1,650
Views
52
CrossRef citations to date
0
Altmetric
Research Article

Hypertension as predictor of sunitinib treatment outcome in metastatic renal cell carcinoma

, , &
Pages 569-573 | Received 27 Jun 2010, Accepted 23 Nov 2010, Published online: 05 Jan 2011

References

  • Rixe O, Billemont B, Izzedine H. Hypertension as a predictive factor of sunitinib activity. Ann Oncol 2007;18:1117.
  • Rini BI, Schiller JH, Fruehauf J, Cohen EE, Tarazi JC, Rosbrook B, . Association of diastolic blood pressure ≥ 90 mmHg with overall survival in patients treated with axitinib. J Clin Oncol 2008;26(18S):3543.
  • Ravaud A, Sire M. Arterial hypertension and clinical benefit of sunitinib, sorafenib and bevacizumab in first and second-line treatment of metastatic renal cell cancer. Ann Oncol 2009;20:966–7.
  • Bono P, Elfving H, Utriainen T, Osterlund P, Saarto T, Alanko T, . Hypertension and clinical benefit of bevacizumab in the treatment of advanced renal cell carcinoma. Ann Oncol 2009;20:393–4.
  • Rini BI, Cohen DP, Lu D, Chen I, Hariharan S, Gore ME. Hypertension (HTN) as a biomarker of efficacy in patients (pts) with metastatic renal cell carcinoma (mRCC) treated with sunitinib. ASCO GU meeting 2010; Abstr 312.
  • van Heeckeren WJ, Ortiz J, Cooney MM, Remick SC. Hypertension, proteinuria, and antagonism of vascular endothelial growth factor signaling: Clinical toxicity, therapeutic target, or novel biomarker? J Clin Oncol 2007;25: 2993–5.
  • Escudier B, Roigas J, Gillessen S, Harmenberg U, Srinivas S, Mulder SF, . Phase II study of sunitinib administered in a continuous once-daily dosing regimen in patients with cytokine-refractory metastatic renal cell carcinoma. J Clin Oncol 2009;27:4068–75.
  • Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L. Guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000;92:205–16.
  • Huang D, Ding Y, Zhou M, Rini BI, Petillo D, Qian CN, . Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. Cancer Res 2010;70: 1063–71.
  • Jubb AM, Hurwitz HI, Bai W, Holmgren EB, Tobin P, Guerrero AS. Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer. J Clin Oncol 2006;24:217–27.
  • Ince WL, Jubb AM, Holden SN, Holmgren EB, Tobin P, Sridhar M, . Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab. J Natl Cancer Inst 2005;97:981–9.
  • Schneider BP, Radovich M, Miller KD. The role of vascular endothelial growth factor genetic variability in cancer. Clin Cancer Res 2009;15:5297–302.
  • Chu TF, Rupnick MA, Kerkela R, Dallabrida SM, Zurakowski D, Nguyen L, . Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet 2007;370: 2011–9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.