Association Between a 27-bp Variable Number of Tandem Repeat Polymorphism in Intron 4 of the eNOS Gene and Risk for Diabetic Retinopathy Type 2 Diabetes Mellitus: A Meta-Analysis

References

• Fong DS, Aiello LP, Ferris FL 3rd, Klein R. Diabetic retinopathy. Diabetes Care 2004;27:2540–2553
   PubMed Web of Science ®Google Scholar
• Tsai DC, Chiou SH, Lee FL, Chou CK, Chen SJ, Peng CH, et al. Possible involvement of nitric oxide in the progression of diabetic retinopathy. Ophthalmologica 2003;217:342–346
   PubMed Web of Science ®Google Scholar
• Schaefer S, Kajimura M, Tsuyama S, Uchida K, Sato E, Inoue M, et al. Aberrant utilization of nitric oxide and regulation of soluble guanylate cyclase in rat diabetic retinopathy. Antioxid Redox Signal 2003;5:457–465
   PubMed Web of Science ®Google Scholar
• Jawa A, Kcomt J, Fonseca VA. Diabetic nephropathy and retinopathy. Med Clin North Am 2004;88:1001–1036
   PubMed Web of Science ®Google Scholar
• Kowluru RA. Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats. Diabetes 2003;52:818–823
   PubMed Web of Science ®Google Scholar
• Joussen AM, Poulaki V, Qin W, Kirchhof B, Mitsiades N, Wiegand SJ, et al. Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. Am J Pathol 2002;160:501–509
   PubMed Web of Science ®Google Scholar
• El-Remessy AB, Abou-Mohamed G, Caldwell RW, Caldwell RB. High glucose-induced tyrosine nitration in endothelial cells: role of eNOS uncoupling and aldose reductase activation. Invest Ophthalmol Vis Sci 2003;44:3135–3143
   PubMed Web of Science ®Google Scholar
• Toda N, Nakanishi-Toda M. Nitric oxide: ocular blood flow, glaucoma, and diabetic retinopathy. Prog Retin Eye Res 2007;26:205–238
   PubMed Web of Science ®Google Scholar
• Li Q, Verma A, Han PY, Nakagawa T, Johnson RJ, Grant MB, et al. Diabetic eNOS-knockout mice develop accelerated retinopathy. Invest Ophthalmol Vis Sci 2010;51:5240–5246
   PubMed Web of Science ®Google Scholar
• Rao AA, Thota H, Gumpeny RS, Akula A, Changalasetty SB, Challa SR, et al. Bioinformatics analysis of diabetic retinopathy using functional protein sequences. Med Hypotheses 2008;70:148–155
   PubMed Web of Science ®Google Scholar
• Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J 2001;357:593–615
   PubMed Web of Science ®Google Scholar
• Farbstein D, Levy AP. The genetics of vascular complications in diabetes mellitus. Cardiol Clin 2010;28:477–496
   PubMed Web of Science ®Google Scholar
• Shimizu T, Onuma T, Kawamori R, Makita Y, Tomino Y. Endothelial nitric oxide synthase gene and the development of diabetic nephropathy. Diabetes Res Clin Pract 2002;58:179–185
   PubMed Web of Science ®Google Scholar
• Rippin JD, Patel A, Belyaev ND, Gill GV, Barnett AH, Bain SC. Nitric oxide synthase gene polymorphisms and diabetic nephropathy. Diabetologia 2003;46:426–428
   PubMed Web of Science ®Google Scholar
• Wilkinson CP, Ferris FL 3rd, Klein RE, Lee PP, Agardh CD, Davis M, et al. Global Diabetic Retinopathy Project Group. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 2003;110:1677–1682
   Google Scholar
• Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959;22:719–748
   PubMed Web of Science ®Google Scholar
• DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177–188
   PubMed Web of Science ®Google Scholar
• Hayashino Y, Noguchi Y, Fukui T. Systematic evaluation and comparison of statistical tests for publication bias. J Epidemiol 2005;15:235–243
   PubMed Web of Science ®Google Scholar
• Zhao S, Li T, Zheng B, Zheng Z. Nitric oxide synthase 3 (NOS3) 4b/a, T-786C and G894T polymorphisms in association with diabetic retinopathy susceptibility: a meta-analysis. Ophthalmic Genet 2012;33:200–207
   PubMed Web of Science ®Google Scholar
• Uthra S, Raman R, Mukesh BN, Padmaja Kumari R, Paul PG, Lakshmipathy P, et al. Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India. Ophthalmic Genet 2007;28:77–81
   PubMed Web of Science ®Google Scholar
• Ezzidi I, Mtiraoui N, Mohamed MB, Mahjoub T, Kacem M, Almawi WY. Endothelial nitric oxide synthase Glu298Asp, 4b/a, and T-786C polymorphisms in type 2 diabetic retinopathy. Clin Endocrinol (Oxf) 2008;68:542–546
   PubMed Web of Science ®Google Scholar
• Santos KG, Crispim D, Canani LH, Ferrugem PT, Gross JL, Roisenberg I. Relationship of endothelial nitric oxide synthase (eNOS) gene polymorphisms with diabetic retinopathy in Caucasians with type 2 diabetes. Ophthalmic Genet 2002;33:23–27
   Google Scholar
• Li MW, Li XX, Zhao MW, Ji LN. Association of genetic polymorphism of nitric oxide synthase and diabetic retinopathy (Chinese). Chin J Ocul Fundus Dis 2010;26:135–138
   Google Scholar
• Awata T, Neda T, Iizuka H, Kurihara S, Ohkubo T, Takata N, et al. Endothelial nitric oxide synthase gene is associated with diabetic macular edema in type 2 diabetes. Diabetes Care 2004;27:2184–2190
   PubMed Web of Science ®Google Scholar
• de Syllos RW, Sandrim VC, Lisboa HR, Tres GS, Tanus-Santos JE. Endothelial nitric oxide synthase genotype and haplotype are not associated with diabetic retinopathy in diabetes type 2 patients. Nitric Oxide 2006;15:417–422
   PubMed Web of Science ®Google Scholar
• Mehrab-Mohseni M, Tabatabaei-Malazy O, Hasani-Ranjbar S, Amiri P, Kouroshnia A, Bazzaz JT, et al. Endothelial nitric oxide synthase VNTR (intron 4 a/b) polymorphism association with type 2 diabetes and its chronic complications. Diabetes Res Clin Pract 2011;91:348–352
   PubMedGoogle Scholar
• Cheema BS, Kohli HS, Sharma R, Bhansali A, Khullar M. Endothelial nitric oxide synthase gene polymorphism and type 2 diabetic retinopathy among Asian Indians. Acta Diabetol 2012;49:481–488
   PubMedGoogle Scholar
• Suganthalakshmi B, Anand R, Kim R, Mahalakshmi R, Karthikprakash S, Namperumalsamy P, et al. Association of VEGF and eNOS gene polymorphisms in type 2 diabetic retinopathy. Mol Vis 2006;12:336–341
   PubMed Web of Science ®Google Scholar
• Chen Y, Huang H, Zhou J, Doumatey A, Lashley K, Chen G, et al. Polymorphism of the endothelial nitric oxide synthase gene is associated with diabetic retinopathy in a cohort of West Africans. Mol Vis 2007;13:2142–2147
   PubMed Web of Science ®Google Scholar
• Cilenšek I, Mankoč S, Globočnik Petrovič M, Petrovič D. The 4a/4a genotype of the VNTR polymorphism for endothelial nitric oxide synthase (eNOS) gene predicts risk for proliferative diabetic retinopathy in Slovenian patients (Caucasians) with type 2 diabetes mellitus. Mol Biol Rep 2012;39:7061–7067
   PubMed Web of Science ®Google Scholar
• Zhang M, Liu H, Xu YS, Wang YM, Song DP, Li H. Endothelial nitric oxide synthase gene intron 4 polymorphism is associated with type 2 diabetic retinopathy (Chinese). Chin J Endocrinol Metab 2005;21:146–147
   Google Scholar
• Yue M, Yu XB, Dai H, Long L. Diabetic retinopathy and variable number tandem repeat polymorphism in intron 4 of endothelial nitric oxide synthase gene (Chinese). Chin J Ocul Fundus Dis 2011;27:214–217
   Google Scholar
• Sun HY, Yang MG, Liu SQ, Wang CJ, Zhang Q, Chen MW, et al. Association of endothelial nitric oxide synthase gene polymorphisms with type 2 diabetes mellitus and diabetic retinopathy (Chinese). Chin J Endocrinol Metab 2004;20:52–53
   Google Scholar
• Petrovic MG, Cilensek I, Petrovic D. Manganese superoxide dismutase gene polymorphism (V16A) is associated with diabetic retinopathy in Slovene (Caucasians) type 2 diabetes patients. Dis Markers 2008;24:59–64
   PubMed Web of Science ®Google Scholar
• Munafò MR, Flint J. Meta-analysis of genetic association studies. Trends Genet 2004;20:439–444
   PubMed Web of Science ®Google Scholar
• Niu PP, Yang G, Zheng BK, Guo ZN, Jin H, Yang Y. Relationship between endothelial nitric oxide synthase gene polymorphisms and ischemic stroke: a meta-analysis. Acta Neurol Scand 2013;128:202–312
   PubMed Web of Science ®Google Scholar
• Dai B, Liu T, Zhang B, Zhang X, Wang Z. The polymorphism for endothelial nitric oxide synthase gene, the level of nitric oxide and the risk for pre-eclampsia: A meta-analysis. Gene 2013;519:187–193
   PubMed Web of Science ®Google Scholar
• Lee YH, Lee HS, Choi SJ, Ji JD, Song GG. Associations between eNOS polymorphisms and susceptibility to systemic lupus erythematosus: a meta-analysis. Inflamm Res 2013;61:135–141
   Google Scholar
• Wang XL, Wang J. Endothelial nitric oxide synthase gene sequence variations and vascular disease. Mol Genet Metab 2000;70:241–251
   PubMed Web of Science ®Google Scholar
• Ezzidi I, Mtiraoui N, Mohamed MB, Mahjoub T, Kacem M, Almawi WY. Association of endothelial nitric oxide synthase Glu298Asp, 4b/a, and -786T > C gene variants with diabetic nephropathy. J Diabetes Complications 2008;22:331–338
   PubMed Web of Science ®Google Scholar