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Original Article

6.1.1.2 Quality Specifications for Determinations of HCG and Related Substances

Pages 283-291 | Published online: 18 Jan 2010

References

  • Alfthan H., Haglund C., Dabek J., Stenman U-H. Concentrations of hCG, βhCG and cβhCG in serum and urine of nonpregnant women and men. Clin Chem 1992; 38: 1981–7
  • Hoermann R., Gerbes A. L., Spoettl G., Jüngst D., Mann K. Immunoreactive human chorionic gonadotropin and its free β subunit in serum and ascites of patients with malignant tumors. Cancer Res 1992; 52: 1520–4
  • Cole L. A., Kardana A., Birken S. The isomers, subunits and fragments of hCG. Structure-function relationship of gonadotropins, D Bellet, J-M Bidart. Raven Press, New York 1989; 59–80
  • O'Connor J. F., Schlatterer J. P., Birken S, Krichevsky A., Armstrong E. G., McMahon D., Canfield R. E. Development of highly sensitive immunoassays to measure human chorionic gonadotropin, its β β-subunit, and β core fragment in the urine: Application to malignancies. Cancer Res 1988; 48: 361–6
  • Marcillac I, Troalen F., Bidart J-M., Ghillani P, Ribrag V, Escudier B, et al. Free human chorionic gonadotropin β subunit in gonadal and nongonadal neoplasms. Cancer Res 1992; 52: 3901–7
  • Stenman U-H., Bidart J-M., Birken S., Alfthan H., Mann K., Nisula B., et al. Standardization of protein immunoprocedures. Choriogonadotropin (CG). Scand J Clin Lab Invest, in press
  • Kardana A., Cole L. A. Polypeptide nicks cause erroneous results in assays of human chorionic gonadotropin free β-subunit. Clin Chem 1992; 38: 26–33
  • Thomas C. M., Segers M. F., Leloux A. M., Houx P. C. Comparison of the analytical characteristics of ten urinary hCG tests for early pregnancy diagnosis. Ann Clin Biochem 1986; 23: 216–22
  • Alfthan H, Björses U-M., Tiitinen A., Stenman U-H. Specificity and detection limit of ten pregnancy tests. Scand J Clin Lab Invest, in press
  • Chard T. Pregnancy tests: a review. Human Reprod 1992; 7: 701–10
  • Storring P. L., Gaines-Das R. E., Bangham D. R. International reference preparation of human chorionic gonadotrophin for immunoassay: Potency estimates in various bioassay and protein binding assay systems; and international reference preparations of α and β subunits of human chorionic gonadotrophin for immunoassay. J Endocrinol 1980; 84: 295–310
  • Weber T. H., Käpyaho K. I., Tanner P. Endogenous interference in immunoassays in clinical chemistry. A review. Scand J Clin Lab Invest 1990; 50(Suppl 201)77–82
  • Stenman U-H., Alfthan H., Turpeinen U. Method dependence of interpretation of immunoassay results. Scand J Clin Lab Invest 1991; 51: 86–94, (Supplement 206)
  • Stenman U-H., Alfthan H., Ranta T., Vartiainen E., Jalkanen J., Seppälä M. Serum levels of human chorionic gonadotropin in nonpregnant women and men are modulated by gonadotropin releasing hormone and sex steroids. J Clin Endocrinol Metab 1987; 64: 730–6
  • Cole L. A., Schwartz P. E., Wang Y. Urinary gonadotropin fragments (UGF) in cancers of the female reproductive system. I. Sensitivity and specificity, comparison with other markers. Gynecol Oncol 1988; 31: 82–90
  • Odell W. D., Griffin J. Pulsatile secretion of human chorionic gonadotropin in normal adults. N Engl J Med 1987; 317: 1688–91
  • Wald N. J., Cuckle H. S., Densem J. W., Nanchahal K., Royston P., Chard T., et al. Maternal serum screening for Down's syndrome in early pregnancy [published erratum appears in BMJ 1988; 297(6655):1029]. Brit Med J 1988; 297: 883–7
  • Spencer K. Evaluation of an assay of the free beta-subunit of choriogonadotropin and its potential value in screening for Down's syndrome [see comments]. Clin Chem 1991; 37: 809–14
  • Khazaeli M. B., Hedayat M. M., Hatch K. D., To A. C.W., Soong S.-J., Shingleton H. M., et al. Radioimmunoassay of free β-subunit of human chorionic gonadotropin as a prognostic test for persisitent trophoblastic disease in molar pregnancy. Am J Obstet Gynecol 1986; 155: 320–4
  • Ozturk M., Berkowitz R., Goldstein D., Bellet D., Wands J. R. Differential production of human chorionic gonadotropin and free subunits in gestational trophoblastic disease. Am J Obstet Gynecol 1988; 158: 193–8
  • Hussa R. O. Human chorionic gonadotropin, a clinical marker: review of its biosynthesis. Ligand Review 1981; 3: 6–44
  • Lange P. H., Nochomovitz L. E., Rosai J., Fraley E. E., Kennedy B. J., Bosl G., et al. Serum alpha-fetoprotein and human chorionic gonadotropin in patients with seminoma. J Urol 1980; 124: 472–8
  • Saller B., Clara R., Spottl G., Siddle K., Mann K. Testicular cancer secretes intact human choriogonadotropin (hCG) and its free beta-subunit: evidence that hCG (+ hCG-beta) assays are the most reliable in diagnosis and follow-up [see comments]. Clin Chem 1990; 36: 234–9
  • Iles R. K., Lee C. L., Oliver R. T., Chard T. Composition of intact hormone and free subunits in the human chorionic gonadotrophin-like material found in serum and urine of patients with carcinoma of the bladder. Clin Endocrinol Oxf 1990; 33: 355–64
  • Alfthan H., Haglund C., Roberts P., Stenman U-H. Elevation of free β subunit of human choriogonadotropin and core β fragment of human choriogonadotropin in serum and urine of patients with malignant pancreatic and biliary disease. Cancer Res 1992; 52: 4628–33
  • Cole L. A., Birken S. Origin and occurrence of human chorionic gonadotropin β-subunit core fragment. Mol Endocrinol 1988; 2: 826–30
  • Öberg K., Wide L. HCG and HCG subunits as tumour markers in patients with endcocrine pancreatic tumours and carcinoids. Acta Endocrinol 1981; 98: 256–60

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