SIRT1 Protects Human Lens Epithelial Cells Against Oxidative Stress by Inhibiting p53-Dependent Apoptosis

References

• Zoric L, Elek-Vlajic S, Jovanovic M, Kisic B, Djokic O, Canadanovic V, et al. Oxidative stress intensity in lens and aqueous depending on age-related cataract type and brunescense. Eur J Ophthalmol 2008;18:669–674.
   PubMed Web of Science ®Google Scholar
• Ottonello S, Foroni C, Carta A, Petrucco S, Maraini G. Oxidative stress and age-related cataract. Ophthalmologica 2000;214:78–85.
   PubMed Web of Science ®Google Scholar
• Fletcher AE. Free radicals, antioxidants and eye diseases: evidence from epidemiological studies on cataract and age-related macular degeneration. Ophthalmic Res 2010;44:191–198.
   PubMed Web of Science ®Google Scholar
• Pendergrass W, Zitnik G, Tsai R, Wolf N. X-ray induced cataract is preceded by LEC loss, and coincident with accumulation of cortical DNA, and ROS; similarities with age-related cataracts. Mol Vis 2010;16:1496–1513.
   PubMed Web of Science ®Google Scholar
• Kernt M, Hirneiss C, Neubauer AS, Ulbig MW, Kampik A. Coenzyme Q10 prevents human lens epithelial cells from light-induced apoptotic cell death by reducing oxidative stress and stabilizing BAX/Bcl-2 ratio. Acta Ophthalmol 2010;88:e78–86.
   PubMed Web of Science ®Google Scholar
• Borchman D, Yappert MC. Lipids and the ocular lens. J Lipid Res 2010;51:2473–2488.
   PubMed Web of Science ®Google Scholar
• Spector A. The search for a solution to senile cataracts. Proctor lecture. Invest Ophthalmol Vis Sci 1984;25:130–146.
   PubMed Web of Science ®Google Scholar
• Harocopos GJ, Alvares KM, Kolker AE, Beebe DC. Human age-related cataract and lens epithelial cell death. Invest Ophthalmol Vis Sci 1998;39:2696–2706.
   PubMed Web of Science ®Google Scholar
• Kim J, Kim OS, Kim CS, Sohn E, Jo K, Kim JS. Accumulation of argpyrimidine, a methylglyoxal-derived advanced glycation end product, increases apoptosis of lens epithelial cells both in vitro and in vivo. Exp Mol Med 2012;44:167–175.
   PubMed Web of Science ®Google Scholar
• Yan Q, Liu JP, Li DW. Apoptosis in lens development and pathology. Differentiation 2006;74:195–211.
   PubMed Web of Science ®Google Scholar
• Li WC, Kuszak JR, Dunn K, Wang RR, Ma W, Wang GM, et al. Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals. J Cell Biol 1995;130:169–181.
   PubMed Web of Science ®Google Scholar
• Arends MJ, Wyllie AH. Apoptosis: mechanisms and roles in pathology. Int Rev Exp Pathol 1991;32:223–254.
   PubMedGoogle Scholar
• Wang K, Li D, Sun F. Dietary caloric restriction may delay the development of cataract by attenuating the oxidative stress in the lenses of Brown Norway rats. Exp Eye Res 2004;78:151–158.
   PubMed Web of Science ®Google Scholar
• Wolf NS, Li Y, Pendergrass W, Schmeider C, Turturro A. Normal mouse and rat strains as models for age-related cataract and the effect of caloric restriction on its development. Exp Eye Res 2000;70:683–692.
   PubMed Web of Science ®Google Scholar
• Barja G. Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts. Antioxid Redox Signal 2013;19:1420–1445.
   PubMed Web of Science ®Google Scholar
• Michan S, Sinclair D. Sirtuins in mammals: insights into their biological function. Biochem J 2007;404:1–13.
   PubMed Web of Science ®Google Scholar
• Longo VD, Kennedy BK. Sirtuins in aging and age-related disease. Cell 2006;126:257–268.
   PubMed Web of Science ®Google Scholar
• Sauve AA, Wolberger C, Schramm VL, Boeke JD. The biochemistry of sirtuins. Annu Rev Biochem 2006;75:435–465.
   PubMed Web of Science ®Google Scholar
• Marmorstein R. Structure and chemistry of the Sir2 family of NAD+-dependent histone/protein deactylases. Biochem Soc Trans 2004;32:904–909.
   PubMed Web of Science ®Google Scholar
• Zeng L, Chen R, Liang F, Tsuchiya H, Murai H, Nakahashi T, et al. Silent information regulator, Sirtuin 1, and age-related diseases. Geriatr Gerontol Int 2009;9:7–15.
   PubMed Web of Science ®Google Scholar
• Appella E, Anderson CW. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 2001;268:2764–2772.
   PubMedGoogle Scholar
• Beumer TL, Roepers-Gajadien HL, Gademan IS, van Buul PP, Gil-Gomez G, Rutgers DH, et al. The role of the tumor suppressor p53 in spermatogenesis. Cell Death Differ 1998;5:669–677.
   PubMed Web of Science ®Google Scholar
• Brooks CL, Gu W. Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol 2003;15:164–171.
   PubMed Web of Science ®Google Scholar
• Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, et al. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 2001;107:137–148.
   PubMed Web of Science ®Google Scholar
• Yamamoto H, Schoonjans K, Auwerx J. Sirtuin functions in health and disease. Mol Endocrinol 2007;21:1745–1755.
   PubMed Web of Science ®Google Scholar
• Mimura T, Kaji Y, Noma H, Funatsu H, Okamoto S. The role of SIRT1 in ocular aging. Exp Eye Res 2013;116:17–26.
   PubMed Web of Science ®Google Scholar
• Zheng T, Lu Y. Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans. Curr Eye Res 2011;36:449–455.
   PubMed Web of Science ®Google Scholar
• Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem 2005;280:17187–17195.
   PubMed Web of Science ®Google Scholar
• Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003;425:191–196.
   PubMed Web of Science ®Google Scholar
• Li G, Luna C, Navarro ID, Epstein DL, Huang W, Gonzalez P, et al. Resveratrol prevention of oxidative stress damage to lens epithelial cell cultures is mediated by forkhead box O activity. Invest Ophthalmol Vis Sci 2011;52:4395–4401.
   PubMed Web of Science ®Google Scholar
• Zheng Y, Liu Y, Ge J, Wang X, Liu L, Bu Z, et al. Resveratrol protects human lens epithelial cells against H2O2-induced oxidative stress by increasing catalase, SOD-1, and HO-1 expression. Mol Vis 2010;16:1467–1474.
   PubMed Web of Science ®Google Scholar
• Duan W, Zhu X, Ladenheim B, Yu QS, Guo Z, Oyler J, et al. p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. Ann Neurol 2002;52:597–606.
   PubMed Web of Science ®Google Scholar
• Culmsee C, Zhu X, Yu QS, Chan SL, Camandola S, Guo Z, et al. A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. J Neurochem 2001;77:220–228.
   PubMed Web of Science ®Google Scholar
• Begum RA, Farah IO, Ishaque AB. Pifithrin-alpha (PFT-alpha) caused differential protection of rat liver cells and HepG2 cell line in response to the selective cytotoxicity of arsenic and cadmium. Biomed Sci Instrum 2002;38:41–46.
   PubMedGoogle Scholar
• Schafer T, Scheuer C, Roemer K, Menger MD, Vollmar B. Inhibition of p53 protects liver tissue against endotoxin-induced apoptotic and necrotic cell death. FASEB J 2003;17:660–667.
   PubMed Web of Science ®Google Scholar
• Komarov PG, Komarova EA, Kondratov RV, Christov-Tselkov K, Coon JS, Chernov MV, et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 1999;285:1733–1737.
   PubMed Web of Science ®Google Scholar
• Komarova EA, Gudkov AV. Suppression of p53: a new approach to overcome side effects of antitumor therapy. Biochemistry (Mosc) 2000;65:41–48.
   PubMed Web of Science ®Google Scholar
• Zhang M, Liu W, Ding D, Salvi R. Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis. Neuroscience 2003;120:191–205.
   PubMed Web of Science ®Google Scholar
• Liu X, Chua CC, Gao J, Chen Z, Landy CL, Hamdy R, et al. Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice. Am J Physiol Heart Circ Physiol 2004;286:H933–939.
   PubMed Web of Science ®Google Scholar
• Jackson MD, Schmidt MT, Oppenheimer NJ, Denu JM. Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases. J Biol Chem 2003;278:50985–50998.
   PubMed Web of Science ®Google Scholar
• Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem 2002;277:45099–45107.
   PubMed Web of Science ®Google Scholar
• Zhao K, Harshaw R, Chai X, Marmorstein R. Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases. Proc Natl Acad Sci USA 2004;101:8563–8568.
   PubMed Web of Science ®Google Scholar
• Bai L, Pang WJ, Yang YJ, Yang GS. Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes. Mol Cell Biochem 2008;307:129–140.
   PubMed Web of Science ®Google Scholar
• Zhang J. Resveratrol inhibits insulin responses in a SirT1-independent pathway. Biochem J 2006;397:519–527.
   PubMed Web of Science ®Google Scholar
• Dong Z. Molecular mechanism of the chemopreventive effect of resveratrol. Mutat Res 2003;523–524:145–150.
   PubMed Web of Science ®Google Scholar
• Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004;305:390–392.
   PubMed Web of Science ®Google Scholar
• Jang JH, Surh YJ. Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells. Mutat Res 2001;496:181–190.
   PubMed Web of Science ®Google Scholar
• van Ginkel PR, Darjatmoko SR, Sareen D, Subramanian L, Bhattacharya S, Lindstrom MJ, et al. Resveratrol inhibits uveal melanoma tumor growth via early mitochondrial dysfunction. Invest Ophthalmol Vis Sci 2008;49:1299–1306.
   PubMed Web of Science ®Google Scholar
• Kalra N, Roy P, Prasad S, Shukla Y. Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis. Life Sci 2008;82:348–358.
   PubMed Web of Science ®Google Scholar
• Doganay S, Borazan M, Iraz M, Cigremis Y. The effect of resveratrol in experimental cataract model formed by sodium selenite. Curr Eye Res 2006;31:147–153.
   PubMed Web of Science ®Google Scholar
• Vahtola E, Louhelainen M, Merasto S, Martonen E, Penttinen S, Aahos I, et al. Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat. J Hypertens 2008;26:334–344.
   PubMed Web of Science ®Google Scholar
• Imai S, Kiess W. Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes. Front Biosci (Landmark Ed) 2009;14:2983–2995.
   PubMed Web of Science ®Google Scholar
• Backesjo CM, Li Y, Lindgren U, Haldosen LA. Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells. J Bone Miner Res 2006;21:993–1002.
   PubMed Web of Science ®Google Scholar