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Articles

A decrease in galectin-1 (Gal-1) levels correlates with an increase in anti-Gal-1 antibodies at the synovial level in patients with rheumatoid arthritis

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Pages 102-107 | Accepted 28 Aug 2012, Published online: 18 Dec 2012

References

  • Elola MT, Wolfenstein-Todel C, Troncoso MF, Vasta GR, Rabinovich GA. Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival. Cell Mol Life Sci 2007;64:1679–700.
  • Rabinovich GA, Toscano MA. Turning ‘sweet’ on immunity: galectin-glycan interactions in immune tolerance and inflammation. Nat Rev Immunol 2009;9:338–52.
  • Haudek KC, Spronk KJ, Voss PG, Patterson RJ, Wang JL, Arnoys EJ. Dynamics of galectin-3 in the nucleus and cytoplasm. Biochim Biophys Acta 2010;1800:181–9.
  • Rabinovich GA, Ariel A, Hershkoviz R, Hirabayashi J, Kasai KI, Lider O. Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1. Immunology 1999;97:100–6.
  • Liu FT, Rabinovich GA. Galectins as modulators of tumour progression. Nat Rev Cancer 2005;5:29–41.
  • Perillo NL, Marcus ME, Baum LG. Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death. J Mol Med 1998;76:402–12.
  • Norling LV, Perretti M, Cooper D. Endogenous galectins and the control of the host inflammatory response. J Endocrinol 2009; 201:169–84.
  • Cedeno-Laurent F, Opperman MJ, Barthel SR, Hays D, Schatton T, Zhan Q, . Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity. J Invest Dermatol 2012;132:410–20.
  • Cedeno-Laurent F, Watanabe R, Teague JE, Kupper TS, Clark RA, Dimitroff CJ. Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma. Blood 2012;119:3534–8.
  • Cedeno-Laurent F, Opperman M, Barthel SR, Kuchroo VK, Dimitroff CJ. Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol 2012;188:3127–37.
  • Perillo NL, Pace KE, Seilhamer JJ, Baum LG. Apoptosis of T cells mediated by galectin-1. Nature 1995;378:736–9.
  • Pace KE, Hahn HP, Pang M, Nguyen JT, Baum LG. CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death. J Immunol 2000;165:2331–4.
  • Hernandez JD, Nguyen JT, He J, Wang W, Ardman B, Green JM, . Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death. J Immunol 2006;177:5328–36.
  • Nguyen JT, Evans DP, Galvan M, Pace KE, Leitenberg D, Bui TN, . CD45 modulates galectin-1-induced T cell death: regulation by expression of core 2 O-glycans. J Immunol 2001;167:5697–707.
  • Rabinovich GA, Liu FT, Hirashima M, Anderson A. An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer. Scand J Immunol 2007;66:143–58.
  • Rabinovich GA. Apoptosis as a target for gene therapy in rheumatoid arthritis. Mem Inst Oswaldo Cruz 2000;95(Suppl 1):225–33.
  • Jiang GX, Cui YF, Zhong XY, Tai S, Liu W, Wang ZD, . Use of a cocktail regimen consisting of soluble galectin-1, rapamycin and histone deacetylase inhibitor may effectively prevent type 1 diabetes. Arch Med Res 2009;40:424–6.
  • Perone MJ, Bertera S, Shufesky WJ, Divito SJ, Montecalvo A, Mathers AR, . Suppression of autoimmune diabetes by soluble galectin-1. J Immunol 2009;182:2641–53.
  • Cedeno-Laurent F, Barthel SR, Opperman MJ, Lee DM, Clark RA, Dimitroff CJ. Development of a nascent galectin-1 chimeric molecule for studying the role of leukocyte galectin-1 ligands and immune disease modulation. J Immunol 2010;185:4659–72.
  • Saussez S, Lorfevre F, Lequeux T, Laurent G, Chantrain G, Vertongen F, . The determination of the levels of circulating galectin-1 and -3 in HNSCC patients could be used to monitor tumor progression and/or responses to therapy. Oral Oncol 2008; 44:86–93.
  • Tang CE, Tan T, Li C, Chen ZC, Ruan L, Wang HH, . Identification of galectin-1 as a novel biomarker in nasopharyngeal carcinoma by proteomic analysis. Oncol Rep 2010;24:495–500.
  • Iwamoto M, Taguchi C, Sasaguri K, Kubo KY, Horie H, Yamamoto T, . The galectin-1 level in serum as a novel marker for stress. Glycoconj J 2010;27:419–25.
  • Rabinovich GA, Daly G, Dreja H, Tailor H, Riera CM, Hirabayashi J, . Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis. J Exp Med 1999;190:385–98.
  • Neidhart M, Rethage J, Kuchen S, Kunzler P, Crowl RM, Billingham ME, . Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression. Arthritis Rheum 2000;43:2634–47.
  • Harjacek M, Diaz-Cano S, De Miguel M, Wolfe H, Maldonado CA, Rabinovich GA. Expression of galectins-1 and -3 correlates with defective mononuclear cell apoptosis in patients with juvenile idiopathic arthritis. J Rheumatol 2001;28:1914–22.
  • Neidhart M, Zaucke F, von Knoch R, Jungel A, Michel BA, Gay RE, . Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein. Ann Rheum Dis 2005;64:419–24.
  • Forsman H, Islander U, Andreasson E, Andersson A, Onnheim K, Karlstrom A, . Galectin 3 aggravates joint inflammation and destruction in antigen-induced arthritis. Arthritis Rheum 2010;63:445–54.
  • Hu CY, Chang SK, Wu CS, Tsai WI, Hsu PN. Galectin-3 gene (LGALS3) +292C allele is a genetic predisposition factor for rheumatoid arthritis in Taiwan. Clin Rheumatol 2011;30: 1227–33.
  • Li X, Zhao QY, Yuan FL. Galectin-3 in rheumatoid arthritis, a novel therapeutic target. Arthritis Rheum 2011;63:3179–80.
  • Mathews KP, Konstantinov KN, Kuwabara I, Hill PN, Hsu DK, Zuraw BL, . Evidence for IgG autoantibodies to galectin-3, a beta-galactoside-binding lectin (Mac-2, epsilon binding protein, or carbohydrate binding protein 35) in human serum. J Clin Immunol 1995;15:329–37.
  • Suk K, Hwang DY, Lee MS. Natural autoantibody to galectin-9 in normal human sera. J Clin Immunol 1999;19:158–65.
  • Jensen-Jarolim E, Neumann C, Oberhuber G, Gscheidlinger R, Neuchrist C, Reinisch W, . Anti-Galectin-3 IgG autoantibodies in patients with Crohn’s disease characterized by means of phage display peptide libraries. J Clin Immunol 2001;21:348–56.
  • Suarez-Alvarez B, Garcia Suarez MM, Arguelles ME, Sampedro A, Alvarez Marcos C, Mira E, . Circulating IgG response to stromelysin-3, collagenase-3, galectin-3 and mesothelin in patients with pharynx/larynx squamous cell carcinoma. Anticancer Res 2001;21:3677–84.
  • Lim Y, Lee DY, Lee S, Park SY, Kim J, Cho B, . Identification of autoantibodies associated with systemic lupus erythematosus. Biochem Biophys Res Commun 2002;295:119–24.
  • Rabinovich GA, Toscano MA, Ilarregui JM, Rubinstein N. Shedding light on the immunomodulatory properties of galectins: novel regulators of innate and adaptive immune responses. Glycoconj J 2004;19:565–73.
  • Pardo E, Carcamo C, Massardo L, Mezzano V, Jacobelli S, Gonzalez A . Antibodies against galectin-8 in patients with systemic lupus erythematosus. Rev Med Chil 2006;134:159–66.
  • Montiel J, Monsivais-Urenda A, Figueroa-Vega N, Moctezuma J, Burgos-Varga R, González-Amaro R, . Anti-CD43 and anti-galectin-1 autoantibodies in patients with systemic lupus erythematosus. Scand J Rheumatol 2010;39:50–7.
  • Dhirapong A, Lleo A, Leung P, Gershwin ME, Liu FT. The immunological potential of galectin-1 and -3. Autoimmun Rev 2009;8:360–3.
  • Hirabayashi J, Ubukata T, Kasai K. Purification and molecular characterization of a novel 16-kDa galectin from the nematode Caenorhabditis elegans. J Biol Chem 1996;271:2497–505.
  • Ohshima S, Kuchen S, Seemayer C A, Kyburz D, Hirt A, Klinzing S, . Galectin 3 and its binding protein in rheumatoid arthritis. Arthritis Rheum 2003;48:2788–95.
  • Dasuri K, Antonovici M, Chen K, Wong K, Standing K, Ens W, . The synovial proteome: analysis of fibroblast-like synoviocytes. Arthritis Res Ther 2004;6:R161–8.
  • Kim CW, Cho EH, Lee YJ, Kim YH, Hah YS, Kim DR. Disease-specific proteins from rheumatoid arthritis patients. J Korean Med Sci 2006;21:478–84.
  • Giordanengo L, Gea S, Barbieri G, Rabinovich GA. Anti-galectin-1 autoantibodies in human Trypanosoma cruzi infection: differential expression of this beta-galactoside-binding protein in cardiac Chagas’ disease. Clin Exp Immunol 2001;124:266–73.
  • Lutomski D, Joubert-Caron R, Lefebure C, Salama J, Belin C, Bladier D, . Anti-galectin-1 autoantibodies in serum of patients with neurological diseases. Clin Chim Acta 1997;262:131–8.
  • Romero MD, Muino JC, Bianco GA, Ferrero M, Juarez CP, Luna JD, . Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis. Invest Ophthalmol Vis Sci 2006;47:1550–6.
  • Shou J, Bull CM, Li L, Qian HR, Wei T, Luo S, . Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model. Arthritis Res Ther 2006;8:R28.
  • Lee J, Oh JM, Hwang JW, Ahn JK, Bae EK, Won J, . Expression of human TIM-3 and its correlation with disease activity in rheumatoid arthritis. Scand J Rheumatol 2011;40:334–40.

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