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Review Article

Role of enterohepatic recirculation in drug disposition: cooperation and complications

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Pages 281-327 | Received 17 Sep 2015, Accepted 19 Feb 2016, Published online: 18 Mar 2016

References

  • Abou-El-Makarem MM, Millburn P, Smith RL, Williams RT. (1967). Biliary excretion in foreign compounds. Species difference in biliary excretion. Biochem J 105:1289–1293.
  • Abshagen U, Von Grodzicki U, Hirschberger U, Rennekamp H. (1977). Effect of entekohepatic circulation on the pharmacokinetics of spironolactone in man. Naunyn Schmiedebergs Arch Pharmacol 300:281–287.
  • Abu-Hayyeh S, Papacleovoulou G, Williamson C. (2013). Nuclear receptors, bile acids and cholesterol homeostasis series – Bile acids and pregnancy. Mol Cell Endocrinol 368:120–128.
  • Adedoyin A, Arns PA, Richards WO, et al. (1998). Selective effect of liver disease on the activities of specific metabolizing enzymes: Investigation of cytochromes P450 2C19 and 2D6. Clin Pharmacol Ther 64:8–17.
  • Adkin DA, Davis SS, Sparrow RA, et al. (1995). The effect of different concentrations of mannitol in solution on small intestinal transit: Implications for drug absorption. Pharm Res 12:393–396.
  • Adlercreutz H, Martin F. (1980). Biliary excretion and intestinal metabolism of progesterone and estrogens in man. J Steroid Biochem 13:231–244.
  • Adlercreutz H, Martin F, Jarvenpaa P, Fotsis T. (1979). Steroid absorption and enterohepatic recycling. Contraception 20:201–223.
  • Akita H, Suzuki H, Ito K, et al. (2001). Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump. Biochim Biophys Acta 1511:7–16.
  • Aldini R, Roda A, Labate AM, et al. (1982). Hepatic bile acid uptake: Effect of conjugation, hydroxyl and keto groups, and albumin binding. J Lipid Res 23:1167–1173.
  • Aldini R, Roda A, Simoni P, et al. (1989). Uptake of bile acids by perfused rat liver: Evidence of a structure-activity relationship. Hepatology 10:840–845.
  • Andrade RJ, Lopez-Ortega S, Lopez-Vega MC, et al. (2008). Idiosyncratic drug hepatotoxicity: A 2008 update. Expert Rev Clin Pharmacol 1:261–276.
  • Annaert PP, Turncliff RZ, Booth CL, et al. (2001). P-glycoprotein-mediated in vitro biliary excretion in sandwich-cultured rat hepatocytes. Drug Metab Dispos 29:1277–1283.
  • Araujo RG, Casella Filho A, Chagas AC. (2005). Ezetimibe – Pharmacokinetics and therapeutics. Arq Bras Cardiol 85:20–24.
  • Arboleda RN, Schneider BG, Bravo LE, et al. (2013). Use of the noninvasive entero-test in the detection of Helicobacter pylori in children in an endemic area in Colombia. J Pediatr Gastroenterol Nutr 57:192–196.
  • Arbuck SG, Douglass HO, Crom WR, et al. (1986). Etoposide pharmacokinetics in patients with normal and abnormal organ function. J Clin Oncol 4:1690–1695.
  • Atcheson BA, Taylor PJ, Mudge DW, et al. (2005). Mycophenolic acid pharmacokinetics and related outcomes early after renal transplant. Br J Clin Pharmacol 59:271–280.
  • Aw MM, Brown NW, Itsuka T, et al. (2003). Mycophenolic acid pharmacokinetics in pediatric liver transplant recipients. Liver Transpl 9:383–388.
  • Back DJ, Bates M, Breckenridge AM, et al. (1981a). The pharmacokinetics of levonorgestrel and ethynylestradiol in women – Studies with Ovran and Ovranette. Contraception 23:229–239.
  • Back DJ, Breckenridge AM, Challiner M, et al. (1978). The effect of antibiotics on the enterohepatic circulation of ethinylestradiol and norethisterone in the rat. J Steroid Biochem 9:527–531.
  • Back DJ, Breckenridge AM, Crawford FE, et al. (1980). Reduction of the enterohepatic circulation of norethisterone by antibiotics in the rat: Correlation with changes in the gut flora. J Steroid Biochem 13:95–100.
  • Back DJ, Breckenridge AM, Crawford FE, et al. (1981b). The pharmacokinetics of oestrone sulphate in the rat. J Steroid Biochem 14:1045–1047.
  • Back DJ, Breckenridge AM, Maciver M, et al. (1982). The effects of ampicillin on oral contraceptive steroids in women. Br J Clin Pharmacol 14:43–48.
  • Back DJ, Grimmer SF, Orme ML, et al. (1988). Evaluation of Committee on Safety of Medicines yellow card reports on oral contraceptive-drug interactions with anticonvulsants and antibiotics. Br J Clin Pharmacol 25:527–532.
  • Balabaud C, Saric J, Gonzalez P, Delphy C. (1981). Bile collection in free moving rats. Lab Anim Sci 31:273–275.
  • Barton HA, Lai Y, Goosen TC, et al. (2013). Model-based approaches to predict drug–drug interactions associated with hepatic uptake transporters: Preclinical, clinical and beyond. Expert Opin Drug Metab Toxicol 9:459–472.
  • Barza M, Weinstein L. (1976). Pharmacokinetics of the penicillins in man. Clin Pharmacokinet 1:297–308.
  • Beaufort TM, Proost JH, Maring J, et al. (2001). Effect of hypothermia on the hepatic uptake and biliary excretion of vecuronium in the isolated perfused rat liver. Anesthesiology 94:270–279.
  • Bellward GD, Warren PM, Howald W, et al. (1977). Methadone maintenance: Effect of urinary pH on renal clearance in chronic high and low doses. Clin Pharmacol Ther 22:92–99.
  • Berg AK, Mandrekar SJ, Ziegler KL, et al. (2013). Population pharmacokinetic model for cancer chemoprevention with sulindac in healthy subjects. J Clin Pharmacol 53:403–412.
  • Bergman E, Forsell P, Tevell A, et al. (2006). Biliary secretion of rosuvastatin and bile acids in humans during the absorption phase. Eur J Pharm Sci 29:205–214.
  • Bergman E, Hedeland M, Bondesson U, Lennernas H. (2010). The effect of acute administration of rifampicin and imatinib on the enterohepatic transport of rosuvastatin in vivo. Xenobiotica 40:558–568.
  • Bergman E, Lundahl A, Fridblom P, et al. (2009). Enterohepatic disposition of rosuvastatin in pigs and the impact of concomitant dosing with cyclosporine and gemfibrozil. Drug Metab Dispos 37:2349–2358.
  • Berry MN, Grivell AR, Grivell M, Phillips JW. (1997). Isolated hepatocytes-past, present and future. Cell Biol Toxicol 13:223–233.
  • Biehl ML, Prelusky DB, Koritz GD, et al. (1993). Biliary excretion and enterohepatic cycling of zearalenone in immature pigs. Toxicol Appl Pharmacol 121:152–159.
  • Blaschke TF, Rubin PC. (1979). Hepatic first-pass metabolism in liver disease. Clin Pharmacokinet 4:423–432.
  • Blom A, Scaf AH, Meijer DK. (1982). Hepatic drug transport in the rat. A comparison between isolated hepatocytes, the isolated perfused liver and the liver in vivo. Biochem Pharmacol 31:1553–1565.
  • Bohme M, Buchler M, Muller M, Keppler D. (1993). Differential inhibition by cyclosporins of primary-active ATP-dependent transporters in the hepatocyte canalicular membrane. FEBS Lett 333:193–196.
  • Bohme M, Jedlitschky G, Leier I, et al. (1994). ATP-dependent export pumps and their inhibition by cyclosporins. Adv Enzyme Regul 34:371–380.
  • Booth CL, Brouwer KR, Brouwer KL. (1998). Effect of multidrug resistance modulators on the hepatobiliary disposition of doxorubicin in the isolated perfused rat liver. Cancer Res 58:3641–3648.
  • Borst P, Elferink RO. (2002). Mammalian ABC transporters in health and disease. Annu Rev Biochem 71:537–592.
  • Bosma PJ, Chowdhury JR, Bakker C, et al. (1995). The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med 333:1171–1175.
  • Boyer JL. (1986). Mechanisms of bile secretion and hepatic transport. In: Andreoli TE, Fanestil DD, Hoffman JF, eds. Physiology of membrane disorders. 2nd ed. New York: Plenum Medical Book Company, 609–636.
  • Boyer JL. (2013). Bile formation and secretion. Compr Physiol 3:1035–1078.
  • Bredberg U, Paalzow L. (1990). Pharmacokinetics of methylergometrine in the rat: Evidence for enterohepatic recirculation by a linked-rat model. Pharm Res 7:14–20.
  • Brodersen R. (1979). Bilirubin. Solubility and interaction with albumin and phospholipid. J Biol Chem 254:2364–2369.
  • Brogard JM, Kopferschmitt J, Arnaud JP, et al. (1980). Biliary elimination of mezlocillin: An experimental and clinical study. Antimicrob Agents Chemother 18:69–76.
  • Brown NW, Aw MM, Mieli-Vergani G, et al. (2002). Mycophenolic acid and mycophenolic acid glucuronide pharmacokinetics in pediatric liver transplant recipients: Effect of cyclosporine and tacrolimus comedication. Ther Drug Monit 24:598–606.
  • Brune K, Nuernberg B, Schneider HT. (1993). Biliary elimination of aspirin after oral and intravenous administration in patients. Agents Actions Suppl 44:51–57.
  • Buchler M, Lebranchu Y, Beneton M, et al. (2005). Higher exposure to mycophenolic acid with sirolimus than with cyclosporine cotreatment. Clin Pharmacol Ther 78:34–42.
  • Bui K, She F, Sostek M. (2014). The effects of mild or moderate hepatic impairment on the pharmacokinetics, safety, and tolerability of naloxegol. J Clin Pharmacol 54:1368–1374.
  • Bullingham RE, Nicholls AJ, Kamm BR. (1998). Clinical pharmacokinetics of mycophenolate mofetil. Clin Pharmacokinet 34:429–455.
  • Burmester E, Niehaus J, Leineweber T, Huetteroth T. (2003). EUS-cholangio-drainage of the bile duct: Report of 4 cases. Gastrointest Endosc 57:246–251.
  • Byrne JA, Strautnieks SS, Mieli-Vergani G, et al. (2002). The human bile salt export pump: Characterization of substrate specificity and identification of inhibitors. Gastroenterology 123:1649–1658.
  • Cai JS, Chen JH. (2014). The mechanism of enterohepatic circulation in the formation of gallstone disease. J Membr Biol 247:1067–1082.
  • Caldwell JH, Bush CA, Greenberger NJ. (1971). Interruption of the enterohepatic circulation of digitoxin by cholestyramine. II. Effect on metabolic disposition of tritium-labeled digitoxin and cardiac systolic intervals in man. J Clin Invest 50:2638–2644.
  • Caldwell JH, Cline CT. (1976). Biliary excretion of digoxin in man. Clin Pharmacol Ther 19:410–415.
  • Cali JJ, Russell DW. (1991). Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis. J Biol Chem 266:7774–7778.
  • Carriaga MT, Henson DE. (1995). Liver, gallbladder, extrahepatic bile ducts, and pancreas. Cancer 75:171–190.
  • Chabot GG, Abigerges D, Catimel G, et al. (1995). Population pharmacokinetics and pharmacodynamics of irinotecan (CPT-11) and active metabolite SN-38 during phase I trials. Ann Oncol 6:141–151.
  • Challa VR, Babu PR, Challa SR, et al. (2013). Pharmacokinetic interaction study between quercetin and valsartan in rats and in vitro models. Drug Dev Ind Pharm 39:865–872.
  • Chang Y, Burckart GJ, Lesko LJ, Dowling TC. (2013). Evaluation of hepatic impairment dosing recommendations in FDA-approved product labels. J Clin Pharmacol 53:962–966.
  • Chen HS, Gross JF. (1979). Pharmacokinetics of drugs subject to enterohepatic circulation. J Pharm Sci 68:792–794.
  • Chen YJ, Huang SM, Liu CY, et al. (2008). Hepatobiliary excretion and enterohepatic circulation of colchicine in rats. Int J Pharm 350:230–239.
  • Cheng H, Schwartz MS, Vickers S, et al. (1994). Metabolic disposition of simvastatin in patients with T-tube drainage. Drug Metab Dispos 22:139–142.
  • Chipman JK, Cropper NC. (1977). A technique for chronic intermittent bile collection from the rat. Res Vet Sci 22:366–370.
  • Chowdhury NR, Chowdhury JR, (2001). Disorders of bilirubin metabolism. In: Arias IM, Wolkoff A, Boyer J, Shafritz D, Fausto N, Alter H, Cohen D, eds. The liver: Biology and pathobiology. 5th ed. Malden, MA: Wiley-Blackwell, 251–256.
  • Clark AG, Cooke R. (1978). The effect of route of administration on the biliary excretion of phenolphthalein and its glucuronide. J Pharm Pharmacol 30:383–383.
  • Claudel T, Staels B, Kuipers F. (2005). The Farnesoid X receptor: A molecular link between bile acid and lipid and glucose metabolism. Arterioscler Thromb Vasc Biol 25:2020–2030.
  • Clements MR, Chalmers TM, Fraser DR. (1984). Enterohepatic circulation of vitamin D: A reappraisal of the hypothesis. Lancet 1:1376–1379.
  • Colburn WA, Hirom PC, Parker RJ, Milburn P. (1979). A pharmacokinetic model for enterohepatic recirculation in the rat: Phenolphthalein, a model drug. Drug Metab Dispos 7:100–102.
  • Collins BJ, Grizzle TB, Dunnick JK. (2000). Toxicokinetics of phenolphthalein in male and female rats and mice. Toxicol Sci 56:271–281.
  • Cowling P, Rogers S, Mcmullin CM, et al. (1991). The pharmacokinetics of lomefloxacin in elderly patients with urinary tract infection following daily dosing with 400 mg. J Antimicrob Chemother 28:101–107.
  • Cremers S, Schoemaker R, Scholten E, et al. (2005). Characterizing the role of enterohepatic recycling in the interactions between mycophenolate mofetil and calcineurin inhibitors in renal transplant patients by pharmacokinetic modelling. Br J Clin Pharmacol 60:249–256.
  • Cui Y, Konig J, Keppler D. (2001). Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol Pharmacol 60:934–943.
  • Dahlstrom BE, Paalzow LK. (1978). Pharmacokinetic interpretation of the enterohepatic recirculation and first-pass elimination of morphine in the rat. J Pharmacokinet Biopharm 6:505–519.
  • Davi H, Tronquet C, Miscoria G, et al. (2000). Disposition of irbesartan, an angiotensin II AT1-receptor antagonist, in mice, rats, rabbits, and macaques. Drug Metab Dispos 28:79–88.
  • Davies B, Morris T. (1993). Physiological parameters in laboratory animals and humans. Pharm Res 10:1093–1095.
  • Davies NM, Takemoto JK, Brocks DR, Yanez JA. (2010). Multiple peaking phenomena in pharmacokinetic disposition. Clin Pharmacokinet 49:351–377.
  • Davies NM, Wallace JL. (1997). Nonsteroidal anti-inflammatory drug-induced gastrointestinal toxicity: New insights into an old problem. J Gastroenterol 32:127–133.
  • Davis TM, Daly F, Walsh JP, et al. (2000). Pharmacokinetics and pharmacodynamics of gliclazide in Caucasians and Australian Aborigines with type 2 diabetes. Br J Clin Pharmacol 49:223–230.
  • Dawson S, Stahl S, Paul N, et al. (2012). In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug Metab Dispos 40:130–138.
  • De Jong FA, Scott-Horton TJ, Kroetz DL, et al. (2007). Irinotecan-induced diarrhea: Functional significance of the polymorphic ABCC2 transporter protein. Clin Pharmacol Ther 81:42–49.
  • Deng J, Zhuang X, Shen G, et al. (2012). Biliary excretion and enterohepatic circulation of thienorphine and its glucuronide conjugate in rats. Acta Pharm Sin B 2:174–180.
  • Deo AK, Prasad B, Balogh L, et al. (2012). Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): Quantification by liquid chromatography/tandem mass spectrometry. Drug Metab Dispos 40:852–855.
  • Doherty MM, Pang KS. (1997). First-pass effect: Significance of the intestine for absorption and metabolism. Drug Chem Toxicol 20:329–344.
  • Drescher S, Glaeser H, Murdter T, et al. (2003). P-glycoprotein-mediated intestinal and biliary digoxin transport in humans. Clin Pharmacol Ther 73:223–231.
  • Duane WC, Levitt DG, Mueller SM, Behrens JC. (1983). Regulation of bile acid synthesis in man. Presence of a diurnal rhythm. J Clin Invest 72:1930–1936.
  • Duez H, Van Der Veen JN, Duhem C, et al. (2008). Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha. Gastroenterology 135:689–698.
  • Edmiston CE, Jr, Suarez EC, Walker AP, et al. (1996). Penetration of ciprofloxacin and fleroxacin into biliary tract. Antimicrob Agents Chemother 40:787–791.
  • Eeckhoudt SL, Evrard PA, Verbeeck RK. (1997). Biliary excretion and enterohepatic cycling of R- and S-flurbiprofen in the rat. Drug Metab Dispos 25:428–430.
  • Eggertsen G, Olin M, Andersson U, et al. (1996). Molecular cloning and expression of rabbit sterol 12alpha-hydroxylase. J Biol Chem 271:32269–32275.
  • Elaut G, Vanhaecke T, Heyden YV, Rogiers V. (2005). Spontaneous apoptosis, necrosis, energy status, glutathione levels and biotransformation capacities of isolated rat hepatocytes in suspension: Effect of the incubation medium. Biochem Pharmacol 69:1829–1838.
  • Elmquist WF, Sawchuk RJ. (1997). Application of microdialysis in pharmacokinetic studies. Pharm Res 14:267–288.
  • Elomaa K, Ranta S, Tuominen J, Lahteenmaki P. (2001a). Charcoal treatment and risk of escape ovulation in oral contraceptive users. Hum Reprod 16:76–81.
  • Elomaa K, Ranta S, Tuominen J, Lahteenmaki P. (2001b). The possible role of enterohepatic cycling on bioavailability of norethisterone and gestodene in women using combined oral contraceptives. Contraception 63:13–18.
  • Erlinger S. (1996). Review article: New insights into the mechanisms of hepatic transport and bile secretion. J Gastroenterol Hepatol 11:575–579.
  • Ezzet F, Krishna G, Wexler DB, et al. (2001). A population pharmacokinetic model that describes multiple peaks due to enterohepatic recirculation of ezetimibe. Clin Ther 23:871–885.
  • Fabre J, Pitton JS, Virieux C, et al. (1967). Doxycycline. Absorption, distribution and excretion of a new broad spectrum antibiotic in man. Schweiz Med Wochenschr 97:915–924.
  • Fagerholm U. (2008). Prediction of human pharmacokinetics – Biliary and intestinal clearance and enterohepatic circulation. J Pharm Pharmacol 60:535–542.
  • Farmer JA. (2001). Learning from the cerivastatin experience. Lancet. 358:1383–1385.
  • Fattinger K, Funk C, Pantze M, et al. (2001). The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions. Clin Pharmacol Ther 69:223–231.
  • Ferenci P, Grimm G, Meryn S, Gangl A. (1989). Successful long-term treatment of portal-systemic encephalopathy by the benzodiazepine antagonist flumazenil. Gastroenterology 96:240–243.
  • Ferguson KJ, Yesalis CE, Pomrehn PR, Kirkpatrick MB. (1989). Attitudes, knowledge, and beliefs as predictors of exercise intent and behavior in schoolchildren. J Sch Health 59:112–115.
  • Ferrebee CB, Dawson PA. (2015). Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids. Acta Pharm Sin B 5:129–134.
  • Filler G, Lepage N, Delisle B, Mai I. (2001). Effect of cyclosporine on mycophenolic acid area under the concentration-time curve in pediatric kidney transplant recipients. Ther Drug Monit 23:514–519.
  • Filler G, Zimmering M, Mai I. (2000). Pharmacokinetics of mycophenolate mofetil are influenced by concomitant immunosuppression. Pediatr Nephrol 14:100–104.
  • Fortun PJ, Hawkey CJ. (2007). Nonsteroidal antiinflammatory drugs and the small intestine. Curr Opin Gastroenterol 23:134–141.
  • Frye RF, Zgheib NK, Matzke GR, et al. (2006). Liver disease selectively modulates cytochrome P450-mediated metabolism. Clin Pharmacol Ther 80:235–245.
  • Fu S, Rowe A, Ramzan I. (2012). Kavalactone metabolism in the isolated perfused rat liver. Phytother Res 26:1813–1816.
  • Funaki T. (1999). Enterohepatic circulation model for population pharmacokinetic analysis. J Pharm Pharmacol 51:1143–1148.
  • Funk C, Ponelle C, Scheuermann G, Pantze M. (2001). Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: In vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat. Mol Pharmacol 59:627–635.
  • Funk RS, Brown JT, Abdel-Rahman SM. (2012). Pediatric pharmacokinetics: Human development and drug disposition. Pediatr Clin North Am 59:1001–1016.
  • Gabrielsson JL, Weiner DL. (1999). Methodology for pharmacokinetic/pharmacodynamic data analysis. Pharm Sci Technol Today 2:244–252.
  • Galatola G, Jazrawi RP, Bridges C, et al. (1991). Direct measurement of first-pass ileal clearance of a bile acid in humans. Gastroenterology 100:1100–1105.
  • Gantla S, Bakker CT, Deocharan B, et al. (1998). Splice-site mutations: A novel genetic mechanism of Crigler-Najjar syndrome type 1. Am J Hum Genet 62:585–592.
  • Gao Y, Shao J, Jiang Z, et al. (2014). Drug enterohepatic circulation and disposition: Constituents of systems pharmacokinetics. Drug Discov Today 19:326–340.
  • Garbutt JT, Heaton KW, Lack L, Tyor MP. (1969). Increased ratio of glycine- to taurine-conjugated bile salts in patients with ileal disorders. Gastroenterology 56:711–720.
  • Garbutt JT, Kenney TJ. (1972). Effect of cholestyramine on bile acid metabolism in normal man. J Clin Invest 51:2781–2789.
  • Garg DC, Weidler DJ, Eshelman FN. (1983). Ranitidine bioavailability and kinetics in normal male subjects. Clin Pharmacol Ther 33:445–452.
  • Garnock-Jones KP. (2015). Naloxegol: A review of its use in patients with opioid-induced constipation. Drugs 75:419–425.
  • George J, Murray M, Byth K, Farrell GC. (1995). Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease. Hepatology 21:120–128.
  • Gerk PM, Vore M. (2002). Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition. J Pharmacol Exp Ther 302:407–415.
  • Ghibellini G, Johnson BM, Kowalsky RJ, et al. (2004). A novel method for the determination of biliary clearance in humans. AAPS J 6:e33.
  • Ghibellini G, Leslie EM, Brouwer KL. (2006). Methods to evaluate biliary excretion of drugs in humans: An updated review. Mol Pharm 3:198–211.
  • Glass GB, Mersheimer WL. (1960). Metabolic turnover of vitamin B12 in the normal and diseased liver. Am J Clin Nutr 8:285–292.
  • Godfrey KR, Arundel PA, Dong Z, Bryant R. (2011). Modelling the double peak phenomenon in pharmacokinetics. Comput Methods Programs Biomed 104:62–69.
  • Goldin BR, Adlercreutz H, Gorbach SL, et al. (1982). Estrogen excretion patterns and plasma levels in vegetarian and omnivorous women. N Engl J Med 307:1542–1547.
  • Goldsmith RS. (1982). Enterohepatic cycling of vitamin D and its metabolites. Miner Electrolyte Metab 8:289–292.
  • Gorbach SL, Goldin BR. (1987). Diet and the excretion and enterohepatic cycling of estrogens. Prev Med 16:525–531.
  • Gramatte T, El Desoky E, Klotz U. (1994). Site-dependent small intestinal absorption of ranitidine. Eur J Clin Pharmacol 46:253–259.
  • Granero GE, Amidon GL. (2008). Possibility of enterohepatic recycling of ketoprofen in dogs. Int J Pharm 349:166–171.
  • Grime K, Paine SW. (2013). Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. Drug Metab Dispos 41:372–378.
  • Groen AK, Van Wijland MJ, Frederiks WM, et al. (1995). Regulation of protein secretion into bile: Studies in mice with a disrupted mdr2 p-glycoprotein gene. Gastroenterology 109:1997–2006.
  • Grundy SM, Metzger AL. (1972). A physiological method for estimation of hepatic secretion of biliary lipids in man. Gastroenterology 62:1200–1217.
  • Guiney WJ, Beaumont C, Thomas SR, et al. (2011). Use of Entero-Test, a simple approach for non-invasive clinical evaluation of the biliary disposition of drugs. Br J Clin Pharmacol 72:133–142.
  • Gundert-Remy U, Forster D, Schacht P, Weber E. (1982a). Kinetics of mezlocillin in patients with biliary t-tube drainage. J Antimicrob Chemother 9:65–75.
  • Gundert-Remy U, Frohnapfel F, Jourdan W, et al. (1982b). Estimation of biliary excretion of ureidopenicillins in healthy volunteers using marker dilution technique. Br J Clin Pharmacol 13:795–801.
  • Gustavson LE, Mengel HB. (1995). Pharmacokinetics of tiagabine, a gamma-aminobutyric acid-uptake inhibitor, in healthy subjects after single and multiple doses. Epilepsia 36:605–611.
  • Hagenbuch B, Gui C. (2008). Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family. Xenobiotica 38:778–801.
  • Hagenbuch B, Meier PJ. (1996). Sinusoidal (basolateral) bile salt uptake systems of hepatocytes. Semin Liver Dis 16:129–136.
  • Halilovic J, Heintz BH. (2014). Antibiotic dosing in cirrhosis. Am J Health Syst Pharm 71:1621–1634.
  • Hary L, Andrejak M, Leleu S, et al. (1989). The pharmacokinetics of ceftriaxone and cefotaxime in cirrhotic patients with ascites. Eur J Clin Pharmacol 36:613–616.
  • Hasselstrom J, Eriksson S, Persson A, et al. (1990). The metabolism and bioavailability of morphine in patients with severe liver cirrhosis. Br J Clin Pharmacol 29:289–297.
  • Hayes PC, Plevris JN, Bouchier IA. (1989). Pharmacokinetics of enalapril and lisinopril in subjects with normal and impaired hepatic function. J Hum Hypertens 3:153–158.
  • Hazell AS, Butterworth RF. (1999). Hepatic encephalopathy: An update of pathophysiologic mechanisms. Proc Soc Exp Biol Med 222:99–112.
  • Heimer GM, Englund DE. (1986). Enterohepatic recirculation of oestriol: Inhibition by activated charcoal. Acta Endocrinol (Copenh) 113:93–95.
  • Heitmeyer SA, Powers JF. (1992). Improved method for bile collection in unrestrained conscious rats. Lab Anim Sci 42:312–315.
  • Hellstern A, Hildebrand M, Humpel M, et al. (1990). Minimal biliary excretion and enterohepatic recirculation of lormetazepam in man as investigated by a new nasobiliary drainage technique. Int J Clin Pharmacol Ther Toxicol 28:256–261.
  • Hengstler JG, Utesch D, Steinberg P, et al. (2000). Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction. Drug Metab Rev 32:81–118.
  • Herman RJ, Chaudhary A, Szakacs CB. (1994). Disposition of lorazepam in Gilbert's syndrome: Effects of fasting, feeding, and enterohepatic circulation. J Clin Pharmacol 34:978–984.
  • Herman RJ, Van Pham JD, Szakacs CB. (1989). Disposition of lorazepam in human beings: Enterohepatic recirculation and first-pass effect. Clin Pharmacol Ther 46:18–25.
  • Heubi JE, Setchell KD, Bove KE. (2007). Inborn errors of bile acid metabolism. Semin Liver Dis 27:282–294.
  • Hidaka K, Yamamoto H, Harada S, et al. (1988). Excretion of antibiotics into bile and urine in patients with external cholecystostomy done in order to treat obstructive jaundice. Jpn J Antibiot 41:1295–1303.
  • Hiller A, Nguyen N, Strassburg CP, et al. (1999). Retigabine N-glucuronidation and its potential role in enterohepatic circulation. Drug Metab Dispos 27:605–612.
  • Hirano M, Maeda K, Hayashi H, et al. (2005). Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. J Pharmacol Exp Ther 314:876–882.
  • Hirschfield GM. (2013). Genetic determinants of cholestasis. Clin Liver Dis 17:147–159.
  • Hobbs DC. (1983). Pharmacokinetics of piroxicam in man. Eur J Rheumatol Inflamm 6:46–55.
  • Hoeijmakers M, Janszen B, Coert A, Horspool L. (2003). Pharmacokinetics of oestriol after repeated oral administration to dogs. Res Vet Sci 75:55–59.
  • Hofmann AF. (1976). The enterohepatic circulation of bile acids in man. In: Taylor W, ed. The hepatobiliary system. Berlin: Springer, 517–527.
  • Hofmann AF, Hagey LR. (2014). Key discoveries in bile acid chemistry and biology and their clinical applications: History of the last eight decades. J Lipid Res 55:1553–1595.
  • Hogben CM. (1971). Biological membranes and their passage by drugs. In: Brodie BB, Gillette JR, Ackerman HS, eds. Concepts in biochemical pharmacology. New York: Springer, 1–8.
  • Hong G, Bazin-Redureau M, Gires P, Scherrmann JM. (1998). Hepatic disposition and toxicity of cationized goat immunoglobulin G and fab fragments in isolated perfused rat liver. Drug Metab Dispos 26:661–669.
  • Horii Y, Ikenaga M, Shimoda M, Kokue E. (2004). Pharmacokinetics of flunixin in the cat: Enterohepatic circulation and active transport mechanism in the liver. J Vet Pharmacol Ther 27:65–69.
  • Horikawa M, Kato Y, Tyson CA, Sugiyama Y. (2003). Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans. Drug Metab Pharmacokinet 18:16–22.
  • Hosey CM, Broccatelli F, Benet LZ. (2014). Predicting when biliary excretion of parent drug is a major route of elimination in humans. AAPS J 16:1085–1098.
  • Huang SM, Marriott TB, Weintraub HS, et al. (1988). Clinical pharmacokinetics of etintidine. Biopharm Drug Dispos 9:477–486.
  • Huang YJ, Liao JF, Tsai TH. (2005). Concurrent determination of thalidomide in rat blood, brain and bile using multiple microdialysis coupled to liquid chromatography. Biomed Chromatogr 19:488–493.
  • Hudson RJ, Thomson IR, Burgess PM, Rosenbloom M. (1991). Alfentanil pharmacokinetics in patients undergoing abdominal aortic surgery. Can J Anaesth 38:61–67.
  • Hughes RD, Millburn P, Williams RT. (1973). Molecular weight as a factor in the excretion of monoquaternary ammonium cations in the bile of the rat, rabbit and guinea pig. Biochem J 136:967–978.
  • Huntjens DR, Strougo A, Chain A, et al. (2008). Population pharmacokinetic modelling of the enterohepatic recirculation of diclofenac and rofecoxib in rats. Br J Pharmacol 153:1072–1084.
  • Ibarra M, Vazquez M, Fagiolino P. (2014). Population pharmacokinetic model to analyze nevirapine multiple-peaks profile after a single oral dose. J Pharmacokinet Pharmacodyn 41:363–373.
  • Ichikawa R, Takayama T, Yoneno K, et al. (2012). Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway. Immunology 136:153–162.
  • Iga T, Klaassen CD. (1982). Hepatic extraction of bile acids in rats. Biochem Pharmacol 31:205–209.
  • Ikeuchi N, Itoi T. (2015). Endoscopic ultrasonography (EUS)-guided biliary drainage: An alternative to percutaneous transhepatic puncture. Gastrointest Interv 4:31–39.
  • Inagaki T, Choi M, Moschetta A, et al. (2005). Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2:217–225.
  • Ishizuka H, Konno K, Shiina T, et al. (1999). Species differences in the transport activity for organic anions across the bile canalicular membrane. J Pharmacol Exp Ther 290:1324–1330.
  • Jain AK, Stoll B, Burrin DG, et al. (2012). Enteral bile acid treatment improves parenteral nutrition-related liver disease and intestinal mucosal atrophy in neonatal pigs. Am J Physiol Gastrointest Liver Physiol 302:G218–G224.
  • Jamali F, Berry BW, Tehrani MR, Russell AS. (1988). Stereoselective pharmacokinetics of flurbiprofen in humans and rats. J Pharm Sci 77:666–669.
  • Janowitz P, Swobodnik W, Wechsler JG, et al. (1990). Comparison of gall bladder bile and endoscopically obtained duodenal bile. Gut 31:1407–1410.
  • Jeu L, Cheng JW. (2003). Pharmacology and therapeutics of ezetimibe (SCH 58235), a cholesterol-absorption inhibitor. Clin Ther 25:2352–2387.
  • Jiang ZY, Parini P, Eggertsen G, et al. (2008). Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients. J Lipid Res 49:464–472.
  • Kalser SC, Kelly MP, Forbes EB, Randolph MM. (1969). Drug metabolism in hypothermia. Uptake, metabolism and biliary excretion of pentobarbital-2-C14 by the isolated, perfused rat liver in hypothermia and euthermia. J Pharmacol Exp Ther 170:145–152.
  • Kalser SC, Kelvington EJ, Randolph MM. (1968). Drug metabolism in hypothermia. Uptake, metabolism and excretion of S35-sulfanilamide by the isolated, perfused rat liver. J Pharmacol Exp Ther 159:389–398.
  • Kalser SC, Kelvington EJ, Randolph MM, Santomenna DM. (1965a). Drug metabolism in hypothermia. I. Biliary excretion of C 14-atropine metabolites in the intact and nephrectomized rat. J Pharmacol Exp Ther 147:252–259.
  • Kalser SC, Kelvington EJ, Randolph MM, Santomenna DM. (1965b). Drug metabolism in hypothermia. II. C 14-atropine uptake, metabolism and excretion by the isolated, perfused rat liver. J Pharmacol Exp Ther 147:260–269.
  • Kamimoto Y, Gatmaitan Z, Hsu J, Arias IM. (1989). The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. J Biol Chem 264:11693–11698.
  • Kanazawa S, Herbert V, Herzlich B, et al. (1983). Removal of cobalamin analogue in bile by enterohepatic circulation of vitamin B12. Lancet 1:707–708.
  • Katzung BG, Meyers FH. (1965). Excretion of radioactive digitoxin by the dog. J Pharmacol Exp Ther 149:257–262.
  • Kawakami J, Yamamura Y, Santa T, et al. (1993). Kinetic analysis of glycyrrhetic acid, an active metabolite of glycyrrhizin, in rats: Role of enterohepatic circulation. J Pharm Sci 82:301–305.
  • Keitel V, Nies AT, Brom M, et al. (2003). A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2). Am J Physiol Gastrointest Liver Physiol 284:G165–G174.
  • Keppler D, Konig J. (2000). Hepatic secretion of conjugated drugs and endogenous substances. Semin Liver Dis 20:265–272.
  • Kerkadi A, Barriault C, Marquardt RR, et al. (1999). Cholestyramine protection against ochratoxin A toxicity: Role of ochratoxin A sorption by the resin and bile acid enterohepatic circulation. J Food Prot 62:1461–1465.
  • Kim HG, Lee JH, Lee SJ, et al. (2012). The increased cellular uptake and biliary excretion of curcumin by quercetin: A possible role of albumin binding interaction. Drug Metab Dispos 40:1452–1455.
  • Kim TH, Shin S, Bashir M, et al. (2014). Pharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats. Xenobiotica 44:913–925.
  • Klaassen CD. (1973). Hepatic excretory function in the newborn rat. J Pharmacol Exp Ther 184:721–728.
  • Klaassen CD, Watkins JB, III. (1984). Mechanisms of bile formation, hepatic uptake, and biliary excretion. Pharmacol Rev 36:1–67.
  • Kleeberg U, Fishcer E, Gregus Z, et al. (1979). Effect of 3-methylcholanthrene on the biliary excretion of bromsulphthalein and eosine in newborn rats. Acta Physiol Acad Sci Hung 53:363–367.
  • Klotz U, Antonin KH. (1977). Biliary excretion studies with digoxin in man. Int J Clin Pharmacol Biopharm 15:332–334.
  • Knutson L, Odlind B, Hallgren R. (1989). A new technique for segmental jejunal perfusion in man. Am J Gastroenterol 84:1278.
  • Kobuchi S, Fukushima K, Maeda Y, et al. (2013). Effects of bile duct stricture on the pharmacokinetics of the immunosuppressant tacrolimus in rats. Interact Med Chem 1:1.
  • Kojima J, Ohshima T, Yoneda M, Sawada H. (2001). Effect of biliary excretion on the pharmacokinetics of pitavastatin (NK-104) in dogs. Drug Metab Pharmacokinet 16:497–502.
  • Kok T, Hulzebos CV, Wolters H, et al. (2003). Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: Efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein. J Biol Chem 278:41930–41937.
  • Konig J, Nies AT, Cui Y, et al. (1999). Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance. Biochim Biophys Acta 1461:377–394.
  • Konigsson K, Torneke K, Engeland IV, et al. (2003). Pharmacokinetics and pharmacodynamic effects of flunixin after intravenous, intramuscular and oral administration to dairy goats. Acta Vet Scand 44:153–159.
  • Kopplow K, Letschert K, Konig J, et al. (2005). Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol 68:1031–1038.
  • Koren G, Barker C, Bohn D, et al. (1985). Influence of hypothermia on the pharmacokinetics of gentamicin and theophylline in piglets. Crit Care Med 13:844–847.
  • Kosoglou T, Statkevich P, Johnson-Levonas AO, et al. (2005). Ezetimibe: A review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet 44:467–494.
  • Kucera O, Lotkova H, Krivakova P, et al. (2006). Model systems for study of toxic injury of hepatocytes in vitro. Cesk Fysiol 55:103–110.
  • Kuipers F, Bloks VW, Groen AK. (2014). Beyond intestinal soap-bile acids in metabolic control. Nat Rev Endocrinol 10:488–498.
  • Kuipers F, Havinga R, Bosschieter H, et al. (1985). Enterohepatic circulation in the rat. Gastroenterology 88:403–411.
  • Kullak-Ublick GA, Stieger B, Meier PJ. (2004). Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology 126:322–342.
  • Kumar D, Khanna AK, Pratap R, et al. (2012). Dose escalation pharmacokinetics and lipid lowering activity of a novel farnesoid X receptor modulator: 16-Dehydropregnenolone. Indian J Pharmacol 44:57–62.
  • Kumar Jain A, Teckman JH. (2014). Newly identified mechanisms of total parenteral nutrition related liver injury. Adv Hepatol. 2014:493087.
  • Kyrklund C, Backman JT, Neuvonen M, Neuvonen PJ. (2003). Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance. Clin Pharmacol Ther 73:538–544.
  • Lai Y. (2009). Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion. Expert Opin Drug Metab Toxicol 5:1175–1187.
  • Laidlaw J, Read AE, Sherlock S. (1961). Morphine tolerance in hepatic cirrhosis. Gastroenterology 40:389–396.
  • Landskroner KA, Hess P, Treiber A. (2011). Surgical and pharmacological animal models used in drug metabolism and pharmacokinetics. Xenobiotica 41:687–700.
  • Lasocki A, Vote B, Fassett R, Zamir E. (2007). Simvastatin-induced rhabdomyolysis following cyclosporine treatment for uveitis. Ocul Immunol Inflamm 15:345–346.
  • Lecureur V, Courtois A, Payen L, et al. (2000). Expression and regulation of hepatic drug and bile acid transporters. Toxicology 153:203–219.
  • Lees P, Pelligand L, Elliott J, et al. (2015). Pharmacokinetics, pharmacodynamics, toxicology and therapeutics of mavacoxib in the dog: A review. J Vet Pharmacol Ther 38:1–14.
  • Lehr T, Staab A, Tillmann C, et al. (2009). A quantitative enterohepatic circulation model: Development and evaluation with tesofensine and meloxicam. Clin Pharmacokinet 48:529–542.
  • Leng DD, Han WJ, Rui Y, et al. (2013). In vivo disposition and metabolism of madecassoside, a major bioactive constituent in Centella asiatica (L.) Urb. J Ethnopharmacol 150:601–608.
  • Lennernas H, Regardh CG. (1993). Evidence for an interaction between the beta-blocker pafenolol and bile salts in the intestinal lumen of the rat leading to dose-dependent oral absorption and double peaks in the plasma concentration-time profile. Pharm Res 10:879–883.
  • Leung JW, Chan RC, Cheung SW, et al. (1990). The effect of obstruction on the biliary excretion of cefoperazone and ceftazidime. J Antimicrob Chemother 25:399–406.
  • Levine WG. (1981). Biliary excretion of drugs and other xenobiotics. Prog Drug Res 25:361–420.
  • Levison ME, Levison JH. (2009). Pharmacokinetics and pharmacodynamics of antibacterial agents. Infect Dis Clin North Am 23:791–815.
  • Li-Hawkins J, Lund EG, Bronson AD, Russell DW. (2000). Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. J Biol Chem 275:16543–16549.
  • Li P, Zhang Y, Xiao L, et al. (2007). Simultaneous determination of harpagoside and cinnamic acid in rat plasma by high-performance liquid chromatography: Application to a pharmacokinetic study. Analyt Bioanalyt Chem 389:2259–2264.
  • Li R, Barton HA, Varma MV. (2014). Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved. Clin Pharmacokinet 53:659–678.
  • Li T, Chiang JY. (2014). Bile acid signaling in metabolic disease and drug therapy. Pharmacol Rev 66:948–983.
  • Li T, Chiang JY. (2015). Bile acids as metabolic regulators. Curr Opin Gastroenterol 31:159–165.
  • Lin JH. (1995). Species similarities and differences in pharmacokinetics. Drug Metab Dispos 23:1008–1021.
  • Liu A, Krausz KW, Fang ZZ, et al. (2014). Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity. Arch Toxicol 88:983–996.
  • Liu MJ, Pollack GM. (1993). Pharmacokinetics and pharmacodynamics of valproate analogs in rats. II. Pharmacokinetics of octanoic acid, cyclohexanecarboxylic acid, and 1-methyl-1-cyclohexanecarboxylic acid. Biopharm Drug Dispos 14:325–339.
  • Liu X, Chism JP, Lecluyse EL, et al. (1999). Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats. Drug Metab Dispos 27:637–644.
  • Loguidice A, Wallace BD, Bendel L, et al. (2012). Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice . J Pharmacol Exp Ther 341:447–454.
  • Lou Y, Hu H, Liu Y, et al. (2011). Determination of chamaechromone in rat plasma by liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic study. J Pharm Biomed Anal 55:1163–1169.
  • Luke DR, Foulds G, Cohen SF, Levy B. (1996). Safety, toleration, and pharmacokinetics of intravenous azithromycin. Antimicrob Agents Chemother 40:2577–2581.
  • Lundahl A, Lennernas H, Knutson L, et al. (2009). Identification of finasteride metabolites in human bile and urine by high-performance liquid chromatography/tandem mass spectrometry. Drug Metab Dispos 37:2008–2017.
  • Luo G, Johnson S, Hsueh MM, et al. (2010). In silico prediction of biliary excretion of drugs in rats based on physicochemical properties. Drug Metab Dispos 38:422–430.
  • Lyons MA, Reisfeld B, Yang RS, Lenaerts AJ. (2013). A physiologically based pharmacokinetic model of rifampin in mice. Antimicrob Agents Chemother 57:1763–1771.
  • Ma Y, Li P, Chen D, et al. (2006). LC/MS/MS quantitation assay for pharmacokinetics of naringenin and double peaks phenomenon in rats plasma. Int J Pharm 307:292–299.
  • Maeda K, Sugiyama Y. (2008). Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs. Drug Metab Pharmacokinet 23:223–235.
  • Mahmood I. (2005). Interspecies scaling of biliary excreted drugs: A comparison of several methods. J Pharm Sci 94:883–892.
  • Mahmood I. (2012). Interspecies scaling of biliary excreted drugs: Prediction of human clearance and volume of distribution. Drug Metabol Drug Interact 27:157–164.
  • Mahmood I, Sahajwalla C. (2002). Interspecies scaling of biliary excreted drugs. J Pharm Sci 91:1908–1914.
  • Manautou JE, De Waart DR, Kunne C, et al. (2005). Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene. Hepatology 42:1091–1098.
  • Marier JF, Vachon P, Gritsas A, et al. (2002). Metabolism and disposition of resveratrol in rats: Extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model. J Pharmacol Exp Ther 302:369–373.
  • Marinelli RA, Larusso NF. (1996). Solute and water transport pathways in cholangiocytes. Semin Liver Dis 16:221–229.
  • Martinez SE, Sayre CL, Davies NM. (2013). Pharmacometrics of 3-methoxypterostilbene: A component of traditional chinese medicinal plants. Evid Based Complement Alternat Med 2013:261468
  • Matsubara T, Li F, Gonzalez FJ. (2013). FXR signaling in the enterohepatic system. Mol Cell Endocrinol 368:17–29.
  • Matsui H, Takeuchi S, Osada T, et al. (2012). Enhanced bile canaliculi formation enabling direct recovery of biliary metabolites of hepatocytes in 3D collagen gel microcavities. Lab Chip 12:1857–1864.
  • Matsushima S, Maeda K, Kondo C, et al. (2005). Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther 314:1059–1067.
  • Mcclain DA, Hug CC. Jr. (1980). Intravenous fentanyl kinetics. Clin Pharmacol Ther 28:106–114.
  • Mcginnity DF, Soars MG, Urbanowicz RA, Riley RJ. (2004). Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance. Drug Metab Dispos 32:1247–1253.
  • Mclean AJ, Morgan DJ. (1991). Clinical pharmacokinetics in patients with liver disease. Clin Pharmacokinet 21:42–69.
  • Mcmaster P, Mirza DF, Ismail T, et al. (1995). Therapeutic drug monitoring of tacrolimus in clinical transplantation. Ther Drug Monit 17:602–605.
  • Mcpherson GA, Benjamin IS, Boobis AR, et al. (1982). Antipyrine elimination as a dynamic test of hepatic functional integrity in obstructive jaundice. Gut 23:734–738.
  • Meier PJ, Stieger B. (2002). Bile salt transporters. Annu Rev Physiol 64:635–661.
  • Meijer DK, Bognacki J, Levine WG. (1975). Effect of nafenopin (SU-13,437) on liver function: Influence on the hepatic transport of organic anions. Naunyn Schmiedebergs Arch Pharmacol 290:235–250.
  • Meinertz T, Gilfrich HJ, Groth U, et al. (1977a). Interruption of the enterohepatic circulation of phenprocoumon by cholestyramine. Clin Pharmacol Ther 21:731–735.
  • Meinertz T, Gilfrich MJ, Bork R, Jahnchen E. (1977b). Treatment of phenprocoumon intoxication with cholestyramine. Br Med J 2:439
  • Melander A. (1987). Clinical pharmacology of sulfonylureas. Metab Clin Exp 36:12–16.
  • Melander A, Wåhlin-Boll E. (1983). Clinical pharmacology of glipizide. Am J Med 75:41–45.
  • Meng LJ, Reyes H, Palma J, et al. (1997). Profiles of bile acids and progesterone metabolites in the urine and serum of women with intrahepatic cholestasis of pregnancy. J Hepatol 27:346–357.
  • Metsugi Y, Miyaji Y, Ogawara K, et al. (2008). Appearance of double peaks in plasma concentration-time profile after oral administration depends on gastric emptying profile and weight function. Pharm Res 25:886–895.
  • Millburn P, Smith RL, Williams RT. (1967). Biliary excretion of foreign compounds. Biphenyl, stilboestrol and phenolphthalein in the rat: Molecular weight, polarity and metabolism as factors in biliary excretion. Biochem J 105:1275–1281.
  • Miller RD, Agoston S, Van Der Pol F, et al. (1978). Hypothermia and the pharmacokinetics and pharmacodynamics of pancuronium in the cat. J Pharmacol Exp Ther 207:532–538.
  • Mirfazaelian A, Mahmoudian M. (1995). A comprehensive computer programme for evaluation and teaching drug pharmacokinetics. Abst. 12th Iranian Congress on Physiology and Pharmacology, Tehran, Iran; Paper P3-18.
  • Mirfazaelian A, Mahmoudian M. (2006). A simple pharmacokinetics subroutine for modeling double peak phenomenon. Biopharm Drug Dispos 27:119–124.
  • Miura M, Satoh S, Inoue K, et al. (2007). Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol 63:1161–1169.
  • Miyauchi S, Sawada Y, Iga T, et al. (1993). Comparison of the hepatic uptake clearances of fifteen drugs with a wide range of membrane permeabilities in isolated rat hepatocytes and perfused rat livers. Pharm Res 10:434–440.
  • Miyazaki T, Kinouchi T, Mizukoshi H, Araki Y. (1974). Mode of estrogen conjugation and hepato-intestinal circulation: With special reference to man. Nihon Rinsho 32:3296–3301.
  • Montagnani M, Aldini R, Roda A, et al. (1996). Species differences in hepatic bile acid uptake: Comparative evaluation of taurocholate and tauroursodeoxycholate extraction in rat and rabbit. Comp Biochem Physiol a Physiol 113:157–164.
  • Moon Yj, Sagawa K, Frederick K, et al. (2006). Pharmacokinetics and bioavailability of the isoflavone biochanin a in rats. AAPS J 8:E433–E442. [Pmc][https://doi.org/10.1208/Aapsj080351] [https://doi.org/17025260][pubmedMismatch]
  • Morgan DJ, Blackman GL, Paull JD, Wolf LJ. (1981). Pharmacokinetics and plasma binding of thiopental. II: Studies at cesarean section. Anesthesiology 54:474–480.
  • Morimoto K, Kishimura K, Nagami T, et al. (2011). Effect of milk on the pharmacokinetics of oseltamivir in healthy volunteers. J Pharm Sci 100:3854–3861.
  • Mortimer PR, Mackie DB, Haynes S. (1969). Ampicillin levels in human bile in the presence of biliary tract disease. Br Med J 3:88–89.
  • Moseley RH. (1986). Mechanisms of bile formation and cholestasis: Clinical significance of recent experimental work. Am J Gastroenterol 81:731–735.
  • Moseley RH, Smit H, Van Solkema BG, et al. (1996). Mechanisms for the hepatic uptake and biliary excretion of tributylmethylammonium: studies with rat liver plasma membrane vesicles. J Pharmacol Exp Ther 276:561–567.
  • Munjal B, Pawar YB, Patel SB, Bansal AK. (2011). Comparative oral bioavailability advantage from curcumin formulations. Drug Deliv Transl Res 1:322–331.
  • Muraca M, Vilei MT, Miconi L, et al. (1991). A simple method for the determination of lipid composition of human bile. J Lipid Res 32:371–374.
  • Murata K, Noda K. (1993). Pharmacokinetic analysis of an oral sustained-release diltiazem preparation using multifraction absorption models. Pharm Res 10:757–762.
  • Murata K, Noda K, Kohno K, Samejima M. (1987). Pharmacokinetic analysis of concentration data of drugs with irregular absorption profiles using multi-fraction absorption models. J Pharm Sci 76:109–113.
  • Murphy AA, Zacur HA, Charache P, Burkman RT. (1991). The effect of tetracycline on levels of oral contraceptives. Am J Obstet Gynecol 164:28–33.
  • Nayudu SK, Badipatla S, Niazi M, Balar B. (2013). Cholestatic hepatitis with small duct injury associated with celecoxib. Case Rep Med 2013:315479.
  • Neugebauer G, Gabor M, Reiff K (1988). Pharmacokinetics and bioavailability of carvedilol in patients with liver cirrhosis. Drugs, 36,148–54
  • Nies AT, Koepsell H, Winter S, et al. (2009). Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. Hepatology 50:1227–1240.
  • Nishida K, Okazaki M, Sakamoto R, et al. (2007). Change in pharmacokinetics of model compounds with different elimination processes in rats during hypothermia. Biol Pharm Bull 30:1763–1767.
  • Norlin M, Andersson U, Bjorkhem I, Wikvall K. (2000). Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A). J Biol Chem 275:34046–34053.
  • Nutescu EA, Shapiro NL. (2003). Ezetimibe: A selective cholesterol absorption inhibitor. Pharmacotherapy 23:1463–1474.
  • O'dwyer PJ, Szarka C, Brennan JM, et al. (2000). Pharmacokinetics of the chemopreventive agent oltipraz and of its metabolite M3 in human subjects after a single oral dose. Clin Cancer Res 6:4692–4696.
  • O'maille ER, Richards TG, Short AH. (1967). The influence of conjugation of cholic acid on its uptake and secretion: Hepatic extraction of taurocholate and cholate in the dog. J Physiol 189:337–350.
  • Oberle RL, Amidon GL. (1987). The influence of variable gastric emptying and intestinal transit rates on the plasma level curve of cimetidine; an explanation for the double peak phenomenon. J Pharmacokinet Biopharm 15:529–544.
  • Okusanya O, Forrest A, Difrancesco R, et al. (2007). Compartmental pharmacokinetic analysis of oral amprenavir with secondary peaks. Antimicrob Agents Chemother 51:1822–1826.
  • Orme ML, Back DJ. (1990). Factors affecting the enterohepatic circulation of oral contraceptive steroids. Am J Obstet Gynecol 163:2146–2152.
  • Oude Elferink RP, Meijer DK, Kuipers F, et al. (1995). Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport. Biochim Biophys Acta 1241:215–268.
  • Oude Elferink RP, Ottenhoff R, Liefting WG, et al. (1990). ATP-dependent efflux of GSSG and GS-conjugate from isolated rat hepatocytes. Am J Physiol 258:G699–G706.
  • Ouellet DM, Pollack GM. (1995). Biliary excretion and enterohepatic recirculation of morphine-3-glucuronide in rats. Drug Metab Dispos 23:478–484.
  • Padda MS, Sanchez M, Akhtar AJ, Boyer JL. (2011). Drug-induced cholestasis. Hepatology 53:1377–1387.
  • Padowski JM, Pollack GM. (2012). Influence of enterohepatic recycling on the time course of brain-to-blood partitioning of valproic acid in rats. Drug Metab Dispos 40:1846–1853.
  • Pang KS. (1995). Acinar factors in drug processing: protein binding, futile cycling, and cosubstrate. Drug Metab Rev 27:325–368.
  • Park SC, Chun HJ, Kang CD, Sul D. (2011). Prevention and management of non-steroidal anti-inflammatory drugs-induced small intestinal injury. World J Gastroenterol 17:4647–4653.
  • Parker RJ, Hirom PC, Millburn P. (1980). Enterohepatic recycling of phenolphthalein, morphine, lysergic acid diethylamide (LSD) and diphenylacetic acid in the rat. Hydrolysis of glucuronic acid conjugates in the gut lumen. Xenobiotica 10:689–703.
  • Pastan I, Gottesman M. (1987). Multiple-drug resistance in human cancer. N Engl J Med 316:1388–1393.
  • Patel NJ, Zamek-Gliszczynski MJ, Zhang P, et al. (2003). Phenobarbital alters hepatic Mrp2 function by direct and indirect interactions. Mol Pharmacol 64:154–159.
  • Pauli-Magnus C, Meier PJ. (2005). Hepatocellular transporters and cholestasis. J Clin Gastroenterol 39:S103–S110.
  • Pauli-Magnus C, Meier PJ, Stieger B. (2010). Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy. Semin Liver Dis 30:147–159.
  • Pawar YB, Munjal B, Arora S, et al. (2012). Bioavailability of a lipidic formulation of curcumin in healthy human volunteers. Pharmaceutics 4:517–530.
  • Pedersen PV, Miller R. (1980). Pharmacokinetics and bioavailability of cimetidine in humans. J Pharm Sci 69:394–398.
  • Pena MA, Horga JF, Zapater P. (2016). Variations of pharmacokinetics of drugs in patients with cirrhosis. Expert Rev Clin Pharmacol 9:441–458.
  • Pentikainen PJ, Neuvonen PJ, Jostell KG. (1980). Pharmacokinetics of chlormethiazole in healthy volunteers and patients with cirrhosis of the liver. Eur J Clin Pharmacol 17:275–284.
  • Pescovitz MD, Bumgardner G, Gaston RS, et al. (2003). Pharmacokinetics of daclizumab and mycophenolate mofetil with cyclosporine and steroids in renal transplantation. Clin Transplant 17:511–517.
  • Phillips J. (1991). Food and chemical toxicology. In: Haley TJ, Berndt WO, eds. Handbook of toxicology. Vol. 29. London: Hemisphere Publishing Corp., 135–136.
  • Picard N, Premaud A, Rousseau A, et al. (2006). A comparison of the effect of ciclosporin and sirolimus on the pharmokinetics of mycophenolate in renal transplant patients. Br J Clin Pharmacol 62:477–484.
  • Ploeger BA, Meulenbelt J, Dejongh J. (2000). Physiologically based pharmacokinetic modeling of glycyrrhizic acid, a compound subject to presystemic metabolism and enterohepatic cycling. Toxicol Appl Pharmacol 162:177–188.
  • Plusquellec Y, Arnaud R, Saivin S, et al. (1998). Enterohepatic recirculation of the new antihypertensive drug UP 269-6 in humans. A possible model to account for multiple plasma peaks. Arzneimittelforschung 48:138–144.
  • Plusquellec Y, Houin G. (1994). Pharmacokinetic compartmental model with n sites of absorption along the gastrointestinal tract. Arzneimittelforschung 44:679–682.
  • Prasad B, Evers R, Gupta A, et al. (2014). Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: Quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex. Drug Metab Dispos 42:78–88.
  • Prasad B, Lai Y, Lin Y, Unadkat JD. (2013). Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotype. J Pharm Sci 102:787–793.
  • Ranheim B, Ween H, Egeli AK, et al. (2002). Benzathine penicillin G and procaine penicillin G in piglets: Comparison of intramuscular and subcutaneous injection. Vet Res Commun 26:459–465.
  • Rath L, Hutchison M. (1989). A new method of bile duct cannulation allowing bile collection and re-infusion in the conscious rat. Lab Anim 23:163–168.
  • Repa JJ, Berge KE, Pomajzl C, et al. (2002). Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem 277:18793–18800.
  • Reshetnyak VI. (2013). Physiological and molecular biochemical mechanisms of bile formation. World J Gastroenterol 19:7341–7360.
  • Reuter BK, Davies NM, Wallace JL. (1997). Nonsteroidal anti-inflammatory drug enteropathy in rats: Role of permeability, bacteria, and enterohepatic circulation. Gastroenterology 112:109–117.
  • Reynolds KS, Song MH, Heizer WD, et al. (1998). Effect of pancreatico-biliary secretions and GI transit time on the absorption and pharmacokinetic profile of ranitidine in humans. Pharm Res 15:1281–1285.
  • Riippa P, Kauppila A, Sundstrom H, Vihko R. (1984). Hepatic impairment during simultaneous administration of medroxyprogesterone acetate and tamoxifen in the treatment of endometrial and ovarian carcinoma. Anticancer Res 4:109–112.
  • Riond JL, Riviere JE. (1990). Pharmacokinetics and metabolic inertness of doxycycline in young pigs. Am J Vet Res 51:1271–1275.
  • Robert WK, Jr. (2014). Gastrointestinal toxicology. In: Hayes AW, Kruger CL, eds. Hayes' principles and methods of toxicology. Florida: CRC Press, 1521–1566.
  • Roberts MS, Magnusson BM, Burczynski FJ, Weiss M. (2002). Enterohepatic circulation: Physiological, pharmacokinetic and clinical implications. Clin Pharmacokinet 41:751–790.
  • Robinson JD, Morris BA, Aherne GW, Marks V. (1975). Pharmacokinetics of a single dose of phenytoin in man measured by radioimmunoassay. Br J Clin Pharmacol 2:345–349.
  • Rollins DE, Klaassen CD. (1979). Biliary excretion of drugs in man. Clin Pharmacokinet 4:368–379.
  • Rossi M, Vajro P, Iorio R, et al. (2005). Characterization of liver involvement in defects of cholesterol biosynthesis: Long-term follow-up and review. Am J Med Genet a 132A:144–151.
  • Roth A, Chakor K, Creppy EE, et al. (1988). Evidence for an enterohepatic circulation of ochratoxin A in mice. Toxicology 48:293–308.
  • Roth M, Obaidat A, Hagenbuch B. (2012). OATPs, OATs and OCTs: The organic anion and cation transporters of the SLCO and SLC22A gene superfamilies. Br J Pharmacol 165:1260–1287.
  • Saitta KS, Zhang C, Lee KK, et al. (2014). Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: Mode of action and pharmacokinetics . Xenobiotica 44:28–35.
  • Sales JE, Sutcliffe M, O'grady F. (1972). Cephalexin levels in human bile in presence of biliary tract disease. Br Med J 3:441–443
  • Sarda S, Page C, Pickup K, et al. (2012). Diclofenac metabolism in the mouse: Novel in vivo metabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry. Xenobiotica 42:179–194.
  • Sasaki M, Suzuki H, Aoki J, et al. (2004). Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2. Mol Pharmacol 66:450–459.
  • Sasaki M, Suzuki H, Ito K, et al. (2002). Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2). J Biol Chem 277:6497–6503.
  • Scarpignato C, Hunt RH. (2010). Nonsteroidal antiinflammatory drug-related injury to the gastrointestinal tract: Clinical picture, pathogenesis, and prevention. Gastroenterol Clin North Am 39:433–464.
  • Schaiquevich P, Niselman A, Rubio M. (2002a). Comparison of two compartmental models for describing ranitidine's plasmatic profiles. Pharmacol Res 45:399–405.
  • Schaiquevich P, Niselman A, Rubio M. (2002b). Importance of entero-salivary recirculation in paracetamol pharmacokinetics. Biopharm Drug Dispos 23:245–249.
  • Schiavon G, Eechoute K, Mathijssen RH, et al. (2012). Biliary excretion of imatinib and its active metabolite CGP74588 during severe hepatic dysfunction. J Clin Pharmacol 52:1115–1120.
  • Schjonsby H. (1989). Vitamin B12 absorption and malabsorption. Gut 30:1686–1691.
  • Schrenk D, Gant TW, Preisegger KH, et al. (1993). Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates. Hepatology 17:854–860.
  • Schroepfer GJ Jr. (2000). Oxysterols: Modulators of cholesterol metabolism and other processes. Physiol Rev 80:361–554.
  • Schwarz M, Lund EG, Lathe R, et al. (1997). Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA. J Biol Chem 272:23995–24001.
  • Schwenk M. (1980). Transport systems of isolated hepatocytes. Studies on the transport of biliary compounds. Arch Toxicol 44:113–126.
  • Scott DO, Lunte CE. (1993). In vivo microdialysis sampling in the bile, blood, and liver of rats to study the disposition of phenol. Pharm Res 10:335–342.
  • Sharifi M, Ghafourian T. (2014). Estimation of biliary excretion of foreign compounds using properties of molecular structure. AAPS J 16:65–78.
  • Sheikh-Bahaei S, Ropella GE, Hunt CA. (2006). In silico hepatocyte: Agent-based modeling of the biliary excretion of drugs in vitro. Simulat Ser 38:157.
  • Sheng J, Tian X, Xu G, et al. (2015). The hepatobiliary disposition of timosaponin b2 is highly dependent on influx/efflux transporters but not metabolism. Drug Metab Dispos 43:63–72.
  • Shepard TA, Lockwood GF, Aarons LJ, Abrahams ID. (1989). Mean residence time for drugs subject to enterohepatic cycling. J Pharmacokinet Biopharm 17:327–345.
  • Shepard TA, Reuning RH, Aarons LJ. (1985). Estimation of area under the curve for drugs subject to enterohepatic cycling. J Pharmacokinet Biopharm 13:589–608.
  • Sher A, Rahman A. (1994). Role of diet on the enterohepatic recycling of estrogen in women taking contraceptive pills. J Pak Med Assoc 44:213.
  • Shichiri M, Fukai N, Kono Y, Tanaka Y. (2009). Rifampicin as an oral angiogenesis inhibitor targeting hepatic cancers. Cancer Res 69:4760–4768.
  • Shilling AD, Azam F, Kao J, Leung L. (2006). Use of canalicular membrane vesicles (CMVs) from rats, dogs, monkeys and humans to assess drug transport across the canalicular membrane. J Pharmacol Toxicol Methods 53:186–197.
  • Shim CK, Hong JS. (1989). Inter- and intrasubject variations of ranitidine pharmacokinetics after oral administration to normal male subjects. J Pharm Sci 78:990–994.
  • Shitara Y, Maeda K, Ikejiri K, et al. (2013). Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: Their roles in hepatic clearance and intestinal absorption. Biopharm Drug Dispos 34:45–78.
  • Silva JM, Day SH, Nicoll-Griffith DA. (1999). Induction of cytochrome-P450 in cryopreserved rat and human hepatocytes. Chem Biol Interact 121:49–63.
  • Silverman JA. (1999). Multidrug-resistance transporters. Pharm Biotechnol 12:353–386.
  • Simonson SG, Raza A, Martin PD, et al. (2004). Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine. Clin Pharmacol Ther 76:167–177.
  • Sjogren E, Bredberg U, Lennernas H. (2012). The pharmacokinetics and hepatic disposition of repaglinide in pigs: Mechanistic modeling of metabolism and transport. Mol Pharm 9:823–841.
  • Smak Gregoor PJ, Van Gelder T, Hesse CJ, et al. (1999). Mycophenolic acid plasma concentrations in kidney allograft recipients with or without cyclosporin: A cross-sectional study. Nephrol Dial Transplant 14:706–708.
  • Smith MS, Verghese CP, Shand DG, Pritchett EL. (1983). Pharmacokinetic and pharmacodynamic effects of diltiazem. Am J Cardiol 51:1369–1374.
  • Staatz CE, Tett SE. (2007). Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients. Clin Pharmacokinet 46:13–58.
  • Steimer JL, Plusquellec Y, Guillaume A, Boisvieux JF. (1982). A time-lag model for pharmacokinetics of drugs subject to enterohepatic circulation. J Pharm Sci 71:297–302.
  • Stieger B, Fattinger K, Madon J, et al. (2000). Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology 118:422–430.
  • Stieger B, Meier PJ. (2011). Pharmacogenetics of drug transporters in the enterohepatic circulation. Pharmacogenomics 12:611–631.
  • Storstein L. (1975). Studies on digitalis. III. Biliary excretion and enterohepatic circulation of digitoxin and its cardioactive metabolites. Clin Pharmacol Ther 17:313–320.
  • Stoupi S, Williamson G, Viton F, et al. (2010). In vivo bioavailability, absorption, excretion, and pharmacokinetics of [14C]procyanidin B2 in male rats. Drug Metab Dispos 38:287–291.
  • Suttle AB, Brouwer KL. (1994). Bile flow but not enterohepatic recirculation influences the pharmacokinetics of ranitidine in the rat. Drug Metab Dispos 22:224–232.
  • Suttle AB, Brouwer KL. (1995). Gastrointestinal transit and distribution of ranitidine in the rat. Pharm Res 12:1316–1322.
  • Suttle AB, Pollack GM, Brouwer KL. (1992). Use of a pharmacokinetic model incorporating discontinuous gastrointestinal absorption to examine the occurrence of double peaks in oral concentration-time profiles. Pharm Res 9:350–356.
  • Suzuki M, Suzuki H, Sugimoto Y, Sugiyama Y. (2003). ABCG2 transports sulfated conjugates of steroids and xenobiotics. J Biol Chem 278:22644–22649.
  • Symonds HW, Prime GR, Pullar RA. (1994). Preliminary evidence for the enterohepatic circulation of progesterone in the pig. Br Vet J 150:585–593.
  • Tan HH, Schiano T. (2012). Effects of liver disease on drug metabolism in humans. In: Lyubimov A, ed. Encyclopedia of drug metabolism and interactions. Hoboken: Wiley-Blackwell Inc, 3795–3840.
  • Teng S, Piquette-Miller M. (2007). Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis. Br J Pharmacol 151:367–376.
  • Thomas C, Auwerx J, Schoonjans K. (2008). Bile acids and the membrane bile acid receptor TGR5 connecting nutrition and metabolism. Thyroid 18:167–174.
  • Thomas C, Gioiello A, Noriega L, et al. (2009). TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab 10:167–177.
  • Tomer G, Shneider BL. (2003). Disorders of bile formation and biliary transport. Gastroenterol Clin North Am 32:839–855, vi.
  • Toscano E, Cotta J, Robles M, et al. (2010). Hepatotoxicity induced by new immunosuppressants. Gastroenterol Hepatol 33:54–65.
  • Trauner M, Claudel T, Fickert P, et al. (2010). Bile acids as regulators of hepatic lipid and glucose metabolism. Dig Dis 28:220–224.
  • Trauner M, Fickert P, Zollner G. (2001). Genetic disorders and molecular mechanisms in cholestatic liver disease – A clinical approach. Semin Gastrointest Dis 12:66–88.
  • Trauner M, Wagner M, Fickert P, Zollner G. (2005). Molecular regulation of hepatobiliary transport systems: Clinical implications for understanding and treating cholestasis. J Clin Gastroenterol 39:S111–S124.
  • Tripathi KD. (2013). Introduction, routes of drug administration. In: Tripathi KD, ed. Essentials of medical pharmacology. New Delhi, India: Jaypee Publishers, 3–6.
  • Tsai TH, Huang CT, Shum AY, Chen CF. (1999). Simultaneous blood and biliary sampling of esculetin by microdialysis in the rat. Life Sci 65:1647–1655.
  • Tse FL, Ballard F, Jaffe JM. (1982). A practical method for monitoring drug excretion and enterohepatic circulation in the rat. J Pharmacol Methods 7:139–144.
  • Tubic M, Wagner D, Spahn-Langguth H, et al. (2006). Effects of controlled-release on the pharmacokinetics and absorption characteristics of a compound undergoing intestinal efflux in humans. Eur J Pharm Sci 29:231–239.
  • Tvrdonova M, Dedik L, Mircioiu C, et al. (2009). Physiologically motivated time-delay model to account for mechanisms underlying enterohepatic circulation of piroxicam in human beings. Basic Clin Pharmacol Toxicol 104:35–42.
  • Van Den Broek MP, Groenendaal F, Egberts AC, Rademaker CM. (2010). Effects of hypothermia on pharmacokinetics and pharmacodynamics: A systematic review of preclinical and clinical studies. Clin Pharmacokinet 49:277–294.
  • Van Hest RM, Van Gelder T, Vulto AG, et al. (2009). Pharmacokinetic modelling of the plasma protein binding of mycophenolic acid in renal transplant recipients. Clin Pharmacokinet 48:463–476.
  • Van Wijk H, Donachie P, Mann DL, et al. (2001). A novel bile duct cannulation method with tail cuff exteriorization allowing continuous intravenous infusion and enterohepatic recirculation in the unrestrained rat. Lab Anim 35:325–333.
  • Varma MV, Lai Y, Kimoto E, et al. (2013). Mechanistic modeling to predict the transporter- and enzyme-mediated drug-drug interactions of repaglinide. Pharm Res 30:1188–1199.
  • Verbeeck RK. (2008). Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction. Eur J Clin Pharmacol 64:1147–1161.
  • Veronese L, Rautaureau J, Sadler BM, et al. (2000). Single-dose pharmacokinetics of amprenavir, a human immunodeficiency virus type 1 protease inhibitor, in subjects with normal or impaired hepatic function. Antimicrob Agents Chemother 44:821–826.
  • Vonk RJ, Kneepkens CM, Havinga R, et al. (1986). Enterohepatic circulation in man. A simple method for the determination of duodenal bile acids. J Lipid Res 27:901–904.
  • Vonk RJ, Van Doorn AB, Strubbe JH. (1978). Bile secretion and bile composition in the freely moving, unanaesthetized rat with a permanent biliary drainage: Influence of food intake on bile flow. Clin Sci Mol Med 55:253–259.
  • Vuoristo M, Miettinen TA. (1985). Increased biliary lipid secretion in celiac disease. Gastroenterology 88:134–142.
  • Wajima T, Yano Y, Oguma T. (2002). A pharmacokinetic model for analysis of drug disposition profiles undergoing enterohepatic circulation. J Pharm Pharmacol 54:929–934.
  • Walkenstein SS, Dubb JW, Randolph WC, et al. (1978). Bioavailability of cimetidine in man. Gastroenterology 74:360–365.
  • Wallace JL. (2012). NSAID gastropathy and enteropathy: Distinct pathogenesis likely necessitates distinct prevention strategies. Br J Pharmacol 165:67–74.
  • Wang Y, Roy A, Sun L, Lau CE. (1999). A double-peak phenomenon in the pharmacokinetics of alprazolam after oral administration. Drug Metab Dispos 27:855–859.
  • Wang YM, Reuning RH. (1994). A comparison of two surgical techniques for preparation of rats with chronic bile duct cannulae for the investigation of enterohepatic circulation. Lab Anim Sci 44:479–485.
  • Watanabe T, Suzuki H, Sawada Y, et al. (1995). Induction of hepatic P-glycoprotein enhances biliary excretion of vincristine in rats. J Hepatol 23:440–448.
  • Watanabe T, Kusuhara H, Maeda K, et al. (2008). Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans. J Pharmacol Exp Ther 23:440–448.
  • Webborn PJ, Parker AJ, Denton RL, Riley RJ. (2007). In vitro-in vivo extrapolation of hepatic clearance involving active uptake: Theoretical and experimental aspects. Xenobiotica 37:1090–1109.
  • Wenzel E, Somoza V. (2005). Metabolism and bioavailability of trans-resveratrol. Mol Nutr Food Res 49:472–481.
  • West WL, Cheatham LR, Gaillard ET, Wright M. (2002). A chronic bile duct and intravenous cannulation model in conscious rabbits for pharmacokinetic studies. J Invest Surg 15:81–89.
  • Westphal JF, Brogard JM, Caro-Sampara F, et al. (1997). Assessment of biliary excretion of piperacillin-tazobactam in humans. Antimicrob Agents Chemother 41:1636–1640.
  • Wigg AJ, Barritt GJ, Young GP, Phillips JW. (2009). Inhibition of oxidative stress and apoptosis enables extended maintenance of integrity and function of isolated hepatocytes in suspension. J Gastroenterol Hepatol 24:1082–1088.
  • Williams RT, Millburn P, Smith RL. (1965). The influence of enterohepatic circulation on toxicity of drugs. Ann NY Acad Sci 123:110–124.
  • Wilson CG. (2000). Gastrointestinal transit and drug absorption. In: Dressman JB, Lennernäs H, eds. Oral drug absorption: Prediction and assessment. New York: Marcel Decker, Inc., 1–17.
  • Wolkoff AW, Samuelson AC, Johansen KL, et al. (1987). Influence of Cl- on organic anion transport in short-term cultured rat hepatocytes and isolated perfused rat liver. J Clin Invest 79:1259–1268.
  • Xie R, Mathijssen RH, Sparreboom A, et al. (2002). Clinical pharmacokinetics of irinotecan and its metabolites in relation with diarrhea. Clin Pharmacol Ther 72:265–275.
  • Xing J, Chen X, Zhong D. (2005). Absorption and enterohepatic circulation of baicalin in rats. Life Sci 78:140–146.
  • Xu R, Wang Q, Zhang J, et al. (2014). Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat. Xenobiotica 44:541–546.
  • Yabe Y, Galetin A, Houston JB. (2011). Kinetic characterization of rat hepatic uptake of 16 actively transported drugs. Drug Metab Dispos 39:1808–1814.
  • Yabuuchi H, Tanaka K, Maeda M, et al. (2008). Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins. Biopharm Drug Dispos 29:441–448.
  • Yamaguchi T, Oida T, Ikeda C, Sekine Y. (1986). Intestinal absorption of a beta-adrenergic blocking agent nadolol. III. Nuclear magnetic resonance spectroscopic study on nadolol-sodium cholate micellar complex and intestinal absorption of nadolol derivatives in rats. Chem Pharm Bull (Tokyo) 34:4259–4264.
  • Yamamoto S, Kubota Y, Takaoka M, et al. (2002). The effect of biliary decompression on antibiotic biliary excretion. Hepatogastroenterology 49:330–334.
  • Yamazaki M, Suzuki H, Sugiyama Y. (1996). Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics. Pharm Res 13:497–513.
  • Yeomans ND, Vajda FJ, Baldas J. (1982). Bioavailability of valproate after gastric and direct intestinal administration in rats. Clin Exp Pharmacol Physiol 9:173–177.
  • Yoshida K, Maeda K, Sugiyama Y. (2013). Hepatic and intestinal drug transporters: Prediction of pharmacokinetic effects caused by drug-drug interactions and genetic polymorphisms. Annu Rev Pharmacol Toxicol 53:581–612.
  • Younis IR, Malone S, Friedman HS, et al. (2009). Enterohepatic recirculation model of irinotecan (CPT-11) and metabolite pharmacokinetics in patients with glioma. Cancer Chemother Pharmacol 63:517–524.
  • Yu L, Hammer RE, Li-Hawkins J, et al. (2002). Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci USA 99:16237–16242.
  • Zhang YK, Guo GL, Klaassen CD. (2011). Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters. PLoS One 6:e16683.
  • Zhou HW, Shen JQ, Lu M, et al. (1992). Pharmacokinetic analysis of enterohepatic circulation of piroxicam in rabbits. Zhongguo Yao Li Xue Bao 13:180–182.
  • Zucker SD, Goessling W, Gollan JL. (1996). Intracellular transport of small hydrophobic compounds by the hepatocyte. Semin Liver Dis 16:159–167.

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