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Acta Radiologica Volume 28, 1987 - Issue 5
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Original Article

Excretion of Iohexol and Metrizoate in Human Breast Milk

S. T. Nielsen Department of Radiology, Aalborg Hospital South, Aalborg, Denmark; Department of Pharmacotherapeutics, University of Oslo, Oslo, Norway; Department of Analytical Chemistry and Clinical Research Development, Nycomed as, Oslo, Norway; Department of Radiology, Ullevål University Hospital, Oslo, Norway
,
I. Matheson Department of Radiology, Aalborg Hospital South, Aalborg, Denmark; Department of Pharmacotherapeutics, University of Oslo, Oslo, Norway; Department of Analytical Chemistry and Clinical Research Development, Nycomed as, Oslo, Norway; Department of Radiology, Ullevål University Hospital, Oslo, Norway
,
J. N. Rasmussen Department of Radiology, Aalborg Hospital South, Aalborg, Denmark; Department of Pharmacotherapeutics, University of Oslo, Oslo, Norway; Department of Analytical Chemistry and Clinical Research Development, Nycomed as, Oslo, Norway; Department of Radiology, Ullevål University Hospital, Oslo, Norway
,
K. Skinnemoen Department of Radiology, Aalborg Hospital South, Aalborg, Denmark; Department of Pharmacotherapeutics, University of Oslo, Oslo, Norway; Department of Analytical Chemistry and Clinical Research Development, Nycomed as, Oslo, Norway; Department of Radiology, Ullevål University Hospital, Oslo, Norway
,
E. Andrew Department of Radiology, Aalborg Hospital South, Aalborg, Denmark; Department of Pharmacotherapeutics, University of Oslo, Oslo, Norway; Department of Analytical Chemistry and Clinical Research Development, Nycomed as, Oslo, Norway; Department of Radiology, Ullevål University Hospital, Oslo, Norway
&
G. Hafsahl Department of Radiology, Aalborg Hospital South, Aalborg, Denmark; Department of Pharmacotherapeutics, University of Oslo, Oslo, Norway; Department of Analytical Chemistry and Clinical Research Development, Nycomed as, Oslo, Norway; Department of Radiology, Ullevål University Hospital, Oslo, Norway
Pages 523-526 | Accepted 09 Mar 1987, Published online: 07 Jan 2010

References

  • Dawson J. B., McChesney E. W., Teller F. F. Excretion of metrizoate in man. Acta Radiol. Diagnosis 1968; 7: 502
  • Edelson I., Shaw D., Palace G. Pharmacokinetics of iohexol, a new non-ionic radiocontrast agent in humans. J. Pharm. Sei 1984; 73: 993
  • Fitz-John T. P., Williams D. G., Laker M. F., Owen J. P. Intravenous urography during lactation. Brit. J. Radiol 1982; 55: 603
  • Holmdahl K. H. Son. Cholecystography during lactation. Acta Radiol 1956; 45: 305
  • Ilett K. F., Hackett L. P., Paterson J. W. Excretion of metrizamide in milk. Brit. J. Radiol 1981; 54: 537
  • Jacobsen T. Comparison/of partition/coefficients in octanol/water and butanol/water. Oslo 1979, Report of 10.12.79 in files at Nycomed AS
  • Johansen J. G. Assessment of a non-ionic contrast medium (Amipaque) in the gastrointestinal tract. Invest. Radiol 1978; 13: 523
  • Jorulf H. Iohexol compared with diatrizoate in pediatrie urography. Acta Radiol 1983, Suppl. No. 366: 42
  • Mützel W., Siefert H.-M, Speck U. Biochemical-pharmacologic properties of iohexol. Acta Radiol 1980, Suppl. No. 362: 111
  • Neville M. C., Allen I. C., Watten C. The mechanisms of milk secretion. Lactation, M. C. Neville, M. R. Neifert. Plenum Press, New York 1983; 54
  • Olsson B., Aulie Å., Sveen K., Andrew E. Human pharmacokinetics of iohexol. A new non-ionic contrast medium. Invest. Radiol 1983; 18: 177
  • Skinnemoen K. Pka,/partition coefficient (1-octanol/buffer pH 7.4) and protein-binding of metrizoate. Oslo 1986, Report in the files at Nycomed AS
  • Skinnemoen K., Fagervoll R., Jacobsen T. Determination of iopentol and other non-ionic contrast media in biologic fluids by high-performance liquid chromatography. Acta Radiol 1987, Suppl. (in press)
  • Speck U., Mützel W., Weimann H. I. Chemistry, physiochemistry and pharmacology of known and new contrast media for angiography, urography and CT-enhancement. Contrast media, V. Taenzer, E. Zeitler. Georg Thieme Verlag, Stuttgart 1983; 6
  • Wilson J. T., Brown R. D., Cherek D. R., et al. Drug excretion in human breast milk. Principles, pharmacokinetics and projected consequences. Clin. Pharmacokinet 1980; 5: 1

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