The interaction between aggrecan gene VNTR polymorphism and cigarette smoking in predicting incident symptomatic intervertebral disc degeneration

REFERENCES

• Nemoto, Y., Matsuzaki, H., Tokuhasi, Y., Okawa, A., Uematu, Y., Nishimura, T., and Oda, H. (2006). Histological changes in intervertebral discs after smoking and cessation: Experimental study using a rat passive smoking model. J. Orthop. Sci. 11(2):191–197.
   PubMed Web of Science ®Google Scholar
• Akmal, M., Kesani, A., Anand, B., Singh, A., Wiseman, M., and Goodship, A. (2004). Effect of nicotine on spinal disc cells: A cellular mechanism for disc degeneration. Spine 29(5):568–575.
   PubMed Web of Science ®Google Scholar
• Oda, H., Matsuzaki, H., Tokuhashi, Y., Wakabayashi, K., Uematsu, Y., and Iwahashi, M. (2004). Degeneration of intervertebral discs due to smoking: Experimental assessment in a rat-smoking model. J. Orthop. Sci. 9(2):135–141.
   PubMed Web of Science ®Google Scholar
• Iwahashi, M., Matsuzaki, H., Tokuhashi, Y., Wakabayashi, K., and Uematsu, Y. (2002). Mechanism of intervertebral disc degeneration caused by nicotine in rabbits to explicate intervertebral disc disorders caused by smoking. Spine 27(13):1396–1401.
   PubMed Web of Science ®Google Scholar
• Roughley, P., Martens, D., Rantakokko, J., Alini, M., Mwale, F., and Antoniou, J. (2006). The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage. Eur. Cell. Mater. 11:1–7.
   PubMed Web of Science ®Google Scholar
• Doege, K.J., Coulter, S.N., Meek, L.M., Maslen, K., and Wood, J.G. (1997). A human-specific polymorphism in the coding region of the aggrecan gene: Variable number of tandem repeats produce a range of core protein sizes in the general population. J. Biol. Chem. 272(21):13974–13979.
   PubMed Web of Science ®Google Scholar
• Kämäräinen, O.P., Solovieva, S., Vehmas, T., Luoma, K., Leino-Arjas, P., Riihimäki, H., Ala-Kokko, L., and Männikkö, M. (2006). Aggrecan core protein of a certain length is protective against hand osteoarthritis. Osteoarthr. Cartil. 14(10):1075–1080.
   PubMed Web of Science ®Google Scholar
• Kirk, K.M., Doege, K.J., Hecht, J., Bellamy, N., and Martin, N.G. (2003). Osteoarthritis of the hands, hips and knees in an Australian twin sample: Evidence of association with the aggrecan VNTR polymorphism. Twin Res. 6(1):62–66.
   PubMedGoogle Scholar
• Roughley, P.J., Alini, M., and Antoniou, J. (2002). The role of proteoglycans in aging, degeneration and repair of the intervertebral disc. Biochem. Soc. Trans. 30(Pt 6):869–874.
   PubMedGoogle Scholar
• Kawaguchi, Y., Osada, R., Kanamori, M., Ishihara, H., Ohmori, K., Matsui, H., and Kimura, T. (1999). Association between an aggrecan gene polymorphism and lumbar disc degeneration. Spine 24(23):2456–2460.
   PubMed Web of Science ®Google Scholar
• Cheung, K.M., Karppinen, J., Chan, D., Ho, D.W., Song, Y.Q., Sham, P., Cheah, K.S., Leong, J.C., Luk, K.D. (2009). Prevalence and pattern of lumbar magnetic resonance imaging changes in a population study of one thousand forty-three individuals. Spine 34(9):934–940.
   PubMed Web of Science ®Google Scholar
• Bernaards, C.M., Twisk, J.W., Snel, J., Van Mechelen,W., and Kemper, H.C. (2001). Is calculating pack-years retrospectively a valid method to estimate life-time tobacco smoking? A comparison between prospectively calculated pack-years and retrospectively calculated pack-years. Addiction 96(11):1653–1661.
   PubMed Web of Science ®Google Scholar
• Luoma, K., Raininko, R., Nummi, P., and Luukkonen, R. (1993). Is the signal intensity of cerebrospinal fluid constant? Intensity measurements with high and low field magnetic resonance imagers. Magn. Reson. Imaging 11(4):549–555.
   PubMed Web of Science ®Google Scholar
• Schneiderman, G., Flannigan, B., Kingston, S., Thomas, J., Dillin, W.H., and Watkins, R.G. (1987). Magnetic resonance imaging in the diagnosis of disc degeneration: Correlation with discography. Spine 12(3):276–281.
   PubMed Web of Science ®Google Scholar
• Hwang, S.J., Beaty, T.H., Panny, S.R., Street, N.A., Joseph, J.M., Gordon, S., McIntosh, I., and Francomano, C.A. (1995). Association study of transforming growth factor alpha (TGF alpha) TaqI polymorphism and oral clefts: Indication of gene-environment interaction in a population-based sample of infants with birth defects. Am. J. Epidemiol. 141(7):629–636.
   PubMed Web of Science ®Google Scholar
• Guo, S.W., and Thompson, E.A. (1992). Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics 48(2):361–372.
   PubMed Web of Science ®Google Scholar
• Cs-Szabo, G., Ragasa-San Juan, D., Turumella, V., Masuda, K., Thonar, E.J., and An, H.S. (2002). Changes in mRNA and protein levels of proteoglycans of the anulus fibrosus and nucleus pulposus during intervertebral disc degeneration. Spine 27(20):2212–2219.
   PubMed Web of Science ®Google Scholar
• Tertti, M., Paajanen, H., Laato, M., Aho, H., Komu, M., and Kormano, M. (1991). Disc degeneration in magnetic resonance imaging: A comparative biochemical, histologic, and radiologic study in cadaver spines. Spine 16(6):629–634.
   PubMed Web of Science ®Google Scholar
• Adams, M.A., and Roughley, P.J. (2006). What is intervertebral disc degeneration, and what causes it? Spine 31(18):2151–2161.
   PubMed Web of Science ®Google Scholar
• Luoma, K., Vehmas, T., Riihimäki, H., and Raininko, R. (2001). Disc height and signal intensity of the nucleus pulposus on magnetic resonance imaging as indicators of lumbar disc degeneration. Spine 26(6):680–686.
   PubMed Web of Science ®Google Scholar
• Dooms, G.C., Hricak, H., Margulis, A.R., and de Geer, G. (1986). MR imaging of fat. Radiology 158(1):51–54.
   PubMed Web of Science ®Google Scholar
• Modic, M.T., Steinberg, P.M., Ross, J.S., Masaryk, T.J., and Carter, J.R. (1988). Degenerative disk disease: Assessment of changes in vertebral body marrow with MR imaging. Radiology 166(1 Pt 1):193–199.
   PubMed Web of Science ®Google Scholar
• Luoma, E.K., Raininko, R., Nummi, P.J., Luukkonen, R., Manninen, H.I., and Riihimäki, H.A. (1997). Suitability of cerebrospinal fluid as a signal-intensity reference on MRI: Evaluation of signal-intensity variations in the lumbosacral dural sac. Neuroradiology 39(10):728–732.
   PubMed Web of Science ®Google Scholar
• Solovieva, S., Noponen, N., Männikkö, M., Leino-Arjas, P., Luoma, K., Raininko, R., Ala-Kokko, L., and Riihimäki, H. (2007). Association between the aggrecan gene variable number of tandem repeats polymorphism and intervertebral disc degeneration. Spine 32(16):1700–1705.
   PubMed Web of Science ®Google Scholar