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Research Article

Effects of IL-1 Receptor-Associated Kinase-4 Gene Silencing on Human Osteoblast-Like Cells

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Pages 498-507 | Received 06 Dec 2011, Accepted 15 May 2012, Published online: 20 Jul 2012

References

  • Hansson, G.K., and Edfeldt, K. (2005). Toll to be paid at the gateway to the vessel wall. Arterioscler. Thromb. Vasc. Biol. 25:1085–1087.
  • Blasius, A.L., and Beutler, B. (2010). Intracellular toll-like receptors. Immunity 32:305–315.
  • Akira, S., Takeda, K., and Kaisho, T. (2001). Toll-like receptors: Critical proteins linking innate and acquired immunity. Nat. Immunol. 2:675–680.
  • Qin, L., Li, G., Qian, X., Liu, Y., Wu, X., Liu, B., Hong, J.S., and Block, M.L. (2005). Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation. Glia 52:78–84.
  • Akira, S., Hoshino, K., and Kaisho, T. (2000). The role of Toll-like receptors and MyD88 in innate immune responses. J. Endotoxin. Res. 6:383–387.
  • Kaisho, T., Hoshino, K., Iwabe, T., Takeuchi, O., Yasui, T., and Akira, S. (2002). Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation. Int. Immunol. 14:695–700.
  • Li, S., Strelow, A., Fontana, E.J., and Wesche, H. (2002). IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase. Proc. Natl. Acad. Sci. U.S.A. 99:5567–5572.
  • O‘Neill, L.A., and Greene, C. (1998). Signal transduction pathways activated by the IL-1 receptor family: Ancient signaling machinery in mammals, insects, and plants. J. Leukoc. Biol. 63:650–657.
  • Janssens, S., and Beyaert, R. (2003). Functional diversity and regulation of different Interleukin-1 receptor-associated kinase (IRAK) family members. Mol. Cell 2:293–302.
  • Suzuki, N., Suzuki, S., Eriksson, U., Hara, H., Mirtosis, C., Chen, N.J., Wada, T., Bouchard, D., Hwang, I., Takeda, K., Fujita, T., Der, S., Penninger, J.M., Akira, S., Saito, T., and Yeh, W.C. (2003). IL-1R-associated kinase 4 is required for lipopolysaccharide- induced activation of APC[J]. J. Immunol. 171:6065–6071.
  • Song, K.W., Talamas, F.X., Suttmann, R.T., Olson, P.S., Barnett, J.W., Lee, S.W., Thompson, K.D., Jin, S., Hekmat-Nejad, M., Cai, T.Z., Manning, A.M., Hill, R.J., and Wong, B.R. (2009). The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells. Mol. Immunol. 2974:1–9.
  • Hall, M.J., and Owings, M.F. (2002). 2000 National hospital discharge survey. Adv. Data 329:1–18.
  • Kurtz, S., Ong, K., Lau, E., Mowat, F., and Halpern, M. (2007). Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J. Bone Joint Surg. Am. 89(4):780–785.
  • Berry, D.J., Harmsen, W.S., Cabanela, M.E., and Morrey, B.F. (2002). Twenty-five-year survivorship of two thousand consecutive primary Charnley total hip replacements: Factors affecting survivorship of acetabular and femoral components. J. Bone Joint Surg. Am. 84(2):171–177.
  • Keener, J.D., Callaghan, J.J., Goetz, D.D., Pederson, D.R., Sullivan, P.M., and Johnston, R.C. (2003). Twenty-five-year results after Charnley total hip arthroplasty in patients less than fifty years old: A concise follow-up of a previous report. J Bone Joint Surg. Am. 85–A(6):1066–1072.
  • Bauer, T.W. (2002). Particles and periimplant bone resorption. Clin. Orthop. Relat. Res. 405:138–143.
  • Yang, S.Y., Zhang, K., Bai, L., Song, Z., Yu, H., McQueen, D.A., and Wooley, P.H. (2011). Polymethylmethacrylate and titanium alloy particles activate peripheral monocytes during periprosthetic inflammation and osteolysis. J. Orthop. Res. 29(5):781–786.
  • Lye, E., Mirtsos, C., Suzuki, N., Suzuki, S., and Yeh, W.C. (2004). The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J. Biol. Chem. 279(39):40653–40658.
  • Kyo, F., Futani, H., Matsui, K., Terada, M., Adachi, K., Nagata, K., Sano, H., Tateishi, H., Tsutsui, H., and Nakanishi, K. (2005). Endogenous interleukin-6, but not tumor necrosis factor alpha, contributes to the development of toll-like receptor 4/myeloid differentiation factor 88-mediated acute arthritis in mice. Arthritis Rheum. 52(8):2530–2540.
  • Kwan, T.S., Padrines, M., Théoleyre, S., Heymann, D., and Fortun, Y. (2004). IL-6, RANKL, TNF-alpha/IL-1: Interrelations in bone resorption pathophysiology. Cytokine Growth Factor Rev. 15:49–60.
  • Stashenko, P., Dewhirst, F.E., Peros, W.J., Kent, R.L., and Ago, J.M. (1987). Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption. J. Immunol. 138:1464–1468.
  • Thomson, B.M., Mundy, G.R., and Chambers, T.J. (1987). Tumor necrosis factors alpha and beta induce osteoblastic cells to stimulate osteoclastic bone resorption. J. Immunol. 138:775–779.
  • Yamaguchi, A., Komori, T., and Suda, T. (2000). Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocr. Rev. 21:393–411.
  • Dinarello, C.A. (1994). The interleukin-1 family: 10 years of discovery. FASEB J. 8:1314–1315.
  • Olmedo, M.L., Landry, P.S., Sadasivan, K.K., Albright, J.A., Meek, W.D., Routh, R., and Marino, A.A. (1999). Regulation of osteoblast levels during bone healing. J. Orthop. Trauma 13:356–362.
  • Gowen, M., Nedwin, G.E., and Mundy, G.R. (1985). Stimulation of the proliferation of human bone cells in vitro by human monocyte products with interleukin-1 activity. J. Clin. Invest. 75:1223–1229.
  • Ikeda, E., Kusaka, M., Hakeda, Y., Yokota, K., Kumegawa, M., and Yamamoto, S. (1988). Effect of interleukin 1 beta on osteoblastic clone MC3T3-E1 cells. Calcif. Tissue Int. 43:162–166.
  • Shen, V., Cheng, S.L., Kohler, N.G., and Peck, W.A. (1990). Characterization and hormonal modulation of IL-1 binding in neonatal mouse osteoblast-like cells. J. Bone Miner. Res. 5:507–515.
  • Zhao, G., Raines, A.L., Wieland, M., Schwartz, Z., and Boyan, B.D. (2007). Requirement for both micron- and submicron scale structure for synergistic responses of osteoblasts to substrate surface energy and topography. Biomaterials 28:2821–2829.
  • Milona, M.A., Gough, J.E., and Edgar, A.J. (2003). Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells. BMC Genomics 4:43.
  • Schwartz, Z., Bell, B.F., Wang, L., Zhao, G., Olivares-Navarrete, R., and Boyan, B.D. (2007). Beta-1 integrins mediate substrate dependent effects of 1alpha, 25(OH)2D3 on osteoblasts. J. Steroid Biochem. Mol. Biol. 103:606–609.
  • Pedrazzoni, M., Alfano, F.S., Girasole, G., Giuliani, N., Fantuzzi, M., Gatti, C., Campanini, C., and Passeri, M. (1996). Clinical observations with a new specific assay for bone alkaline phosphatase: A cross-sectional study in osteoporosis and pagetic subjects and a longitudinal evaluation of the response to ovariectomy, estrogens, and bisphosphonates. Calcif. Tissue Int. 59:334–338.
  • Lincks, J., Boyan, B.D., Blanchard, C.R., Lohmann, C.H., Liu, Y., Cochran, D.L., Dean, D.D., and Schwartz, Z. (1998). Response of MG63 osteoblast-like cells to titanium and titanium alloy is dependent on surface roughness and composition. Biomaterials 19:2219–2232.
  • Tang, L.Q., Gong, M.Z., Liu, Z.H., Si, H.P., Xing, D.G., and Zhao, J.J. (2006). Change of osteocalcin in rats with diabetes after fractures. Chi. J. Exp. Surg. 23:617–618.
  • Weaver, C.M., Peacock, M., Martin, B.R., McCabe, G.P., Zhao, J., Smith, D.L., and Wastney, M.E. (1997). Quantification of biochemical markers of bone turnover by kinetic measures of bone formation and resorption in young healthy females. J. Bone Miner. Res. 12:1714–1720.
  • Conus, S., Kaufmann, T., Fellay, I., Otter, I., Rossé, T., and Borner, C. (2000). Bcl-2 is a monomeric protein: Prevention of homodimerization by structural constraints. EMBO J. 19:1534–1544.
  • Webb, S.J., Harrison, D.J., and Wyllie, A.H. (1997). Apoptosis: An overview of the process and its relevance in disease. Adv. Pharmacol. 41:1–34.
  • Cui, Y.F., Xia, G.W., Fu, X.B., Yang, H., Peng, R.Y., Zhang, Y., Gu, Q.Y., Gao, Y.B., Cui, X.M., and Hu, W.H. (2003). Relationship between expression of Bax and Bcl-2 proteins and apoptosis in radiation compound wound healing of rats. Chin. J. Traumatol. 6:135–138.
  • Harrison, J.C., Zyla, T.R., Bardes, E.S., and Lew, D.J. (2004). Stress-specific activation mechanisms for the “cell integrity” MAPK pathway. Biol. Chem. 279:2616–2622.
  • Johnson, G.L., and Lapadat, R. (2002). Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911–1912.
  • Hipskind, R.A., and Bilbe, G. (1998). MAP kinase signaling cascades and gene expression in osteoblasts. Front. Biosci. 3:d804–d816.
  • Lai, C.F., Chaudhary, L., Fausto, A., Halstead, L.R., Ory, D.S., Avioli, L.V., and Cheng, S.L. (2001). Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells. J. Biol. Chem. 276:14443–14450.
  • Suzuki, A., Guicheux, J., Palmer, G., Miura, Y., Oiso, Y., Bonjour, J.P., and Caverzasio, J. (2002). Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation. Bone 30:91–98.
  • Koziczak-Holbro, M., Littlewood-Evans, A., Pöllinger, B., Kovarik, J., Dawson, J., Zenke, G., Burkhart, C., Müller, M., and Gram, H. (2009). The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation. Arthritis Rheum. 60(6):1661–1671.
  • Li, X. (2008). IRAK4 in TLR/IL-1R signaling: Possible clinical applications. Eur. J. Immunol. 38(3):614–618.
  • Suzuki, N., Suzuki, S., Duncan, G.S., Millar, D.G., Wada, T., Mirtsos, C., Takada, H., Wakeham, A., Itie, A., Li, S., Penninger, J.M., Wesche, H., Ohashi, P.S., Mak, T.W., and Yeh, W.C. (2002). Severe impairment of interleukin-1 and Toll-like receptor signaling in mice lacking IRAK-4. Nature 416:750–756.
  • Ding, J., Ghali, O., Lencel, P., Broux, O., Chauveau, C., Devedjian, J.C., Hardouin, P., and Magne, D. (2009). TNF-alpha and IL-1beta inhibit RUNX2 and collagen expression but increase alkaline phosphatase activity and mineralization in human mesenchymal stem cells. Life Sci. 84(15–16):499–504.
  • Komatsu, D.E., Bosch-Marce, M., Semenza, G.L., and Hadjiargyrou, M. (2007). Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency. J. Bone Miner. Res. 22(3):366–374.
  • Street, J., and Lenehan, B. (2009). Vascular endothelial growth factor regulates osteoblast survival - evidence for an autocrine feedback mechanism. J. Orthop. Surg. Res. 16(4):19.
  • Bae, S., Siu, P.M., Choudhury, S., Ke, Q., Choi, J.H., Koh, Y.Y., and Kang, P.M. (2010). Delayed activation of caspase-independent apoptosis during heart failure in transgenic mice overexpressing caspase inhibitor CrmA. Am. J. Physiol. Heart Circ. Physiol. 299(5):H1374–H1381.
  • Guicheux, J., Lemonnier, J., Ghayor, C., Suzuki, A., Palmer, G., and Caverzasio, J. (2003). Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation. J. Bone Miner. Res. 18(11):2060–2068.
  • Pautke, C., Schieker, M., Tischer, T., Kolk, A., Neth, P., Mutschler, W., and Milz, S. (2004). Characterization of osteosarcoma cell lines MG-63, Saos-2 and U-2 OS in comparison to human osteoblasts. Anticancer Res. 24(6):3743–3748.

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