Effect of mitochondrial, APOE. ACE and NOS3 gene polymorphisms on cardiovascular risk factors among the Vaqueiros de Alzada, a Northern Spain human isolate

References

• Alfonso-Sanchez MA, Cardoso S, Martinez-Bouzas C, Pena JA, Herrera RJ, Castro A, Fernández-Fernández I, De Pancorbo MM. 2008. Mitochondrial DNA haplogroup diversity in Basques: a reassessment based on HVI and HVII polymorphisms. Am J Hum Biol 20:154–164
   PubMed Web of Science ®Google Scholar
• Alvarez R, Reguero JR, Batalla A, Iglesias-Cubero G, Cortina A, Alvarez V, Coto E. 1998. Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphisms: association with early coronary disease. Cardiovasc Res 40:375–379
   PubMed Web of Science ®Google Scholar
• Álvarez R, González P, Batalla A, Reguero JR, Iglesias-Cubero G, Hevia S, Cortina A, et al. 2001. Association between the NOS3 (-786 T/C) and the ACE (I/D) DNA genotypes and early coronary artery disease. Nitric Oxide 5:343–348
   PubMedGoogle Scholar
• Alvarez-Iglesias V, Mosquera-Miguel A, Cerezo M, Quintans B, Zarrabeitia MT, Cusco I, Lareu MV, et al. 2009. New population and phylogenetic features of the internal variation within mitochondrial DNA macro-haplogroup R0. PLoS One 4:e5112 . doi: 10.1371/journal.pone.0005112
   PubMed Web of Science ®Google Scholar
• Batalla A, Alvarez R, Reguero JR, Hevia S, Iglesias-Cubero G, Alvarez V, Cortina A, et al. 2000. Synergistic effect between apolipoprotein E and angiotensin gene polymorphisms in the risk for early myocardial infarction. Clin Chem 46:1910–1915
   PubMed Web of Science ®Google Scholar
• Cardoso S, Alfonso-Sánchez MA, Valverde L, Odriozola A, Pérez-Miranda AM, Peña JA, de Pancorbo MM. 2011. The maternal legacy of Basques in northern navarre: new insights into the mitochondrial DNA diversity of the Franco-Cantabrian area. Am J Phys Anthropol 145:480–488
   PubMedGoogle Scholar
• Castro MG, Huerta C, Reguero JR, Soto MI, Doménech E, Alvarez V, Gómez-Zaera M, et al. 2006. Mitochondrial DNA haplogroups in Spanish patients with hypertrophic cardiomyopathy. Int J Cardiol 112:202–206
   PubMed Web of Science ®Google Scholar
• Cátedra Tomás M. 1989. La vida y el mundo de los vaqueiros de alzada. Madrid, Spain: Centro de Investigaciones Sociológicas (Spanish)
   Google Scholar
• Corte-Real HB, Macaulay VA, Richards MB, Hariti G, Issad MS, Cambon-Thomsen A, Papiha S, et al. 1996. Genetic diversity in the Iberian Peninsula determined from mitochondrial sequence analysis. Ann Hum Genet 60:331–350
   PubMed Web of Science ®Google Scholar
• Coto E, Gómez J, Alonso B, Corao AI, Díaz M, Menéndez M, Martínez C, Calatayud MT, Morís G, Alvarez V. 2011. Late-onset Alzheimer's disease is associated with mitochondrial DNA 7028C/haplogroup H and D310 poly-C tract heteroplasmy. Neurogenetics 12:345--346
   Google Scholar
• García O, Fregel R, Larruga JM, Álvarez V, Yurrebaso I, Cabrera VM, González AM. 2011. Using mitochondrial DNA to test the hypothesis of a European post-glacial human recolonization from the Franco-Cantabrian refuge. Heredity 106:37–45
   PubMed Web of Science ®Google Scholar
• García Martinez A. 2009. Los vaqueiros de alzada de Asturias. Oviedo, Spain: KRK Ediciones (Spanish)
   Google Scholar
• Gómez P. 2013. Los asturianos, los vaqueiros de alzada y el mito de la raza. Oviedo, Spain: Servicio de Publicaciones de la Universidad de Oviedo (Spanish)
   Google Scholar
• Huyghe JR, Fransen E, Hannula S, Van Laer L, Van Eyken E, Mäki-Torkko E, Aikio P, et al. 2011. A genome-wide analysis of population structure in the Finnish Saami with implications for genetic association studies. Eur J Hum Genet 19:347–352
   PubMedGoogle Scholar
• Loogvali EL, Roostalu U, Malyarchuk BA, Derenko MV, Kivisild T, Metspalu E, Tambets K, et al. 2004. Disuniting uniformity: a pied cladistic canvas of mtDNA haplogroup H in Eurasia. Mol Biol Evol 21:2012–2021
   PubMed Web of Science ®Google Scholar
• Maca-Meyer N, Sánchez-Velasco P, Flores C, Larruga JM, González AM, Oterino A, Leyva-Cobián F. 2003. Y chromosome and mitochondrial DNA characterization of Pasiegos, a human isolate from Cantabria (Spain). Ann Hum Genet 67:329–339
   PubMed Web of Science ®Google Scholar
• Palacín M, Alvarez V, Martín M, Díaz M, Corao AI, Alonso B, Díaz-Molina B, et al. 2011. Mitochondrial DNA and TFAM gene variation in early-onset myocardial infarction: evidence for an association to haplogroup H. Mitochondrion 11:176–181
   PubMed Web of Science ®Google Scholar
• Peltonen L, Paloti A, Lange K. 2000. Use of population isolates for mapping complex traits. Nature Rev Genet 1:182–190
   PubMed Web of Science ®Google Scholar
• Pereira L, Richards M, Goios A, Alonso A, Albarran C, Garcia O, Behar DM, et al. 2005. High-resolution mtDNA evidence for the lateglacial resettlement of Europe from an Iberian refugium. Genome Res 15:19–24
   PubMed Web of Science ®Google Scholar
• Roostalu U, Kutuev I, Loogvali EL, Metspalu E, Tambets K, Reidla M, Khusnutdinova EK, et al. 2007. Origin and expansion of haplogroup H, the dominant human mitochondrial DNA lineage in West Eurasia: the Near Eastern and Caucasian perspective. Mol Biol Evol 24:436–448
   PubMed Web of Science ®Google Scholar
• Ruiz-Pesini E, Mishmar D, Brandon M, Procaccio V, Wallace DC. 2004. Effects of purifying and adaptive selection on regional variation in human mtDNA. Science 303:223–226
   PubMed Web of Science ®Google Scholar
• Torroni A, Bandelt HJ, D'Urbano L, Lahermo P, Moral P, Sellitto D, Rengo C, et al. 1998. mtDNA analysis reveals a major late Paleolithic population expansion from southwestern to northeastern Europe. Am J Hum Genet 62:1137–1152
   PubMed Web of Science ®Google Scholar
• Torroni A, Bandelt HJ, Macaulay V, Richards M, Cruciani F, Rengo C, Martinez-Cabrera V, et al. 2001. A signal, from human mtDNA, of postglacial recolonization in Europe. Am J Hum Genet 69:844–852
   PubMed Web of Science ®Google Scholar
• Torroni A, Huoponen K, Francalacci P, Petrozzi M, Morelli L, Scozzari R, Obinu D, et al. 1996. Classification of European mtDNAs from an analysis of three European populations. Genetics 144:1835–1850
   PubMed Web of Science ®Google Scholar
• Wenham PR, Price WH, Blundell G. 1991. Apolipoprotein E genotyping by one-stage PCR. Lancet 337:1158–1159
   PubMed Web of Science ®Google Scholar