Advanced search
Publication Cover
Current Eye Research Volume 41, 2016 - Issue 3
Submit an article Journal homepage
219
Views
11
CrossRef citations to date
0
Altmetric
Original Articles

Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus

Guey-Chuen PerngDepartment of Microbiology and Immunology, National Cheng Kung University, Taian, Taiwan,
,
Nelson OsorioVirology Research, Gavin Herbert Eye Institute and Department of Ophthalmology, University of California Irvine, School of Medicine, Irvine, CA, USA,
,
Xianzhi JiangVirology Research, Gavin Herbert Eye Institute and Department of Ophthalmology, University of California Irvine, School of Medicine, Irvine, CA, USA,
,
Roger GeertsemaUniversity Laboratory Animal Resources, University of California Irvine, Irvine, CA, USA,
,
Chinhui HsiangVirology Research, Gavin Herbert Eye Institute and Department of Ophthalmology, University of California Irvine, School of Medicine, Irvine, CA, USA,
,
Don BrownVirology Research, Gavin Herbert Eye Institute and Department of Ophthalmology, University of California Irvine, School of Medicine, Irvine, CA, USA,
,
Lbachir BenMohamedVirology Research, Gavin Herbert Eye Institute and Department of Ophthalmology, University of California Irvine, School of Medicine, Irvine, CA, USA, ;Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute and Department of Ophthalmology, University of California Irvine, School of Medicine, Irvine, CA, USA, ;Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, Irvine, CA, USA, ;Institute for Immunology, University of California Irvine, School of Medicine, Irvine, CA, USA,
&
Steven L. WechslerVirology Research, Gavin Herbert Eye Institute and Department of Ophthalmology, University of California Irvine, School of Medicine, Irvine, CA, USA, ;Department of Microbiology and Molecular Genetics, University of California Irvine, School of Medicine, Irvine, CA, USA, and ;Center for Virus Research, University of California Irvine, Irvine, CA, USACorrespondence[email protected]
 show all
Pages 284-291 | Received 19 Jan 2015, Accepted 10 Feb 2015, Published online: 10 Apr 2015

References

  • Xu F, Sternberg MR, Kottiri BJ, McQuillan GM, Lee FK, Nahmias AJ, et al. Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States. Jama 2006;296:964–973
  • Nahmias AJ, Roizman B. Infection with herpes-simplex viruses 1 and 2. 3. N Engl J Med 1973;28915:781–789
  • Farooq AV, Shukla D. Herpes simplex epithelial and stromal keratitis: an epidemiologic update. Surv Ophthalmol 2012;57:448–462
  • Kaufman HE, Azcuy AM, Varnell ED, Sloop GD, Thompson HW, Hill JM. HSV-1 DNA in tears and saliva of normal adults. Invest Ophthalmol Vis Sci 2005;46:241–247
  • Xu F, Schillinger JA, Sternberg MR, Johnson RE, Lee FK, Nahmias AJ, et al. Seroprevalence and coinfection with herpes simplex virus type 1 and type 2 in the United States, 1988–1994. J Infect Dis 2002;185:1019–1024
  • Fukuda M, Deai T, Higaki S, Hayashi K, Shimomura Y. Presence of a large amount of herpes simplex virus genome in tear fluid of herpetic stromal keratitis and persistent epithelial defect patients. Semin Ophthalmol 2008;23:217–220
  • Kumaraguru U, Davis I, Rouse BT. Chemokines and ocular pathology caused by corneal infection with herpes simplex virus. J Neurovirol 1999;5:42–47
  • Rowe AM, St Leger A, Jeon S, Dhaliwal DK, Knickelbein JE, Hendricks RL. Herpes keratitis. Prog Retin Eye Res 2013;32:88–101
  • Nesburn AB. Report of the corneal disease panel: vision research: a national plan 1983–1987. Vol II, Part III. St. Louis: C.V. Mosby Co.; 1983
  • HEDS. Acyclovir for the prevention of recurrent herpes simplex virus eye disease. Herpetic Eye Disease Study Group. N Engl J Med 1998;339:300–306
  • Mori Y, Inoue Y, Shimomura Y. Herpetic epithelial keratitis caused by acyclovir-resistant strain. Jpn J Ophthalmol 1994;38:407–410
  • Reyes M, Shaik NS, Graber JM, Nisenbaum R, Wetherall NT, Fukuda K, et al. Acyclovir-resistant genital herpes among persons attending sexually transmitted disease and human immunodeficiency virus clinics. Arch Intern Med 2003;163:76–80
  • Ziyaeyan M, Alborzi A, Japoni A, Kadivar M, Davarpanah MA, Pourabbas B, et al. Frequency of acyclovir-resistant herpes simplex viruses isolated from the general immunocompetent population and patients with acquired immunodeficiency syndrome. Int J Dermatol 2007;46:1263–1266
  • Longerich T, Eisenbach C, Penzel R, Kremer T, Flechtenmacher C, Helmke B, et al. Recurrent herpes simplex virus hepatitis after liver retransplantation despite acyclovir therapy. Liver Transplant 2005;11:1289–1294
  • Pillay D. Emergence and control of resistance to antiviral drugs in resistance in herpes viruses, hepatitis B virus, and HIV. Commun Dis Public health/PHLS. 1998;1:5–13
  • Pillay D, Schinazi RF. Antiviral drug resistance: from the laboratory to the patient. Antivir Ther 1998;3:237
  • Perng GC, Dunkel EC, Geary PA, Slanina SM, Ghiasi H, Kaiwar R, et al. The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency. J Virol 1994;68:8045–8055
  • Berman EJ, Hill JM. Spontaneous ocular shedding of HSV-1 in latently infected rabbits. Invest Ophthalmol Vis Sci 1985;26:587–590
  • Barsam CA, Brick DJ, Jones C, Wechsler SL, Perng GC. A viral model for corneal scarring and neovascularization following ocular infection of rabbits with a herpes simplex virus type 1 (HSV-1) mutant. Cornea 2005;24:460–466
  • Feldman LT, Ellison AR, Voytek CC, Yang L, Krause P, Margolis TP. Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice. Proc Natl Acad Sci USA 2002;99:978–983
  • Gebhardt BM, Halford WP. Evidence that spontaneous reactivation of herpes virus does not occur in mice. Virol J 2005;2:67--69
  • Perng GC, Esmaili D, Slanina SM, Yukht A, Ghiasi H, Osorio N, et al. Three herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits. J Virol 2001;75:9018–9028
  • Perng GC, Slanina SM, Ghiasi H, Nesburn AB, Wechsler SL. The effect of latency-associated transcript on the herpes simplex virus type 1 latency-reactivation phenotype is mouse strain-dependent. J Gen Virol 2001;82:1117–1122
  • Jin L, Carpenter D, Moerdyk-Schauwecker M, Vanarsdall AL, Osorio N, Hsiang C, et al. Cellular FLIP can substitute for the herpes simplex virus type 1 latency-associated transcript gene to support a wild-type virus reactivation phenotype in mice. J Neurovirol 2008;14:389–400
  • Sawtell NM, Thompson RL. Rapid in vivo reactivation of herpes simplex virus in latently infected murine ganglionic neurons after transient hyperthermia. J Virol 1992;66:2150–2156

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.