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Original Article

Does the Multidrug-Resistance Modulator Cyclosporin a Increase the Cardiotoxicity of High-Dose Anthracycline Chemotherapy?

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Pages 735-740 | Received 16 Apr 1997, Accepted 14 Aug 1997, Published online: 08 Jul 2009

References

  • Booser D J, Hortobagyi G N. Anthracycline antibiotics in cancer therapy. Focus on drug resistance. Drugs 1994; 47: 223–58
  • Sokolove P M. Inhibition by cyclosporin A and butylated hydroxytoluene of the inner mitochondrial membrane permeability transition induced by adriamycin aglycones. Biochem Pharmacol 1990; 40: 2733–6
  • Kolar F, MacNaughton C, Papousek F, Korecky B. Systolic performance of heterotopically transplanted hearts in rats treated with cyclosporin. Cardiovasc Res 1993; 27: 1244–7
  • von Hoff D D, Layard M W, Basa P, et al. Risk factors for doxorubicin-induced congestive heart failure. Ann Int Med 1979; 91: 710–7
  • Goodman J, Hochstein P. Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin. Biochem Biophys Res Comm 1977; 77: 797–803
  • Chabner B A, Collins J M. Cancer chemotherapy: principles and practice. Lippincott, Philadelphia 1990
  • Allen A. The cardiotoxicity of chemotherapeutic drugs. Sem Oncol 1992; 19: 529–42
  • Schwartsmann G, Dekker A W, Verhoff J. Complications of cytotoxic therapy. Oxford Textbook of Oncology, M Peckham, H Pinedo, U Veronesi. Oxford University Press, Oxford 1995; Vol. 2
  • Bristow M R, Billingham M E, Mason J W, Daniels J R. Clinical spectrum of anthracycline antibiotic cardiotoxicity. Cancer Treat Rep 1978; 62: 873–9
  • Treat J, Greenspan A, Forst D, Sanchez J A, Ferrans V J, Potkul L A, Woolley P V, Rahmen A. Antitumor activity of liposome-encapsulated doxorubicin in advanced breast cancer: phase II study. J Natl Cancer Inst 1990; 82: 1706–10
  • Basser R L, Green M D. Complications of treatment: Strategies for prevention of anthracycline cardiotoxicity. Cancer Treat Rev 1993; 19: 57–77
  • Carlson R W. Reducing the cardiotoxicity of the anthracy-clines. Oncology Williston Park 1992; 6: 95–100; 104, discussion 107–8
  • Doroshow J H. Doxorubicin-induced cardiac toxicity. New Engl J Med 1991; 324: 843–5
  • Brown K A, Blow A J, Weiss R M, Stewart J A. Acute effects of doxorubicin on human left ventricular systolic and diastolic function. Am Heart J 1989; 118: 979–82
  • Steinherz L J, Graham T, Hurwitz R, et al. Guidelines for cardiac monitoring of children during and after anthracycline therapy: Report of the cardiology committee of the childrens cancer study group. Pediatrics 1992; 89: 942–9
  • Adam W E, Clausen M, Hellwig D, Henze E, Bitter F. Radionuclide ventriculography (equilibrium gated blood pool scanning)—its present clinical position and developments. Eur J Nucl Med 1988; 13: 637–47
  • Corbett J R, Jansen D E, Willerson J T. Radionuclide ventriculography. Am J Physiol Imaging 1987; 2: 33–43; 85–104
  • Felipe R F, Prpic H, Arndt J W, van der Wall E E, Pauwels E K. Role of radionuclide ventriculography in evaluating cardiac function. Eur J Radiol 1991; 12: 20–9
  • Schwartz R G, McKenzie W B, Alexander J, et al. Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy. Am J Med 1987; 82: 1109–18
  • McKillop J H, Bristow M R, Goris M L, Billingham M E, Bockemuehl K. Sensitivity and specificity of radionuclide ejection fractions in doxorubicin cardiotoxicity. Am Heart J 1983; 106: 1048–56
  • Parmentier S, Melin J A, Piret L, Beckers C. Assessment of left ventricular diastolic function in patients receiving anthracycline therapy. Eur J Nucl Med 1988; 13: 563–7
  • Pauwels E KJ, Feitsma R IJ, Blom J. Influence of adriamycin on red blood cell labelling: a pitfall in scintigraphic blood pool imaging. Nucl Med Comm 1983; 4: 290–3
  • Solem L E, Wallace K B. Selective activation of the sodium-independent, cyclosporin A-sensitive calcium pore of cardiac mitochondria by doxorubicin. Toxicol Appl Pharmacol 1993; 121: 50–7
  • Kadmon M, Klünemann C, Böhme M, Ishikawa T, Gorgas K, Otto G, Herfarth C, Keppler D. Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile. Gastroenterology 1993; 104: 1507–14
  • Lum B L, Kaubisch S, Yahanda A M, Adler K M, Jew L, Ehsan M N, Brophy N A, Halsey J, Gosland M P, Sikic B I. Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance. J Clin Oncol 1992; 10: 1635–42
  • Erlichmann C, Moore M, Thiessen J J, Kerr I G, Walker S, Goodman P, Bjarnason G, DeAngelis C, Bunting P. Phase I pharmacokinetic study of cyclosporine A combined with doxorubicin. Cancer Res 1993; 53: 4837–42
  • List A F, Spier C M, Greer J, Wolff S, Hutter J, Dorr R, Salmon S, Futscher B, Baier M, Dalton W. Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia. J Clin Oncol 1993; 11: 1652–60
  • Yahanda A M, Adler K M, Fisher G A, Brophy N A, Halsey J, Hardy R I, Gosland M P, Lum B L, Sikic B I. Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance. J Clin Oncol 1992; 10: 1624–34
  • Scheulen M E, Eggert J, Schütte J, Budach W, Annweiler H, Mengelkoch B, Borquez D, Skorzec M, Wiefelspütz J, Sack H, Seeber S. Influence of cyclosporin A on the pharmacokinetics and pharmacodynamics of doxorubicin and epirubicin. Onkologie 1993; 16: 9, (Suppl 1)

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