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Acta Oncologica Volume 50, 2011 - Issue 4
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Research Article

Bevacizumab-induced nasal septal perforation: Incidence of symptomatic, confirmed event(s) in colorectal cancer patients

Judi Anne B. Ramiscal Mayo Clinic Medical School, Rochester, Minnesota 55905, USA
&
Aminah Jatoi Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905, USACorrespondence[email protected]
Pages 578-581 | Received 08 Oct 2010, Accepted 01 Nov 2010, Published online: 26 Nov 2010

References

  • Maillez A, Baldini C, Van JT, Servent V, Mallet Y, Bonneterre J. Nasal septum perforation: A side effect of bevacizumab chemotherapy in breast cancer patients. Br J Cancer 2010; 103:772–5.
  • Hurwitz H, Fehrebbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, . Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335–42.
  • Cohen MH, Gootenberg J, Keegan P, Pazdur R. FDA drug approval summary: Bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer. Oncologist 2007; 12:356–61.
  • Fakih MG, Lombardo JC. Bevacizumab-induced nasal septum perforation. Oncologist 2006;11:85–6.
  • Power DG, Kemeny NE. Nasal septum perforation and bevacizumab. Med Oncol. Epub 2010 Mar 6.
  • Traina TA, Norton L, Drucker K, Singh B. Nasal septum perforation in a bevacizumab-treated patient with metastatic breast cancer. Oncologist 2006;11:1070–1.
  • Ruiz N, Fernandez-Martos C, Romero I, Pla A, Maiquez J, Calatrava A, . Invasive fungal infection and nasal septum perforation with bevacizumab-based therapy in advanced colon cancer. J Clin Oncol 2007;25:3376–7.
  • Burkart CM, Grisel JJ, Hom DB. Spontaneous nasal septal perforation with antiangiogenic bevacizumab therapy. Laryngoscope 2008;118:1539–41.
  • Marin AP, Sanchez AR, Arranz EE. Nasal septum perforation in a breast cancer patient treated with bevacizumab. Ann Oncol 2009;20:1901–2.

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