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Research Papers

An estimation of the number of cells in the human body

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Pages 463-471 | Received 26 Sep 2012, Accepted 09 May 2013, Published online: 05 Jul 2013

References

  • Adler CP, Costabel U. 1975. Cell number in human heart in atrophy, hypertrophy, and under the influence of cytostatics. Recent Adv Stud Cardiac Struct Metab 6:343–355
  • Albanes D, Winick M. 1988. Are cell number and cell proliferation risk factors for cancer? J Natl Cancer Inst 80:772–774
  • Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. 2002. Molecular biology of the cell. 4th ed. New York: Garland Science
  • Asimov I. 1963. The human body: its structure and operation. Boston, MA: Houghton Mifflin
  • Avram MM, Avram AS, James WD. 2007. Subcutaneous fat in normal and diseased states 3. Adipogenesis: from stem cell to fat cell. J Am Acad Dermatol 56:472–492
  • Baldock R, Burger A. 2005. Anatomical ontologies: names and places in biology. Genome Biol 6:108
  • Barker DJ. 1995. Intrauterine programming of adult disease. Mol Med Today 1:418–423
  • Baron S. 1996. Medical microbiology. Galveston, TX: University of Texas Medical Branch
  • Baserga R. 1985. The Biology of cell reproduction. Cambridge: Harvard University Press
  • Baysal O, Baysal T, Alkan A, Altay Z, Yologlu S. 2004. Comparison of MRI graded cartilage and MRI based volume measurement in knee osteoarthritis. Swiss Med Wkly 134:283–288
  • Bergman RA, Afifi AK, Jew JJ, Reimann PC. 2004. Anatomy atlases. Atlas of microscopic anatomy: section 10 – Digestive System. Available online at: http://www.anatomyatlases.org/MicroscopicAnatomy/Section10/Plate10220.shtml (accessed May 2012)
  • Bocian-Sobkowska J, Malendowicz LK, Woźniak W. 1997. Comparative stereological studies on zonation and cellular composition of adrenal glands of normal and anencephalic human fetuses. II. Cellular composition of the gland. Histol Histopathol 12:391–399
  • Boncinelli E. 2007. Prima lezione di Biologia. Roma: Laterza
  • Borley NR. 2005a. Gallbladder and biliary tree. In: Gray H, Standring S, editors. Gray’s Anatomy: the anatomical basis of clinical practice. 39th ed. Philadelphia, PA: Elsevier Churchill Livingston. p 1227–1230
  • Borley NR. 2005b. Liver. In: Gray H, Standring S, editors. Gray’s Anatomy: the anatomical basis of clinical practice. 39th ed. Philadelphia, PA: Elsevier Churchill Livingston. p 1213–1226
  • Borley NR. 2005c. Jejunum and ileum. In: Gray H, Standring S, editors. Gray’s Anatomy: the anatomical basis of clinical practice. 39th ed. Philadelphia, PA: Elsevier Churchill Livingston. p 1167–1172
  • Borley NR. 2005d. Supradrenal (adrenal) gland. In: Gray H, Standring S, editors. Gray’s Anatomy: the anatomical basis of clinical practice. 39th ed. Philadelphia, PA: Elsevier Churchill Livingston. p 1245–1249
  • Boulais N, Misery L. 2007. Merkel cells. J Am Acad Dermatol 57:147–165
  • Brown TA. 2002. Genomes. Oxford: Wiley-Liss
  • Bry L, Kelly K, Sethi RJ. 1995. MadSci Network, anatomy. Available online at: http://www.madsci.org/posts/archives/2001-02/981770369.An.r.html (accessed Feb 2011)
  • Castelain M, Grimaldi C, Harris AG, Caroli-Bosc FX, Hastier P, Dumas R, Delmont JP. 1993. Relationship between cystic duct diameter and the presence of cholelithiasis. Dig Dis Sci 38:2220–2224
  • Cattaneo L, Baratta L. 1989. Stereogrammi di anatomia dell'uomo: aspetti istologici e molecolari, Vol. 3. Origgio: Ciba-Geigy Edizioni
  • Claybourne A. 2006. The human body. London: Evans Brothers
  • Conlon I, Raff M. 1999. Size control in animal development. Cell 96:235–244
  • Cooper GM. 2000. The Cell: a molecular approach. Sunderland: Sinauer Associates
  • Cox AJ. 1952. Stomach size and its relation to chronic peptic ulcer. AMA Arch Pathol 54:407–422
  • Crapo JD, Barry BE, Gehr P, Bachofen M, Weibel ER. 1982. Cell number and cell characteristics of the normal human lung. Am Rev Respir Dis 125:740–745
  • Depaepe V, Suarez-Gonzalez N, Dufour A, Passante L, Gorski JA, Jones KR, Ledent C, Vanderhaeghen P. 2005. Ephrin signalling controls brain size by regulating apoptosis of neural progenitors. Nature 435:1244–1250
  • Dong Z, Wei H, Sun R, Tian Z. 2007. The roles of innate immune cells in liver injury and regeneration. Cell Mol Immunol 4:241–252
  • Ehrenfeucht A, Harju T, Petre I, Prescott DM, Rozenberg G. 2004. Computation in living cells: gene assembly in ciliates. New York: Springer
  • E-Notes Study Matter. 2011. How many cells are in the human body? Available online at: http://www.enotes.com/science-fact-finder/human-body/how-many-cells-human-body (accessed Feb 2011)
  • Félétou M. 2011. The Endothelium, part 1: multiple functions of the endothelial cells. Focus on endothelium-derived vasoactive mediators. San Rafael, CA: Morgan & Claypool Life Sciences
  • Frank SA. 2007. Dynamics of cancer: incidence, inheritance, and evolution. Princeton, NJ: Princeton University Press
  • Freitas RA. 1999. Nanomedicine, Vol 1: basic capabilities. Austin, TX: Landes Bioscience
  • Ganong WF. 2006. Fisiologia Medica. Padova: Piccin
  • Geerts A. 2001. History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells. Semin Liver Dis 21:311–335
  • Genest J, Kuchel O, Hamet P, Cantin M, editors. 1983. Hypertension. New York: McGraw-Hill
  • Geraghty EM, Boone JM, McGahan JP, Jain K. 2004. Normal organ volume assessment from abdominal CT. Abdom Imaging 29:482–490
  • Germann WJ, Stanfield CL. 2006. Fisiologia. Napoli: EdiSES
  • Gibson WG, Peng TC, Croker BP. 1982. Age-associated C-cell hyperplasia in the human thyroid. Am J Pathol 106:388–393
  • Gomer RH. 2001. Not being the wrong size. Nat Rev Mol Cell Biol 2:48–54
  • Goodsell DS. 2010. The machinery of Life. New York: Springer
  • Griffiths AJF, Gelbart WM, Miller JH, Lewontin RC. 1999. Modern genetic analysis. New York: WH Freeman
  • Griffiths AJF, Miller JH, Suzuki DT, Lewontin RC, Gelbart WM. 2000. An introduction to genetic analysis. New York: WH Freeman
  • Grimbaldeston MA, Skov L, Baadsgaard O, Skov BG, Marshman G, Finlay-Jones JJ, Hart PH. 2000. Communications: high dermal mast cell prevalence is a predisposing factor for basal cell carcinoma in humans. J Invest Dermatol 115:317–320
  • Grizzi F, Chiriva-Internati M. 2005. The complexity of anatomical systems. Theor Biol Med Model 2:26--34
  • Guyton AC, Hall JE. 2002. Fisiologia medica II. Napoli: EdiSES
  • Hafen E, Stocker H. 2003. How are the sizes of cells, organs, and bodies controlled? PLoS Biol 1:319--323. Article ID e86
  • Hanslmeier A. 2009. Habitability and cosmic catastrophes. Berlin and Heidelberg: Springer-Verlag and GmbH & Co K
  • Harrison WJ. 1962. The total cellularity of the bone marrow in man. J Clin Pathol 15:254–259
  • Hayamizu TF, Mangan M, Corradi JP, Kadin JA, Ringwald M. 2005. The Adult Mouse Anatomical Dictionary: a tool for annotating and integrating data. Genome Biol 6(3):R29
  • Herculano-Houzel S. 2011. Not all brains are made the same: new views on brain scaling in evolution. Brain Behav Evol 78:22–36
  • Hinescu ME, Ardeleanu C, Gherghiceanu M, Popescu LM. 2007. Interstitial Cajal-like cells in human gallbladder. J Mol Histol 38:275–284
  • Hoath SB, Leahy DG. 2003. The organization of human epidermis: functional epidermal units and phi proportionality. J Invest Dermatol 121:1440–1446
  • Hollenhorst MI, Richter K, Fronius M. 2011. Ion transport by pulmonary epithelia. J Biomed Biotechnol 2011:174306
  • Hood L, Galas D. 2003. The digital code of DNA. Nature 421:444–448
  • Howell WH, Fulton JF. 1949. A textbook of physiology. Philadelphia, PA: WB Saunders
  • Hui XG, Akahira J, Suzuki T, Nio M, Nakamura Y, Suzuki H, Rainey WE, Sasano H. 2009. Development of the human adrenal zona reticularis: morphometricand immunohistochemical studies from birth to adolescence. J Endocrinol 203:241–252
  • Imamura H, Kawasaki S, Shiga J, Bandai Y, Sanjo K, Idezuki Y. 1991. Quantitative evaluation of parenchymal liver cell volume and total hepatocyte number in cirrhotic patients. Hepatology 14:448–453
  • Irving PH. 2007. The physics of the human body: a physical view of physiology biological and medical physics, biomedical engineering. New York: Springer
  • Johnson D, Shah P, Collins P, Wigley C. 2005. Hearth and great vessels. Nervous system. In: Gray H, Standring S, editors. Gray’s Anatomy: the anatomical basis of clinical practice. 39th ed. Philadelphia, PA: Elsevier Churchill Livingston. p 995–1028
  • Kandel ER, Schwartz JH, Jessel TM. 2000. Principles of neural science. 4th ed. New York: McGraw-Hill, Health Professions Division
  • Khalil MM, Islam MN, Khalil MM, Khan ZI, Adiluzzaman AA, Hossain MI. 2005. Topography and morphometry of the common bile duct and major duodenal papilla of man and principal domesticated animals. Mymensingh Med J 14:6–12
  • Kothari LK, Patni MK, Jain ML. 1978. The total Leydig cell volume of the testis in some common mammals. Andrologia 10:218–222
  • Lackland DT. 2005. Mechanisms and fetal origins of kidney disease. J Am Soc Nephrol 16:2531–2532
  • Landing BH, Shankle WR. 1995. Considerations of quantitative data on organ sizes and cell numbers and sizes in Down syndrome. Prog Clin Biol Res 393:177–191
  • Leevers SJ, McNeill H. 2005. Controlling the size of organs and organisms. Curr Opin Cell Biol 17:604–660
  • Lodish H, Berk A, Zipursky LS, Matsudaira P, Baltimore D, Darnell J. 2000. Molecular cell biology. New York: WH Freeman
  • Loe MJ, Edwards WD. 2004. A light-hearted look at a lion-hearted organ or, a perspective from three standard deviations beyond the norm. Part 1 of 2 parts. Cardiovasc Pathol 13:282–292
  • Makarieva AM, Gorshkov VG, Li BL, Chown SL, Reich PB, Gavrilov VM. 2008. Mean mass-specific metabolic rates are strikingly similar across life's major domains: evidence for life's metabolic optimum. Proc Natl Acad Sci USA 105:16994–16999
  • Malluche HH, Faugere MC. 1986. Atlas of mineralized bone histology. New York: Karger
  • Martini F. 1994. Fondamenti di anatomia e fisiologia. Napoli: EdiSES
  • Mazzarello P. 1999. A unifying concept: the history of cell theory. Nat Cell Biol 1:E13–15
  • Meier JJ, Butler AE, Saisho Y, Monchamp T, Galasso R, Bhushan A, Rizza RA, Butler PC. 2008. β-cell replication is the primary mechanism subserving the postnatal expansion of β-cell mass in humans. Diabetes 57:1584–1594
  • Mercer RR, Russell ML, Roggli VL, Crapo JD. 1994. Cell number and distribution in human and rat airways. Am J Respir Cell Mol Biol 10:613–624
  • Millington SA, Grabner M, Wozelka R, Anderson DD, Hurwitz SR, Crandall JR. 2007. Quantification of ankle articular cartilage topography and thickness using a high resolution stereophotography system. Osteoarthr Cartilage 15:205–211
  • Moore P. 2003. Controlling how many cells make a fly. J Biol 2:16
  • Morgan JE, Partridge TA. 2003. Muscle satellite cells. Int J Biochem Cell Biol 35:1151–1156
  • Mountcastle VB, editor. 1980. Medical physiology. St Louis, Toronto; London: The C.V. Mosby Co
  • Nagao N, Tamaki K, Kuchiki T, Nagao M. 1995. A new gas dilution method for measuring body volume. Br J Sports Med 29:134–138
  • Naik SR, Bajaj SC, Goyal RK, Gupta DN, Chuttani HK. 1971. Parietal cell mass in healthy human stomach. Gastroenterology 61:682–685
  • National Institutes of Health. 2007. Biological Sciences Curriculum Study. NIH curriculum supplement series internet. Bethesda, MD: National Institutes of Health US
  • New Encyclopaedia Britannica. 1976. New encyclopaedia britannica, volume 6. Tucson, AZ: William Benton Pub
  • Pisania A, Weir GC, O'Neil JJ, Omer A, Tchipashvili V, Lei J, Colton CK, Bonner-Weir S. 2010. Quantitative analysis of cell composition and purity of human pancreatic islet preparations. Lab Invest 90:1661–1675
  • Pittman RN. 2011. Regulation of tissue oxygenation. San Rafael, CA: Morgan & Claypool Life Sciences
  • Portincasa P, Di Ciaula A, vanBerge-Henegouwen GP. 2004. Smooth muscle function and dysfunction in gallbladder disease. Curr Gastroenterol Rep 6:151–162
  • Prothero JW. 1982. Organ scaling in mammals: the liver. Comp Biochem Physiol A Comp Physiol 71:567–577
  • Purves D, Augustine GJ, Fitzpatrick D, Katz LC, LaMantia AS, McNamara JO, Williams SM. 2001. Neuroscience. Sunderland: Sinauer Associates
  • Randolph RK, Simon M. 1998. Dermal fibroblasts actively metabolize retinoic acid but not retinol. J Invest Dermatol 111:478–484
  • Ratner BD, Bankman I. 2009. Biomedical engineering desk reference. Philadelphia, PA: Elsevier Academic Press
  • Rhoodes R, Planzer R. 2004. Fisiologia generale e umana. Padova: Piccin
  • Roisin-Bouffay C, Gomer RH. 2004. How to reach the right size? Med Sci Paris 20:219–224
  • Royston CM, Polak J, Bloom SR, Cooke WM, Russell RC, Pearse AG, Spencer J, Welbourn RB, Baron JH. 1978. G cell population of the gastric antrum, plasma gastrin, and gastric acid secretion in patients with and without duodenal ulcer. Gut 19:689–698
  • Salans LB, Cushman SW, Weismann RE. 1973. Studies of human adipose tissue. Adipose cell size and number in nonobese and obese patients. J Clin Invest 52:929–941
  • Samaras T, Bartke A, Rollo CD. 2007. Human body size and the laws of scaling: physiological, performance, growth, longevity and ecological ramifications. New York: Nova Science Publishers
  • Seale RU. 1959. The weight of the dry fat-free skeleton of American whites and Negroes. Am J Phys Anthropol 17:37–48
  • Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, Bergmann O, Blomqvist L, Hoffstedt J, Näslund E, Britton T, Concha H, Hassan M, Rydén M, Frisén J, Arner P. 2008. Dynamics of fat cell turnover in humans. Nature 453:783–787
  • Standring S, Wigley C, Collins P, Williams A. 2005. Nervous system. In: Gray H, Standring S, editors. Gray’s Anatomy: the anatomical basis of clinical practice. 39th ed. Philadelphia, PA: Elsevier Churchill Livingston. p 443–468
  • Staton BA, Mixon RL, Dharia S, Brissie RM, Parker CR, Jr. 2004. Is reduced cell size the mechanism for shrinkage of the adrenal zona reticularis in aging? Endocr Res 30:529–534
  • Stecca B, Ruiz i Altaba A. 2009. A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers. EMBO J 28:663–676
  • Steffes MW, Schmidt D, McCrery R, Basgen JM, International Diabetic Nephropathy Study Group. 2001. Glomerular cell number in normal subjects and in type 1 diabetic patients. Kidney Int 59:2104–2113
  • Stock W, Hoffman R. 2000. White blood cells 1: non-malignant disorders. Lancet 355:1351–1357
  • Stockwell RA. 1971. The interrelationship of cell density and cartilage thickness in mammalian articular cartilage. J Anat 109:411–421
  • Stone KC, Mercer RR, Gehr P, Stockstill B, Crapo JD. 1992. Allometric relationship of cell numbers and size in the mammalian lung. Am J Respir Cell Mol Biol 6:235–243
  • Strachan T, Read AP. 1999. Human molecular genetics. New York: Wiley-Liss
  • Su TT, O'Farrell PH. 1998. Size control: cell proliferation does not equal growth. Curr Biol 8:R687–689
  • Swenson RA. 2000. More than meets the eye: fascinating glimpses of god's power and design. Colorado Springs, CO: NavPress
  • Szathmary E, Jordan F, Pal C. 2001. Can genes explain biological complexity? Science 292:1315–1316
  • Tassani S, Ohman C, Baruffaldi F, Baleani M, Viceconti M. 2011. Volume to density relation in adult human bone tissue. J Biomech 44:103–108
  • Teodori U. 1987. Trattato di Medicina Interna. Roma: Società Editrice Universo
  • Testut L, Latarjet A. 1959. Trattato di anatomia umana. Torino: Unione Tipografica Editrice Torinese
  • The Carnegie Library of Pittsburgh. 2011. The handy science answer book. Canton: Visible Ink Press
  • Tønnesen H, Hejberg L, Frobenius S, Andersen J. 1986. Erythrocyte mean cell volume-correlation to drinking pattern in heavy alcoholics. Acta Med Scand 219:515–518
  • Torres-Lagares D, Tulasne JF, Pouget C, Llorens A, Saffar JL, Lesclous P. 2010. Structure and remodelling of the human parietal bone: an age and gender histomorphometric study. J Craniomaxillofac Surg 38:325–330
  • Trotter M. 1954. A preliminary study of estimation of weight of the skeleton. Am J Phys Anthropol 12:537–551
  • Trumpp A, Refaeli Y, Oskarsson T, Gasser S, Martin GR, Bishop JM. 2001. C-Myc regulates mammalian body size by controlling cell number but not cell size. Nature 414:768–773
  • Van Amerongen C, Trad C, Van Amerongen A. 1979. The Way Things work book of the body. New York: Simon & Schuster
  • Vanwanseele B, Eckstein F, Hadwighorst H, Knecht H, Spaepen A, Stüssi E. 2004. In vivo precision of quantitative shoulder cartilage measurements, and changes after spinal cord injury. Magn Reson Med 51:1026–1030
  • Weiss L, Greep RO. 1981. Istologia. Bologna: Zanichelli
  • Williams RW, Herrup K. 1988. The control of neuron number. Annu Rev Neurosci 11:423–453
  • Wolf M, Scarbrough M. 2012. The JayDoc HistoWeb. GI system, 39, Gall Bladder. Available online at: http://www.kumc.edu/instruction/medicine/anatomy/histoweb/gitract/gi39.htm (accessed May 2012)
  • Yang X, Xu T. 2011. Molecular mechanism of size control in development and human diseases. Cell Res 21:715–729
  • Young B, Heath JW. 2001. Wheater(‘s) Istologia e anatomia microscopica. Milano: Casa Editrice Ambrosiana
  • Zweiger G. 2002. Genomica. Columbus, OH: Mc-Graw Hill

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