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Current Eye Research Volume 10, 1991 - Issue 4
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Original Article

Depletion of glutathione by L-buthionine sulfoximine does not promote inactivation of myo-inositol transport in cultured bovine lens epithelial cells

Patrick R. Cammarata Department of Anatomy and Cell Biology, Texas College of Osteopathic Medicine/University of North Texas, Forth Worth, TX, USA
,
Daniel Tse And Department of Anatomy and Cell Biology, Texas College of Osteopathic Medicine/University of North Texas, Forth Worth, TX, USA
&
Thomas Yorio Department of Pharmacology, Texas College of Osteopathic Medicine/University of North Texas, Forth Worth, TX, USA
Pages 321-330 | Received 26 Nov 1990, Accepted 06 Mar 1991, Published online: 02 Jul 2009

References

  • Meister A., Anderson M. E. Glutathione. Ann. Rev. Biochem. 1983; 52: 711–760
  • Kinoshita J. H., Futterman S., Satoh K., Merola L. O. Factors affecting the formation of sugar alcohols in the ocular lens. Biochem. Biophys. Acta 1963; 74: 340–350
  • Gonzalez A. M., Sochor M., McLean P. The effect of an aldose reductase inhibitor (Sorbinil) on the level of metabolites in lenses of diabetic rats. Diabetes 1983; 32: 482–485
  • Cammarata P. R., Yorio T. L-buthio- nine sulfoximine-induced loss of glutathione does not elicit PGH synthase inactivation in cultured bovine lens epithelial cells. J. Ocular Pharmacol 1990; 6: 43–49
  • Kawaba T., Cheng H-M., Kinoshita J. H. The accumulation of myo-inositol and rubidium ions in galactose-exposed rat lens. Invest. Ophthalmol. Vis. Sci. 1986; 27: 1522–1526
  • Cammarata P. R., Tse D., Yorio T. Sorbinil prevents the hypergalactosemic-induced reduction in [H]-myo-inositol uptake and decreased [3H]-myo-inositol incorporation into the phosphoinositide cycle in bovine lens epithelial cells in vitro. Curr. Eye Res. 1990; 9: 561–568
  • Cammarata P. R., Jackson T., Yorio T. Sorbinil prevents the galactose-induced inhibition of prostaglandin synthesis in lens cells. Invest. Ophthalmol. Vis. Sci. 1988; 29: 1452–1460
  • Bradford M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976; 72: 248–254
  • Tallarido R. J., Murray R. B. Manual of Pharmacological Calculations2nd edition. Springer-Veriag, New York 1987
  • Sippel T. O. Changes in water, protein, and glutathione content in the lens in the course of galactose cataract development in rats. Invest. Ophthalmol. 1966; 5: 568–575
  • Gonzalez R. G., Barnett P., Agnayo J., Cheng H-M., Chylack L. T. Direct measurement of polyol pathway activity in the ocular lens. Diabetes 1984; 33: 196–199
  • Sies H., Bartoli G. M., Burk R. F., Waydhas C. Glutathione efflux from perfused rat after liver phenobarbital treatment, durinci drug oxidations and in selenium deficiency. Eur. J. Biochem. 1978; 89: 113–118
  • Megaw J. M. Glutathione and ocular photobiology. Curr. Top. Eye Res. 1984; 3: 83–87
  • Sies H. Hydroperoxides and thiol oxidants in the study of oxidative stress in intact cells and organs. “Oxidative Stress”, H. Sies. Academic Press, New York 1985; 73–78
  • Cotlier E. Myo-inositol: active transport bythe crystalline lens. Invest. Ophthalmol. 1970; 2: 681–691
  • Varma S. D., Chakrapani B., Reddy V. N. Intraocular transport of myoinositol II. Accumulation in the rabbit lens in vitro. Invest. Ophthalmol. 1970; 9: 794–800
  • Unakar N. J., Tsui J. Y. Sodium-potassium-dependent ATPase: I. Cytochemical localization in normal and cataractous rat lenses. Invest. Ophthalmol. Vis. Sci. 1980; 19: 630–641
  • Unakar N. J., Tsui J. Y. Inhibition of galactose-induced alterations in ocular lens with sorbinil. Exp. Eye Res. 1983; 36: 685–694
  • Unakar N. J., Tsui J., Johnson M. Aldose reductase inhibitors and prevention of galactose cataracts in rats. Invest. Ophthalmol. Vis. Sci. 1989; 30: 1623–1632
  • Griffith O. W., Meister A. Glutathione: interorgan translocation, turnover, and metabolism. Proc. Natl. Acad. Sci. 1979; 76: 5605–5610
  • Martensson J., Meister A. Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione monoester. Proc. Natl. Acad. Sci. 1989; 86: 471–475
  • Martensson J., Jain A., Frayer W., Meister A. Glutathione metabolism in the lung: inhibition of its synthesis leads to lamellar body and mitochondrial defects. Proc. Natl. Acad. Sci. 1989; 86: 5296–5300
  • Calvin H. I., Medvedovsky C., Worgul B. V. Near-total glutathione depletion and age-specific cataracts induced by buthionine sulfoximine in mice. Science 1986; 233: 553–555
  • Murray D. L., Rathbun W. B. Conditions for maximizing and inhibiting synthesis ofglutathione in cultured rat lenses: an application of HP1.C with radioisotope detection. Curr. Eye Res. 1990; 9: 55–63
  • Anderson M. E., Meister A. Transport and direct utilization of γ-glutamylcyst(e)ine for glutathione synthesis. Natl. Acad. Sci. 1983; 80: 707–711
  • Martensson J., Steinherz R., Jain A., Meister A. Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage. Proc. Natl. Acad. Sci. 1989; 86: 8727–8731
  • Anderson M. E., Powrie F., Puri R. N., Meister A. Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione. Arch. Biochem. Biophys. 1985; 239: 538–548

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