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Current Eye Research Volume 41, 2016 - Issue 7
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Inflammation/Immunology

Dexamethasone Disodium Phosphate Penetration Into the Human Aqueous Humor After Topical Application

Carlo Caginia Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, ItalyCorrespondence[email protected] [email protected]
,
Francesco Cometaa Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy
,
Giovanni Torronia Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy
,
Adriana Pellegrinoa Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy
,
Roberto Pellegrinob Department of Chemistry, University of Perugia, Perugia, Italy
&
Gian Maria Cavallinic Institute of Ophthalmology, University of Modena, Modena, Italy
Pages 897-899 | Received 13 Apr 2015, Accepted 30 Jul 2015, Published online: 18 Nov 2015

References

  • McGhee CN, Dean S, Danesh-Meyer H. Locally administered ocular corticosteroids: benefits and risks. Drug Saf 2002;25:33–55.
  • Raizman M. Corticosteroid therapy of eye disease. Fifty years later. Arch Ophthalmol 1996;114:1000–1001.
  • Salminen L. Review: systemic absorption of topically applied ocular drugs in humans. J Ocul Pharmacol 1990;6:243–249.
  • Hosseini K, Matsushima D, Johnson J, Widera G, Nyam K, Kim L, et al. Pharmacokinetic study of dexamethasone disodium phosphate using intravitreal, subconjunctival, and intravenous delivery routes in rabbits. J Ocul Pharmacol Ther 2008;24:301–308.
  • McGhee CN. Pharmacokinetics of ophthalmic corticosteroids. Br J Ophthalmol 1992;76:681–684.
  • McGhee CN, Watson DG, Midgley JM, Noble MJ, Dutton GN, Fern A. Penetration of synthetic corticosteroids into human aqueous humor. Eye 1990;4:526–530.
  • Weijtens O, Schoemaker RC, Romijn FP, Cohen AF, van Meurs JC. Intraocular penetration and systemic absorption after topical application of dexamethasone disodium phosphate. Ophthalmology 2002;109:1887–1891.
  • Sigurdsson HH, Konráethsdóttir F, Loftsson T, Stefánsson E. Topical and systemic absorption in delivery of dexamethasone to the anterior and posterior segments of the eye. Acta Ophthalmol Scand 2007;85:598–602.
  • Awan MA, Agarwal PK, Watson DG, McGhee CN, Dutton GN. Penetration of topical and subconjunctival corticosteroids into human aqueous humour and its therapeutic significance. Br J Ophthalmol 2009;93:708–713.
  • Nourry H, Viard C, Cambourieu C, Warnet JM. A relevant choice for corticoid eye drops: solution or suspension? JFR Ophtalmol 2011;34:691–696.
  • Watson D, Noble MJ, Dutton GN, Midgley JM, Healey TM. Penetration of topically applied dexamethasone alcohol into human aqueous humor. Arch Ophthalmol 1988;106:686–687.
  • McGhee CN, Noble MJ, Watson DG, Dutton GN, Fern AI, Healey TM. Penetration of topically applied prednisolone sodium phosphate into human aqueous humour. Eye (Lond) 1989;3:463–467.
  • Watson DG, McGhee CN, Midgley JM, Dutton GN, Noble MJ. Penetration of topically applied betamethasone sodium phosphate into human aqueous humour. Eye (Lond) 1990;4:603–606.
  • Kristinsson JK, Fridriksdóttir H, Thórisdóttir S, Sigurdardóttir AM, Stefánsson E, Loftsson T. Dexamethasone–cyclodextrin–polymer co-complexes in aqueous eye drops. Aqueous humor pharmacokinetics in humans. Invest Ophthalmol Vis Sci 1996;37:1199–1203.
  • Green K, Downs SJ. Prednisolone phosphate penetration into and through the cornea. Invest Ophthalmol 1974;13:316–318.
  • Kupferman A, Leibowitz HM. Topically applied steroids in corneal disease. IV. The role of drug concentration in stromal absorption of prednisolone acetate. Arch Ophthalmol 1974;91:377–380.
  • Watson DG, Midgley JM, McGhee CN. The analysis of corticosteroid acetates by gas chromatography/negative ion chemical ionization mass spectrometry. Rapid Commun Mass Spectrom 1989;3:8–10.
  • Rosenblum C, Dengler RE Jr, Geoffroy RF. Ocular absorption of dexamethasone phosphate disodium by the rabbit. Arch Ophthalmol 1967;77:234–237.
  • Schoenwald RD, Stewart P. Effect of particle size on ophthalmic bioavailability of dexamethasone suspensions in rabbits. J Pharm Sci 1980;69:391–394.
  • Carnahan MC, Goldstein DA. Ocular complications of topical, peri-ocular, and systemic corticosteroids. Curr Opin Ophthalmol 2000;11:478–483.
  • Burch PG, Migeon CJ. Systemic absorption of topical steroids. Arch Ophthalmol 1968;79:174–176.
  • Krupin T, Mandell AI, Podos SM, Becker B. Topical corticosteroid therapy and pituitary-adrenal function. Arch Ophthalmol 1976;94:919–920.

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