Patent Briefing

PATENT BRIEFING

CANADA

• Microencapsulation of living tissue and cells M. F. A. Goosen, G. M. O'Shea and A. M. SunCONNAUGHT LABORATORIES LTD A core material of living tissue and cells, such as Islets of Langerhans rat cell cultures, is microencapsulated in a semipermeable membrane for implantation into an animal body. Canadian Patent 1,215,922 (1986)
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• Acrolein microspheres A . Rembaum.CALIFORNIA INSTITUTE OF TECHNOLOGY Polymer microspheres prepared from acrolein or a derivative thereof can be derivatized with amines or proteins without aggregation and are useful in SEM for localization of antigens etc on cell surfaces. Canadian Patent 1,218,185 (1987)
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EUROPE

• Preparation of a biodegradable high molecular polymer and its use as a pharmaceutical excipient M . Yamamoto, H. Okada, Y. Ogawa and T. Miyagawa.TAKEDA CHEMICAL INDUSTRIES, LTD. WAKO PURE CHEMICAL INDUSTRIES, LTD. The title polymer is used for manufacture of drug-containing microcapsules for injectable sustained release. European Patent Application 202,065 (1986)
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• Vaccine for generating an immunogenic T cell response protective against a virus E . Heber-Katz.WISTAR INSTITUTE A vaccine for generating an immunogenic T-cell response protective against herpes simplex virus, for example, contains a liposome composition. European Patent Application 203,676 (1986)
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• Carbonless system including solvent-only microcapsules R . J. Jerabek.MOORE BUSINESS FORMS, INC.
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• A carbonless copying system consists of dye precursor and solvent separately microencapsulated. The images produced have improved density. European Patent Application 204,460 (1986)
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• Encapsulated color electrostatographic tones R . J. Gruber, R. A. Yourd, P. C. Julien, J. F. Knapp and S. B. Bolte.XEROX CORP.Microencapsulated toners have improved electrical stability, triboelectric charging values and an extended number of copying cycles without significant aging. Eeropean Patent Application 211,583 (1987)
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• Method and composition for making liposomes J . Y. Park and S. A. Thompson.ALLERGAN PHARMACEUTICALS Mixtures of a hydrating agent e.g. glutamic acid or arganine with liposome-forming materials produce a gel which spontaneously forms highly stable liposomes with very high capture efficiency in aqueous solution. European Patent Application 211,647 (1987)
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• Spherically shaped silica particles K . Unger, H. Giesche and J. Kinkel.MERCK PATENT G.M.B.H. Highly monodisperse, nonporous, spherical silica particles with diameter 0.05-10 pm were prepared as sorbents of proteins etc. in chromatography. European Patent Application 216,278 (1987)
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• Solid-phase analytical device containing fiber-entrapped particles with bound reagents and method for using same W . E. Brown III, S. M. Devereaux, K. M. Knigge, J. M. Clemens, J. G. Hofler and S. E. Safford.ABBOTT LABORATORIES The device consists of a porous matrix of fibres containing entrapped spherical solid micro-particles, diameter 0.1-10 gm, carrying on their surfaces a reagent for detection of an analyte by solid-phase assay. European Patent Application 217,403 (1987)
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• Security paper containing vesiculated beads. R. H. Hamilton.DE SOTO, INC. A security paper contains transparent, polymeric, vesicular beads of diameter 10–35 µ containing a pigment or dye, difficult to see in visible light, but which glows in nonvisible radiation, e.g. UV light. Eeropean Patent Application 219,743 (1987)
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• New aerosol composition for in vivo imaging and therapy Y . C. Nicolau, A. Le Pape and R. Baro-Ciobaru.CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEAn aerosol composition for in vivo imaging or ex vivo diagnosis contains a soluble fragment of bacterial cell wall or peptidoglycan labelled with a radioactive, paramagnetic or fluorescent element and encapsulated in liposomes. European Patent Application 221,821 (1987)
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FRANCE

• Sustained release drug formulation J . Y. Drouin and M. Veillard.RHONE-POULENC SANTE The formulations are microparticles containing the drug, a polymer and a lipid excipient. French Demande 2,581,541 (1986)
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• Oral insulin formulation D . J. P. Tressens. The formulation consists of encapsulated liposomes coated with a gastric juice-resistant substance. French Denzande 2,581,543 (1986)
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FEDERAL REPUBLIC OF GERMANY

• Continuous preparation of microcapsules with walls of melamine-formaldehyde condensate in aqueous dispersion W . Sliwka.BASF A.-G. The process described gives microcapsules without agglomeration. German Offenlegungsschrift 3,532,878 (1987)
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• Back coatings for carbonless copying systems G . 0. Langlais, P. Y. H. Wang and J. S. Chaplick.NASHUA CORP. Copying systems prepared using microencapsulated back coatings with high solids content are useful for computer printers and matrix printers. German Offenlegungsschrift 3,534,031 (1986)
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• Offset printing plate production S . Ishikawa and F. Shinogaki.FUJI PHOTO FILM CO., LTD. The preparation of a microencapsulated offset printing plate is described. German Offenlegungsschrift 3,605,120 (1986)
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• Photosensitive, pressure-sensitive recording sheet of the plain-paper-transfer type. T. Matsushita, S. Hiraishi and S. Morishita.MITSUBISHI PAPER MILLS, LTD. A microencapsulated photosensitive, pressure-sensitive recording sheet which can be used in combination with a plain paper to produce transfer recordings of coloured originals was prepared. German Offenlegungsschrift 3,614,434 (1986)
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• Photosensitive thermal-transfer recording sheet, and photosensitive pressure-sensitive recording sheet and their preparation T . Matsushita, S. Hiraishi and S. Morishita.MITSUBISHI PAPER MILLS, LTD. The sheets, which contain microencapsulated pigment or dye and a polymerization initiator, can be used to produce multicoloured images on plain paper. German Offenlegungsschrift 3,627,617 (1987)
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GERMAN DEMOCRATIC REPUBLIC

• Preparation of aminoplast microcapsules R . Nastke, K. Dietrich, I. Leibnitz and W. Teige.AKADEMIE DER WISSENSCHAFTEN DER DDRThe preparation of microcapsules, average diameter 200 inn, with liquid cores is described. German Patentschrift 241,556 (1986)
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JAPAN

• Polymetizable phospholipids H . Tsuchida, K. Ejima, Y. Matsushita and H. Tsuchida.
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• Phospholipids were prepared in water to form liposomes which can be polymerized under photoirradiation to form microcapsules useful for encapsulating pharmaceuticals and enzymes. Japan Kokai Tokkyo Koho 61 129,192 (1986)
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• Pressure-sensitive copying paper for optical reading of copied images S . Shioi, K. Shinko, N. Kanda, M. Kondo and A. Mujake. A pressure-sensitive copying paper employs a chelate-type recording material. Colour images are obtained from visible to IR range, and the copies obtained are easily read with an optical character reader. Japan Kokai Tokkyo Koho 61 202,883 (1986)
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• Microcapsules of low free formaldehyde content H . Horiuchi, S. Ura, S. Kawakami and S. Sakai.SUMITOMO CHEMICAL CO., LTD. A slurry containing microcapsules of low formaldehyde content was prepared which was useful in making pressure-sensitive copying paper. Japan Kokai Tokkyo Koho 61 204,035 (1986)
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• Pressure-sensitive recording sheets M . Sano, M. Satomura, K. Iwakura and Y. Saeki.FUJI PHOTO FILM CO., LTD.
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• Pressure-sensitive recording sheets contain an almost colourless electron-donating dye precursor and a p-phenylenediamine derivative. They show excellent light resistance. Japan Kokai Tokkyo Koho 61 211,079 (1986)
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• One-component low-temperature pressure-fixing toner compositions XEROX CORP. Toners consist of magnetite granules with solvent microencapsulated in polymer shells. Japan Kokai Tokkyo Koho 61 228,459 (1986)
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• Unified pressure-sensitive coloring sheets S . Ohara and H. Kawahara.GOY0 SH1K0 K.K. Sheets are coated with a microencapsulated colour former and laminated with a resin layer containing a developer. Japan Kokai Tokkyo Koho 61 248,783 (1986)
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• Microencapsulation of enzyme M . Takizawa and H. Takahashi.LION CORP. Enzyme-containing microcapsules exhibit good retention of enzyme activity during storage in detergent powders. Japan Kokai Tokkyo Koho 61 254,244 (1986)
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• Thermal recording material S . Yoshida and S. Tatsuta.Flip PHOTO FILM CO., LTD. A thermal recording material containing microencapsulated diazo compound and coupler and giving a blue image, has high thermal sensitivity and improved storage stability. Japan Kokai Tokkyo Koho 61 254,388 (1986)
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• Thermal recording material S . Yoshida and S. Tatsuta.FUJI PHOTO FILM CO., LTD. A thermal recording material containing 1 microencapsulated colour-forming component produces a blue image with high density and low stain. It also shows improved storage stability. Japan Kokai Tokkyo Koho 61 254,389 (1986)
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• Thermal recording material S . Yoshida and S. Tatsuta.FUJI PHOTO FILM CO., LTD. A thermal recording layer has 2 kinds of microcapsule in the imaging layer. It has improved shelf life and high thermal sensitivity and is also able to record half-tone images. Japan Kokai Tokkyo Koho 61 262,180 (1986)
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• Heat-sensitive recording material S . Yoshida, T. Endo, S. Tatsuta and T. Usami.FUJI PHOTO FILM CO., LTD. A microencapsulated heat-sensitive recording material shows good storage stability and gives images with high optical density. Japan Kokai Tokkyo Koho 61 277,490 (1986)
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• Thermal recording material M . Sano, K. Iwakura, M. Satomura and T. Usami.FUJI PHOTO FILM CO., LTD. A microencapsulated thermal recording material provides an image with high developed density and high contrast, and a reduced tendency to generate light-induced stains. Japan Kokai Tokkyo Koho 61 283,591 (1986)
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• 1-Toly1-2-phenylpropane as dye solvent for pressure-sensitive recording papers T . Nakamura, T. Terauchi and S. Hoshi.KUREHA CHEMICAL INDUSTRY CO., LTD. The title compound is useful as a dye solvent in microencapsulated pressure-sensitive recording papers. Japan Kokai Tokkyo Koho 61 286,337 (1986)
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• Thermobreakable microcapsules and their preparation S . Shioi, K. Aramitsu and A. Miyake.KANZAKI PAPER MFG CO., LTD.Thermobreakable microcapsules useful for thermal recording papers were prepared. Japan Kokai Tokkyo Koho 61 287,442 (1986)
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• Thermal-transfer materials N . Kushida, K. Tanaka, M. Katamaya and H. Sato.CANON K.K. Microencapsulated thermal-transfer materials provide clear high-density images even on recording media with low surface smoothness. Japan Kokai Tokkyo Koho 61 295,088 (1986)
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• Waterproof sewing threads H . Otsubo and S. Yamagaki.NIPPON RUBBER CO., LTD. The sewing threads, useful in the making of raincoats, tents and shoes, are impregnated with microencapsulated heat-expandable thermoplastic resin. Japan Kokai Tokkyo Koho 61 296,181 (1986)
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• Manufacture of microcapsules H . Fukuo and T. Onoguchi.SAKURA COLOR PRODUCTS CORP. Microcapsules, useful for encapsulating leuco dyes in the manufacture of thermal inks or inks for carbonless paper, were prepared. Japan Kokai Tokkyo Koho 62 01,451 (1987)
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• Photosensitive imaging materials containing optically inert silver salts H . Hara.FUJI PHOTO FILM CO., LTD. Photothermographic photosensitive materials in which the polymerizable compounds and the image-forming substances are microencapsulated together were prepared. The colour images were fixed by thermal polymerization. Japan Kokai Tokkyo Koho 62 03,246 (1987)
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• Coagulation and recovery of colloidal particles H . Yasui, Y. Miki and W. Okada.KANEGAFUCHI CHEMICAL INDUSTRY CO., LTD. The preparation of powders composed of uniform spherical particles of cores encapsulated in fused colloid shells is described. Japan Kokai Tokkyo Koho 62 07,430 (1987)
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• Multicolor diazo copying process H . Sakoshiri.SEIKO INSTRUMENTS AND ELECTRONICS, LTD. The process involves cyan, magenta and yellow colour forming compounds separately microencapsulated which are exposed to 3 different colour lights and then hot-pressed on to a receptor sheet coated with couplers and a base. Japan Kokai Tokkyo Koho 62 07,593 (1987)
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• Electrostatographic developers S . Kuramoto.RICOH CO., LTD. The electrostatographic developers contain microencapsulated toners and fillers which produce well-resolved fine images resistant to rubbing. Japan Kokai Tokkyo Koho 62 14,168 (1987)
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• Polysaccharides as carriers of pharmaceuticals and pesticides S . Kio, N. Tanaka and T. Nakajima.NIPPON STARCH REFINING CO., LTD. The carriers are prepared from polysaccharides of molecular weight 103–105 and the complexes, in which the pharmaceuticals are strongly bound, are effective, when added to feed, in controlling diseases in fish. Polysaccharide-bound insecticides can also control pests in apple trees. Japan Kokai Tokkyo Koho 62 20,576 (1987)
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• Diazo-type copying materials T . Hoshina, N. Takahashi and M. Toshimoto.RICOH CO., LTD. Microencapsulated diazo-type copying materials show good preservability and form copy images which disappear in relatively short periods. Japan Kokai Tokkyo Koho 62 25,749 (1987) Magnetic toner for pressure- fixation M . Asanae.HITACHI METALS, LTD.
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• A toner suitable for high-speed fixation and with excellent storage stability contains microcapsules containing a polyester and a sublimable dye in the core and a waxy shell. Japan Kokai Tokkyo Koho 62, 32,468 (1987) Thermal recording material T . Usami, T. Tanaka and H. Kamikawa.FUJI PHOTO FILM CO., LTD. A thermal recording material containing microencapsulated diazo compound has good storage stability, high thermal sensitivity and excellent image stability. Japan Kokai Tokkyo Koho 62 39,283 (1987)
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• Heat insulating pattern coatings S . AtOMura.SIIIKOKE KAKEN KOGY0 K. K. A composition from thermally expandable microcapsules was coated on an asbestos slate board and pressed with a hot embossing roll to make a pattern coating. Japan Kokai Tokkyo Kohn 62 .39,674 (1987)
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• Preparation of microcapsule compositions in nonaqueous media S . Shioi, K. Shinko and A. Miyake.KANZAKI PAPER MEG. CO., LTD.
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• Microencapsulated flexographic ink was prepared for use in pressure-sensitive copying papers which give sharp image by typing. Japan Kokai Tokkyo Koho 62 42,732 (1987)
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• Microencapsulated smectic liquid crystals TALIQ CORP. Liquid crystal devices contain microencapsulated smectic liquid crystals so orientated that they absorb or scatter light in the absence of an external electric field. Japan Kokai Tokkyo Koho 62 48,789 (1987)
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• Determination of Mycoplasma pneumoniae antibody potency in blood serum based on complement lysis immunoassay S . Motoda, S. Sekine and R. Watabe.DENKO SEIKEN K. K. Marker-containing liposomes sensitized with M. pneumoniae lipid antigen are combined with complement and a sample containing the test antibody to release the marker for the quantitative determination of antibody potency. Japan Kokai Tokkyo Koho 62 50,665 (1987)
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• Colored sheet for thermal molding T . Nogami and M. Sato.YAMATOYA AND CO., LTD. A thermoplastic resin sheet is coated with a formulation of expandable hollow thermoplastic resin microspheres, a colouring agent and a binder to prepare a coloured sheet for vacuum packaging. Japan Kokai Tokkyo Koho 62 53,344 (1987)
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• Manufacture of thermoplastic polymer films K . Ito, K. Tsunashima and T. Saeki.TORAY INDUSTRIES, INC. Abrasion-resistant plastic base films for magnetic recording tapes were prepared from mixtures of thermoplastic polymers and porous inorganic microcapsules containing polymers. Japan Kokai Tokkyo Koho 62 53,374 (1978)
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• Preparation of pure or ultrapure water K . Watanabe.ASAHI CHEMICAL INDUSTRY CO., LTD. Pure or ultrapure water is prepared by passing water through an ion-exchange resin tower, and then contacting it with activated carbon enclosed microcapsules containing polyacrylonitrile. Japan Kokai Tokkyo Kohn 62 53,786 (1987)
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• Electrophotographic fixing for nt icroencapsulated toner images A . Hawke.) arm' and 'I'. Niikattli.FUJI PHOTO FILM CO., III). The fixing of the microencapsulated toner is effected by simultaneous application of low pressure and lower temperature than that used for conventional heat fixing. Japan Kokai Tokkyo Koho 62 55,664 (1987)
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• Thermoplastic films K . Tsunashima, K. Ito and T. Saeki.TORAY INDUSTRIES, INC. A 2pm thick film was prepared using inorganic porous microcapsules. Japan Kokai Tokkyo Koho 62 57,459 (1987)
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• Microencapsulation of pharmaceuticals with acrylic polymers H . Takeuchi, Y. Kawashima, T. Handa and Y. Chikamatsu.ICHIMARU FARUKOSU K. K.; HIGUCHI OILCO., LTD. Pharmaceuticals were microencapsulated in acrylic polymers producing uniform particles. Japan Kokai Tokkyo Koho 62 59,207 (1987)
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• Latex-coated resin microspheres K . Oka.TORAY INDUSTRIES, INC. Epoxy resin microspheres coated with a latex polymer are useful in electrostatic printing toners, cosmetics, adhesives, inks, etc. Japan Kokai Tokkyo Koho 62 59,666 (1987)
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• Immobilization of physiologically active substances on magnetic microparticles T . Matsunaga.TDK CORP. AFP antibody was immobilized on magnetic microparticles isolated from magnetotactic bacteria. Japan Kokai Tokkyo Koho 62 61,584 (1987)
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• Encapsulation of inorganic particles with polymers S . Saito and K. Arai Polymer -encapsulated calcium carbonate particles, diameter 0.3-0.6 pm, were prepared. Japan Kokai Tokkyo Koho 62 61,633 (1987)
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• Resin microspheres coated with powder K . Oka.TORAY INDUSTRIES, INC. Epoxy resin microspheres coated with a powder of diameter 20 per cent of that of the microspheres are useful in electrostatic printing toners, cosmetics, adhesives, inks, etc. Japan Kokai Tokkyo Koho 62 62,826 (1987)
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• Fine powder-coated epoxy resin microspheres K . Oka.TORAY INDUSTRIES, INC. Epoxy resin microspheres coated with powder, particle size 20 per cent of that of the microspheres, are hydrophilic, non-caking, free flowing and useful in toners, cosmetics, adhesives, inks, etc. Japan Kokai Tokkyo Koho 62 62,828 (1987)
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• Fluid as blood substitute for studies on mechanical and flow properties of artificial organs Y. Murakami, K. Imaichi and S. Goto. The simulated blood is a Newtonian fluid and simulated blood cells which are microencapsulated saline, glycerin and other liquids with a volume ratio similar to that of blood plasma and cells in human blood. Japan Kokai Tokkyo Koho 62 63,863 (1987)
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• Coloring irreversible temperature indicators H . Tsutsumi, T. Yamaguchi, N. Hirayama, H. Akahori and M. Asano.MITSUI TOATSU CHEMICALS,INC. Colouring temperature indicator irreversibly activated in a controlled time at an activating temperature consists of a coating layer between a microencapsulated oil layer and a colouring material layer. Japan Kokai Tokkyo Koho 62 66,132 (1987)
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• Thermochromic composition Y . Shibahashi, K. Nakasuji, T. Kataoka, K. Inagaki and T. Kito.PILOT INK CO., LTD. A microencapsulated thermochromic composition suitable for use in a temperature-indicating/warning ink or paint was prepared. Japan Kokai Tokkyo Koho 62 68,880 (1987)
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• Thermal-transfer sheet and thermal-transfer method T . Fujio and T. Kawakami.TOPPAN PRINTING CO., LTD. The method, which incorporates a microencapsulated organic solvent layer with an image-receiving paper and a thermal-transfer sheet, permits printing abrasion-resistant images even on rough surfaced paper. Japan Kokai Tokkyo Koho 62 70,090 (1987)
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• Antislip adhesive nonwoven cloths K . Nohara, M. Kamo, H. Shiraki and N. Nihei.NIPPON KAKO SEISHI CO., LTD. The cloths are prepared by laminating a non-woven cloth on one side with a foamed microcapsule layer and an adhesive on the other side. Japan Kokai Tokkyo Kohn 62 73,940 (1987)
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• Electrophotographic pressure-fixable encapsulated toner particles H . Adachi, T. Watanabe, T. Nakamura, K. Nakahata, M. Yamazaki and N. Ushiyama.CANON K. K.The microencapsulated toner particles have pressure-fixable spherical cores and thin hard shells. Japan Kokai Tokkyo Koho 62 75,540 (1987) Electrophotographic pressure-fixable encapsulated toner particles Adachi, 'I'. Watanabe, T. Nakamura, K. Nakahata, N. Ushiyama and M. Yamazaki.CANON K. K.The microencapsulated toner particles consist of spherical cores and thin hard shells having uneven surfaces. Japan Kokai Tokkyo Koho 62 75,541 (1987)
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• Manufacturing steps for electrophotographic pressure-fixable encapsulated toners M . Yamazaki and T. Matsumoto.CANON K. K. A method for the manufacture of microencapsulated pressure-fixable toners is described. Japan Kokai Tokkyo Koho 62 75,543 (1987)
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• Microcapsules containing enzymes and pharmaceuticals. K. Ishihara and K. Matsui.SAGAMI CHEMICAL RESEARCH CENTER Microcapsules are prepared for the encapsulation of enzymes and pharmaceuticals which are released from the microcapsules in a controlled manner. Japan Kokai Tokkyo Koho 62 77,331 (1987)
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• Microencapsulation of magnetic ultrafines H . Tsunoda.RESEARCH DEVELOPMENT CORP. OF JAPAN Magnetic ultrafines from iron, cobalt, nickel or magnetite, useful in carriers for catalysts, microorganisms or cells are microencapsulated in a polymer shell, giving improved corrosion resistance and dispersability. Japan Kokai Tokkyo Koho 62 83,039 (1987)
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• Radiographic image conversion panel using phosphor microcapsules S . Arakawa, M. Waki and N. Mori.FUJI PHOTO FILM CO., LTD. A radiographic image conversion panel with improved sensitivity contains a substrate with a layer of binder containing stimulative phosphor grains encapsulated in polymer. Japan Kokai Tokkyo Koho 62 83,700 (1987)
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• Polymer microspheres with uniform diameter T . Asano, K. Noda, Y. Moroishi and T. Matsumoto.NITTO ELECTRIC INDUSTRIAL CO., LTD.The preparation of microspheres of diameter 20 pm useful as pigments, fillers, chromatographic packings, etc. is described. Japan Kokai Tokkyo Koho 62 84,156 (1987) Manufacture of doped silica glass T . Mori, S. Kanbe, M. Ikejiri, S. Uchiyama and M. Aoki.SEIKO EPSON CORP. In the manufacture of doped silica glass by a sol-gel process, microencapsulated dopant powder is dispersed in the solution. Japan Kokai Tokkyo Koho 62 100,428 (1987)
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• Fabric filters for liquid separation I . Ichinukizaka.KANAI, HIROYUKI Liquid filters for separation of colloids are fabrics coated with spherical microcapsules of organic polymer of diameter 01–50 gm, or aluminium sulphate powder encapsulated in silica with microporous surface. Japan Kokai Tokkyo Koho 62 106,814 (1987)
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• Binding of liposome pharmaceutical carriers to apolipoproteins to decrease antigenicity of the liposome Y . Shibata.JAPAN PHARMACEUTICAL CO., LTD. The antigenicity of liposomes used as drug carriers is reduced by treating the liposomes with serum apolipoprotein C-I I I or A-I isolated from human blood plasma. Japan Kokai Tokkyo Koho 62 108,811 (1987)
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• Immunoantitumor agents containing macrophage activator-interferon liposomes bound to monoclonal antibodies to human cancer cells T . Osawa, K. Watanabe, M. Sugimoto and M. Higuchi.DENKI KAGAKU KOGYO K. K. Human macrophage activator and interferon-y are encapsulated in liposomes or monoclonal antibody-modified liposomes for the treatment of cancer. Japan Kokai Tokkyo Koho 62 111,934 (1987)
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• Carrier particles for diagnostic reagents S . Yasukawa, K. Kasai and S. Aotani.JAPAN SYNTHETIC RUBBER CO., LTD. A copolymer of particle size 0.69 inn is used as a particle carrier for diagnostic reagents. Japan Kokai Tokkyo Koho 62 118,256 (1987)
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• Sensitized microcapsules for immunoassay of antigens and antibodies F . Kakimi, N. Hiratsuka and K. Matsukawa.FUJI PHOTO FILM CO., LTD. Label-containing or coated sensitized microcapsules are used in immunoassay. A blood sample was mixed with the microcapsules for agglutination in the detection of antibodies. Japan Tokkyo Koho 62 07,508(1987)
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PCT

• Aerosol of drug-containing liposomes J . A. Hayward.BIOCOMPATIBLES LTD. An inhalation aerosol consists of a therapeutic or diagnostic substance contained in phospholipid liposomes suspended in the carrier fluid. Altering the lipid composition controls the time release of the entrapped core material. PCT International Application 87 01,586 (1987)
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• Microcapsules containing liposomes S . R. Simon.BIOCOMPATIBLES LTD. Nutritional or pharmacologically active substances are microencapsulated in bio-active lipids, the liposomes being encapsulated in a matrix of an alginate salt and gelatin. PCT International Application 87 01,587 (1987)
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• Hydrophobic cis-platinum complexes efficiently incorporated into liposomes as antitumor agents A . R. Khokhar, G. Lopez-Berestein and R. Perez-Soler.UNIVERSITY OF TEXAS SYSTEM cis -Platinum complexes were encapsulated into liposomes for use as anticancer agents. They were tested in vivo in mice. PCT International Application 87 02,364 (1987)
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• Pharmaceutical compositions containing compounds microencapsulated by polar lipids, especially mono-fatty glycerides B . M. Ekman, K. V. Larsson, A. R. Lindahl and U. S. E. Rothman.BIOGRAM AB. Pharmaceutical microcapsules have the core material surrounded by surface-active solid crystals of polar lipids which protect it from contact with its surroundings. PCT International Application 87 02,582 (1987)
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• Liposome immunoassay reagent and method V . T. Kung, E. Canova-Davis and C. T. Redemann.COOPER-LIPOTECH, INC. A liposome assay reagent for the determination of an analyte in a homogeneous immunoassay is described. The assay performed for phenytoin showed linearity and sensitivity over a 2-5-30 kig/m1 phenytoin range. PCT International Application 86 04,682 (1986)
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• Liposomes comprising sterol ester salts A . S. Janoff, L. E. Bolcsak, P. A. Tremblay and C. E. Swenson.LIPOSOME co., LTD. Compounds to be administered in vivo are encapsulated in liposomes, bilayers of which consist of a sterol ester salt. PCT International Application 86 05,977 (1986)
   Google Scholar
• Preparing an extemporaneous homogeneous microcapsule suspension M . Calanchi, L. Gentilini and M. Marconi.ECRAND ITALIA S.P.A. Drug microcapsules were prepared then used to make single dose bags containing 10 milliequiv. K PC T International Application 86 06,626 (1986)
   Google Scholar
• Liposome inhalation method and system P . J. Mihalko and R. M. Abra.LIPOSOME TECHNOLOGY, INC. The preparation of liposome-entrapped controlled-release drugs for inhalation into the respiratory tract with the desired rate of drug release controlled by the phospholipid composition of the liposomes is described. PCT International Application 86 06,959 (1986)
   Google Scholar

SPAIN

• Self-copying paper P . Ylla Badia Copies are produced automatically by writing on a sheet of paper with a backing of microencapsulated chromatogenic materials. Spanish Patent 534,979 (1985)
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UK

• Fluorescent microbeads simulating stained cells for calibration A . Schwartz.FLOW CYTOMETRY STANDARDS CORP.
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USA

• Microbeads, useful in calibrating flow cytometers or fluorescent microscopes were prepared from copolymers covalently bonded to fluorescent dyes. UK Patent Application 2,172,104 (1986)
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• NMR, X-ray and ultrasonographic diagnosis with complex salts of paramagnetic metals with diamines as imaging agents H . Gries, D. Rosenberg and H. J. Weinmann.SCHERING A.-G. A complex salt of paramagnetic metals was encapsulated in cholesterol-lecithin liposomes and freeze-dried for use in liver imaging. US Patent 4,647,447 (1987)
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• Fluorescent microbead quenching assay R . F. Zuk and D. J. Litman.SYNTAX (U.S.A.), INC. Reagents are prepared for competitive immunoassay of ligands. An assay was performed using fluorescent particles of immunobeads conjugated with antibodies. US Potent 1,654,300 (1987)
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• Assay for a ligand by use of supported binder and sac lysing agent D . B. Wagner.BECTON, DICKINSON AND CO. A solid support carrying a sac lysing agent and an analyte binder attached to both the sample and a tracer composed of a ligand coupled to sacs e.g. liposomes, is used in a homogeneous assay for an analyte. US Patent 4,656,129 (1987)
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• Explosive systems J . P. Cunnion Jnr and B. W. Sands.PQ CORP. Water-containing slurry explosives are sensitized with hollow microspheres containing alkali, silica and boron, and stabilized to pH and viscosity by the addition of an inorganic salt. US Patent 4,664,728 (1987)
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• Pigment encapsulated latex aqueous colorant dispersions F . J. IVECale.KOH-I-NOOR RAPIDOGRAPH, INC. Stable aqueous colourants, useful for textiles, writing inks and cosmetics contain ultrafine primary particles microencapsulated in polymers. US Patent 4,665,107 (1987)
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• Lipid tubules P . E. Shoen, P. Yager and J. M. Schnur.UNITED STATES DEPT. OF THE NAVY The preparation of lipid tubules from liposomes is described. They are useful in rocket propellants, optical elements, fuses for small electrical circuits, microsyringes etc. US Patent Application 852,596 (1986)
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• Monoclonal antibodies to cholesterol and methods for detection of high levels of cholesterol in biological specimens C . R. Alving and G. M. Swartz Jnr.UNITED STATES DEPT. OF THE ARMY Monoclonal antibodies were prepared which are highly specific for high-cholesterol liposomes and useful for detection of high concentrations of cholesterol in biological specimens. US Patent Application 875,048 (1987)
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• Method for detecting, separating or purifying inositol and phosphatidylinositol through binding to concanavalin A UNITED STATES DEPT. OF THE ARMY Concanavalin A is useful for detecting, separating or purifying inositol and phosphatidylinositol by binding specifically to inositol. Binding of concavalin A to liposomes increased by 5-fold in the presence of phosphatidylinositol. US Patent Application 884,691 (1987)
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USSR

• Apparatus for preparing multilayer particles, particularly with liposomes R . Noreika, M. Slamas, V. Brusokas and G. Dudenas."SANITAS" INDUSTRIAL-EXPERIMENTAL PLANT The apparatus contains a magnetic system and ferromagnetic spherical particles. A product with uniform granulometric composition is obtained. USSR Patent 1,318,280 (1987)
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