962
Views
43
CrossRef citations to date
0
Altmetric
Original Article

Effects of Eye Drops Containing a Mixture of Omega-3 Essential Fatty Acids and Hyaluronic Acid on the Ocular Surface in Desiccating Stress-induced Murine Dry Eye

, , , , &
Pages 871-878 | Received 25 Jun 2013, Accepted 11 Jan 2014, Published online: 21 Feb 2014

References

  • Moss SE, Klein R, Klein BE. Prevalence of and risk factors for dry eye syndrome. Arch Ophthalmol 2000;118:1264–1268
  • Schein OD, Muñoz B, Tielsch JM, Bandeen-Roche K, West S. Prevalence of dry eye among the elderly. Am J Ophthalmol 1997;124:723–728
  • Lee AJ, Lee J, Saw SM, Gazzard G, Koh D, Widjaja D, Tan DT. Prevalence and risk factors associated with dry eye symptoms: a population based study in Indonesia. Br J Ophthalmol 2002;86:1347–1351
  • Lin PY, Tsai SY, Cheng CY, Liu JH, Chou P, Hsu WM. Prevalence of dry eye among an elderly Chinese population in Taiwan: the Shihpai Eye Study. Ophthalmology 2003;110:1096–1101
  • Stern ME, Pflugfelder SC. Inflammation in dry eye. Ocul Surf 2004;2:124–130
  • Pflugfelder SC, de Paiva CS, Li DQ, Stern ME. Epithelialimmune cell interaction in dry eye. Cornea 2008;27:S9–11
  • Pflugfelder SC, Stern ME. Symposium participants. Immunoregulation on the ocular surface: 2nd Cullen Symposium. Ocul Surf 2009;7:67–77
  • Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, et al. Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. Invest Ophthalmol Vis Sci 2007;48:2561–2569
  • Yoon KC, Park CS, You IC, Choi HJ, Lee KH, Im SK, et al. Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome. Invest Ophthalmol Vis Sci 2010;51:643–650
  • Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, et al. Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice. J Autoimmun 2008;30:212–221
  • Uchino Y, Kawakita T, Ishii T, Ishii N, Tsubota K. A new mouse model of dry eye disease: oxidative stress affects functional decline in the lacrimal gland. Cornea 2012;31:S63–67
  • Uchino Y, Kawakita T, Miyazawa M, Ishii T, Onouchi H, Yasuda K, et al. Oxidative stress induced inflammation initiates functional decline of tear production. PLoS One 2012;7:e45805
  • Saccà SC, Roszkowska AM, Izzotti A. Environmental light and endogenous antioxidants as the main determinants of non-cancer ocular diseases. Mutat Res 2013;752:153–171
  • Augustin AJ, Spitznas M, Kaviani N, Meller D, Koch FH, Grus F, et al. Oxidative reactions in the tear fluid of patients suffering from dry eyes. Graefes Arch Clin Exp Ophthalmol 1995;233:694–698
  • Mori TA, Beilin LJ. ω3 Fatty acids, blood lipids and cardiovascular risk reduction. Curr Opin Lipidol 2001;12:11–17
  • Connor SL, Connor WE. Are fish oils beneficial in the prevention and treatment of coronary artery disease? Am J Clin Nutr 1997;66:S1020–1031
  • de Assis AM, Rech A, Longoni A, Rotta LN, Denardin CC, Pasquali MA, et al. Ω3-Polyunsaturated fatty acids prevent lipoperoxidation, modulate antioxidant enzymes and reduce lipid content but do not alter glycogen metabolism in the livers of diabetic rats fed on a high fat thermolyzed diet. Mol Cell Biochem 2012;361:151–160
  • Takahashi M, Tsuboyama-Kasaoka N, Nakatani T, Ishii M, Tsutsumi S, Aburatani H, et al. Fish oil feeding alters liver gene expressions to defend against PPARalpha activation and ROS production. Am J Physiol Gastrointest Liver Physiol 2002;282:G338–348
  • Rashid S, Jin Y, Ecoiffier T, Barabino S, Schaumberg DA, Dana MR. Topical omega-3 and omega-6 fatty acids for treatment of dry eye. Arch Ophthalmol 2008;126:219–225
  • McGahon B, Martin D, Horrobin D, Lynch M. Age-related changes in synaptic function: analysis of the effect of dietary supplementation with omega-3 fatty acids. Neuroscience 1999;94:305–314
  • De Paiva CS, Schwartz CE, Gjörstrup P, Pflugfelder SC. Resolvin E1 (RX-10001) reduces corneal epithelial barrier disruption and protects against goblet cell loss in a murine model of dry eye. Cornea 2012;31:1299–1303
  • Li N, He J, Schwartz CE, Gjorstrup P, Bazan HE. Resolvin E1 improves tear production and decreases inflammation in a dry eye mouse model. J Ocul Pharmacol Ther 2010;26:431–439
  • Vogel R, Crockett RS, Oden N, Laliberte TW, Molina L. Demonstration of efficacy in the treatment of dry eye disease with 0.18% sodium hyaluronate ophthalmic solution (vismed, rejena). Am J Ophthalmol 2010;149:594–601
  • De Paiva CS, Corrales RM, Villarreal AL, Farley WJ, Li DQ, Stern ME, et al. Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. Exp Eye Res 2006;83:526–535
  • De Paiva CS, Villarreal AL, Corrales RM, Rahman HT, Chang VY, Farley WJ, et al. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci 2007;48:2553–2560
  • Niederkorn JY, Stern ME, Pflugfelder SC, De Paiva CS, Corrales RM, Gao J, et al. Desiccating stress induces T cell-mediated Sjögren’s syndrome-like lacrimal keratoconjunctivitis. J Immunol 2006;176:3950–3957
  • De Paiva CS, Corrales RM, Villarreal AL, Farley W, Li DQ, Stern ME, et al. Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline. Invest Ophthalmol Vis Sci 2006;47:2847–2856
  • Li Z, Choi W, Oh HJ, Yoon KC. Effectiveness of topical infliximab in a mouse model of experimental dry eye. Cornea 2012;31:S25–31
  • Li Z, Woo JM, Chung SW, Kwon MY, Choi JS, Oh HJ, et al. Therapeutic effect of topical adiponectin in a mouse model of desiccating stress-induced dry eye. Invest Ophthalmol Vis Sci 2013;54:155–162
  • Pauly A, Brignole-Baudouin F, Labbé A, Liang H, Warnet JM, Baudouin C. New tools for the evaluation of toxic ocular surface changes in the rat. Invest Ophthalmol Vis Sci 2007;48:5473–5483
  • Yoon KC, Ahn KY, Choi W, Li Z, Choi JS, Lee SH. Tear production and ocular surface changes in experimental dry eye after elimination of desiccating stress. Invest Ophthalmol Vis Sci 2011;52:7267–7273
  • Oh HJ, Jang JY, Li Z, Park SH, Yoon KC. Effects of umbilical cord serum eye drops in a mouse model of ocular chemical burn. Curr Eye Res 2012;37:1084–1090
  • Park JW, Li Z, Choi JS, Oh HJ, Park SH, Yoon KC. Expression of CXCL9, -10 and -11 in the aqueous humor of patients with herpetic endotheliitis. Cornea 2012;31:1246–1250
  • Choi W, Li Z, Oh HJ, Im SK, Lee SH, Park SH, et al. Expression of CCR5 and its ligands CCL3, -4 and -5 in the tear film and ocular surface of patients with dry eye disease. Curr Eye Res 2012;37:12–17
  • Roncone M, Bartlett H, Eperjesi F. Essential fatty acids for dry eye: a review. Cont Lens Anterior Eye 2010;33:49–54
  • Aragona P, Bucolo C, Spinella R, Giuffrida S, Ferreri G. Systemic omega-6 fatty acid treatment and PGE1 tear content in Sjogren’s patients. Invest Ophthalmol Vis Sci 2005;46:4474–4479
  • Calder P, Zurier R. Polyunsaturated fatty acids and rheumatoid arthritis. Curr Opin Clin Nutr Metab Care 2001;4:115–121
  • Hiramatsu K, Arimori S. Increased superoxide production by mononuclear cells of patients with hypertriglyceridemia and diabetes. Diabetes 1988;37:832–837
  • Thompson PJ, Misso NL, Passarelli M, Phillips MJ. The effect of eicosapentaenoic acid consumption on human neutrophil chemiluminescence. Lipids 1991;26:1223–1226
  • Varming K, Schmidt EB, Svaneborg N, Møller JM, Lervang HH, Grunnet N, et al. The effect of n-3 fatty acids on neutrophil chemiluminescence. Scand J Clin Lab Invest 1995;55:47–52
  • Fisher M, Levine PH, Weiner BH, Johnson MH, Doyle EM, Ellis PA, et al. Dietary n-3 fatty acid supplementation reduces superoxide production and chemiluminescence in a monocyte-enriched preparation of leukocytes. Am J Clin Nutr 1990;51:804–808
  • Fisher M, Upchurch KS, Levine PH, Johnson MH, Vaudreuil CH, Natale A, et al. Effects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential. Inflammation 1986;10:387–392
  • Sirtori CR, Gatti E, Tremoli E, Galli C, Gianfranceschi G, Franceschini G, et al. Olive oil, corn oil, and n-3 fatty acids differently affect lipids, lipoproteins, platelets, and superoxide formation in Type 2 hypercholesterolemia. Am J Clin Nutr 1992;56:113–122
  • Carbonell T, Rodenas J, Miret S, Mitjavila MT. Fish oil and oxidative stress by inflammatory leukocytes. Free Radic Res 1997;27:591–597
  • Applegate KR, Glomset JA. Computer-based modeling of the conformation and packing properties of docosahexaenoic acid. J Lipid Res 1986;27:658–680
  • von Schacky C, Siess W, Fischer S, Weber PC. A comparative study of eicosapentaenoic acid metabolism by human platelets in vivo and in vitro. J Lipid Res 1985;26:457– 464
  • Wakamatsu TH, Dogru M, Ayako I, Takano Y, Matsumoto Y, Ibrahim OM, et al. Evaluation of lipid oxidative stress status and inflammation in atopic ocular surface disease. Mol Vis 2010;16:2465-2475
  • Wakamatsu TH, Dogru M, Matsumoto Y, Kojima T, Kaido M, Ibrahim OM, et al. Evaluation of lipid oxidative stress status in Sjögren syndrome patients. Invest Ophthalmol Vis Sci 2013;54:201–210
  • Cai F, Dupertuis YM, Pichard C. Role of polyunsaturated fatty acids and lipid peroxidation on colorectal cancer risk and treatments. Curr Opin Clin Nutr Metab Care 2012;15:99–106
  • Entwistle J, Hall CL, Turley EA. HA receptors: regulators of signaling to the cytoskeleton. J Cell Biochem 1996;61:569–577
  • Nishida T, Nakamura M, Mishima H, Otori T. Hyaluronan stimulates corneal epithelial migration. Exp Eye Res 1991;53:753–758
  • Aragona P, Di Stefano G, Ferreri F, Spinella R, Stilo A. Sodium hyaluronate eye drops of different osmolarity for treatment of dry eye in Sjogren syndrome patients. Br J Ophthalmol 2002;86:879–884
  • Stern ME, Beuerman RW, Fox RI, Goa J, Mircheff AK, Pflugfelder SC. The pathology of dry eye: the interaction between the ocular surface and lacrimal gland. Cornea 1998;17:584–589
  • Brignole F, Pisella PJ, Dupas B, Baeyens V, Baudouin C. Efficacy and safety of 0.18% sodium hyaluronate in patients with moderate dry eye syndrome and superficial keratitis. Graefes Arch Clin Exp Ophthalmol 2005;243:531–538

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.