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Current Eye Research Volume 12, 1993 - Issue 7
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Original Article

Ocular inflammatory effects of intravitreally injected interleukin-2

John R. Samples Department of Ophthalmology, Oregon Health Sciences University, Casey Eye Institute, 3375 SW Terwilliger, Boulevard, Portland, OR, 97201, USA
,
Richard S. Boney Department of Ophthalmology, Oregon Health Sciences University, Casey Eye Institute, 3375 SW Terwilliger, Boulevard, Portland, OR, 97201, USA
&
James T. Rosenbaum Department of Ophthalmology, Oregon Health Sciences University, Casey Eye Institute, 3375 SW Terwilliger, Boulevard, Portland, OR, 97201, USA
Pages 649-654 | Received 25 Feb 1993, Accepted 11 Jun 1993, Published online: 02 Jul 2009

References

  • Rosenbaum J. T., Samples J. R., Hefeneider S. H., Howes E. L., Jr. Ocular inflammatory effects of intravitreal interleukin-1. Arch. Ophthalmol. 1987; 105: 1117–1120
  • Beutler B., Cerami A. Tumor necrosis, cachexia, shock, and inflammation: a common mediator. Ann. Rev. Biochem. 1988; 57: 505–518
  • Hoekzema R., Murray P. I., Kijlstra A. Cytokines and intraocular inflammation. Curr. Eye Res. 1990; 9: 207–211
  • Ferrick M. R., Thurau S. R., Oppenheim M. H., Herbort C. P., Ni M., Zachariae C O., Matsushima K., Chan C.-C. Ocular inflammation stimulated by intravitreal interleukin-8 and interleukin-1. Invest. Ophthalmol. Vis. Sci. 1991; 32: 1534–1539
  • Rosenbaum J. T., Howes E. L., Rubin R. M., Samples J. R. Ocular iflammatory effects of intravitreally injected tumor necrosis factor. Am. J. Pathol. 1988; 133: 47–53
  • Smith K. A. Interluekin-2: Inception, impact, and implications. Science 1988; 240: 1169–1176
  • Rosenberg S. A., Lotze M. T., Mule J. J. New approaches to the immunotherapy of cancer using interleukin-2. Ann. Int. Med. 1988; 108: 853–864
  • Ferro T. J., Johnson A., Everitt J., Malik A. B. IL-2 induces pulmonary edema and vasoconstriction independent of circulating lymphocytes. J. Immunol. 1989; 142: 1916–1927
  • Hibbs J. B., Westenfelder C., Taintor R., Vavrin Z., Kablitz C., Baranowski R. L., Ward J. H., Menlove R. L., McMurry M. P., Kushner J. P., Samlowski W. E. Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy. J. Clin. Invest. 1992; 89: 867–877
  • Hooks J. J., Chan C. C., Detrick B. Identification of the lymphokines, interferon-gamma and interleukin-2, in inflammatory eye diseases. Invest. Ophthalmol. Vis. Sci. 1988; 29: 1444–1451
  • Mondino B. J., Sidikaro Y., Mayer F. J., Sumner H. L. Inflammatory mediators in the vitreous humor of AIDS patients with retinitis. Invest. Ophthalmol. Vis. Sci. 1990; 31: 798–804
  • Bradford M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976; 72: 248–254
  • Howes E. L., Jr., Rosenbaum J. T. LPS tolerance inhibits eye inflammation: II. Preliminary studies on the mechanism. Arch. Ophthalmol. 1985; 103: 261–265
  • Bhattacherjee P., Henderson B. Inflammatory responses to intraocularly injected interleukin 1. Curr. Eye Res. 1987; 6: 929–934
  • Kulkarni P. S., Mancino M. Studies on intraocular inflammation produced by intravitreal human interleukins in rabbits. Exp. Eye Res. 1993; 56: 275–279
  • Hoekzema R., Verhagen C, van Haren M., Kijlstra A. Endotoxin-induced uveitis in the rat. The significance of intraocular interleukin-6. Invest. Ophthalmol. Vis. Sci. 1992; 33: 532–539
  • Fleisher L. N., Ferrell J. B., McGahan M. C. Ocular inflammatory effects of intravitreally injected tumor necrosis factor-alpha and endotoxin. Inflammation 1990; 14: 325–335
  • Numerof R. P., Aronson F. R., Mier J. W. 11-2 stimulates the production of IL-1 alpha and IL-1 beta by human peripheral blood mononuclear cells. J. Immunol. 1988; 141: 4250–4257
  • Musso T., Espinoza-Delgado I., Pulkki K., Gusella G. L., Longo D. L., Varesio L. IL-2 induces IL-6 production in human monocytes. J. Immunol. 1992; 148: 795–800
  • Fraker D. L., Langstein H. N., Norton J. A. Passive immunization against tumor necrosis factor partially abrogates interleukin 2 toxicity. J. Exp. Med. 1989; 170: 1015–1020
  • Reem G. H., Cook D. M. Interleukin 2 regulates expression of its receptor and synthesis of gamma interferon by human T lymphocytes. Science 1984; 225: 429–430
  • Degiannis D., Stein S., Czarnecki M., Raskova J., Raska K. Cyclosporine-induced enhancement of interleukin 1 receptor expression by PHA-stimulated lymphocytes. Transplantation 1990; 50: 1074–1075
  • Nussenblatt R. B., Palestine A. G., Chan C. C., Stevens G., Mellow S. D., Breen S. B. Randomized, double-masked study of Cyclosporine compared to Prednisolone in the treatment of endogenous uveitis. Am. J. Ophthalmol. 1991; 112: 138–146

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