124
Views
13
CrossRef citations to date
0
Altmetric
Research Article

Effect of Norcantharidin on the Human Breast Cancer Bcap-37 Cells

, , , &
Pages 508-512 | Received 17 Jan 2012, Accepted 15 May 2012, Published online: 20 Jul 2012

References

  • Park, M.T., Kim, M.J., Kang, Y.H., Choi, S.Y., Lee, J.H., Choi, J.A., Kang, C.M., Cho, C.K., Kang, S., Bae, S., Lee, Y.S., Chung, H.Y., and Lee, S.J. (2005). Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release. Blood 105:1724–1733.
  • Wang, R., Wang, X., Li, B., Lin, F., Dong, K., Gao, P., and Zhang, H.Z. (2009). Tumor-specific adenovirus-mediated PUMA gene transfer using the survivin promoter enhances radiosensitivity of breast cancer cells in vitro and in vivo. Breast Cancer Res. Treat. 117:45–54.
  • Liao, H.F., Su, S.L., Chen, Y.J., Chou, C.H., and Kuo, C.D. (2007). Norcantharidin preferentially induces apoptosis in human leukemic Jurkat cells without affecting viability of normal blood mononuclear cells. Food Chem. Toxicol. 45:1678–1687.
  • Chen, Y.J., Kuo, C.D., Tsai, Y.M., Yu, C.C., Wang, G.S., and Liao, H.F. (2008). Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells. Anticancer Drug. 19:55–64.
  • Hill, T.A., Stewart, S.G., Sauer, B., Gilbert, J., Ackland, S.P., Sakoff, J.A., and McCluskey, A. (2007). Heterocyclic substituted cantharidin and norcantharidin analogues-synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity. Bioorg. Med. Chem. Lett. 17:3392–3397.
  • Huang, Y., Liu, Q., Liu, K., Yagasaki, K., and Zhang, G. (2009). Supp ression of growth of highly-metastatic human breast cancer cells by norcantharidin and its mechanisms of action. Cytotechnology 59:201–208.
  • Fan, Y.Z., Fu, J.Y., Zhao, Z.M., and Chen, C.Q. (2007). Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro. Hepatobiliary Pancreat. Dis. Int. 6:72–80.
  • Wang, G.S. (1989). Medical uses of mylabris in ancient China and recent studies. J. Ethnopharmacol. 26:147–162.
  • Hong, C.Y., Huang, S.C., Lin, S.K., Lee, J.J., Chueh, L.L., and Lee, C.H. (2000). Norcantharidin-induced post-G(2)/M apoptosis is dependent on wild-type p53 gene. Biochem. Biophys. Res. Commun. 276:278–285.
  • McCluskey, A., Bowyer, M.C., Collins, E., Sim, A.T.R., Sakoff, J.A., and Baldwin, M.L. (2000). Anhydride modified cantharidin analogues: Synthesis, inhibition of protein phosphatases 1 and 2A and anticancer activity. Bioorg. Med. Chem. Lett. 10:1687–1690.
  • Yi, S.N., Wass, J., Vincent, P., and Iland, H. (1991). Inhibitory effect of norcantharidin on K562 human myeloid leukemia cells in vitro. Leuk. Res. 15:883–886.
  • Li, J.L., Cai, Y.C., Liu, X.H., and Xian, L.J. (2006). Norcantharidin inhibits DNA replication and induces apoptosis with the cleavage of initiation protein Cdc6 in HL-60 cells. Anticancer Drug. 17:307–314.
  • Peng, F., Wei, Y.Q., Tian, L., Yang, L., Zhao, X., Lu, Y., Mao, Y.Q., Kan, B., Lei, S., Wang, G.S., Jiang, Y., Wang, Q.R., Luo, F., Zou, L.Q., and Liu, J.Y. (2002). Induction of apoptosis by norcantharidin in human colorectal carcinoma cell lines: Involvement of the CD95 receptor/ligand. J. Cancer Res. Clin. Oncol. 128:223–230.
  • An, W.W., Wang, M.W., Tashiro, S., Onodera, S., and Ikejima, T. (2004). Norcantharidin induces human melanoma A375-S2 cell apoptosis through mitochondrial and caspase pathways. J. Korean Med. Sci. 19:560–566.
  • Yan, M.S., Xiue, S., Wei, L.X., and Piao, X.H. (1993). The preliminary observation on immunosuppressive effect of norcantharidin in mice. Immunopharmacol. Immunotoxicol. 15:79–85.
  • Kok, S.H., Cheng, S.J., Hong, C.Y., Lee, J.J., Lin, S.K., Kuo, Y.S., Chiang, C.P., and Kuo, M.Y. (2005). Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio. Cancer Lett. 217:43–52.
  • Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T., Mazur, M., and Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 39:44–84.
  • Huo, Y., Qiu, W.Y., Pan, Q., Yao, Y.F., Xing, K., and Lou, M.F. (2009). Reactive oxygen species (ROS) are essential mediators in epidermal growth factor (EGF)-stimulated corneal epithelial cell proliferation, adhesion, migration, and wound healing. Exp. Eye Res. 89:876–886.
  • Cao, X.H., Wang, A.H., Wang, C.L., Mao, D.Z., Lu, M.F., Cui, Y.Q., and Jiao, R.Z. (2010). Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway. Chem-Biol. Interact. 183:357–362.
  • Ralph, S.J., and Neuzil, J. (2009). Mitochondria as targets for cancer therapy. Mol. Nutr. Food Res. 53:9–28.
  • Ralph, S.J., Rodriguez-Enriquez, S., Neuzil, J., and Moreno-Sanchez, R. (2010). Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger. Mol. Aspects. Med. 31:29–59.
  • Kroemer, G., Galluzzi, L., and Brenner, C. (2007). Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 87:99–163.
  • McDonnell, M.A., Wang, D., Khan, S.M., Vander Heiden, M.G., and Kelekar, A. (2003). Caspase-9 is activated in a cytochrome c-independent manner early during TNFalpha-induced apoptosis in murine cells. Cell Death Differ. 10:1005–1015.
  • Collins, A.R., Dobson, V.L., Dusinska, M., Kennedy, G., and Stetina, R. (1997). The comet assay: What can it really tell us? Mutat. Res. 375:183–193.
  • Dhawan, A., Bajpayee, M., and Parmar, D. (2009). Comet assay: A reliable tool for the assessment of DNA damage in different models. Cell Biol. Toxicol. 25:5–32.
  • Piperakis, S.M. (2009). Comet assay: A brief history. Cell Biol. Toxicol. 25:1–3.
  • Choucroun, P., Gillet, D., Dorange, G., Sawicki, B., and Dewitte, J.D. (2001). Comet assay and early apoptosis. Mutat. Res. 478:89–96.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.