High sputum total adiponectin is associated with low odds for asthma

References

• Steffes MW, Gross MD, Schreiner PJ, Yu X, Hilner JE, Gingerich R, Jacobs DR Jr. Serum adiponectin in young adults – interactions with central adiposity, circulating levels of glucose, and insulin resistance: the CARDIA study. Ann Epidemiol 2004;14:492–498
   PubMed Web of Science ®Google Scholar
• Bruun JM, Lihn AS, Verdich C, Pedersen SB, Toubro S, Astrup A, Richelsen B. Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab 2003;285:E52733
   Google Scholar
• Jeon MJ, Leem J, Ko MS, Jang JE, Park HS, Kim HS, Kim M, et al. Mitochondrial dysfunction and activation of iNOS are responsible for the palmitate-induced decrease in adiponectin synthesis in 3T3L1 adipocytes. Experiment Molec Med 2012;44:562–570
   Google Scholar
• Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, Wagner JA, et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 2004;279:12152–12162
   PubMed Web of Science ®Google Scholar
• Hug C, Wang J, Ahmad NS, Bogan JS, Tsao TS, Lodish HF. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci U S A 2004;101:10308–10313
   PubMed Web of Science ®Google Scholar
• Takemura Y, Ouchi N, Shibata R, Aprahamian T, Kirber MT, Summer RS, Kihara S, et al. Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest 2007;117:375–386
   PubMed Web of Science ®Google Scholar
• Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, Okada-Iwabu M, et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med 2007;13:332–339
   PubMed Web of Science ®Google Scholar
• Shore SA, Terry RD, Flynt L, Xu A, Hug C. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 2006;118:389–395
   PubMed Web of Science ®Google Scholar
• Medoff BD, Okamoto Y, Leyton P, Weng M, Sandall BP, Raher MJ, Kihara S, et al. Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling. Am J Respirat Cell Molec Biol 2009;41:397–406
   PubMed Web of Science ®Google Scholar
• Sood A, Qualls C, Schuyler M, Thyagarajan B, Steffes MW, Smith LJ, Jacobs DR Jr. Low serum adiponectin predicts future risk for asthma in women. Am J Respir Crit Care Med 2012;186:41–47
   PubMed Web of Science ®Google Scholar
• Efstathiou SP, Skeva II, Dimas C, Panagiotou A, Parisi K, Tzanoumis L, Kafouri A, et al. Smoking cessation increases serum adiponectin levels in an apparently healthy Greek population. Atherosclerosis 2009;205:632–636
   Google Scholar
• Miller M, Cho JY, Pham A, Ramsdell J, Broide DH. Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease. J Immunol 2009;182:684–691
   Google Scholar
• Sood A, Qualls C, Schuyler M, Arynchyn A, Alvarado JH, Smith LJ, Jacobs DR Jr. Adult-onset asthma becomes the dominant phenotype among women by age 40 years. The longitudinal CARDIA study. Ann Am Thorac Soc 2013;10:188–197
   PubMedGoogle Scholar
• Komakula S, Khatri S, Mermis J, Savill S, Haque S, Rojas M, Brown L, et al. Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics. Respir Res 2007;8:32
   PubMed Web of Science ®Google Scholar
• Dorevitch S, Conroy L, Karadkhele A, Rosul L, Stacewicz-Sapuntzakis M, Fantuzzi G. Associations between obesity and asthma in a low-income, urban, minority population. Ann Allergy Asthma Immunol 2013;110:340–346
   Google Scholar
• Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG, MacIntyre NR, et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med 2000;161:309–329
   PubMed Web of Science ®Google Scholar
• Ferris BG. Epidemiology Standardization Project (American Thoracic Society). Am Rev Respir Dis 1978;118:1–120
   PubMed Web of Science ®Google Scholar
• Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention -NIH Publication No 02-3659 I. The GINA reports are available from www.ginasthma.org: Issued January 1995 updated 2002 Management Segment Chapter 7 Updated 2005 from the 2002 document
   Google Scholar
• Locke GR, Talley NJ, Weaver AL, Zinsmeister AR. A new questionnaire for gastroesophageal reflux disease. Mayo Clin Proc 1994;69:539–547
   PubMed Web of Science ®Google Scholar
• Kriska AM, Knowler WC, LaPorte RE, Drash AL, Wing RR, Blair SN, Bennett PH, et al. Development of questionnaire to examine relationship of physical activity and diabetes in Pima Indians. Diabetes Care 1990;13:401–411
   PubMed Web of Science ®Google Scholar
• Nagase M, Ando K, Nagase T, Kaname S, Sawamura T, Fujita T. Redox-sensitive regulation of lox-1 gene expression in vascular endothelium. Biochem Biophys Res Commun 2001;281:720–725
   PubMed Web of Science ®Google Scholar
• Pizzichini E, Pizzichini MM, Efthimiadis A, Hargreave FE, Dolovich J. Measurement of inflammatory indices in induced sputum: effects of selection of sputum to minimize salivary contamination. Eur Respir J 1996;9:1174–1180
   PubMed Web of Science ®Google Scholar
• Kim CK, Callaway Z, Kim DW, Kita H. Eosinophil degranulation is more important than eosinophilia in identifying asthma in chronic cough. J Asthma 2011;48:994–1000
   PubMed Web of Science ®Google Scholar
• Pizzichini E, Pizzichini MM, Efthimiadis A, Evans S, Morris MM, Squillace D, Gleich GJ, et al. Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. Am J Respir Crit Care Med 1996;154:308–317
   PubMed Web of Science ®Google Scholar
• Broekhuizen R, Vernooy JH, Schols AM, Dentener MA, Wouters EF. Leptin as local inflammatory marker in COPD. Respir Med 2005;99:70–74
   PubMed Web of Science ®Google Scholar
• Horvath I, Hunt J, Barnes PJ, Alving K, Antczak A, Baraldi E, Becher G, et al. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 2005;26:523–548
   PubMed Web of Science ®Google Scholar
• Sood A, Qualls C, Seagrave J, McDonald J, Shohreh R, Chiavaroli A, Schuyler M. Effect of allergen inhalation on airway oxidant stress, using exhaled breath condensate 8-isoprostane, in mild asthma. J Asthma 2013;50:449–456
   PubMed Web of Science ®Google Scholar
• Janicka M, Kot-Wasik A, Kot J, Namiesnik J. Isoprostanes-biomarkers of lipid peroxidation: their utility in evaluating oxidative stress and analysis. Int J Molec Sci 2010;11:4631–4659
   PubMed Web of Science ®Google Scholar
• Van Hoydonck PG, Wuyts WA, Vanaudenaerde BM, Schouten EG, Dupont LJ, Temme EH. Quantitative analysis of 8-isoprostane and hydrogen peroxide in exhaled breath condensate. Eur Respir J 2004;23:189–192
   PubMed Web of Science ®Google Scholar
• Sack U, Scheibe R, Wotzel M, Hammerschmidt S, Kuhn H, Emmrich F, Hoheisel G, et al. Multiplex analysis of cytokines in exhaled breath condensate. Cytometry A 2006;69:169–172
   PubMedGoogle Scholar
• Montuschi P, Ragazzoni E, Valente S, Corbo G, Mondino C, Ciappi G, Ciabattoni G. Validation of 8-isoprostane and prostaglandin E(2) measurements in exhaled breath condensate. Inflamm Res 2003;52:502–507
   PubMed Web of Science ®Google Scholar
• Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, et al. Standardisation of spirometry. Eur Respir J 2005;26:319–338
   PubMed Web of Science ®Google Scholar
• Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med 1999;159:179–187
   PubMed Web of Science ®Google Scholar
• Chai H, Farr RS, Froehlich LA, Mathison DA, McLean JA, Rosenthal RR, Sheffer AL, et al. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol 1975;56:323–327
   PubMed Web of Science ®Google Scholar
• Sood A, Qualls C, Arynchyn A, Beckett WS, Gross MD, Steffes MW, Smith LJ, et al. Obesity-asthma association: is it explained by systemic oxidant stress? Chest 2009;136:1055–1062
   Google Scholar
• Sood A, Ford ES, Camargo Jr CA. Association between leptin and asthma in adults. Thorax 2006;61:300–305
   PubMed Web of Science ®Google Scholar
• Sood A, Cui X, Qualls C, Beckett WS, Gross MD, Steffes MW, Smith LJ, et al. Association between asthma and serum adiponectin concentration in women. Thorax 2008;63:877–882
   PubMed Web of Science ®Google Scholar
• Tsaroucha A, Daniil Z, Malli F, Georgoulias P, Minas M, Kostikas K, Bargiota A, et al. Leptin, adiponectin, and ghrelin levels in female patients with asthma during stable and exacerbation periods. J Asthma: Off J Assoc Care of Asthma 2013;50:188–197
   Google Scholar
• Sideleva O, Suratt BT, Black KE, Tharp WG, Pratley RE, Forgione P, Dienz O, et al. Obesity and asthma: an inflammatory disease of adipose tissue not the airway. Am J Respir Crit Care Med 2012;186:598–605
   PubMed Web of Science ®Google Scholar
• da Silva PL, de Mello MT, Cheik NC, Sanches PL, Correia FA, de Piano A, Corgosinho FC, et al. Interdisciplinary therapy improves biomarkers profile and lung function in asthmatic obese adolescents. Pediatr Pulmonol 2012;47:8–17
   PubMed Web of Science ®Google Scholar
• Sood A, Qualls C, Seagrave J, Stidley C, Archibeque T, Berwick M, Schuyler M. Effect of specific allergen inhalation on serum adiponectin in human asthma. Chest 2009;135:287–294
   Google Scholar
• Holguin F, Rojas M, Brown LA, Fitzpatrick AM. Airway and plasma leptin and adiponectin in lean and obese asthmatics and controls. J Asthma 2011;48:217–223
   PubMed Web of Science ®Google Scholar
• Sood A, Dominic E, Qualls C, Steffes MW, Thyagarajan B, Smith LJ, Lewis CE, et al. Serum adiponectin is associated with adverse outcomes of asthma in men but not in women. Front Pharmacol 2011;2:55
   Google Scholar
• Baek HS, Kim YD, Shin JH, Kim JH, Oh JW, Lee HB. Serum leptin and adiponectin levels correlate with exercise-induced bronchoconstriction in children with asthma. Ann Allergy Asthma Immunol 2011;107:14–21
   PubMed Web of Science ®Google Scholar
• Kattan M, Kumar R, Bloomberg GR, Mitchell HE, Calatroni A, Gergen PJ, Kercsmar CM, et al. Asthma control, adiposity, and adipokines among inner-city adolescents. J Allergy Clin Immunol 2010;125:584–592
   PubMed Web of Science ®Google Scholar
• Aaron SD, Vandemheen KL, Boulet LP, McIvor RA, Fitzgerald JM, Hernandez P, Lemiere C, et al. Overdiagnosis of asthma in obese and nonobese adults. CMAJ 2008;179:1121–1131
   PubMed Web of Science ®Google Scholar
• Miller M, Pham A, Cho JY, Rosenthal P, Broide DH. Adiponectin-deficient mice are protected against tobacco-induced inflammation and increased emphysema. Am J Physiol Lung Cellular Molec Physiol 2010;299:L834–L842
   PubMed Web of Science ®Google Scholar