Stromal Cell-Derived Factor 1α-Stimulated Mesenchymal Stem Cells Confer Enhanced Protection Against Light-Induced Retinal Degeneration in Rats

References

• Uccelli A, Laroni A, Freedman MS. Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases. Lancet Neurol 2011;10:649–656
   PubMed Web of Science ®Google Scholar
• Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008;3:301–313
   PubMed Web of Science ®Google Scholar
• Armulik A, Genove G, Betsholtz C. Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell 2011;21:193–215
   PubMed Web of Science ®Google Scholar
• Feng J, Mantesso A, De Bari C, Nishiyama A, Sharpe PT. Dual origin of mesenchymal stem cells contributing to organ growth and repair. Proc Natl Acad Sci U S A 2011;108:6503–6508
   PubMed Web of Science ®Google Scholar
• Caplan AI, Correa D. The MSC: an injury drugstore. Cell Stem Cell 2011;9:11–15
   PubMed Web of Science ®Google Scholar
• Connick P, Kolappan M, Crawley C, Webber DJ, Patani R, Michell AW, et al. Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. Lancet Neurol 2012;11:150–156
   PubMed Web of Science ®Google Scholar
• Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008;371:1579–1586
   PubMed Web of Science ®Google Scholar
• Inoue Y, Iriyama A, Ueno S, Takahashi H, Kondo M, Tamaki Y, et al. Subretinal transplantation of bone marrow mesenchymal stem cells delays retinal degeneration in the RCS rat model of retinal degeneration. Exp Eye Res 2007;85:234–241
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang W. Effects of bone marrow mesenchymal stem cell transplantation on light-damaged retina. Invest Ophthalmol Vis Sci 2010;51:3742–3748
   PubMed Web of Science ®Google Scholar
• Kicic A, Shen WY, Wilson AS, Constable IJ, Robertson T, Rakoczy PE. Differentiation of marrow stromal cells into photoreceptors in the rat eye. J Neurosci 2003;23:7742–7749
   PubMed Web of Science ®Google Scholar
• Arriola A, Kiel ME, Shi Y, McKinnon RD. Adjunctive MSCs enhance myelin formation by xenogenic oligodendrocyte precursors transplanted in the retina. Cell Res 2010;20:728–731
   Google Scholar
• Zwart I, Hill AJ, Al-Allaf F, Shah M, Girdlestone J, Sanusi AB, et al. Umbilical cord blood mesenchymal stromal cells are neuroprotective and promote regeneration in a rat optic tract model. Exp Neurol 2009;216:439–448
   PubMed Web of Science ®Google Scholar
• Joe AW, Gregory-Evans K. Mesenchymal stem cells and potential applications in treating ocular disease. Curr Eye Res 2010;35:941–952
   PubMed Web of Science ®Google Scholar
• Wang S, Lu B, Girman S, Duan J, McFarland T, Zhang QS, et al. Non-invasive stem cell therapy in a rat model for retinal degeneration and vascular pathology. PLoS One 2010;5:e9200
   PubMed Web of Science ®Google Scholar
• Bianco P, Robey PG, Simmons PJ. Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell 2008;2:313–319
   PubMed Web of Science ®Google Scholar
• Honmou O, Onodera R, Sasaki M, Waxman SG, Kocsis JD. Mesenchymal stem cells: therapeutic outlook for stroke. Trends Mol Med 2012;18:292–297
   PubMed Web of Science ®Google Scholar
• Tasso R, Ilengo C, Quarto R, Cancedda R, Caspi RR, Pennesi G. Mesenchymal stem cells induce functionally active T-regulatory lymphocytes in a paracrine fashion and ameliorate experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 2012;53:786–793
   PubMed Web of Science ®Google Scholar
• Hou HY, Liang HL, Wang YS, Zhang ZX, Wang BR, Shi YY, et al. A therapeutic strategy for choroidal neovascularization based on recruitment of mesenchymal stem cells to the sites of lesions. Mol Ther 2010;18:1837–1845
   Google Scholar
• Yang Z, Li K, Yan X, Dong F, Zhao C. Amelioration of diabetic retinopathy by engrafted human adipose-derived mesenchymal stem cells in streptozotocin diabetic rats. Graefes Arch Clin Exp Ophthalmol 2010;248:1415–1422
   PubMed Web of Science ®Google Scholar
• Valter K, Bisti S, Stone J. Location of CNTFRalpha on outer segments: evidence of the site of action of CNTF in rat retina. Brain Res 2003;985:169–175
   PubMed Web of Science ®Google Scholar
• Li Y, Tao W, Luo L, Huang D, Kauper K, Stabila P, et al. CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration. PLoS One 2010;5:e9495
   PubMed Web of Science ®Google Scholar
• Lipinski DM, Singh MS, MacLaren RE. Assessment of cone survival in response to CNTF, GDNF, and VEGF165b in a novel ex vivo model of end-stage retinitis pigmentosa. Invest Ophthalmol Vis Sci 2011;52:7340–7346
   PubMed Web of Science ®Google Scholar
• Fischer AJ, Omar G, Eubanks J, McGuire CR, Dierks BD, Reh TA. Different aspects of gliosis in retinal Muller glia can be induced by CNTF, insulin, and FGF2 in the absence of damage. Mol Vis 2004;10:973–986
   Google Scholar
• Wen R, Tao W, Li Y, Sieving PA. CNTF and retina. Prog Retin Eye Res 2012;31:136–151
   PubMed Web of Science ®Google Scholar
• Xue W, Cojocaru RI, Dudley VJ, Brooks M, Swaroop A, Sarthy VP. Ciliary neurotrophic factor induces genes associated with inflammation and gliosis in the retina: a gene profiling study of flow-sorted, Muller cells. PLoS One 2011;6:e20326
   PubMed Web of Science ®Google Scholar
• Yu X, Chen D, Zhang Y, Wu X, Huang Z, Zhou H, et al. Overexpression of CXCR4 in mesenchymal stem cells promotes migration, neuroprotection and angiogenesis in a rat model of stroke. J Neurol Sci 2012;316:141–149
   PubMed Web of Science ®Google Scholar
• Huang YC, Liu TJ. Mobilization of mesenchymal stem cells by stromal cell-derived factor-1 released from chitosan/tripolyphosphate/fucoidan nanoparticles. Acta Biomater 2012;8:1048–1056
   PubMed Web of Science ®Google Scholar
• Zhang ZX, Wang YS, Shi YY, Hou HY, Zhang C, Cai Y, et al. Hypoxia specific SDF-1 expression by retinal pigment epithelium initiates bone marrow-derived cells to participate in Choroidal neovascularization in a laser-induced mouse model. Curr Eye Res 2011;36:838–849
   PubMed Web of Science ®Google Scholar
• Machalińska A, Kłos P, Baumert B, Baśkiewicz M, Kawa M, Rudnicki M, et al. Stem Cells are mobilized from the bone marrow into the peripheral circulation in response to retinal pigment epithelium damage–a pathophysiological attempt to induce endogenous regeneration. Curr Eye Res 2011;36:663–672
   PubMed Web of Science ®Google Scholar
• Ryu CH, Park SA, Kim SM, Lim JY, Jeong CH, Jun JA, et al. Migration of human umbilical cord blood mesenchymal stem cells mediated by stromal cell-derived factor-1/CXCR4 axis via Akt, ERK, and p38 signal transduction pathways. Biochem Biophys Res Commun 2010;398:105–110
   PubMed Web of Science ®Google Scholar
• Johnson TV, Bull ND, Hunt DP, Marina N, Tomarev SI, Martin KR. Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma. Invest Ophthalmol Vis Sci 2010;51:2051–2059
   PubMed Web of Science ®Google Scholar
• Marc RE, Jones BW, Watt CB, Vazquez-Chona F, Vaughan DK, Organisciak DT. Extreme retinal remodeling triggered by light damage: implications for age related macular degeneration. Mol Vis 2008;14:782–806
   PubMed Web of Science ®Google Scholar
• Organisciak DT, Vaughan DK. Retinal light damage: mechanisms and protection. Prog Retin Eye Res 2010;29:113–134
   PubMed Web of Science ®Google Scholar