnez N G. Ultrastructural observations on smooth muscle tumors. Ultrastruct Pathol 1987; 11: 593–607
  • Suster S, Huszar M. Epithelioid leiomyosarcoma of the stomach. A case study of the intermediate filaments. Am J Surg Pathol 1987; 11: 575–580
  • Debus E, Weber K, Osborn M. Monoclonal antibodies to desmin, the muscle specific intermediate filament protein. EMBO J 1983; 2: 2305–2312
  • Miettinen M. Gastrointestinal stromal tumors. An immunohistochemical study of cellular differentiation. Am J Clin Pathol 1988; 89: 601–610
  • Knapp R H, Wick M R, Goellner J R. Leiomy-oblastomas and their relationship to other smooth-muscle tumors of the gastrointestinal tract. An electron-microscopic study. Am J Surg Pathol 1984; 8: 449–461
  • Erlandson R A. The ultrastructural distinction between rhabdomyosarcoma and other undifferentiated “sarcomas”. Ultrastruct Pathol 1987; 11: 83–101
  • Boram L H, Erlandson R A, Hajdu S I. Mesodermal mixed tumor of the uterus. A cytologic, histologic, and electron microscopic correlation. Cancer 1972; 30: 1295–1306
  • Tremblay M. Ultrastructure of a Wilms' tumour and myogenesis. J Pathol 1971; 105: 269–277
  • Brooks J SJ, Freeman M, Enterline H T. Malignant “Triton” tumors. Natural history and immunohsitochemistry of nine new cases with literature review. Cancer 1985; 55: 2543–2549
  • Seidal T, Kindblom L-G. The ultrastructure of alveolar and embryonal rhabdomyosarcoma. A correlative light and electron microscopic study of 17 cases. Acta Pathol Microbiol Immunol Scand Sect A 1984; 92: 231–248
  • Leader M, Collins M, Patel J, Henry K. Desmin: Its value as a marker of muscle derived tumours using a commercial antibody. Virchows Arch A 1987; 411: 345–349
  • Shimada H, Newton W A, Jr, Soule E H, et al. Pathology of fatal rhabdomyosarcoma. Report from Intergroup Rhabdomyosarcoma Study (IRS-I and IRS-II). Cancer 1987; 59: 459–465
  • Haas J E, Palmer N F, Weinberg A G, Beckwith J B. Ultrastructure of malignant rhabdoid tumor of the kidney. A distinctive renal tumor of children. Hum Pathol 1981; 12: 646–657
  • Vogel A M, Gown A M, Caughlan J, Haas J E, Beckwith J B. Rhabdoid tumors of the kidney contain mesenchymal specific and epithelial specific intermediate filament proteins. Lab Invest 1984; 50: 232–238
  • Schmidt D, Harms D, Zieger G. Malignant rhabdoid tumor of the kidney. Histopathology, ultrastructure and comments on differential diagnosis. Virchows Arch (Pathol Anat) 1982; 398: 101–108
  • Lynch H T, Shurin S B, Dahms B B, Izant R J, Jr, Lynch J, Danes B S. Paravertebral malignant rhabdoid tumor in infancy. In vitro studies of a familial tumor. Cancer 1983; 52: 290–296
  • Balaton A J, Vaury P, Videgrain M. Paravertebral malignant rhabdoid tumor in an adult. A case report with immunocytochemical study. Pathol Res Pract 1987; 182: 713–716
  • Frierson H F, Jr, Mills S E, Innes D J, Jr. Malignant rhabdoid tumor of the pelvis. Cancer 1985; 55: 1963–1967
  • Ekfors T O, Aho H J, Kekomaki M. Malignant rhabdoid tumor of the prostatic region. Im-munohistological and ultrastructural evidence for epithelial origin. Virchows Arch (Pathol Anat) 1985; 406: 381–388
  • Harris M, Eyden B P, Joglekar V M. Rhabdoid tumour of the bladder: A histological, ultrastructural and immunohistochemical study. Histopathology 1987; 11: 1083–1092
  • Small E J, Gordon G J, Barrett Dahms B. Malignant rhabdoid tumor of the heart in an infant. Cancer 1985; 55: 2850–2853
  • Biggs P J, Garen P D, Powers J M, Garvin A J. Malignant rhabdoid tumor of the central nervous system. Hum Pathol 1987; 18: 332–337
  • Dabbs D J, Park H K. Malignant rhabdoid skin tumor: An uncommon primary skin neoplasm. Ultrastructural and immunohistochemical analysis. J Cutan Pathol 1988; 15: 109–115
  • Parham D M, Peiper S C, Robicheaux G, Ri-Beiro R C, Douglass E C. Malignant rhabdoid tumor of the liver. Arch Pathol Lab Med 1988; 112: 61–64
  • Tsuneyoshi M, Daimaru Y, Hashimoto M, Enjoji M. Malignant soft ti neoplasms with the histologic features of renal rhabdoid tumors: An ultrastructural and immunohistochemical study. Hum Pathol 1985; 16: 1235–1242
  • Scarpelli D G. Multipotent developmental capacity of cells in the adult animal. Lab Invest (editorial) 1985; 52: 331–333
  • Gould V E. Histogenesis and differentiation: A re-evaluation of these concepts as criteria for the classification of tumors. Hum Pathol 1986; 17: 212–215
  • Ogawa K, Kim Y-C, Nakashima Y, Yamabe H, Takeda T, Hamashima Y. Expression of epithelial markers in sarcomatoid carcinoma: An immunohistochemical study. Histopathology 1987; 11: 511–522
  • Santeusanio G, Pascal R R, Bisceglia M, Con-Tantino A M, Bosman C. Metaplastic breast carcinoma with epithelial phenotype of pseudosarcomatous components. Arch Pathol Lab Med 1988; 112: 82–85
  • Ellis G L, Langloss J M, Enzinger F M. Coex-pression of keratin and desmin in a carcinosarcoma involving the maxillary alveolar ridge. Oral Pathol 1985; 60: 410–416
  • Huszar M, Herczeg E, Lieberman Y, Geiger B. Distinctive immunofluorescent labeling of epithelial and mesenchymal elements of carcinosarcoma with antibodies specific for different intermediate filaments. Hum Pathol 1984; 15: 532–538
  • Bolen J W, Hammar S P, McNutt M A. Reactive and neoplastic serosal ti. A light-microscopic, ultrastructural, and immuno-cytochemical study. Am J Surg Pathol 1986; 10: 34–47
  • Bolen J W, Thorning D. Mesotheliomas. A light- and electron-microscopical study concerning histogenetic relationships between the epithelial and the mesenchymal variants. Am J Surg Pathol 1980; 4: 451–464
  • Klima M, Bassart M L. Sarcomatous type of malignant mesothelioma. Ultrastruct Pathol 1983; 4: 349–358
  • Blobel G A, Moll R, Franke W W, Kayser K W, Gould V E. The intermediate filament cyto-skeleton of malignant mesothelioma and its diagnostic significance. Am J Pathol 1985; 121: 235–247
  • Hammar S P, Bolen J W. Sarcomatoid pleural mesothelioma. Ultrastruct Pathol 1985; 9: 337–343
  • Dardick I, Jabi M, Elliot McCaughey W T, Oeadhare S, van Nostrand A WP, Srigley J R. Diffuse epithelial mesothelioma: A review of the ultrastructural spectrum. Ultrastruct Pathol 1987; 11: 503–533
  • Pfaltz M, Odermatt B, Christen B, Rüttner J R. Immunohistochemistry in the diagnosis of malignant mesothelioma. Virchows Arch A 1987; 411: 387–393
  • Yousem S A, Hochholzer L. Malignant mesothelioma with osseous and cartilagenous differentiation. Arch Pathol Lab Med 1987; 111: 62–66
  • Erlandson R A, Cordon-Cardo C. Neoplasms of complex or uncertain histogenesis. Pathology of Human Neoplasms. An Atlas of Diagnostic Electron Microscopy and Immunohistochemistry, H A Azar. Raven Press, New York 1988; 533–611
  • Yousem S A, Flynn S D. Intrapulmonary localized fibrous tumor. Intraparenchymal so-called localized fibrous mesothelioma. Am J Clin Pathol 1988; 89: 365–369
  • Achstätter T, Moll R, Anderson A, Kuhn C, Pitz S, Schwechheimer K, Franke W W. Expression of glial filament protein (GFP) in nerve sheaths and non-neural cells reexamined using monoclonal antibodies, with special emphasis on the coexpression of GFP and cytokeratins in epithelial cells of human salivary gland and pleomorphic adenomas. Differentiation 1986; 31: 206–227
  • Zarbo R J, Hatfield J S, Trojanowski J Q, Criss-Man J D, Regezi J A, Maisel H, Batsakis J G. Immunoreactive glial fibrillary acidic protein in normal and neoplastic salivary glands: A combined immunohistochemical and im-munoblot study. Surg Pathol 1988; 1: 55–63
  • Sciubba J J, Brannon R B. Myoepithelioma of salivary glands: Report of 23 cases. Cancer 1982; 49: 562–572
  • Dardick I. Malignant myoepithelioma of parotid salivary gland. Ultrastruct Pathol 1985; 9: 163–168
  • Erlandson R A, Rosen P P. Infiltrating myoepithelioma of the breast. Am J Surg Pathol 1982; 6: 785–793
  • Thorner P S, Kahn H J, Baumal R, Leek Mof-fatt W. Malignant myoepithelioma of the breast. An immunohistochemical study by light and electron microscopy. Cancer 1986; 57: 745–750
  • Kiaer H, Nielsen B, Paulsen S, Sorensen I M, Dyreborg U, Blichert-Toft M. Adeno-myoepithelial adenosis and low-grade malignant adenomyoepithelioma of the breast. Virchows Arch (Pathol Anat) 1984; 405: 55–67
  • Jabi M, Dardick I, Cardigos N. Adenomyoepithelioma of the breast. Arch Pathol Lab Med 1988; 112: 73–76
  • Dardick I, van Nostrand P, Phillips M J. Histogenesis of salivary gland pleomorphic adenoma (mixed tumor) with an evaluation of the role of the myoepithelial cell. Hum Pathol 1982; 13: 62–75
  • Erlandson R A, Cordon-Cardo C, Higgins P J. Histogenesis of benign pleomorphic adenoma (mixed tumor) of the major salivary glands. An ultrastructural and immunohistochemical study. Am J Surg Pathol 1984; 8: 803–820
  • Kepler R, Denk H, Artlieb U, Moll R. Immuno-cytochemistry of intermediate filament proteins present in pleomorphic adenomas of the human parotid gland: Characterization of different cell types in the same tumor. Differentiation 1982; 21: 191–199
  • Stead R H, Qizilbash A H, Kontozoglou T, Daya A D, Riddel R H. An immunohistochemical study of pleomorphic adenomas of the salivary gland: Glial fibrillary acidic protein-like immunoreactivity identifies a major myoepithelial component. Hum Pathol 1988; 19: 32–40
  • Caselitz J, Osborn M, Hamper K, Wustrow J, Rauchfuss A, Weber K. Pleomorphic adenomas, adenoid cystic carcinomas and adeno-lymphomas of salivary glands analysed by a monoclonal antibody against myoepithelial/basal cells. An immunohistochemical study. Virchows Arch (Pathol Anat) 1986; 409: 805–816
  • Chase D R, Enzinger F M, Weiss S W, Langloss J M. Keratin in epithelioid sarcoma. An immunohistochemical study. Am J Surg Pathol 1984; 8: 435–441
  • Daimaru Y, Hashimoto H, Tsuneyoshi M, Enjoji M. Epithelial profile of epithelioid sarcoma. An immunohistochemical analysis of eight cases. Cancer 1987; 59: 134–141
  • Manivel J C, Wick M R, Dehner L P, Sibley R K. Epithelioid sarcoma. An immunohistochemical study. Am J Clin Pathol 1987; 87: 319–326
  • Schmidt D, Harms D. Epithelioid sarcoma in children and adolescents. An immunohistochemical study. Virchows Arch A 1987; 410: 423–431
  • Corson J M, Weiss L M, Banks-Schlegel S P, Pinkus G S. Keratin proteins and carcinoem-bryonic antigen in synovial sarcomas: An immunohistochemical study of 24 cases. Hum Pathol 1984; 15: 615–621
  • Miettinen M, Virtanen I. Synovial sarcoma-a misnomer. Am J Pathol 1984; 117: 18–25
  • Abenoza P, Manivel J C, Swanson P E, Wick M R. Synovial sarcoma: Ultrastructural study and immunohistochemical analysis by a combined peroxidase-antiperoxidase/avidin-biotin-peroxidase complex procedure. Hum Pathol 1986; 17: 1107–1115
  • Fisher C. Synovial sarcoma: Ultrastructural and immunohistochemical features of epithelial differentiation in monophasic and biphasic tumors. Hum Pathol 1986; 17: 996–1008
  • Erlandson R A, Tandler B, Lieberman P H, Higinbotham N L. Ultrastructure of human chordoma. Cancer Res 1968; 28: 2115–2125
  • Abenoza P, Sibley R K. Chordoma: An im-munohistologic study. Hum Pathol 1986; 17: 744–747
  • Coindre J-M, Rivel J, Trojani M, de Mascarel I, de Mascarel A. Immunohistological study in chordomas. J pathol 1986; 150: 61–63
  • Rutherfoord G S, Davies A G. Chordomas- ultrastructure and immunohistochemistry: A report based on the examination of six cases. Histopathology 1987; 11: 775–787
  • Salisbury J R. Demonstration of cytokera-tins and an epithelial membrane antigen in chondroid chordoma. J Pathol 1987; 153: 37–40
  • Huitfeldt H S, Brandtzaeg P. Various keratin antibodies produce immunohistochemical staining of human myocardium and myometrium. Histochemistry 1985; 83: 381–389
  • Brown D C, Theaker J M, Banks P M, Gatter K C, Mason D Y. Cytokeratin expression in smooth muscle and smooth muscle tumours. Histopathology 1987; 11: 477–486
  • Norton A J, Thomas J A, Isaacson P G. Cytokeratin-specific monoclonal antibodies are reactive with tumours of smooth muscle derivation. An immunocytochemical and biochemical study using antibodies to intermediate filament cytoskeletal proteins. Histopathology 1987; 11: 487–499
  • Miettinen M. Immunoreactivity for cytokeratin and epithelial membrane antigen in leiomyosarcoma. Arch Pathol Lab Med 1988; 112: 637–640

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