134
Views
10
CrossRef citations to date
0
Altmetric
Original Article

Formulation-based approach to support early drug discovery and development efforts: a case study with enteric microencapsulation dosage form development for a triarylmethane derivative TRAM-34; a novel potential immunosuppressant

, , , , , & show all
Pages 563-569 | Received 25 Jun 2009, Accepted 10 Sep 2009, Published online: 24 Nov 2009

References

  • Caldwell GW, Ritchie DM, Masucci JA, Hageman W, Yan Z. (2001). The new pre-preclinical paradigm: Compound optimization in early and late phase drug discovery. Curr Top Med Chem, 1:353–66.
  • Li P, Zhao L. (2007). Developing early formulations: Practice and perspective. Int J Pharm, 341:1–19.
  • Jensen BS, Hertz M, Christophersen P, Madsen LS. (2002). The Ca2+-activated K+ channel of intermediate conductance: A possible target for immune suppression. Expert Opin Ther Targets, 6:623–36.
  • Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, . (2000). Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. J Biol Chem, 275:37137–49.
  • Wulff H, Calabresi PA, Allie R, Yun S, Pennington M, Beeton C, . (2003). The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS. J Clin Invest, 111:1703–13.
  • Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG. (2000). Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: A potential immunosuppressant. Proc Natl Acad Sci USA, 97:8151–6.
  • Deasy PB. (1984). Drugs and the pharmaceutical sciences: Microencapsulation and related drug processes. New York: Marcel Dekker.
  • Dong W, Bodmeier R. (2006). Encapsulation of lipophilic drugs within enteric microparticles by a novel coacervation method. Int J Pharm, 326:128–38.
  • Wahlstrom JL, Chiang P, Ghosh S, Warren CJ, Wene SP, Albin LA, . (2007). Pharmacokinetic evaluation of a 1,3-dicyclohexylurea nanosuspension formulation to support early efficacy assessment. Nanoscal Res Lett, 2:291–6.
  • Burgess DJ. (2005). Injectable dispersed systems: Formulation, processing, and performance. Boca Raton: Taylor & Francis.
  • Barton AFM. (1983). CRC handbook of solubility parameters and other cohesion parameters. Florida: CRC Press Inc.
  • Ashford M, Fell JT. (1994). Targeting drugs to the colon: Delivery systems for oral administration. J Drug Target, 2:241–57.
  • Amorim MJ, Ferreira JP. (2001). Microparticles for delivering therapeutic peptides and proteins to the lumen of the small intestine. Eur J Pharm Biopharm, 52:39–44.
  • Dong WY, Maincent P, Bodmeier R. (2007). In vitro and in vivo evaluation of carbamazepine-loaded enteric microparticles. Int J Pharm, 331:84–92.
  • Wils P, Warnery A, Phung-Ba V, Legrain S, Scherman D. (1994). High lipophilicity decreases drug transport across intestinal epithelial cells. J Pharmacol Exp Ther, 269:654–8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.