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Original Article

Penetration and Binding of Monoclonal Antibody in Human Osteosarcoma Multicell Spheroids: Comparison of confocal laser scanning microscopy and autoradiography

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Pages 273-279 | Received 18 Apr 1995, Accepted 08 Sep 1995, Published online: 08 Jul 2009

References

  • Buchsbaum D. J., Langmuir V. K., Wessels B. W. Experimental radioimmunotherapy. Med Phys 1993; 20: 551–67
  • Chen F-M, Hansen E. B., Taylor C. R., Epstein A. L. Diffusion and binding of monoclonal antibody TNT-1 in multicellular tumor spheroids. J Natl Cancer Inst 1991; 83: 200–4
  • Inoue S. Foundations of confocal scanned imaging in light microscopy. Handbook of biological confocal microscopy, J. B. Pawley. Plenum Press. 1990; 1–4
  • Rigaut J. P., Vassy J., Herlin P., et al. Three-dimensional DNA image cytometry by confocal laser scanning microscopy in thick tissue blocks. Cytometry 1991; 12: 511–24
  • Myrdal S., Foster M. Time-resolved confocal analysis of antibody penetration into living solid tumor spheroids. Scanning 1994; 16: 155–67
  • Humm J. L., Macklis R. M., Lu X. Q., et al. The spatial accuracy of cellular dose estimates obtained from 3D reconstructed serial tissue autoradiographs. Phys Med Biol 1995; 40: 163–80
  • Sutherland R. M. Cell and environment interactions in tumor microregions: The multicell spheroid model. Science 1988; 240: 177–84
  • Fodstad Ø, Brøgger A., Bruland Ø, Solheim ØP, Nesland J. M., Pihl A. Characteristics of a cell line established from a patient with multiple osteosarcoma appearing 13 years after treatment for bilateral retinoblastoma. Int J Cancer 1986; 38: 33–40
  • Sutherland R. M., Durand R. E. Radiation response of multicell spheroids. An in vitro tumour model. Curr Top Rad Res 1976; 11: 87–139
  • Bruland Ø, Fodstad Ø, Phil A. The use of multicellular spheroids in establishing human sarcoma cell lines in vitro. Int J Cancer 1985; 35: 793–8
  • Morgan A. C., Gallaoway D. R., Reisfeld R. A. Production and characterization of monoclonal antibody to a melanoma specific glycoprotein. Hybridoma 1981; 1: 27–36
  • Bumol T. F., Reisfeld R. A. Unique glycoprotein-proteoglycan complex defined by monoclonal antibody on human melanoma cells. Proc Natl Acad Sci USA 1982; 79: 1245–9
  • Godal A., Bruland Ø, Haug E., Aas M., Fodstad Ø. Unexpected expression of the 250 kD melanoma-associated antigen in human sarcoma cells. Br J Cancer 1986; 53: 839–41
  • Visser T. D., Oud J. L., Brakenhoff G. J. Refractive index and axial distance measurements in 3-D microscopy. Optik 1992; 1: 17–9
  • Valnes K., Brandtzaeg P. Retardation of immunofluorescence fading during microscopy. J Histochem Cytochem 1985; 33: 755–61
  • Johnson G. D., Davidson R. S., McNamee K. C., Russell G., Goodwin D., Holborow E. J. Fading of immunofluorescence during microscopy: A study of the phenomenon and its remedy. J Immunol Methods 1982; 55: 231–42
  • Olabiran Y., Ledermann J A, Marston N. J., et al. The selection of antibodies for targeted therapy of small-cell lung cancer (SCLC) using a human tumour spheroid model to compare the uptake of cluster 1 and cluster w4 antibodies. Br J Cancer 1994; 69: 247–52
  • Winsor C. P. The Gompertz curve as a growth curve. Proc Natl Acad Sci USA 1932; 18: 1–7
  • Baker J. R. Principles of biological microtechnique. Richard Clay and Company Ltd, Great Britain 1958
  • Rigaut J. P., Vassy J. Analytical and quantitative cytology and histology. Analyt Quant Cytol Histol 1991; 13: 223–32
  • Sten-Knudsen O. Passive transport processes. Membrane transport in biology, vol 1, G. Giebish, D. C. Tosteson, H. H. Ussing. Springer Verlag, Berlin 1978
  • McFadden R., Kwok C. S. Mathematical model of simultaneous diffusion and binding of antitumor antibodies in multicellular human tumor spheroids. Cancer Res 1988; 48: 4032–7
  • Carlsson J., Daniel-Szolgay E., Frykholm G., Glimelius B., Hedin A., Larsson B. Homogeneous penetration but heterogeneous binding of antibodies to carcinoembryonic antigen in human colon carcinoma HT-29 spheroids. Cancer Immunol Immunother 1989; 30: 269–76
  • Swabb E. A., Wei J., Guilino P. M. Diffusion and convection in normal and neoplastic tissues. Cancer Res 1974; 34: 2814–22
  • Shockley T. R., Lin T., Sung C., et al. A quantitative analysis of tumor specific monoclonal antibody uptake by human melanoma xenografts: Effects of antibody immunological properties and tumor antigen expression levels. Cancer Res 1992; 52: 357–66
  • Bruland Ø, Fodstad Ø, Skretting A., Pihl A. Selective localisation of two radioiabelled anti-sarcoma monoclonal antibodies in human osteosarcoma xenografts. Br J Cancer 1987; 56: 21–5
  • Jain R. K. Transport of molecules in the tumor interstitium: A review. Cancer Res 1987; 47: 3039–51
  • Van Osdol W., Fujimori K., Weinstein J. N. An analysis of monoclonal antibody distribution in microscopic nodules: consequences of a ‘binding site barrier’. Cancer Res 1991; 51: 4776–84
  • Davies C, de L, Lindmo T. Hyperthermia-induced shedding and masking of melanoma-associated antigen. Int J Hyperthermia 1990; 6: 1053–64
  • Wells K. S., Sandison, Dr, Strickler J, Webb W. W. Qvantitative fluorescence imaging with laser scanning confocal microscopy. Handbook of biological confocal microscopy, J. B. Pawley. Plenum Press. 1990; 27–39

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