Patent Briefing

PATENT BRIEFING

BELGIUM

• Belgian Patent 900,268 (1984) Therapeutic composition using liposomes and incorporating fructose 1,6-diphosphate BIOMEDICA FOSCAMA INDUSTRIA CHIMICO FARMACEUTICA S.p.A. D. Massino and G. Laggarino. Fructose 1,6-diphosphate when incorporated in liposomes can be used for delivery to cells whose membranes are impermeable to it.
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BRAZIL

• Brazilian Patent 83 00,692 (1984) Cytidine diphosphocholine MAGIS FARMACECTICI s.r.l. M. Adolfo. When incorporated in phosphatidylcholine liposomes, the in ViVO transport of cytidine diphosphocholine is enhanced.
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• Brazil Pedido 83 07,578 (1984) Polymer products of reinforced polyester resins and a resin composition prepared for molding and reinforcement MICHAEL J. DOUGHERTY. J. R. McDougal. Resin compositions were prepared containing microen-capsulated crosslinking catalyst which permits an increased extent of cure and improved homogeneity of the cured moulding.
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EUROPE

• European Patent Application 114,577 (1984) Oral pharmaceutical containing cytidine diphosphate choline ester in liposomes NIAGIS FARN1ACECTICI s.r.l. A. Moroni. The preparation of the title substance is described.
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• European Patent Application 121,162 (1984) Flame resistant paper. HOECHEST A.-G. A. F. Herr, H. Staendeke, F. J. Dany and J. Kandler. The paper consists of ammonium polyphosphate encapsulated in melamine resin, retention agent and cellulose pulp.
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• European Patent Application 123,224 (1984) Heat-sensitive recording materials FUJI PIIOTO FILM CO. LTD. T. Usami, T. Tanaka and F. Shinozaki. A diazo heat-sensitive recording material having a partly microencapsulated recording layer consisting of a diazo compound, a coupling component and a colouring activator has excellent shelf life and provides high colouring speed.
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• European Patent Application 129,382 (1984) Long-acting formulation of cefaclor SHIONOGI AND CO. LTD. T. Sakamoto, S. Kawai, K. Noda, T. Takeda and H. Kato. Long acting formulations of cefaclor for treatment of bacterial infections consist of rapid-release powder and slow-release microcapsules.
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• European Patent Application 130,360 (1985) Self-extinguishing formed thermoplastic bodies based on polycaprolactam CONSIGLIO NAZIONALE DELLS RICERCHE (ISTITUTO CHIM). G. C. Alfonso, S. Russo, E. Pedemonte, A. Turturro and C. Puglisi. The polymerized caprolactam contains red phosphorus powder micro-encapsulated in resin.
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• European Patent Application 130,577 (1985) Liposomes DAIICIII SEIYAKU CO. LTD, IL Kikuchi and H. Yamauchi. Spherical uniform vesicles diameter of approximately 1 gm were prepared by mixing liposome membrane components in a harmless solvent.
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• European Patent Application 133,046 (1985) Introducing a donor DNA into a strain of the genus Lactobacillus YAKULT HONSHA CO. LTD. M. Kadota, S. Kudo and M. Mutai. The DNA is encapsulated in liposomes and the liposomes fused with Lactobacillus spheroplasts.
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• European Patent Application 133,295 (1985) Production of microcapsules MITSUI TOATSU CHEMICALS INC. M. Asano, K. Hasegawa, Y. Tamura and Y. Oono. Microcapsules of a hydrophobic material in dense wall films of an aminoplast have sharp particle size distribution.
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• European Patent Application 134,674 (1985) Pesticide compositions STAUFFER CHEMICAL co. H. B. Scher, M. Rodson and R. L. Morgan. Microencapsulated insecticides maintaining high biological effectiveness in the field and with reduced dermal toxicity were prepared.
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FRANCE

• French Demande 2,543,019 (1984) Microcapsules MITSUBISHI PAPER MILLS LTD. F. Okumura and A. Kawai. Microcapsules of formaldehyde-melamine resin with partially esterified maleic anhydride-styrene copolymer provide carbonless copying paper with decreased transference of desensitizers to the lower paper and improved colour development.
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F.R. GERMANY

• German Offenlegungsschrift 3,401,443 (1984) Coating composition for photocopying purposes MEAD CORP. F. W. Sanders. Diffusion in colour images, formed by imagewise exposure of microen-capsulated photosensitive material and subsequent development is eliminated by inclusion of an organic peroxide hardener.
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• German Offenlegungsschrift 3,402,534 (1985) Correction fluid, especially for copying papers DOEBBELIN UND BOEDER G.M.b.H. L. Boeder and F. Bernsau. The fluid was prepared by adding microencapsulated colour donor and colour developer to a mixture of dispersant, pigment and binder.
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• German Offenlegungsschrift 3,405,206 (1984) Toner in microcapsule form KONISHIROKU PHOTO INDUSTRY CO. LTD. H. Yamazaki, T. Nagai and S. Suzuki. A microencapsulated pressure-fixable toner was prepared giving high quality copies without damaging the paper.
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• German Offenlegungsschrift 3,407,829 (1984) Pressure-fixable toner in microcapsule form KONISHIROKU PHOTO INDUSTRY CO. LTD. T. Nagai, S. Suzuki and H. Yamazaki. A microencapsulated pressure-fixable toner giving high quality electrophotographic copies which do not smudge easily was prepared.
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• German Offenlegungsschrift 3,410,602 (1984) Device and methods for producing lipid bubbles by vaporizing solvents OREAL S.A. R. M. Handjani, A. Ribier and M. Maurelli. Methods are described for the preparation of unilamellar lipid vesicles with diameter >1000 A for the encapsulation of e.g. aqueous solutions of biologically active substances.
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• German Offenlegungsschrift 3,410,808 (1984) Encapsulated electrostatographic toner material FUJI PHOTO FILM CO. LTD. F. Kakimi and T. Mikami. A microencapsulated pressure-fixable toner was prepared which adheres strongly to the receptor paper even at high temperatures or after a long storage period.
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• German Offenlegungsschrift 3,410,809 Encapsulated electrostatographic toner materials FUJI PHOTO FILM CO. LTD. F. Kakimi and T. Mikami. A microencapsulated pressure-fixable toner was prepared with high adhesion to the copy paper and giving non-smudging copies.
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• German Offenlegungsschrift 3,416,978 (1984) Transformation of eukaryotic cells mediated by a liposome STAUFFER CHEMICAL CO. I. J. Mettler. The preparation is described of microencapaulated biologically active molecules (e.g. DNA in liposomes) for delivery into cells (especially plant cells) to effect their transformation.
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GERMAN DEMOCRATIC REPUBLIC

• German D.R. Patentschrift 213,360 (1984) Device for dielectrophoretic collection of suspended particles AKADEMIE DER WISSENSCHAFTEN DER DDR. P. Stolley and G. Dreyer. An apparatus consisting of two coaxial cylindrical electrodes which have a ring cleavage is used for the dielectrophoretic collection of cells or vesicles.
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• German D.R. Patentschrift 213,516 (1984) Device for detecting cell regulatory processes in a model system WILHELM-PIECK-UNIVERSITAET ROSTOCK. W. Schuett, H. L. Jenssen and H. Friemel. An apparatus for detecting changes in the surface charge of e.g. lipid bilayer vesicles for studying cell regulatory processes, detection of immunologically active substances, stability of colloidal solutions etc. is described.
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ISRAEL

• Israeli Patent 61,910 (1984) Fluorescent polymeric microspheres and method of linking them to biologically active proteins YEDA RESEARCH AND DEVELOPMENT CO. LTD. Fluorescent rnicrospheres of acrylate or acrylamide type polymer can be coupled to biologically active proteins for detection and sorting.
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JAPAN

• Japan Kokai Tokkyo Koho 59 46,388 (1984) Sublimable microcapsule tones and fixing of the toner images RICOH CO. LTD. Microcapsule toners with good thermal fixability consist of self-fixing cores of binder and colouring agent in sublimable polymer shells.
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• Japan Kokai Tokkyo Koho 59 73,988 (1984) Pressure-sensitive copying paper set MITSUBISHI PAPER MILLS LTD. The paper set contains an electron-donating leuco dye and an electron accepting colour developer containing polystyrene, also a microencapsulated colour former coating on a paper substrate. Colour images obtained by pressure showed improved stability to sunlight, oxides of nitrogen and humidity.
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• Japan Kokai Tokkyo Koho 59 79,790 (1984) Pressure-sensitive copying paper KANZAKI PAPER MFG CO. LTD. A single sheet pressure-sensitive copying paper consists of microen-capsulated ligand, microencapsulated organic Fe(III) compound and an oil-absorbing pigment. This paper produces low background fog.
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• Japan Kokai Tokkyo Koho 59 83,693 (1984) Color developer for pressure sensitive copying paper and thermal recording paper RICOH CO. LTD. A colour developer sheet and a microencapsulated copying sheet were placed with coated sides together, and copied using an electric typewriter. Images were stable to light and plasticizers and the background brightness was stable to oxidation.
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• Japan Kokai Tokkyo Koho 59 106,991 (1984) Pressure-sensitive copying sheets FUJI XEROX CO. LTD. Sheets having a colour-forming dye and/or a colour developer coated on or impregnated in a paper, give improved ease in use with an electrophotographic copying machine.
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• Japan Kokai Tokkyo Koho 59 136,348 (1984) Thermosetting resin compositions SUMITOMO CHEMICAL CO. LTD. Compositions showing excellent wear resistance for use in floor coverings, road surfaces etc. comprise cold-setting resin and microencapsulated soft resins.
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• Japan Kokai Tokkyo Koho 59 138,487 (1984) Pressure-sensitive copying paper MITSUBISHI PAPER MILLS LTD. The title paper contains microencapsulated solid wax, electron-donating leuco dye and electron acceptor. The uniform sized wax microcapsules protect the copying paper from staining by handling.
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• Japan Kokai Tokkyo Koho 59 142,183 (1984) Plain paper transfer-type pressure-sensitive copying sheet KANZAKI PAPER MFG CO. LTD. A microencapsulated transfer-type copying sheet for a plain paper is described.
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• Japan Kokai Tokkyo Koho 59 156,788 (1984) Manufacture of pressure copying sheet DAINIPPON PRINTING CO. LTD. A method providing copying sheets with prevented premature colouring uses microcapsule coated support.
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• Japan Kokai Tokkyo Koho 59 158,286 (1984) Microcapsules for pressure-sensitive copying sheet KANKAKI PAPER MFG CO. LTD. Microcapsules with a hydrophobic core material containing an organo-phosphorus metal compound for use in the preparation of a pressure-sensitive top copying sheet were prepared.
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• Japan Kokai Tokkyo Koho 59 162,086 (1984) Copying material containing spiro-compound FUJI PHOTO FILM CO. LTD. The microencapsulated spiro-compound is an excellent dye precursor and produces a recording paper with low staining properties and good storage stability.
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• Japan Kokai Tokkyo Koho 59 162,562 (1984) Electrophotographic pressure-fixable microencapsulated toners KONISHIROKU PHOTO INDUSTRY CO. LTD. A pressure-fixable microencapsulated toner was prepared with improved homogeneous particle size distribution.
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• Japan Kokai Tokkyo Koho 59164,795 (1984) Reduction of metal complexes H. TSUCHIDA. Organometallic complexes as clathrates in liposome or lamellar phospholipids can be reduced in an aqueous medium in the presence of quinone compounds.
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• Japan Kokai Tokkyo Koho 59 177,128 (1984) Manufacturing microcapsules MITSUBISHI PAPER MILLS 1.m. Microcapsules useful in carhonless copying papers consist of copolymer shells and hydrophobic cores.
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• Japan Kokai Tokkyo Koho 59 179,128 (1984) Oxygen-carrying inclusion compounds H. TSUCHIDA. Fe(II)-porphyrin complexes which formed oxygen-carrying inclusion compounds with polymeric liposomes were prepared.
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• Japan Kokai Tokkyo Koho 59 185,353 (1984) Development of electrostatic latent image CANON K.K. A microencapsulated nonmagnetic toner, on being impressed with a d.c. bias, produced an electrostatic latent image on a drum at a fixed distance from the supported toner.
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• Japan Kokai Tokkyo Koho 59 187,351 (1984) Microencapsulated toners for electrostatographic developers CANON K.K. Toners consisting of a core containing magnetite and copolymer walls have good pressure fixability, durability, developability and transferability.
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• Japan Kokai Tokkyo Koho 59 187,352 (1984) Microencapsulated toners CANON K.K. Microencapsulated toners with a core containing magnetite and copolymer walls exhibit good pressure fixability, durability, developability and transferability.
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• Japan Kokai Tokkyo Koho 59 189,349 (1984) Electrostatographic developer CANON K.K. The developer consists of a core and two shells which prevents dispersion and elution of the core during capsule formation. The developer can be fixed using low pressures, provides good transfer and good images after 30 000 copies.
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• Japan Kokai Tokkyo Koho 59 189,354 (1984) Microencapsulated toner for electrostatography CANON K.K. The microencapsulated toner, having a copolymer shell, provides good and stable charge control and is fixable by low pressure.
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• Japan Kokai Tokkyo Koho 59 192,591 Two-colour thermal recording material RICOH CO. LTD. A recording material consists of an intermediate microencapsulated layer between lower temperature colouring and higher temperature colouring layers which colour different tones at different temperatures.
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• Japan Kokai Tokkyo Koho 59 192,592 (1984) Two-colour thermal recording material RICOH CO. LTD. The recording material consists of an intermediate microencapsulated layer between a lower temperature colouring layer and a higher temperature colouring layer which colour different tones at different temperatures.
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• Japan Kokai Tokkyo Koho 59 194,887 (1984) Thermal recording material RICOH CO. LTD. The material, which has improved readability in visible-to-IR region, has a heat-sensitive colour-forming layer containing a leuco dye, a colour developer and microencapsulated carbon.
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• Japan Kokai Tokkyo Koho 59 196,328 (1984) Compositions for expansion molding ACHILLES CORP. Compositions useful for preparing elastic, damping and thermal insulating sheets contain elastic substances, microcapsules having thermoplastic substances as interstructure materials and core substances causing the interstructure materials to expand by heating.
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• Japan Kokai Tokkyo Koho 59 198,190 (1984) Microcapsules for pressure-sensitive copying paper DENKI KAGAKU KOGYO K.K. The microcapsules consist of an electron-donating colour former core and an insoluble polyamine wall providing stability of the microcapsule dispersion, durability and heat resistance.
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• Japan Kokai Tokkyo Koho 59 198,668 (1984) Thin alkaline battery MATSUSHITA ELECTRIC INDUSTRIAL CO. LTD. Prevention of electrolyte scattering during battery fabrication is prevented by the microencapsulation of the electrolyte. On sealing the anode and cathode cans, the microcapsules are broken.
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• Japan Kokai Tokkyo Koho 59 199,033 (1984) Manufacturing microcapsules DENKI KAGAKU KOGYO K.K. Microcapsules with improved durability, heat resistance and core holding property comprise a hydrophobic core substance in a polymer shell.
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• Japan Kokai Tokkyo Koho 59 200,255 (1984) Magnetic toner KAO CORP. The toner consists of spherical particles of diameter 12–13 pm composed of magnetic powder coated with a layer of a ketene dimer.
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• Japan Kokai Tokkyo Koho 59 201,892 (1984) Developer sheet for pressure-sensitive copying paper rorrAN mooRE co. LTD. Developer sheet containing phenolic resin developer when contacted with a colour former sheet containing encapsulated leuco dye produces rapid coloration at low temperatures.
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• Japan Kokai Tokkyo Koho 59 203,634 (1984) Microcapsules KANZAKI PAPER MFG CO. LTD. Uniform microcapsules of hydrophobic core material in polymer walls were prepared.
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• Japan Kokai Tokkyo Koho 59 204,591 (1984) Recording material MITSUBISHI PAPER MILLS LTD. A recording material consists of a support with an ink-accepting layer of thermoplastic polymer particles, microencapsulated thermoplastic resin and adhesive. The recording method consists of ink-jet recording, rupture of the microcapsules and optional heat treatment. A clear recorded layer with entrapped ink can be made on transparent or opaque material.
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• Japan Kokai Tokkyo Koho 59 204,592 (1984) Recording material MITSUBISHI PAPER MILLS I.TD. A recording material consists of an ink-accepting sheet with a layer of thermoplastic polymer particles, microencapsulated thermoplastic resin and adhesive. The recording plastic. The method consists of ink-jet process on acceptor sheet, pressure treatment of both sheets and optional heat treatment. Clear recordings are produced on transparent or opaque material by an ink-entrapped film.
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• Japan Kokai Tokkyo Koho 59 207,284 (1984) Preparation of developer sheet for pressure copying FUJI PHOTO FILM CO. LTD. A developer sheet providing high rate and degree of colour formation with a blemish-free surface is a support coated with a metal salt of a carboxylic acid. Pressure tests with a sheet coated with encapsulated leuco dye showed good and fast colour formation.
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• Japan Kokai Tokkyo Koho 59 207,286 (1984) Thermal transfer recording paper MITSUBISHI PAPER MILLS LTD. A recording paper which can form clear transferred images even on rough paper consists of a substrate carrying a layer of thermally melting ink and microencapsulated coloured pigment.
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• Japan Kokai Tokkyo Koho 59 209,115 (1984) Multicolor thick image-forming process TOPPAN PRINTING CO. LTD. A multicolour thick image is produced using coloured PVC solutions and microencapsulated foaming agent.
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• Japan Kokai Tokkyo Koho 59 210,013 (1984) Liposomes containing physiologically-active substances AJINOMOTO CO. INC. Liposomes as blood-components which are mechanically strong were prepared by mixing n-glucosamine polysaccharides with phospholipid double molecular layers.
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• Japan Kokai Tokkyo Koho 59 222,410 (1984) Liposome formulations containing pharmaceuticals TERUMO CORP. Liposomes of lecithins or natural phospholipids containing sterols provide sustained-release stable pharmaceuticals.
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• Japan Kokai Tokkyo Koho 59 223,774 (1984) Adhesive compositions NIPPON SYNTHETIC CHEMICAL INDUSTRY CO. LTD. Adhesive compositions of a polyester, a polyisocyanate and a microencapsulated organic metal catalyst have a long pot life and show high bonding strength in a short period.
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• Japan Kokai Tokkyo Koho 59 226,322 (1984) Liquid crystal display devices and their fabrication MANCHESTER RESEARCH AND DEVELOPMENT PARTNERSHIP. The preparation of several different liquid crystal display devices using nonpleochroic dyes is described, using microencapsulated compositions coated on transparent electrodes.
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• Japan Kokai Tokkyo Koho 59 227,933 (1984) Cellular phenolic resins N. YOSHIMI. A phenolic resin containing expandable microspheres was prepared giving a cellular product having high compression strength and a hard surface.
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• Japan Kokai Tokkyo Koho 59 227,934 (1984) Microencapsulation of powdered plasticizers MATSUMATO YOSIi-SEIN'AKU CO. LTD. CHISSO CORP. The preparation of highly flexible thermoplastics with good processability using microencapsulated powdered plasticizers is described.
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• Japan Kokai Tokkyo Koho 59 228,930 (1984) Microencapsulation KITOKU GAKUEN UNIVERSITY. The core and shell materials flow together down a vertical cone vibrated supersonically, and the microcapsules are hardened by drying or a hardening solution.
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• Japan Kokai Tokkyo Koho 59 229,386 Two-color thermal recording material RICOH CO. LTD. A two-colour thermal recording material contains two colour image-recording layers with different colour-developing temperatures. An interlayer erases diffusing dye so preventing colour contamination.
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• Japan Kokai Tokkyo Koho 59 229,392 (1984) Thermal recording material RICOH CO. LTD. A thermal recording material comprises microcapsules of photohardenable resin, a photopolymerization initiator and a thermally fusible substance as wall materials and either a leuco base or a colour developer as the core material.
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• Japan Kokai Tokkyo Koho 59 230,633 (1984) Coated food additive powder AJINOMOTO CO. INC. A method of microencapsulating food additives and supplements in plastic and powder materials to prevent hygroscopy and improve solubility is described.
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• Japan Kokai Tokkyo Koho 59 230,635 (1984) Microcapsules for pressure-sensitive paper KANZAKI PAPER MFG. CO. LTD. Polyfunctional isocyanate is microencapsulated in PVA and coated on paper to give a sheet suitable for pressure copying in a laminated assembly.
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• Japan Kokai Tokkyo Koho 59 231,451 (1984) Immunochemical analysis TOSHIBA CORP. Microcapsules including erythrocytes, liposomes etc. containing indicator compounds from which the indicators can be released, for use in immunoassays, were prepared.
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• Japan Kokai Tokkyo Koho 59 170,114 (1984) Epoxy resin spherical particles TORAY INDUSTRIES INC. Spherical particles of diameter 1–50 gm and bearing functional groups were prepared.
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• Japan Kokai Tokkyo Koho 59 255,115 (1984) Microencapsulation of unsaturated fatty acids isolated from fish OHTA PHARMACEUTICAL CO. LTD. The odour of anticholesteremic fatty acids obtained from marine fish is controlled by microencapsulation with antioxidants and flavours.
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• Japan Kokai Tokkyo Koho 60 01,125 (1985) Photostable ubidecarenone formulations EISAI CO. LTD. Microcapsules of photostable ubidecarenone formulations were prepared.
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• Japan Kokai Tokkyo Koho 60 03,646 (1985) Toner preparation method FUJI XEROX CO. LTD, A mixture of materials with a microencapsulated foaming agent produces a toner whose surface is microscopically irregular which improves the fixability of the toner and facilitates the pulverization Process.
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• Japan Kokai Tokkyo Koho 60 03,647 (1985) Microcapsule toner FUJI XEROX CO. LTD. An electrostatographic microcapsule toner having a core, an intermediate magnetic layer and a shell has good developability, transferability, fixability and high resistance to blocking in storage, to wear and to mechanical impact.
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• Japan Kokai Tokkyo Koho 60 04,538 (1985) UV-curable acrylic coatings YOSHINO KOGYOSHO CO. LTD, A UV-curable coating composition for plastic containing carbon hollow microspheres gives improved hardness.
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• Japan Kokai Tokkyo Koho 60 09,797 (1985) Metal-containing pressure-sensitive copying sheet FUIJI XEROX CO. LTD. Copying sheets having microencapsulated oil solution of colour former, a colour developer and a metal or metal compound detectable by proximity detector can be used for copying by electrophotography before pressure-copying. Also the use of the detector can prevent unauthorized copying of e.g. confidential documents.
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• Japan Kokai Tokkyo Koho 60 14,935 (1985) Microcapsules of aldehyde donor for phenolic resin hardening NAGOYA YUKAGAKU KOGYO K.K. An aldehyde donor e.g. paraformaldehyde dispersed as a paste in water Or polyhydric alcohol is microencapsulated in a suspension of polymer.
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• Japan Kokai Tokkyo Koho 60 15,645 (1985) Pressure-fixable toner CANON K.K. A pressure-fixable electrophotographic toner containing copolymer has good developing and pressure-fixing properties.
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• Japan Kokai Tokkyo Koho 60 25,790 (1985) Thermal-transfer recording material CANON K.K. A thermal-transfer recording material has a heat-transferable ink layer of microencapsulated colouring agent dispersed in a heat-fusible binder.
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• Japan Kokai Tokkyo Koho 60 25,792 (1985) Thermal-transfer recording material CANON K.K. A microencapsulated thermal-transfer recording material has a heat-transferable ink layer containing a colouring agent, a foaming agent and a heat-fusible binder.
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PCT

• PCT Application 84 01,329 (1984) Monolayer, self color-forming, pressure-sensitive recording sheet MITSUBISHI PAPER MILLS LTD. T. lids. The title sheet consists of a single recording layer of microcapsules of both colour-former and colour-developer in a wax material and shows reduced undesirable coloration on folding.
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• PCT Application 84 02,883 (1984) Carbon-less paper for a letter printer MITSUBISHI PAPER MILLS LTD. A pressure-sensitive carbonless paper for use in either a dry or a wet type letter printer was prepared.
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• PCT Application 84 03,947 (1984) Detecting and measuring by fluorescence a cellular endocytosis dependent on proteins of the cell membrane CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE. INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE. L. D. Leserman, A. Truneh, J. Barbet and P. S. J. Machy. A given ligand is contacted with the cells to be studied in the presence of liposomes covalently coupled to a molecule that can bind the ligand and contain encapsulated fluorochrome sufficient for self-quenching of the fluorescence of the fluorochrome.
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• PCT Application 84 04,396 (1984) Enhanced agglutination method and kit COOPER-LIPOTECH, INC. F. J. Martin and V. J. Kung. Faster and more sensitive agglutination and hemagglutination tests for antigens and antibodies are described using agglutinable particles coated with lipid bodies e.g. liposomes and nonvesicular lipid structures that promote multiple analyte bridge connections between particles and reagents, thereby increasing the visibility of the agglutinate particles.
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• PCT Application 8404,728 Pressure-sensitive sheet material MITSUBISHI PAPER MILLS LTD. H. Senoh, T. Kosaka and N. Kagota. A pressure-sensitive recording paper comprised of a microencapsulated coloration top sheet and a colour-developing bottom sheet had reduced colour smudge by using weak pressure.
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• PCT Application 84 04,730 (1984) Monolayer, self-color-forming, pressure-sensitive recording paper MITSUBISHI PAPER MILLS LTD. T. lids and K. Fukumoto. A pressure-sensitive recording paper was prepared with a monolayer consisting of microencapsulated colouring agent and colour developer for use in a dot printer.
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• PCT Application 85 00,011 (1985) Microdroplets of water-insoluble drugs UNIVERSITY OF MIAMI. D. H. Haynes. The preparation of microdroplets of water-insoluble drugs coated with phospholipid is described.
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SOUTH AFRICA

• South African Patent 83 09,184 (1984) Microencapsulation by interchange of multiple emulsions MOORE BUSINESS FORMS INC. H. Y. Chao. Microencapsulation of reagents for copying systems is achieved by mixing emulsions to form polymer walls enclosing dye precursor. The microcapsules were coated onto a back paper which produced a blue image upon impact on an active clay coated front sheet.
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UK

• UK Patent Application 2,140,745 (1984) Paper for electrostatography using encapsulated toner FUIJI PHOTO FILM CO. LTD. An electrophotographic encapsulated toner image paper receptor with an extremely smooth surface was prepared resulting both in improved fixing property and off-setting.
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USA

• US Patent 4,483,929 (1984) Liposomes with glycolipid-linked antibodies LIPOSOME TECHNOLOGY INC. F. C. Szoka. A method useful for detecting ligands in both fluids for disease diagnosis uses a reagent including a suspension of liposomes containing reported molecules e.g. chromogens.
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• US Patent 4,485,045 (1984) Synthetic phosphatidyl cholines useful in forming liposornes RESEARCH CORP. S. L. Regen. The preparation of the title compounds is described.
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• US Patent 4,486,315 (1984) Immunoassay microparticle washing system and method of use ORTHO DIAGNOSTIC SYSTEMS INC. 3. W. Teipel. The apparatus and method for the separation, collection and washing of particles contained in a fluid, which is useful for immunoassay of blood samples, is described.
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• US Patent 4,487,801 (1984) Fragrance-releasing pull-apart sheet MINNESOTA MINING AND MFG. CO. E. M. Everett and J. W. Charbonneau. The sheet is prepared from paper coated with microencapsulated fragrance.
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• US Patent 4,492,720 (1985) Microspheres for intravascular delivery B. Mosier. Microspheres of average size 100–149 pro were prepared for drug delivery.
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• US Patent 4,495,318 (1985) Low tack microsphere glue INTERNATIONAL CURE CORP. P. H. Howard. Inherently tacky, elastomeric, solvent-dispersable, solvent-insoluble, polymeric microspheres are especially adapted for use as a low-tack glue to provide a reusable adhesive surface.
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• US Patent 4,501,728 (1985) Masking of liposomes from RES recognition TECHNOLOGY UNLIMITED INC. W. B. Geho and J. R. Lau. A drug carrier system coated with sialic acid residues masks the surface of the carrier from the reticuloendothelial system (RES) which thus does not remove the targeted drugs.
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• US Patent 4,503,161 (1985) Encapsulated latent Lewis acid catalysts MINNESOTA MINING AND MFG. CO. G. E. Korbel and R. G. Newell. Microcapsules containing Lewis acid curing catalysts for epoxy resins which are stable in storage were prepared.
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USSR

• USSR Patent 1,135,477 (1985) Induction of interferon IVANOVSKII D.I. INSTITUTE OF VIROLOGY. INSTITUTE OF MEDICAL RADIOLOGY, ACADEMY OF MEDICAL SCIENCES: USSR. S. S. Grigoryan, D. B. Dzhumaev, F. I. Ershov, V. M. Zhdanov, A. M. Poverennyi, V. K. Podgorodnichenko and G. A. Popov. Oral administration of 2-spiral polyribonucleotides with preoral administration of inducer-free liposornes induces the formation of interferon.
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