Investigation of the effect of impeller speed on granules formed using a PMA-1 high shear granulator

References

• Rubino OP. (1999). Fluid-bed technology: overview and criteria for process selection. Pharm Tech, 23:104–113.
   Google Scholar
• Tousey MD. (2002). The granulation process 101: basic technologies for tablet making. Pharm. Tech, 8–13.
   Google Scholar
• Luukkonen P, Fransson M, Björn IN, Hautala J, Lagerholm B, Folestad S. (2008). Real-Time assessment of granule and tablet properties using in-line data from a high-shear granulation process. J Pharm Sci, 97:950–959.
   PubMed Web of Science ®Google Scholar
• Lindberg NO, Jönsson C. (1985). The granulation of lactose and starch in a recording high-speed mixer, Diosna P25. Drug Dev Ind Pharm, 11:387–403.
   Web of Science ®Google Scholar
• Chitu TM, Oulahna D, Hemati M. (2011). Wet granulation in laboratory-scale high shear mixers: effect of chopper presence, design and impeller speed. Powder Tech, 206:34–43.
   Web of Science ®Google Scholar
• Ma H, Andrews GP, Jones DS, Walker GM. (2010). Low shear granulation of pharmaceutical powders: effect of formulation on granulation and tablet properties. Chem Eng J, 164:442–448.
   Web of Science ®Google Scholar
• Saska Zs, Dredan, J, Luhn O, Balogh E, Shafir G, Antal I. (2011). Evaluation of the impact of mixing speed on the compressibility and compactability of paracetamol-isomalt containing granules with factorial design. Powder Tech, 213:132–140.
   Web of Science ®Google Scholar
• Ramaker JS, Albada Jelgersma M, Vonk P, Kossen NWF. (1998). Scale-down of a high-shear pelletisation process: flow profile and growth kinetics. Int J Pharm, 166:89–97.
   Web of Science ®Google Scholar
• Ohno I, Hasegawa S, Yada S, Kusai A, Moribe K, Yamamoto K. (2007). Importance of evaluating the consolidation of granules manufactured by high shear mixer. Int J Pharm, 338:79–86.
   PubMedGoogle Scholar
• Miyamoto Y, Ogawa S, Miyajima M, Sato H, Takayama K, Nagai T. (1995). An evaluation of process variables in wet granulation. Drug Dev Ind Pharm, 21:2213–2225.
   Web of Science ®Google Scholar
• Benali M, Gerbaud V, Hemati M. (2009). Effect of operating conditions and physico-chemical properties on the wet granulation kinetics in a high shear mixer. Powder Tech, 190:160–169.
   Web of Science ®Google Scholar
• Van den Dries K, de Vegt OM, Girard V, Vromaus H. (2003). Granule breakage phenomena in a high shear mixer; influence of process and formulation variables and consequences on granule homogeneity. Powder Tech, 133:228–236.
   Web of Science ®Google Scholar
• Mangwandi C, Adams MJ, Hounslow MJ, Salman AD. (2010). Effect of impeller speed on mechanical and dissolution properties of high-shear granules. Chem Eng J, 164:305–315.
   Web of Science ®Google Scholar
• Wang S, Ye G, Heng PW, Ma M. (2008). Investigation of high shear wet granulation processes using different parameters and formulations. Chem Pharm Bull, 56:22–27.
   PubMed Web of Science ®Google Scholar
• Oulahna D, Cordier F, Galet L, Dodds JA. (2003). Wet granulation: the effect of shear on granule properties. Powder Tech, 130:238–246.
   Web of Science ®Google Scholar
• Bock TK, Kraas U. (2001). Experience with the Diosna mini-granulator and assessment of process scalability. Eur J Pharm Biopharm, 52:297–303.
   PubMed Web of Science ®Google Scholar
• Rahmanian N, Ghadiri M, Jia X, Stepanek F. (2009). Characterization of granule structure and strength made in a high shear granulator. Powder Tech, 192:184–194.
   Web of Science ®Google Scholar
• Guo Z, Ma M, Hao Y, Jiang T, Wang S. (2011). An investigation on the correlation between drug dissolution properties and the growth behaviour of granules in high shear mixer. J Pharm Pharmacol, 63:1548–1558.
   PubMed Web of Science ®Google Scholar
• Badawy SI, Menning MM, Gorko MA, Gilbert DL. (2000). Effect of process parameters on compressibility of granulation manufactured in a high-shear mixer. Int J Pharm, 198:51–61.
   PubMed Web of Science ®Google Scholar
• Kiekens F, Córdoba-Díaz M, Remon JP. (1999). Influence of chopper and mixer speeds and microwave power level during the high-shear granulation process on the final granule characteristics. Drug Dev Ind Pharm, 25:1289–1293.
   PubMed Web of Science ®Google Scholar
• Rahmanian N, Ghadiri M, Ding Y. (2008). Effect of scale of operation in granule strength in high shear granulators. Chem Eng Sci, 63:915–923.
   Web of Science ®Google Scholar
• Alkhatib A, Briens, L. (2011). Influence of initial mixing on granule properties. 5th International Granulation Workshop, Lausanne, Switzerland.
   Google Scholar
• Litster JD, Hapgood KP, Michaels JN, Sims A, Roberst M, Kameneni K. (2002). Scale-up of mixer granulators for effective liquid distribution. Powder Tech, 124:272–280.
   Web of Science ®Google Scholar
• Betz G, Bürgin PJ, Leuenberger H. (2004). Power consumption measurement and temperature recording during granulation. Int J Pharm, 272:137–149.
   PubMedGoogle Scholar
• Abdullah EC, Geldart, D. (1999). The use of bulk density measurements as flowability indicators. Powder Tech, 102:151–65.
   Web of Science ®Google Scholar
• Carr RE. (1965). Fundus Flavimaculatus. Arch Ophthalmol, 74:163–168.
   PubMed Web of Science ®Google Scholar
• Nagel KM, Peck GE. (2003). Investigating the effects of excipients on the powder flow characteristics of theophylline anhydrous powder formulations. Drug Dev Ind Pharm, 29:277–287.
   PubMed Web of Science ®Google Scholar
• Chik Z, Vallejo LE. (2005). Characterization of the angle of repose of binary granular materials. Can Geotec J, 42:683–692.
   Web of Science ®Google Scholar
• Wouters IMF, Geldart D. (1996). Characterizing semi-cohesive powders using angle of repose. Part Part Syst Charact, 13:254–259.
   Web of Science ®Google Scholar
• Emery E, Oliver J, Pugsley T, Sharma J, Zhou J. (2009). Flowability of moist pharmaceutical powders. Powder Tech, 189:409–415.
   Web of Science ®Google Scholar