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Original Article

The Theophylline-Erythromydn Interaction

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Pages 195-204 | Published online: 02 Jul 2009

References

  • Drugs for asthma. Med Letter 1987; 29: 11–16
  • Rall T W. Central nervous system stimulants. The Pharmacological Basis of Therapeutics, 7th ed, A G Gillman, L S Goodman, T W Rall, F Mured. Macmillan, New York 1986; 589–603
  • Hendeles L, Massanari M, Weinberger M. Theophyl-line. Applied Pharmacokinetics, 2nd ed, W E Evans, J J Schentag, W J Jusko. Applied Therapeutics, Spokane, WA 1986; 1105–1188
  • Mitenko P A, Ogilvie R I. Rational intravenous doses of theophylline. N Engl J Med 1973; 289: 600–603
  • Powell J R, Vozeh S, Hopewell P, et al. Theophylline disposition in acutely ill hospitalized patients. Am Rev Reap Die 1978; 118: 229–238
  • Weinberger M, Hendeles L, Wong L, et al. Relationship of formulation and dosing interval to fluctuation of serum theophylline concentration in children with chronic asthma. Pediatrics 1981; 99: 145–152
  • Jonkman J HG, Upton R A. Pharmacokinetic drug interactions with theophylline. Clin Pharmacokin 1984; 9: 309–344
  • Kelly J F, Tang-Liu D DS, Lazo S, et al. The effect of cimetadine on theophylline metabolism in the elderly. Clin Pharmacol Ther 1982; 31: 238–239, (abstract)
  • Ludden T M. Pharmacokinetic interactions of the macrolide antibiotics. Clin Pharmacokin 1985; 10: 63–79
  • Weinberger M, Hudgel D, Specter S, et al. Inhibition of theophylline clearance by troleandomycin. J Allergy Clin Immunol 1977; 59: 228–321
  • Spector S, Katz F, Farr R. Troleandomycin: Effectiveness in steroid-dependent asthma and bronchitis. J Allergy Clin Immunol 1974; 54: 367–369
  • Cummins L H, Kozak P P, Gillman S A. Theophylline determinations. Ann Allergy 1976; 37: 450–451
  • Cummins L H, Kozak P P, Gillman S A. Erythromy-cin's effect on theophylline blood level. Pediatrics 1977; 59: 144
  • Kozak P P, Cummins L H, Gillman S A. Administration of erythromycin to patients on theophylline. J Allergy Clin Immunol 1977; 60: 149–151
  • Pfeifer H J, Greenblatt D J, Freidman P. Effects of three antibiotics on theophylline kinetics. Clin Pharmacol Ther 1979; 26: 36–40
  • Kimelblatt R J, Slaughter R S. Lack of effect of intravenous erythromycin on theophylline kinetics. J Allergy Clin Immunol 1980; 65: 313–314
  • Kelly S J, Pingleton S K, Ryan P B, et al. The lack of influence of erythromycin on plasma theophylline levels. Chest 1980; 78: 523–524
  • LaForce C F, Miller M F, Chai H. Effect of erythromycin of theophylline clearance in asthmatic children. J Pediatr 1981; 99: 153–156
  • Renton K W, Gray J D, Hung O R. Depression on theophylline clearance by erythromycin. Clin Pharmacol Ther 1981; 30: 422–426
  • Prince R A, Wing D S, Weinberger M M, et al. Effect of erythromycin on theophylline kinetics. J Allergy Clin Immunol 1981; 68: 427–431
  • Zarowitz B JM, Szefler S J, Lasezkay G M. Effect of erythromycin base on theophylline kinetics. Clin Pharmacol Ther 1981; 29: 601–605
  • Branigan T A, Robbins R A, Cady W J, et al. The effects of erythromycin on the absorption and disposition kinetics of theophylline. Eur J Clin Pharmacol 1981; 21: 115–120
  • Richer C, Mathieu M, Bah H, et al. Theophylline kinetics and ventilatory flow in bronchial asthma and chronic airflow obstruction: Influence of erythromycin. Clin Pharmacol Ther 1982; 31: 579–586
  • MeIethil S, Dutta A, Ryan P B, et al. Steady state urinary excretion of theophylline and its metabolites in the presence of erythromycin. Res Comm Chem Pathol Pharmacol 1982; 35: 341–344
  • Maddux M S, Leeds N H, Organek H W. The effect of erythromycin on theophylline pharmacokinetics at steady state. Chest 1982; 81: 563–565
  • Illiopoulou A, Aldhous M I, Johnston A, et al. Pharmacokinetic interaction between theophylline and erythromycin. Br J Clin Pharmacol 1982; 14: 495–499
  • May D C, Jarboe C H, Ellenburg D T, et al. The effects of erythromycin on theophylline elimination in normal males. J Clin Pharmacol 1982; 22: 125–130
  • Stratton M A. Theophylline-erythromycin base interaction: Case report and kinetic profile. Clin Pharm 1983; 2: 183–186
  • Reisz G, Pingleton S K, Melethil S, et al. The effect of erythromycin on theophylline pharmacokinetics in chronic bronchitis. Am Rev Resp Dis 1982; 127: 581–584
  • Parish R A, Haulman N J, Burns R M. Interaction of theophylline with erythromycin base in a patient with seizure activity. Pediatrics 1983; 72: 828–830
  • Green J A, Clementi W A. Decrease in theophylline clearance after the administration of erythromycin in a patient with obstructive lung disease. Drug In-tell Clin Pharm 1983; 17: 370–372
  • Stults B M, Felice-Johnson J, Higbee M D, et al. Effect of erythromycin stearate on serum theophylline concentration in patients with chronic obstructive lung disease. South Med J 1983; 76: 714–718
  • Hildebrandt R, Gundert-Remy U, Weber E. Lack of clinically important interaction between erythromycin and theophylline. Eur J Clin Pharmacol 1984; 26: 485–489
  • Wiggins J, Arbab O, Ayres J G, et al. Elevated serum theophylline concentration following cessation of erythromycin treatment. Eur J Resp Dis 1986; 68: 298–300
  • Adebayo G I, Adewumi M O, Mabadeje A FB. Time-dependent inhibition of theophylline elimination by erythromycin stearate. Biopharm Drug Disp 1986; 7: 479–485
  • Paulsen O, Höglund P, Nilsson L G, et al. The interaction of erythromycin with theophylline. Eur J Clin Pharmacol 1987; 32: 493–498
  • Pasic J, Jackson S HD, Johnston A, et al. The interaction between chronic oral slow-release theophylline and single-dose intravenous erythromycin. Xenobiotics 1987; 17: 493–497
  • Dahlqvist R, Billing B, Miners J O, et al. Non-linear metabolitic disposition of theophylline. Ther Drug Monitor 1984; 6: 290–297
  • Tang-Liu D DS, Williams R L, Riegelman S. Nonlinear theophylline elimination. Clin Pharmacol Ther 1982; 31: 358–369
  • Campbell M E, Spielberg S P, Kalow W. A urinary metabolite ratio that reflects systemic caffeine clearance. Clin Pharmacol Ther 1987; 42: 157–165
  • Mansuy D. Formation of reactive intermediates and metabolites: Effects of macrolide antibiotics on cytochrome P-450. Pharmacol Ther 1987; 33: 41–45
  • Danan G, Descatoire V, Pessayre D. Self-induction by erythromycin of its own transformation into a metabolite forming an inactive complex with reduced cytochrome P-450. J Pharmacol Exp Ther 1981; 218: 509–514
  • Hemsworth T C, Renton R W. Depression of theophyl-line metabolism and elimination by troleandomycin and erythromycin. Biochem Pharmacol 1981; 30: 1299–1304
  • Larrey D, Funck-Brentano C, Breil P, et al. Effects of erythromycin on hepatic drug-metabolizing enzymes in humans. Biochem Pharmacol 1983; 32: 1063–1068
  • Lu A YH, West S B. Multiplicity of mammalian microsomal cytochromes P-450. Pharmacol Rev 1980; 31: 277–295
  • Jenne J W. Theophylline: A remarkable window to the hepatic microsomal oxidases. Chest 1982; 81: 529–530
  • Shear N H, Spielberg S P, Grant D M, et al. Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity. Ann Int Med 1986; 105: 179–184
  • Jonkman J HG, Hendeles L. The theophylline-eryth-romycin interaction. Chest 1983; 84: 309–310
  • Weinberger M. The theophylline-erythromycin interaction. Chest 1983; 84: 310–311
  • Maddux M S, Bauman J. The theophylline-erythromycin interaction (reply). Chest 1983; 84: 311–312
  • Slaughter R. Theophylline commentary. Applied Pharmacokinetics, 2nd ed, W E Evans, J J Schentag, W J Jusko. Applied Therapeutics, Spokane, WA 1986; 1105–1188
  • Principi N, Onorato J, Giuliani M G, et al. Effect of miocamycin on theophylline kinetics in children. Eur J Clin Pharmacol 1987; 31: 701–704

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