Benzodiazepine Kinetics: Implications for Therapeutics and Pharmacogeriatrics

References

• Tallman J. F., Paul S. M., Skolnick P., Gallagher D. W. Receptors for the age of anxiety: Pharmacology of the benzodiazepines. Science 1980; 207: 274–281
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Shader R. I., Harmatz J. S., Franke K., Koch-Weser J. Absorption rate, blood concentrations, and early response to oral chlordiazepoxide. Am. J. Psychiatry 1977; 134: 559–562
   PubMed Web of Science ®Google Scholar
• Shader R. I., Georgotas A., Greenblatt D. J., Harmatz J. S., Allen M. D. Impaired absorption of desmethyldiazepam from clorazepate by magnesium aluminum hydroxide. Clin. Pharmacol. Ther. 1978; 24: 308–315
   PubMed Web of Science ®Google Scholar
• Bliding A. Effect of different rates of absorption of two benzodiazepins ‘sic’ on subjective and objective parameters. Eur. J. Clin. Pharmacol. 1974; 7: 201–211
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Shader R. I., Harmatz J. S., Franke K., Koch-Weser J. Influence of magnesium and aluminum hydroxide mixture on chlordiazepoxide absorption. Clin. Pharmacol. Ther. 1976; 19: 234–239
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Allen M. D., MacLaughlin D. S., Harmatz J. S., Shader R. I. Diazepam absorption: Effect of antacids and food. Clin. Pharmacol. Ther. 1978; 24: 600–609
   PubMed Web of Science ®Google Scholar
• Divoll M., Greenblatt D. J., Ciraulo D. A., Puri S. K., Ho I., Shader R. I. Clobazam kinetics: Intra-sub-ject variability, and effect of food on absorption. J. Ciin. Pharmacol. 1982; 22: 69–73
   Web of Science ®Google Scholar
• Ameer B., Greenblatt D. J. Lorazepam: A review of its clinical pharmacological properties and therapeutic uses. Drugs 1981; 21: 161–200
   Web of Science ®Google Scholar
• Mandelli M., Tognoni G., Garattini S. Clinical pharmacokinetics of diazepam. Clin. Pharmacokinet. 1978; 3: 72–91
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J. Clinical pharmacokinetics of oxazepam and lorazepam, Ciin. Pharmacokinet. 1981; 6: 89–105
   PubMed Web of Science ®Google Scholar
• Allen M. D., Greenblatt D. J., Arnold J. D. Single and multiple dose kinetics of estazolam, a triazolo benzodiazepine. Psychopharmacology 1979; 66: 267–274
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Locniskar A., Ochs H. R., Lauven P. M. Automated gas chromatography for studies of midazolam pharmacokinetics. Anesthesiology 1981; 55: 176–179
   PubMed Web of Science ®Google Scholar
• Smith M. T., Eadie M. J., Brophy T. O. The pharmacokinetics of midazolam in man. Eur. J. Clin. Pharmacol. 1981; 19: 271–278
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Shader R. I., MacLeod S. M., Sellers E. M. Clinical pharmacokinetics of chlordiazepoxide. Clin. Pharmacokinet. 1978; 3: 381–394
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Laughren T. P., Allen M. D., Harmatz J. S., Shader R. I. Plasma diazepam and desmethyldiazepam concentrations during long-term diazepam therapy. Br. J. Clin. Pharmacol. 1981; 11: 35–40
   PubMed Web of Science ®Google Scholar
• Tyrer P., Rutherford D., Huggett T. Benzodiazepine withdrawal symptoms and propranolol. Lancet 1981; 1: 520–522
   PubMed Web of Science ®Google Scholar
• Brodie R. R., Chasseaud L. F., Taylor T. Concentrations of N-descyclopropylmethylprazepam in whole-blood, plasma, and milk after administration of prazepam to humans. Biopharm. Drug Dispos. 1981; 2: 59–68
   PubMed Web of Science ®Google Scholar
• Allen M. D., Greenblatt D. J., Harmatz J. S., Shader R. I. Desmethyldiazepam kinetics in the elderly after oral prazepam. Clin. Pharmacol. Ther. 1980; 28: 196–202
   PubMed Web of Science ®Google Scholar
• Allen M. D., Greenblatt D. J., Harmatz J. S., Shader R. I. Single-dose kinetics of prazepam, a precursor of desmethyldiazepam. J. Clin. Pharmacol. 1979; 19: 445–450
   PubMed Web of Science ®Google Scholar
• Smith M. T., Evans L. E. J., Eadie M. J., Tyrer J. H. Pharmacokinetics of prazepam in man. Eur. J. Clin. Pharmacol. 1979; 16: 141–147
   PubMed Web of Science ®Google Scholar
• Abruzzo C. W., Macasieb T., Weinfeld R., Rider J. A., Kaplan S. A. Changes in oral absorption characteristics in man of dipotassium clorazepate at normal and elevated gastric pH. J. Pharmacokinet. Biopharm. 1977; 5: 377–390
   PubMedGoogle Scholar
• Shader R. I., Greenblatt D. J. Clinical implications of benzodiazepine pharmacokinetics. Am. J. Psychiatry 1977; 134: 652–656
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Shader R. I., Koch-Weser J. Flurazepam hydrochloride, a benzodiazepine hypnotic. Ann. Intern. Med. 1975; 83: 237–241
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Shader R. I., Koch-Weser J. Flurazepam hydrochloride. Clin. Pharmacol. Ther. 1975; 17: 1–14
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Divoll M., Harmatz J. S., MacLaughlin D. S., Shader R. I. Kinetics and clinical effects of flurazepam in young and elderly noninsom-niacs. Clin. Pharmacol. Ther. 1981; 30: 475–486
   PubMed Web of Science ®Google Scholar
• Miwa B. J., Garland W. A., Blumenthal P. Determination of flurazepam in human plasma by gas chromatography-electron capture negative chemical ionization mass spectrometry. Anal. Chem. 1981; 53: 793–797
   PubMed Web of Science ®Google Scholar
• Glover W., Earley J., Delaney M., Dixon R. Radioimmunoassay of flurazepam in human plasma. J. Pharm. Sci. 1980; 69: 601–602
   PubMed Web of Science ®Google Scholar
• Oswald I., Adam K., Borrow S., Idzikowski C. The effects of two hypnotics on sleep, subjective feelings and skilled performance. Pharmacology of the States of Alertness, P. Passouant, I. Oswald. Pergamon Press, Oxford and London 1979
   Google Scholar
• Church M. W., Johnson L. C. Mood and performance of poor sleepers during repeated use of flurazepam. Psychopharmacology 1979; 61: 309–316
   PubMed Web of Science ®Google Scholar
• Salkind M. R., Silverstone T. A clinical and psychometric evaluation of flurazepam. Br. J. Clin. Pharmacol. 1975; 2: 233–236
   PubMedGoogle Scholar
• Oswald I. The why and how of hypnotic drugs. Br. Med. J. 1979; 1: 1167–1168
   PubMed Web of Science ®Google Scholar
• Kales A., Scharf M. B., Kales J. D. Rebound insomnia: A new clinical syndrome. Science 1978; 201: 1039–1041
   PubMed Web of Science ®Google Scholar
• Kales A., Scharf M. B., Kales J. D., Soldatos C. R. Rebound insomnia: A potential hazard following withdrawal of certain benzodiazepines. J. Am. Med. Assoc 1979; 241: 1692–1695
   PubMed Web of Science ®Google Scholar
• Hartse K. M., Roth T., Piccione P. M., Zorick F. J. Rebound insomnia, Science 1980; 208: 423–424
   Google Scholar
• Nicholson A. N. Hypnotics: Rebound insomnia and residual sequelae. Br. J. Clin. Pharmacol. 1980; 9: 223–225
   PubMed Web of Science ®Google Scholar
• Eberts F. S., Philopoulos Y., Reineke L. M., Vliek R. W. Triazolam disposition. Clin. Pharmacol. Ther. 1981; 29: 81–93
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Divoll M., Moschitto L. J., Shader R. I. Electron-capture gas chromatographic analysis of the triazolobenzodiazepines alprazolam and triazolam, J. Chromatogr. 1981; 225: 202–207
   Google Scholar
• Cohn J. B. Multicenter double-blind efficacy and safety study comparing alprazolam, diazepam and placebo in clinically anxious patients. J. Clin. Psychiatry 1981; 42: 347–351
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Divoll M., Harmatz J. S., Shader R. I. Oxazepam kinetics: Effects of age and sex. J. Pharmacol. Exp. Ther. 1980; 215: 86–91
   PubMed Web of Science ®Google Scholar
• Divoll M., Greenblatt D. J., Harmatz J. S., Shader R. I. Effect of age and gender on disposition of tem-azepam. J. Pharm. Sci. 1981; 70: 1104–1107
   PubMed Web of Science ®Google Scholar
• Boston Collaborative Drug Surveillance Program. Clinical depression of the central nervous system due to diazepam and chlordiazepoxide in relation to cigarette smoking and age. N. Engl. J. Med. 1973; 288: 277–280
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Allen M. D., Shader R. I. Toxicity of high-dose flurazepam in the elderly. Clin. Pharmacol. Ther. 1977; 21: 355–361
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Allen M. D. Toxicity of nitrazepam in the elderly: A report from the Boston Collaborative Drug Surveillance Program. Br. J. Clin. Pharmacol. 1978; 5: 407–413
   PubMed Web of Science ®Google Scholar
• Castleden C. M., George C. F., Marcer D., Hallett C. Increased sensitivity to nitrazepam in old age. Br. Med. J. 1977; 1: 10–12
   PubMed Web of Science ®Google Scholar
• Reidenberg M. M., Levy M., Warner H., Coutinho C. B., Schwartz M. A., Yu G., Cheripko J. Relationship between diazepam dose, plasma level, age, and central nervous system depression. Clin. Pharmacol. Ther. 1978; 23: 371–374
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Shader R. I. Effects of age and other drugs on benzodiazepine kinetics. Arzneim. For sen. 1980; 30: 886–890
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Divoll M., Abernethy D. R., Harmatz J. S., Shader R. I. Antipyrine kinetics in the elderly: Prediction of age-related changes in benzodiazepine oxidizing capacity. J. Pharmacol. Exp. Ther. 1982; 220: 120–126
   PubMed Web of Science ®Google Scholar
• Abernethy D. R., Greenblatt D. J. Impairment of antipyrine metabolism by low-dose oral contraceptive steroids. Clin. Pharmacol. Ther. 1981; 29: 106–110
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Allen M. D., Harmatz J. S., Shader R. I. Diazepam disposition determinants. Clin. Pharmacol. Ther. 1980; 27: 301–312
   PubMed Web of Science ®Google Scholar
• Macklon A. F., Barton M., James O., Rawlins M. D. The effect of age on the pharmacokinetics of diazepam. Clin. Sci. 1980; 59: 479–483
   PubMed Web of Science ®Google Scholar
• Kanto J., Maenpaa M., Mantyla R., Sellman R., Valovirta E. Effect of age on the pharmacokinetics of diazepam given in conjunction with spinal anesthesia. Anesthesiology 1979; 51: 154–159
   PubMed Web of Science ®Google Scholar
• Ochs H. R., Greenblatt D. J., Divoll M., Abernethy D. R., Feyerabend H., Dengler H. J. Diazepam kinetics in relation to age and sex. Pharmacology 1981; 23: 24–30
   PubMed Web of Science ®Google Scholar
• Klotz U., Avant G. R., Hoyumpa A., Schenker S., Wilkinson G. R. The effects of age and liver disease on the disposition and elimination of diazepam in adult man. J. Clin. Invest 1975; 55: 347–359
   PubMed Web of Science ®Google Scholar
• Abernethy D. R., Greenblatt D. J., Divoll M., Harmatz J. S., Shader R. I. Alterations in drug distribution and clearance due to obesity. J. Pharmacol. Exp. Ther. 1981; 217: 681–685
   PubMed Web of Science ®Google Scholar
• MacLeod S. M., Giles H. G., Bengert B., Liu F. F., Sellers E. M. Age- and gender-related differences in diazepam pharmacokinetics. J. Clin. Pharmacol. 1979; 19: 15–19
   PubMed Web of Science ®Google Scholar
• Roberts R. K., Wilkinson G. R., Branch R. A., Schenker S. Effect of age and parenchymal liver disease on the disposition and elimination of chlordiazepoxide (Librium). Gastroenterology 1978; 75: 479–485
   PubMed Web of Science ®Google Scholar
• Shader R. I., Greenblatt D. J., Harmatz J. S., Franke K., Koch-Weser J. Absorption and disposition of chlordi-azepoxide in young and elderly male volunteers. J. Clin. Pharmacol. 1977; 17: 709–718
   PubMed Web of Science ®Google Scholar
• Klotz U., Muller-Seydlitz P. Altered elimination of des-methyldiazepam in the elderly. Br. J. Clin. Pharmacol. 1979; 7: 119–120
   PubMed Web of Science ®Google Scholar
• Shader R. I., Greenblatt D. J., Ciraulo D. A., Divoll M., Harmatz J. S., Georgotas A. Effect of age and sex on disposition of desmethyldiazepam formed from its precursor clorazepate. Psychopharmacology 1981; 75: 193–197
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Divoll M., Puri S. K., Ho I., Zinny M. A., Shader R. I. Clobazam kinetics in the elderly. Br. J. Clin. Pharmacol. 1981; 12: 631–636
   PubMed Web of Science ®Google Scholar
• Moschitto L. J., Greenblatt D. J., Divoll M., Aber-nethy D. R., Smith R. B., Shader R. I. Alprazolam kinetics in the elderly: Relation to antipyrine disposition. Clin. Pharmacol. Ther. 1981; 29: 267, (abstract)
   Web of Science ®Google Scholar
• Shull H. J., Wilkinson G. R., Johnson R., Schenker S. Normal disposition of oxazepam in acute viral hepatitis and cirrhosis. Ann. Intern. Med. 1976; 84: 420–425
   PubMed Web of Science ®Google Scholar
• Ochs H. R., Greenblatt D. J., Otten H. Disposition of oxazepam in relation to age, sex, and cigarette smoking, Klin. Wochenschr. 1981; 59: 899–903
   PubMedGoogle Scholar
• Greenblatt D. J., Allen M. D., Locniskar A., Harmatz J. S., Shader R. I. Lorazepam kinetics in the elderly. Clin. Pharmacol. Ther. 1979; 26: 103–113
   PubMed Web of Science ®Google Scholar
• Kraus J. W., Desmond P. V., Marshall J. P., Johnson R. F., Schenker S., Wilkinson G. R. Effects of aging and liver disease on disposition of lorazepam. Clin. Pharmacol. Ther. 1978; 24: 411–419
   PubMed Web of Science ®Google Scholar
• Kangas L., lisalo E., Kanto J., Lehtinen V., Pynnonen S., Ruikka I., Salminen J., Sillanpaa M. Human pharmacokinetics of nitrazepam: Effect of age and diseases. Eur. J. Clin. Pharmacol. 1979; 15: 163–170
   PubMed Web of Science ®Google Scholar