468
Views
37
CrossRef citations to date
0
Altmetric
Research Article

Mild traumatic brain injury (MTBI) leads to spatial learning deficits

, PhD, , , &
Pages 151-165 | Received 21 Mar 2011, Accepted 22 Oct 2011, Published online: 23 Feb 2012

References

  • Langlois JA, Rutland-Brown W, Thomas KE, Traumatic brain injury in the United States: emergency department visits, hospitalizations, and deaths. Atlanta, GA: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control; 2006
  • Alexander MP. Mild traumatic brain injury: Pathophysiology natural history and clinical management. Neurology 1995; 45: 1253–1260
  • Aubry M, Cantu R, Dvorak J, Graf-Baumann T, Johnston K, Kelly J, et al. Summary and agreement statement of the first international conference on concussion in sport Vienna (2001). Recommendations for improvement of safety and health of athletes who may suffer concussive injuries. British Journal of Sports Medicine 2002; 36: 888–897
  • Kim E, Lauterbach EC, Reeve A, et al. Neuropsychiatric complications of traumatic brain injury: A critical review of the literature (A report by the ANPA committee on research). Journal of Neuropsychiatry and Clinical Neuroscience 2007; 19: 106–127
  • Halterman CI, Langan J, Drew A, Rodriquez E, Osterring L, Chou LS, et al. Tracking the recovery of visuospatial attention in mild traumatic brain injury. Brain 2006; 129: 747–753
  • Chin-Cheng Y, Yong-Kwang T, Mau-Sun H, Sheng-Jean H. The association between post-concussion syndrome and clinical outcomes for patients with mild traumatic brain injury. Journal of Trauma Injury, Infection and Critical Care 2007; 62: 657–663
  • Dixon CE, Clifton GL, Lighthall JW, Yaghmai AA, Hayes RL. A controlled cortical impact model of traumatic brain injury in the rat. Journal of Neuroscience Methods 1999; 39: 253–262
  • Cernak I. Animal models of head injury. The Journal of the American Society of Experimental Neurotherapeutics 2005; 2: 410–422
  • Ludin A, de Boussard C, Edman G, Borg J. Symptoms and disability until 3 months after mild traumatic brain injury. Brain Injury 2006; 20: 799–806
  • McAllister TW, Flashman LA, McDonald BC, Saykin AJ. Mechanisms of working memory dysfunction after mild and moderate TBI: Evidence from functional MRI and neurogenetics. Journal of Neurotrauma 2006; 23: 1450–1467
  • Dikmen S, Mclean A, Temkin N. Neuropsychological and psychosocial consequences of minor head injury. Journal of Neurology, Neurosurgery, and Psychiatry 1986; 49: 1227–1232
  • Chuah YML, Maybery MT, Fox AM. The long term effects of mild head injury on short term memory for visual form, spatial location and their conjunction in a well-functioning university students. Brain and Cognition 2004; 56: 304–312
  • Zec RF, Zeller D, Belman J, Miller J, Mathews J, Ferneau-Belman D, Robbs R. Long–term consequences of severe closed head injury on episodic memory. Journal of Clinical and Experimental Neuropsychology 2001; 23: 671–695
  • Skelton RW, Bukach CM, Laurance HE, Thomas KGF, Jacobs JW. Humans with traumatic brain injuries show place-learning deficits in computer-generated virtual space. Journal of Clinical and Experimental Neuropsychology 2000; 22: 157–175
  • Hartley T, Bird CM, Chan D, Cipolott L, Husain M, Vargha-Khadem F, Burgess N. The hippocampus is required for short-term topographical memory in humans. Hippocampus 2007; 17: 34–48
  • Shrager Y, Bayley PJ, Botempi B, Hopkins RO, Squire LR. Spatial memory and the human hippocampus. Proceedings of the National Academy of Sciences 2007; 104: 2961–2966
  • Hamm RJ, Dixon CE, Gbadebo DM, Singha AK, Lyeth BG, Jenkins LW, Hayes RL. Cognitive deficits following traumatic brain injury produced by controlled cortical impact. Journal of Neurotrauma 1992; 9: 11–20
  • Scheff SW, Baldwin SA, Brown RW, Kraemer PJ. Morris water maze deficits in rats following traumatic brain injury: Lateral controlled cortical impact. Journal of Neurotrauma 2007; 14: 615–627
  • Kline AE, Massucci JL, Marion DW, Dixon CE. Attenuation of working memory and spatial acquisition deficits after a delayed and chronic bromocriptine treatment regimen in rats subjected to traumatic brain injury by controlled cortical impact. Journal of Neurotrauma 2002; 19: 415–425
  • Whiting MD, Hamm RJ. Traumatic brain injury produce delay dependent memory impairment in rats. Journal of Neurotrauma 2006; 23: 1529–1534
  • Povlishock JT. Pathobiology of traumatically induced axonal injury in animals and man. Annals of Emergency Medicine 1993; 22: 980–986
  • Kant R, Smith-Seemiller L, Isaac G, Duffy J. Tc-hmpao spect in persistent post-concussion syndrome after mild head injury: Comparison with MRI/CT. Brain Injury 1997; 11: 115–124
  • Umile EM, Plotkin RC, Sandel ME. Functional assessment of mild traumatic brain injury using spect and neuropsychological testing. Brain Injury 1998; 12: 577–594
  • Umile EM, Sandel ME, Alavi A, Terry CM, Plotkin RC. Dynamic imaging in mild traumatic brain injury: Support for the theory of medial temporal vulnerability. Archives of Physical Medicine & Rehabilitation 2002; 83: 1506–1513
  • Inglese M, et al. Diffuse axonal injury in mild traumatic brain injury: A diffusion tensor imaging study. Journal of Neurosurgery 2005; 103: 298–303
  • Belanger HG, Vanderploeg RD, Curtiss G, Warden DL. Recent neuroimaging techniques in mild traumatic brain injury. Journal of Neuropsychiatry and Clinical Neuroscience 2007; 19: 5–18
  • Tate DF, Bigler ED. Fornix and hippocampal strophy in traumatic brain injury. Learning and Memory 2000; 7: 442–446
  • Moser M, Moser EI, Forrest E, Andersen P, Morris RGM. Spatial learning with a minislab in the dorsal hippocampus. Proceedings of the National Academy of Sciences 1995; 92: 9697–9701
  • Broadbent NJ, Squire LR, Clark RE. Spatial memory, recognition memory, and the hippocampus. Proceedings of the National Academy of Sciences 2004; 101: 14515–14520
  • Clark RE, Broadbent NJ, Squire LR. Hippocampus and remote spatial memory in rats. Hippocampus 2005; 15: 260–272
  • Martin SJ, Clark RE. The rodent hippocampus and spatial memory: From synapses to systems. Cellular and Molecular Life Sciences 2007; 64: 401–431
  • Lu D, Mahmood A, Goussev A, Schallert T, Qu C, Zhang ZG, Li Y, Lu M, Chopp M. Atorvastatin reduction of intravascular thrombosis, increase in cerebral microvascular patency and integrity, and enhancement of spatial learning in rats subjected to traumatic brain injury. Journal of Neurosurgery 2004; 101: 813–821
  • O’Keefe J, Nadel L. The hippocampus as a cognitive map. Clarendon Press, Oxford 1978
  • Posmantur Kampfl A, Siman R, Liu J, Zhao X, Clifton GL, Hayes RL. Calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat. Neuroscience 1997; 77: 875–888
  • Mahmood A, Lu D, Qu C, Goussev A, Chopp M. Treatment of traumatic brain injury with a combination therapy of marrow stromal cells and atorvastatin in rats. Neurosurgery 2007; 60: 546–553
  • Lu D, Mahmood A, Qu CS, Goussev A, Schallert T, Chopp M. Erythropoietin enhances neurogenesis and restores spatial memory in rats after TBI. Journal of Neurotrauma 2005; 22: 1011–1017
  • Choi SH, Woodlee MT, Hong JJ, Schallert T. A simple modification of the water maze test to enhance daily detection of spatial memory in rats and mice. Journal of Neuroscience Methods 2006; 156: 182–193
  • Day LB, Schallert T. Anticholinergic effects on acquisition of place learning in the Morris water task: Spatial mapping deficit or inability to inhibit non-place strategies?. Behavavioural Neuroscience 2006; 110: 998–1005
  • Morris RGM. Spatial localization does not require the presence of local cues. Learning and Motivation 1981; 12: 239–260
  • Day LB, Weisend M, Sutherland RJ, Schallert T. The hippocampus is not necessary for a place response but may be necessary for pliancy. Behavioural Neuroscience 1999; 113: 914–924
  • Swanson KL. Litter and lingerie. I'll carry the fork: Recovering a life after brain injury. Rising Star Press, California 1999; 13–17
  • Bonanomi DL, Rusconi L, Colombo CA, Benfenati F, Valtorta F. Synaptophysin I selectively specifies the exocytic pathway of synaptobrevin 2/VAMP2. Biochemical Journal 2007; 404: 525–534
  • Fontaine-Lenoir V, Chambraud B, Fellous A, et al. Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor. Proceedings of the National Academy of Sciences 2006; 103: 4711–4716
  • Henninger N, Dutzmann S, Sicard KM, Kollmer R, Bardutzky J, Schwab S. Impaired spatial learning in a novel rat model of mild cerebral concussion injury. Experimental Neurology 2005; 195: 447–457
  • Ramirez-Amaya V, Balderas I, Sandoval J, Escobar ML, Bermudez-Rattoni F. Spatial long-term memory is related to mossy fiber synaptogenesis. The Journal of Neuroscience 2001; 21: 7340–7348
  • Lee I, Kesner RP. Differential roles of dorsal hippocampus subregions in spatial working memory with short versus intermediate delays. Behavioral Neuroscience 2007; 117: 1044–1053
  • Rekart JL, Sandoval J, Bermudez-Rattoni F, Routtenberg A. Remodeling of hippocampal mossy fibers is selectively induced seven days after the acquisition of a spatial but not a cued reference memory task. Learning & Memory 2007; 14: 416–421
  • Sun D, McGinn MJ, Zhou Z, Ben Harvey H, Ross Bullock M, Colello R. Anatomical integration of newly generated dentate granule neurons following traumatic brain injury in adult rats and its association to cognitive recovery. Experimental Neurology 2007; 204: 264–272

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.