6
Views
12
CrossRef citations to date
0
Altmetric
Original Article

The Inhzbitory Effect of D-Penicillamine on Human Lymphocyte Cultures Stimulated by Phytohaemagglutinin, The Antagonistic Action of L-Cysteine and Synergistic Inhibition by Copper Sulphate

, &
Pages 47-56 | Published online: 12 Jul 2009

References

  • Alepa F. P., Zvaifler N. J., Sliwinski J. Immunologic effects of cyclophosphamide treatment in rheumatoid arthritis. Arthritis Rheum 1970; 13: 754
  • Binderup L., Bramm E., Amgoni‐Martelli E. D‐penicillamine and macrophages; modulation of lymphocyte transformation by concanavalin A. Scand J Immunol 1978; 7: 259
  • Chen D. M., Sabato G. D. I., Field L., Gallo A. A., Harsman S. Some immunological effects of penicillamine. Clin Exp Immunol 1977; 30: 317
  • Curtis J. E., Sharp J. T., Lipsky M. D., Hersh E. M. Immune response of patients with rheumatoid arthritis during cyclophosphamide therapy. Arthritis Rheum 1973; 16: 34
  • Denman E. J., Denman A. M., Greenwood B. M., Gall D., Heath R. B. Failure of cytotoxic drugs to suppress immune responses of patients with rheumatoid arthritis. Ann Rheum Dis 1970; 29: 220
  • Fauci A. S. Glucocorticosteroid therapy: Mechanisms of action and clinical considerations. Ann Intern Med 1976; 84: 304
  • Green C. J., Allison A. C. Extensive prolongation of rabbit kidney allograft survival after short‐term cyclosporin‐A treatment. Lancet 1978; 1: 1182
  • Jellum E., Aaseth J., Munthe E. Is the mechanism of action during treatment of rheumatoid arthritis with penicillamine and gold thiomalate the same?. Penicillamine at 21, its place in therapeutics now, W. H. Lyle, R. L. Kleinman. 1977; 70: 136, Proc Royal Society of Medicine, (Suppl. 3)
  • Kendall P. A., Hutchins D. The effect of thiol compounds on lymphocytes stimulated in culture. Immunology 1978; 35: 189
  • Lipsky P. F., Ziff M. Inhibition of antigen‐ and mitogen‐induced human lymphocyte proliferation by gold compounds. J Clin Invest 1977; 59: 455
  • Lipsky P. E., Ziff M. The effect of D‐penicillamine on mitogen‐induced human lymphocyte proliferation; synergistic inhibition by D‐penicillamine and copper salts. J Immunol 1978; 120: 1006
  • Maini R. N., Roffe Lindsay. D‐penicillamine and lymphocyte function in rheumatoid arthritis; the inhibitory and augmenting effects of o‐penicillamine in vitro on phytohaemagglutin‐induced lymphocyte transformation. Penicillamine Research in Rheumatoid Disease, E. Munthe. Fabritius and Sønner, Oslo 1976; 172–182
  • Maini R. N. Immunopathological mechanisms in rheumatoid arthritis at the dual interface of the synovial membrane: the joint cavity and the pannus. Rheumatol Rehab 1979, (in press)
  • Merryman P., Jaffe I. A. Effect of penicillamine on the proliferative response of human lymphocytes. Proc Soc Exp Biol Med 1978; 157: 155
  • Penny R. Effects of anti‐rheumatic drugs on immunological parameters. Aust NZ J Med 1978; 8(Suppl. 1)109
  • Roath S., Wills R. The effects of penicillamine on lymphocytes in culture. Postgrad Med J 1974; 50(Suppl. 2)56
  • Ryzewski J. Effects of cysteine of the evoking and course of post‐adjuvant polyarthritis in rats. Rheumatologia 1966; 4: 227
  • Sorenson J. R. J. Copper chelates as possible active forms of anti‐arthritic agents. J Med Chem 1976; 19: 135

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.