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Original Article

The in vivo interaction between flavone acetic acid and hyperthermia

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Pages 779-789 | Received 21 Aug 1995, Accepted 23 May 1996, Published online: 09 Jul 2009

References

  • Bibby M. C., Double J. A., Phillips R. M., Loadman P. M. Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid). British Journal of Cancer 1987; 55: 159–163
  • Bibby M. C., Double J. A., Loadman P. M., Duke C. V. Reduction of tumor blood flow by flavone acetic acid: a possible component of therapy. Journal of the National Cancer Institute 1989; 81: 216–220
  • Capolongo L. S., Balconi G., Ubezio P., Giavazzi R., Taraboletti G., Regonesi A., Yoder O. C., D'Incalci M. Antiproliferative properties of flavone acetic acid (NSC 347512) (LM 975), a new anticancer agent. European Journal of Cancer Clinical Oncology 1987; 23: 1529–1535
  • Corbett T. H., Bissery M. C., Wozniak A., Plowman J., Polin L., Tapazoglou E., Dieckman J., Valeriote F. Activity of flavone acetic acid (NSC-347512) against solid tumors of mice. Investigation of New Drugs 1986; 4: 207–220
  • Crile G. The effects of heat and radiation on cancers implanted on the feet of mice. Cancer Research 1963; 23: 372–380
  • Dewhirst M. W., Prescott D. M., Clegg S., Samulski T. V., Page R. L., Thrall D. E., Leopold K., Rosner G., Acker J. C., Oleson J. R. The use of hydralazine to manipulate tumour temperatures during hyperthermia. International Journal of Hyperthermia 1990; 6: 971–983
  • Edwards H. S., Bremner J. C. M., Stratford I. J. Induction of hypoxia in the KHT sarcoma by tumour necrosis factor and flavone acetic acid. International Journal of Radiation Biology 1991; 59: 419–432
  • Evelhoch J. L., Bissery M. C., Chabot G. G., Simpson N. E., McCoy C. L., Heilbrun L. K., Corbett T. H. Flavone acetic acid (NSC 347512)-induced modulation of murine tumor physiology monitored by in vivo nuclear magnetic resonance spectroscopy. Cancer Research 1988; 48: 4749–4755
  • Finlay G. J., Smith G. P., Fray L. M., Baguley B. C. Effect of flavone acetic acid on Lewis lung carcinoma: evidence for an indirect effect. Journal of the National Cancer Institute 1988; 80: 241–245
  • Fujimoto S., Konno C., Kobayashi K., Kokubun M., Shrestha R. D., Kiuchi S., Takahashi M., Ohta M., Okui K. Augmented antitumour effects of combined treatment with hyperthermia and tumour necrosis factor on human gastric cancer xenotransplanted into nude mice. International Journal of Hyperthermia 1991; 7: 511–518
  • Gerweck L. E., Nygaard T. G., Burlett M. Response of cells to hyperthermia under acute and chronic hypoxic conditions. Cancer Research 1979; 39: 966–972
  • Hill S. A., Denekamp J. The effect of vascular occlusion on the thermal sensitization of a mouse tumor. British Journal of Radiology 1978; 51: 997–1002
  • Hill S. A., Williams K. B., Denekamp J. Vascular collapse after flavone acetic acid: a possible mechanism of its anti-tumour action. European Journal of Cancer and Clinical Oncology 1989; 25: 1419–1424
  • Honess D. J., Hu D. E., Bleehen N. M. A study of the mechanism of hydralazine enhancement of thermal damage in the KHT tumour. International Journal of Hyperthermia 1991; 7: 667–679
  • Horsman M. R., Chaplin D. J., Overgaard J. The effect of combining flavone acetic acid and hyperthermia on the growth of a C3H mammary carcinoma in vivo. International Journal of Radiation Biology 1991; 60: 385–388
  • Horsman M. R., Christensen K. L., Overgaard J. Hydralazine-induced enhancement of hyperthermic damage in a C3H mammary carcinoma in vivo. International Journal of Hyperthermia 1989; 5: 123–136
  • Jain R. K., Grantham F. H., Gullino P. M. Blood flow and heat transfer in Walker 256 mammary carcinoma. Journal of the National Cancer Institute 1979; 62: 927–933
  • Kallinowski F., Moehle R., Vaupel P. Substantial enhancement of tumor hyperthermic response by tumor necrosis factor. Hyperthermic Oncology, T. Sugahara, M. Saito. Taylor and Francis, London 1989; Vol. 1: 258–259
  • Kalmus J., Okunieff P., Vaupel P. Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSaII tumors. Cancer Research 1990; 50: 15–19
  • Kerr D. J., Maughan T., Newlands E., Rustin G., Bleehen N. M., Lewis C., Kaye S. B. Phase II trials of flavone acetic acid in advanced malignant melanoma and colorectal carcinoma. British Journal of Cancer 1989; 60: 104–106
  • Laws A. L., Matthew A. M., Double J. A., Bibby M. C. Preclinical in vitro and in vivo activity of 5,6-dimethylxanthenone-4-acetic acid. British Journal of Cancer 1995; 71: 1204–1209
  • Lin P. S., Ho K. C., Sung S. J. Combined treatments of heat, radiation and cytokines with flavone acetic acid on the growth of cultured endothelial cells. Interna tional Journal of Hyperthermia 1993; 9: 517–528
  • Mace K. F., Hornung R. L., Wiltrout R. H., Young H. A. Correlation between in vivo induction of cytokine gene expression by flavone acetic acid and strict dose dependency and therapeutic eflicacy against murine renal cancer. Cancer Research 1990; 50: 1742–1747
  • Mahadevan V., Malik S. T. A., Meager A., Fiers W., Lewis G. P., Hart I. R. Role of tumor necrosis factor in flavone acetic acid-induced tumor vasculature shutdown. Cancer Research 1990; 50: 5537–5542
  • Overgaard J. Simultaneous and sequential hyperthermia and radiation treatment of an experimental tumor and its surrounding normal tissue in vivo. International Journal of Radiation Oncology, Biology and Physics 1980; 6: 1507–1517
  • Overgaard J., Bichel P. The influence of hypoxia and acidity on the hyperthermic response of malignant cells in vitro. Radiology 1977; 123: 511–514
  • Overgaard J., Nielsen O. S. The role of tissue environmental factors on the kinetics and morphology of tumor cells exposed to hyperthermia. Annals of the New York Academy of Sciences 1980; 335: 254–280
  • Patterson J., Strang R. The role of blood flow in hyperthermia. International Journal of Radiation Oncology, Biology and Physics 1979; 5: 235–241
  • Plowman J., Narayanan V. L., Dykes D., Szarvasi E., Briet P., Yoder O. C., Paull K. D. Flavone acetic acid: a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice. Cancer Treatment Reports 1986; 70: 631–635
  • Sakaguchi Y., Maehara Y., Baba H., Kusumoto T., Sugimachi K., Newman R. A. Flavone acetic acid increases the antitumor effect of hyperthermia in mice. Cancer Research 1992; 52: 3306–3309
  • Sapirstein L. A. Regional blood flow by fractional distribution of indicators. American Journal of Physiology 1958; 193: 161–168
  • Schroyens W. A., Dodion P. F., Sanders C., Loos M., Dethier N. E., Delforge A. R., Stryckmans P. A., Kenis Y. In vitro chemosensitivity testing of flavone acetic acid (LM975; NSC 347512) and its diethylaminoethyl ester derivative (LM985; NSC 293015). European Journal of Cancer Clinical Oncology 1987; 23: 1135–1139
  • Smith G. P., Calveley S. B., Smith M. J., Baguley B. C. Flavone acetic acid (NSC 347512) induced haemorrhagic necrosis of mouse colon 26 and 28 tumours. European Journal of Cancer and Clinical Oncology 1987; 23: 1209–1211
  • Storm F. K. Hyperthermia in Cancer Therapy. G.K. Hall Publishers, Boston, MA 1983; 107–114, Suit, H. D., 1975, Hyperthermia in the treatment of tumours. Proceedings of the International Symposium on Cancer Therapy by Hyperthermia and Radiation, Washington, 28-3. April (American College of Radiology
  • Sun J. R., Brown J. M. Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma. Cancer Research 1989; 49: 5664–5670
  • Teicher B. A., Holden S. A., Rudolph M. B., Sotomayor E. A., Herman T. S. Effect of environmental conditions (pH, oxygenation and temperature) on the cyto toxicity of flavone acetic acid and its dimethylaminoethyl ester. International Journal of Hyperthermia 1991; 7: 905–915
  • Tomasovic S. P., Vasey T. A., Story M. D., Stephens L. C., Kloster-Gaard J. Cytotoxic manifestations of the interaction between hyperthermia and TNF: DNA fragmentation. International Journal of Hyperthermia 1994; 10: 247–262
  • Van Der Zee J., Van Den Aardweg G. J. M. J., Van Rhoon G. C., Van Den Berg A. P., De Wit R. Thermal enhancement of both tumour necrosis factor alpha-induced systemic toxicity and tumour cure in rats. British Journal of Cancer 1995; 71: 1158–1162
  • Vaupel P. Oxygen supply to malignant tumors. Tumor Blood Circulation: Angiogenesis, Vascular Morphology and Blood Flow of Experimental and Human Tumors, H. I. Peterson. CRC Press Inc., Boca Raton, Florida 1979; 143–168
  • Voorhees W. D., Babbs C. F. Hydralazine-enhanced selective heating of transmissible venereal tumor implants in dogs. European Journal of Cancer and Clinical Oncology 1982; 19: 1027–1033
  • Wallen C. A., Colby T. V., Stewart J. R. Cell kill and tumor control after heat treatment with and without vascular occlusion in RIF-1 tumors. Radiation Research 1986; 106: 215–223
  • Watanabe N., Niitsu Y., Umeno H., Sone H., Neda H., Yamauchi N., Maeda M., Urushizaki I. Synergistic cytotoxic and antitumor effects of recombinant human tumor necrosis factor and hyperthermia. Cancer Research 1988; 48: 650–653
  • Watts M. E., Murray J. C., Smith K. A., Woodcock M. Flavone acetic acid as a modifier of endothelial cell function. International Journal of Radiation Oncology Biology and Physics 1992; 11: 431–435
  • Wike-Hooley J. L., Haveman J., Reinhold H. S. The relevance of tumor pH to the treatment of malignant disease. Radiotherapy and Oncology 1984; 2: 343–366
  • Zwi L. J., Baguley B. C., Gavin J. B., Wilson W. R. Blood flow failure as a major determinant in the antitumour action of flavone acetic acid. Journal of the National Cancer Institute 1989; 81: 1005–1013
  • Zwi L. J., Baguley B. C., Gavin J. B., Wilson W. R. The use of vascularized spheriods to investigate the action of flavone acetic acid on tumour blood vessels. British Journal of Cancer 1990; 62: 31–237

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